Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: AGTR1 💬 Angiotensin II 💬 Angiotensin II 2件: 66, 222 💬
2 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: AGTR1 💬 Angiotensin II 💬 Angiotensin II 2件: 66, 222 💬
3 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: AGTR1 💬 Angiotensin II acetate 💬 Angiotensin II 2件: 66, 222 💬
4 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: AGTR1 💬 Azilsartan 💬 Azilsartan 1件: 66 💬
5 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: AGTR1 💬 Buloxibutid 💬 Buloxibutid 1件: 85 💬
6 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: AGTR1 💬 Buloxibutid sodium 💬 Buloxibutid 1件: 85 💬
7 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: AGTR1 💬 Candesartan 💬 Candesartan 4件: 57, 58, 67, 222 💬
8 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: AGTR1 💬 Irbesartan 💬 Irbesartan 6件: 57, 66, 167, 168, 222, 223 💬
9 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: AGTR1 💬 Losartan potassium 💬 Losartan 20件: 17, 19, 36, 46, 57, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 223, 299 💬
10 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: AGTR1 💬 Losartan 💬 Losartan 20件: 17, 19, 36, 46, 57, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 223, 299 💬
11 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: AGTR1 💬 Olmesartan medoxomil 💬 Olmesartan 2件: 57, 223 💬
12 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: AGTR1 💬 Olmesartan 💬 Olmesartan 2件: 57, 223 💬
13 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: AGTR1 💬 Sparsentan 💬 Sparsentan 4件: 66, 218, 222, 223 💬
14 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: AGTR1 💬 Telmisartan 💬 Telmisartan 5件:  6 , 57, 66, 67, 222 💬
15 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: AGTR1 💬 Valsartan 💬 Valsartan 11件: 28, 57, 58, 66, 75, 86, 210, 218, 222, 223, 224 💬
16 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: BCL2 💬 Obatoclax mesylate 💬 Obatoclax 1件: 60 💬
17 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: BCL2 💬 Sonrotoclax 💬 Sonrotoclax 1件: 28 💬
18 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: BCL2 💬 Venetoclax 💬 Venetoclax 2件: 28, 85 💬
19 AGE-RAGE signaling pathway in diabetic complications 💬
 5件: CCL2, IL1A, IL1B, IL6, TNF 💬 Pirfenidone 💬 Pirfenidone 12件: 13, 34, 40, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
20 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: CDK4 💬 Abemaciclib 💬 Abemaciclib 1件: 34 💬
21 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: ICAM1 💬 Alicaforsen sodium 💬 Alicaforsen 2件: 96, 97 💬
22 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: IL1A 💬 Bermekimab 💬 Bermekimab 1件: 51 💬
23 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: IL1A 💬 Vilamakitug 💬 Vilamakitug 1件: 271 💬
24 AGE-RAGE signaling pathway in diabetic complications 💬
 2件: IL1A, IL1B 💬 Lutikizumab 💬 Lutikizumab 3件: 46, 96, 97 💬
25 AGE-RAGE signaling pathway in diabetic complications 💬
 2件: IL1A, IL1B 💬 Rilonacept 💬 Rilonacept 5件: 51, 84, 106, 107, 266 💬
26 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: IL1B 💬 Canakinumab 💬 Canakinumab 11件: 46, 54, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
27 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: IL1B 💬 Gevokizumab 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
28 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: IL6 💬 Olokizumab 💬 Olokizumab 2件: 46, 96 💬
29 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: IL6 💬 Siltuximab 💬 Siltuximab 2件: 28, 331 💬
30 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: IL6 💬 Sirukumab 💬 Sirukumab 2件: 41, 46 💬
31 AGE-RAGE signaling pathway in diabetic complications 💬
 2件: IL6, TNF 💬 Pomalidomide 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
32 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: JAK2 💬 Baricitinib 💬 Baricitinib 24件:  2 , 13, 40, 41, 46, 49, 50, 51, 53, 54, 56, 63, 65, 84, 93, 107, 135, 162, 265, 268, 269, 300, 325, 345 💬
33 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: JAK2 💬 Delgocitinib 💬 Delgocitinib 1件: 50 💬
34 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: JAK2 💬 Filgotinib maleate 💬 Filgotinib 10件: 46, 53, 56, 96, 97, 107, 222, 271, 300, 331 💬
35 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: JAK2 💬 Gusacitinib 💬 Gusacitinib 1件: 49 💬
36 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: JAK2 💬 Pacritinib 💬 Pacritinib 1件: 331 💬
37 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: JAK2 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
38 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: JAK2 💬 Ruxolitinib 💬 Ruxolitinib 7件: 13, 15, 50, 60, 65, 228, 331 💬
39 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: JAK2 💬 Ruxolitinib phosphate 💬 Ruxolitinib 7件: 13, 15, 50, 60, 65, 228, 331 💬
40 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: JAK2 💬 Tofacitinib citrate 💬 Tofacitinib 23件:  2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 56, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬
41 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: JAK2 💬 Tofacitinib 💬 Tofacitinib 23件:  2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 56, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬
42 AGE-RAGE signaling pathway in diabetic complications 💬
 4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod 2件: 113, 222 💬
43 AGE-RAGE signaling pathway in diabetic complications 💬
 4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod 1件:  8  💬
44 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: NFKB1 💬 Iguratimod 💬 Iguratimod 7件: 46, 49, 51, 53, 63, 271, 300 💬
45 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: PIK3CA 💬 Alpelisib 💬 Alpelisib 4件: 138, 278, 279, 280 💬
46 AGE-RAGE signaling pathway in diabetic complications 💬
 3件: PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
47 AGE-RAGE signaling pathway in diabetic complications 💬
 2件: PIK3CA, PIK3CD 💬 Copanlisib 💬 Copanlisib 1件: 121 💬
48 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: PIK3CD 💬 Leniolisib phosphate 💬 Leniolisib 2件: 53, 65 💬
49 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: PIK3CD 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
50 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: PRKCB 💬 Enzastaurin hydrochloride 💬 Enzastaurin 1件: 168 💬
51 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: PRKCB 💬 Enzastaurin 💬 Enzastaurin 1件: 168 💬
52 AGE-RAGE signaling pathway in diabetic complications 💬
 2件: PRKCD, PRKCE 💬 Sotrastaurin 💬 Sotrastaurin 1件: 97 💬
53 AGE-RAGE signaling pathway in diabetic complications 💬
 2件: PRKCD, PRKCE 💬 Sotrastaurin acetate 💬 Sotrastaurin 1件: 97 💬
54 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: RELA 💬 Edasalonexent 💬 Edasalonexent 1件: 113 💬
55 AGE-RAGE signaling pathway in diabetic complications 💬
 3件: TGFB1, TGFB2, TGFB3 💬 Fresolimumab 💬 Fresolimumab 3件: 51, 222, 274 💬
56 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: TGFBR1 💬 Galunisertib 💬 Galunisertib 1件:  2  💬
57 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: TNF 💬 Adalimumab 💬 Adalimumab 22件: 19, 37, 38, 40, 41, 46, 55, 56, 84, 90, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
58 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: TNF 💬 Certolizumab pegol 💬 Certolizumab pegol 10件: 37, 40, 46, 48, 49, 96, 97, 107, 226, 271 💬
59 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: TNF 💬 Etanercept 💬 Etanercept 16件: 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
60 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: TNF 💬 Golimumab 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
61 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: TNF 💬 Infliximab 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 162, 164, 223, 269, 270, 271 💬
62 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: TNF 💬 Lenalidomide 💬 Lenalidomide 9件: 16, 26, 28, 34, 49, 56, 284, 300, 331 💬
63 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: TNF 💬 Ozoralizumab 💬 Ozoralizumab 1件: 46 💬
64 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: TNF 💬 Pegsunercept 💬 Pegsunercept 1件: 46 💬
65 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: TNF 💬 Thalidomide 💬 Thalidomide 22件:  2 , 16, 20, 28, 49, 51, 53, 56, 63, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬
66 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: VEGFA 💬 Bevacizumab 💬 Bevacizumab 9件: 13, 34, 85, 86, 87, 89, 227, 280, 331 💬
67 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: VEGFA 💬 Ranibizumab 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
68 AGE-RAGE signaling pathway in diabetic complications 💬
 2件: VEGFA, VEGFB 💬 Aflibercept 💬 Aflibercept 2件: 90, 166 💬