Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Regulation of actin cytoskeleton 💬
1件: BDKRB2 💬 Deucrictibant 💬 Deucrictibant 1件: 65 💬
2 Regulation of actin cytoskeleton 💬
1件: BDKRB2 💬 Icatibant acetate 💬 Icatibant 1件: 65 💬
3 Regulation of actin cytoskeleton 💬
1件: BRAF 💬 Dabrafenib 💬 Dabrafenib 1件: 34 💬
4 Regulation of actin cytoskeleton 💬
1件: BRAF 💬 Dabrafenib mesylate 💬 Dabrafenib 1件: 34 💬
5 Regulation of actin cytoskeleton 💬
3件: BRAF, PDGFRB, RAF1 💬 Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
6 Regulation of actin cytoskeleton 💬
3件: BRAF, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬
7 Regulation of actin cytoskeleton 💬
1件: C5 💬 Avacincaptad pegol sodium 💬 Avacincaptad pegol 1件: 301 💬
8 Regulation of actin cytoskeleton 💬
1件: C5 💬 Crovalimab 💬 Crovalimab 2件: 62, 109 💬
9 Regulation of actin cytoskeleton 💬
1件: C5 💬 Eculizumab 💬 Eculizumab 8件: 11, 13, 14, 61, 62, 109, 221, 222 💬
10 Regulation of actin cytoskeleton 💬
1件: C5 💬 Gefurulimab 💬 Gefurulimab 1件: 11 💬
11 Regulation of actin cytoskeleton 💬
1件: C5 💬 Nomacopan 💬 Nomacopan 3件: 62, 109, 162 💬
12 Regulation of actin cytoskeleton 💬
1件: C5 💬 Pozelimab 💬 Pozelimab 3件: 11, 15, 62 💬
13 Regulation of actin cytoskeleton 💬
1件: C5 💬 Ravulizumab 💬 Ravulizumab 7件:  2 , 11, 13, 50, 62, 66, 109 💬
14 Regulation of actin cytoskeleton 💬
1件: C5 💬 Vilobelimab 💬 Vilobelimab 3件: 43, 44, 269 💬
15 Regulation of actin cytoskeleton 💬
1件: C5 💬 Zilucoplan sodium 💬 Zilucoplan 2件: 11, 62 💬
16 Regulation of actin cytoskeleton 💬
1件: C5 💬 Zilucoplan 💬 Zilucoplan 2件: 11, 62 💬
17 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Atropine 💬 Atropine 1件: 299 💬
18 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Atropine sulfate 💬 Atropine 1件: 299 💬
19 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Bethanechol chloride 💬 Bethanechol 1件: 98 💬
20 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Blarcamesine 💬 Blarcamesine 2件:  6 , 156 💬
21 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Blarcamesine hydrochloride 💬 Blarcamesine 2件:  6 , 156 💬
22 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Chlorpromazine 💬 Chlorpromazine 1件: 254 💬
23 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Chlorpromazine hydrochloride 💬 Chlorpromazine 1件: 254 💬
24 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Glycopyrronium tosylate 💬 Glycopyrronium 2件:  6 , 34 💬
25 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Methacholine chloride 💬 Methacholine 1件: 96 💬
26 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Oxybutynin 💬 Oxybutynin 3件:  6 , 13, 53 💬
27 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Oxybutynin chloride 💬 Oxybutynin 3件:  6 , 13, 53 💬
28 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Propantheline bromide 💬 Propantheline 1件: 26 💬
29 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Propiverine hydrochloride 💬 Propiverine 1件: 226 💬
30 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Propiverine 💬 Propiverine 1件: 226 💬
31 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Rocuronium bromide 💬 Rocuronium 2件: 70, 296 💬
32 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Scopolamine 💬 Scopolamine 1件:  2  💬
33 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Trihexyphenidyl hydrochloride 💬 Trihexyphenidyl 2件:  5 ,  6  💬
34 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Trihexyphenidyl 💬 Trihexyphenidyl 2件:  5 ,  6  💬
35 Regulation of actin cytoskeleton 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Tropicamide 💬 Tropicamide 1件: 19 💬
36 Regulation of actin cytoskeleton 💬
2件: CHRM2, CHRM3 💬 Fesoterodine 💬 Fesoterodine 1件:  6  💬
37 Regulation of actin cytoskeleton 💬
2件: CHRM2, CHRM3 💬 Fesoterodine fumarate 💬 Fesoterodine 1件:  6  💬
38 Regulation of actin cytoskeleton 💬
2件: CHRM2, CHRM3 💬 Pilocarpine 💬 Pilocarpine 3件:  6 , 53, 299 💬
39 Regulation of actin cytoskeleton 💬
2件: CHRM2, CHRM3 💬 Pilocarpine hydrochloride 💬 Pilocarpine 3件:  6 , 53, 299 💬
40 Regulation of actin cytoskeleton 💬
2件: CHRM2, CHRM3 💬 Pilocarpine nitrate 💬 Pilocarpine 3件:  6 , 53, 299 💬
41 Regulation of actin cytoskeleton 💬
1件: CHRM3 💬 Cevimeline hydrochloride 💬 Cevimeline 1件: 53 💬
42 Regulation of actin cytoskeleton 💬
1件: CHRM3 💬 Cevimeline 💬 Cevimeline 1件: 53 💬
43 Regulation of actin cytoskeleton 💬
1件: CHRM3 💬 Darifenacin hydrobromide 💬 Darifenacin 3件:  2 , 13, 26 💬
44 Regulation of actin cytoskeleton 💬
1件: CHRM3 💬 Darifenacin 💬 Darifenacin 3件:  2 , 13, 26 💬
45 Regulation of actin cytoskeleton 💬
1件: CHRM3 💬 Glycopyrrolate 💬 Glycopyrronium 2件:  6 , 34 💬
46 Regulation of actin cytoskeleton 💬
1件: CHRM3 💬 Glycopyrronium 💬 Glycopyrronium 2件:  6 , 34 💬
47 Regulation of actin cytoskeleton 💬
1件: CHRM3 💬 Solifenacin succinate 💬 Solifenacin 2件:  6 , 13 💬
48 Regulation of actin cytoskeleton 💬
1件: CHRM3 💬 Solifenacin 💬 Solifenacin 2件:  6 , 13 💬
49 Regulation of actin cytoskeleton 💬
1件: CHRM3 💬 Tiotropium bromide hydrate 💬 Tiotropium 3件: 55, 85, 299 💬
50 Regulation of actin cytoskeleton 💬
1件: CHRM3 💬 Tolterodine 💬 Tolterodine 1件: 17 💬
51 Regulation of actin cytoskeleton 💬
1件: CHRM3 💬 Tolterodine tartrate 💬 Tolterodine 1件: 17 💬
52 Regulation of actin cytoskeleton 💬
1件: CXCR4 💬 Mavorixafor 💬 Mavorixafor 1件: 65 💬
53 Regulation of actin cytoskeleton 💬
1件: CXCR4 💬 Plerixafor 💬 Plerixafor 5件: 20, 51, 65, 285, 299 💬
54 Regulation of actin cytoskeleton 💬
1件: EGFR 💬 Afatinib 💬 Afatinib 1件: 285 💬
55 Regulation of actin cytoskeleton 💬
1件: EGFR 💬 Afatinib dimaleate 💬 Afatinib 1件: 285 💬
56 Regulation of actin cytoskeleton 💬
1件: EGFR 💬 Cetuximab 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
57 Regulation of actin cytoskeleton 💬
1件: EGFR 💬 Erlotinib hydrochloride 💬 Erlotinib 2件: 94, 160 💬
58 Regulation of actin cytoskeleton 💬
1件: EGFR 💬 Erlotinib 💬 Erlotinib 2件: 94, 160 💬
59 Regulation of actin cytoskeleton 💬
1件: EGFR 💬 Gefitinib 💬 Gefitinib 1件: 75 💬
60 Regulation of actin cytoskeleton 💬
1件: EGFR 💬 Icotinib 💬 Icotinib 1件: 34 💬
61 Regulation of actin cytoskeleton 💬
1件: EGFR 💬 Lapatinib ditosylate 💬 Lapatinib 3件: 34, 74, 75 💬
62 Regulation of actin cytoskeleton 💬
1件: EGFR 💬 Lapatinib 💬 Lapatinib 3件: 34, 74, 75 💬
63 Regulation of actin cytoskeleton 💬
1件: EGFR 💬 Neratinib 💬 Neratinib 1件: 34 💬
64 Regulation of actin cytoskeleton 💬
1件: EGFR 💬 Neratinib maleate 💬 Neratinib 1件: 34 💬
65 Regulation of actin cytoskeleton 💬
1件: EGFR 💬 Tesevatinib 💬 Tesevatinib 1件: 67 💬
66 Regulation of actin cytoskeleton 💬
1件: F2 💬 Dabigatran 💬 Dabigatran 5件: 51, 75, 85, 91, 124 💬
67 Regulation of actin cytoskeleton 💬
1件: F2 💬 Dabigatran etexilate mesylate 💬 Dabigatran etexilate 2件: 51, 75 💬
68 Regulation of actin cytoskeleton 💬
1件: F2 💬 Dabigatran etexilate 💬 Dabigatran etexilate 2件: 51, 75 💬
69 Regulation of actin cytoskeleton 💬
1件: F2 💬 Thrombomodulin alfa 💬 Thrombomodulin Alfa 1件: 85 💬
70 Regulation of actin cytoskeleton 💬
1件: FGF19 💬 Aldafermin 💬 Aldafermin 1件: 94 💬
71 Regulation of actin cytoskeleton 💬
1件: FGF23 💬 Burosumab 💬 Burosumab 1件: 238 💬
72 Regulation of actin cytoskeleton 💬
3件: FGFR1, FGFR2, FGFR3 💬 Infigratinib 💬 Infigratinib 1件: 276 💬
73 Regulation of actin cytoskeleton 💬
3件: FGFR1, FGFR2, FGFR3 💬 Infigratinib phosphate 💬 Infigratinib 1件: 276 💬
74 Regulation of actin cytoskeleton 💬
6件: FGFR1, FGFR2, FGFR3, FGFR4, PDGFRA, PDGFRB 💬 Catequentinib 💬 Anlotinib 1件: 85 💬
75 Regulation of actin cytoskeleton 💬
5件: FGFR1, FGFR2, FGFR3, PDGFRA, PDGFRB 💬 Nintedanib esylate 💬 Nintedanib 7件: 51, 84, 85, 89, 227, 228, 331 💬
76 Regulation of actin cytoskeleton 💬
5件: FGFR1, FGFR2, FGFR3, PDGFRA, PDGFRB 💬 Nintedanib 💬 Nintedanib 7件: 51, 84, 85, 89, 227, 228, 331 💬
77 Regulation of actin cytoskeleton 💬
1件: FGFR2 💬 Palifermin 💬 Palifermin 6件: 13, 36, 38, 39, 65, 96 💬
78 Regulation of actin cytoskeleton 💬
1件: FGFR3 💬 Recifercept 💬 Recifercept 1件: 276 💬
79 Regulation of actin cytoskeleton 💬
1件: ITGA4 💬 Firategrast 💬 Firategrast 1件: 13 💬
80 Regulation of actin cytoskeleton 💬
1件: ITGA4 💬 Natalizumab 💬 Natalizumab 5件: 13, 15, 25, 46, 96 💬
81 Regulation of actin cytoskeleton 💬
3件: ITGA4, ITGB1, ITGB7 💬 Carotegrast methyl 💬 Carotegrast methyl 1件: 97 💬
82 Regulation of actin cytoskeleton 💬
2件: ITGA4, ITGB7 💬 Abrilumab 💬 Abrilumab 2件: 96, 97 💬
83 Regulation of actin cytoskeleton 💬
2件: ITGA4, ITGB7 💬 Vedolizumab 💬 Vedolizumab 3件: 94, 96, 97 💬
84 Regulation of actin cytoskeleton 💬
3件: ITGA5, ITGB1, ITGB6 💬 Bexotegrast 💬 Bexotegrast 1件: 94 💬
85 Regulation of actin cytoskeleton 💬
1件: ITGAL 💬 Anti-human thymocyte immunoglobulin, rabbit 💬 Antithymocyte immunoglobulin (rabbit) 13件: 13, 36, 49, 51, 60, 62, 65, 96, 283, 284, 285, 286, 326 💬
86 Regulation of actin cytoskeleton 💬
1件: ITGAL 💬 Efalizumab 💬 Efalizumab 9件: 11, 13, 37, 46, 53, 61, 95, 96, 221 💬
87 Regulation of actin cytoskeleton 💬
1件: ITGB7 💬 Etrolizumab 💬 Etrolizumab 2件: 96, 97 💬
88 Regulation of actin cytoskeleton 💬
2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
89 Regulation of actin cytoskeleton 💬
2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
90 Regulation of actin cytoskeleton 💬
2件: MAP2K1, MAP2K2 💬 Cobimetinib fumarate 💬 Cobimetinib 1件: 280 💬
91 Regulation of actin cytoskeleton 💬
2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 4件: 34, 278, 279, 280 💬
92 Regulation of actin cytoskeleton 💬
2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
93 Regulation of actin cytoskeleton 💬
2件: MAP2K1, MAP2K2 💬 Selumetinib sulfate 💬 Selumetinib 1件: 34 💬
94 Regulation of actin cytoskeleton 💬
2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
95 Regulation of actin cytoskeleton 💬
2件: MAP2K1, MAP2K2 💬 Trametinib dimethyl sulfoxide 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
96 Regulation of actin cytoskeleton 💬
1件: MYL2 💬 Aficamten 💬 Aficamten 1件: 58 💬
97 Regulation of actin cytoskeleton 💬
1件: PDGFRA 💬 Imatinib mesylate 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
98 Regulation of actin cytoskeleton 💬
1件: PDGFRA 💬 Imatinib 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
99 Regulation of actin cytoskeleton 💬
2件: PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib 5件:  6 ,  8 , 34, 51, 86 💬
100 Regulation of actin cytoskeleton 💬
2件: PDGFRA, PDGFRB 💬 Pazopanib hydrochloride 💬 Pazopanib 1件: 227 💬
101 Regulation of actin cytoskeleton 💬
2件: PDGFRA, PDGFRB 💬 Seralutinib 💬 Seralutinib 1件: 86 💬
102 Regulation of actin cytoskeleton 💬
2件: PDGFRA, PDGFRB 💬 Sunitinib malate 💬 Sunitinib 2件: 28, 34 💬
103 Regulation of actin cytoskeleton 💬
2件: PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib 2件: 28, 34 💬
104 Regulation of actin cytoskeleton 💬
2件: PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
105 Regulation of actin cytoskeleton 💬
2件: PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
106 Regulation of actin cytoskeleton 💬
1件: PIK3CA_B_D 💬 Alpelisib 💬 Alpelisib 4件: 138, 278, 279, 280 💬
107 Regulation of actin cytoskeleton 💬
1件: PIK3CA_B_D 💬 Leniolisib phosphate 💬 Leniolisib 2件: 53, 65 💬
108 Regulation of actin cytoskeleton 💬
1件: PIK3CA_B_D 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
109 Regulation of actin cytoskeleton 💬
2件: PIK3CA_B_D, PIK3CA_B_D 💬 Copanlisib 💬 Copanlisib 1件: 121 💬
110 Regulation of actin cytoskeleton 💬
3件: PIK3CA_B_D, PIK3CA_B_D, PIK3CA_B_D 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
111 Regulation of actin cytoskeleton 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
112 Regulation of actin cytoskeleton 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
113 Regulation of actin cytoskeleton 💬
1件: ROCK2 💬 Belumosudil 💬 Belumosudil 3件: 51, 85, 228 💬
114 Regulation of actin cytoskeleton 💬
1件: ROCK2 💬 Belumosudil mesylate 💬 Belumosudil 3件: 51, 85, 228 💬
115 Regulation of actin cytoskeleton 💬
1件: SRC 💬 Bosutinib 💬 Bosutinib 2件:  2 , 67 💬
116 Regulation of actin cytoskeleton 💬
1件: SRC 💬 Bosutinib hydrate 💬 Bosutinib 2件:  2 , 67 💬
117 Regulation of actin cytoskeleton 💬
1件: SRC 💬 Saracatinib 💬 Saracatinib 3件:  6 , 89, 272 💬