Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Morphine addiction 💬
1件: ADORA1 💬 Adenosine 💬 Adenosine 3件: 13, 58, 65 💬
2 Morphine addiction 💬
1件: ADORA1 💬 Adenosine phosphate 💬 Adenosine phosphate 1件: 46 💬
3 Morphine addiction 💬
17件: ADORA1, PDE1, PDE1, PDE1, PDE10, PDE11, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4, PDE7, PDE7, PDE8, PDE8 💬 Theophylline sodium glycinate 💬 Theophylline 2件: 236, 299 💬
4 Morphine addiction 💬
17件: ADORA1, PDE1, PDE1, PDE1, PDE10, PDE11, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4, PDE7, PDE7, PDE8, PDE8 💬 Theophylline 💬 Theophylline 2件: 236, 299 💬
5 Morphine addiction 💬
17件: ADORA1, PDE1, PDE1, PDE1, PDE10, PDE11, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4, PDE7, PDE7, PDE8, PDE8 💬 Aminophylline 💬 Aminophylline 1件: 63 💬
6 Morphine addiction 💬
17件: ADORA1, PDE1, PDE1, PDE1, PDE10, PDE11, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4, PDE7, PDE7, PDE8, PDE8 💬 Aminophylline dihydrate 💬 Aminophylline 1件: 63 💬
7 Morphine addiction 💬
17件: ADORA1, PDE1, PDE1, PDE1, PDE10, PDE11, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4, PDE7, PDE7, PDE8, PDE8 💬 Theophylline 💬 Theophylline 2件: 236, 299 💬
8 Morphine addiction 💬
9件: ADORA1, PDE1, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4 💬 Caffeine hydrate 💬 Caffeine 8件:  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
9 Morphine addiction 💬
9件: ADORA1, PDE1, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4 💬 Caffeine citrate 💬 Caffeine 8件:  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
10 Morphine addiction 💬
9件: ADORA1, PDE1, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4 💬 Caffeine 💬 Caffeine 8件:  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
11 Morphine addiction 💬
1件: CACNA1B 💬 Cilnidipine 💬 Cilnidipine 1件: 67 💬
12 Morphine addiction 💬
1件: DRD1 💬 Apomorphine hydrochloride 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
13 Morphine addiction 💬
1件: DRD1 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
14 Morphine addiction 💬
1件: DRD1 💬 Dexpramipexole 💬 Dexpramipexole 1件:  2  💬
15 Morphine addiction 💬
1件: DRD1 💬 Dopamine hydrochloride 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
16 Morphine addiction 💬
1件: DRD1 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
17 Morphine addiction 💬
1件: DRD1 💬 Flupentixol 💬 Flupentixol 1件: 97 💬
18 Morphine addiction 💬
1件: DRD1 💬 Flupentixol dihydrochloride 💬 Flupentixol 1件: 97 💬
19 Morphine addiction 💬
1件: DRD1 💬 Flupentixol decanoate 💬 Flupentixol 1件: 97 💬
20 Morphine addiction 💬
1件: DRD1 💬 Foslevodopa 💬 Foslevodopa 1件:  6  💬
21 Morphine addiction 💬
1件: DRD1 💬 Levodopa 💬 Levodopa 6件:  6 , 17, 90, 140, 164, 201 💬
22 Morphine addiction 💬
1件: DRD1 💬 Pergolide mesylate 💬 Pergolide 1件:  6  💬
23 Morphine addiction 💬
1件: DRD1 💬 Pergolide 💬 Pergolide 1件:  6  💬
24 Morphine addiction 💬
1件: DRD1 💬 Tavapadon 💬 Tavapadon 1件:  6  💬
25 Morphine addiction 💬
2件: GABBR, GABBR 💬 Arbaclofen placarbil 💬 Arbaclofen Placarbil 1件: 13 💬
26 Morphine addiction 💬
2件: GABBR, GABBR 💬 Baclofen 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
27 Morphine addiction 💬
2件: GABBR, GABBR 💬 Arbaclofen 💬 Arbaclofen 2件: 13, 206 💬
28 Morphine addiction 💬
2件: GABBR, GABBR 💬 Valiloxybate 💬 Valiloxibic acid 1件:  6  💬
29 Morphine addiction 💬
18件: GABBR, GABBR, GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 gamma-Aminobutyric acid 💬 gamma-Aminobutyric acid 1件: 140 💬
30 Morphine addiction 💬
1件: GABRA 💬 Etomidate 💬 Etomidate 2件:  6 , 11 💬
31 Morphine addiction 💬
1件: GABRA 💬 Alogabat 💬 Alogabat 1件: 201 💬
32 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Ganaxolone 💬 Ganaxolone 4件: 145, 152, 158, 206 💬
33 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Midazolam hydrochloride 💬 Midazolam 13件:  2 ,  3 ,  6 , 13, 21, 46, 67, 96, 97, 231, 272, 298, 299 💬
34 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Fospropofol disodium 💬 Fospropofol 1件: 226 💬
35 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Zolpidem tartrate 💬 Zolpidem 3件:  5 ,  6 , 46 💬
36 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Clobazam 💬 Clobazam 2件: 140, 144 💬
37 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Diazepam 💬 Diazepam 3件: 46, 155, 298 💬
38 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Propofol 💬 Propofol 10件:  3 ,  6 , 21, 22, 34, 46, 70, 97, 98, 296 💬
39 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Gaboxadol 💬 Gaboxadol 2件: 201, 206 💬
40 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Brexanolone 💬 Brexanolone 2件:  6 , 205 💬
41 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Flumazenil 💬 Flumazenil 5件:  6 , 13, 17, 18, 206 💬
42 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Midazolam 💬 Midazolam 13件:  2 ,  3 ,  6 , 13, 21, 46, 67, 96, 97, 231, 272, 298, 299 💬
43 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Chlordiazepoxide hydrochloride 💬 Chlordiazepoxide 1件: 46 💬
44 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Chlordiazepoxide 💬 Chlordiazepoxide 1件: 46 💬
45 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Eszopiclone 💬 Eszopiclone 3件:  6 , 13, 46 💬
46 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Remimazolam 💬 Remimazolam 1件:  6  💬
47 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Midazolam maleate 💬 Midazolam 13件:  2 ,  3 ,  6 , 13, 21, 46, 67, 96, 97, 231, 272, 298, 299 💬
48 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Clonazepam 💬 Clonazepam 1件:  6  💬
49 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Lorazepam 💬 Lorazepam 2件: 36, 231 💬
50 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Alprazolam 💬 Alprazolam 2件:  8 , 75 💬
51 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Remimazolam besylate 💬 Remimazolam 1件:  6  💬
52 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Topiramate 💬 Topiramate 5件:  6 , 140, 144, 156, 193 💬
53 Morphine addiction 💬
16件: GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Zolpidem 💬 Zolpidem 3件:  5 ,  6 , 46 💬
54 Morphine addiction 💬
2件: KCNJ3, KCNJ5 💬 Amiodarone hydrochloride 💬 Amiodarone 1件: 127 💬
55 Morphine addiction 💬
2件: KCNJ3, KCNJ5 💬 Amiodarone 💬 Amiodarone 1件: 127 💬
56 Morphine addiction 💬
1件: OPRM1 💬 Buprenorphine hydrochloride 💬 Buprenorphine 3件: 46, 70, 298 💬
57 Morphine addiction 💬
1件: OPRM1 💬 Buprenorphine 💬 Buprenorphine 3件: 46, 70, 298 💬
58 Morphine addiction 💬
1件: OPRM1 💬 Dezocine 💬 Dezocine 1件: 46 💬
59 Morphine addiction 💬
1件: OPRM1 💬 Dihydrocodeine phosphate 💬 Dihydrocodeine 1件: 310 💬
60 Morphine addiction 💬
1件: OPRM1 💬 Dihydrocodeine bitartrate 💬 Dihydrocodeine 1件: 310 💬
61 Morphine addiction 💬
1件: OPRM1 💬 Dihydrocodeine 💬 Dihydrocodeine 1件: 310 💬
62 Morphine addiction 💬
1件: OPRM1 💬 Dihydrocodeine thiocyanate 💬 Dihydrocodeine 1件: 310 💬
63 Morphine addiction 💬
1件: OPRM1 💬 Fentanyl 💬 Fentanyl 6件: 46, 70, 97, 215, 231, 298 💬
64 Morphine addiction 💬
1件: OPRM1 💬 Fentanyl citrate 💬 Fentanyl 6件: 46, 70, 97, 215, 231, 298 💬
65 Morphine addiction 💬
1件: OPRM1 💬 Fentanyl hydrochloride 💬 Fentanyl 6件: 46, 70, 97, 215, 231, 298 💬
66 Morphine addiction 💬
1件: OPRM1 💬 Hydromorphone hydrochloride 💬 Hydromorphone 1件: 70 💬
67 Morphine addiction 💬
1件: OPRM1 💬 Hydromorphone 💬 Hydromorphone 1件: 70 💬
68 Morphine addiction 💬
1件: OPRM1 💬 Loperamide hydrochloride 💬 Loperamide 2件: 13, 97 💬
69 Morphine addiction 💬
1件: OPRM1 💬 Loperamide 💬 Loperamide 2件: 13, 97 💬
70 Morphine addiction 💬
1件: OPRM1 💬 Meperidine hydrochloride 💬 Meperidine 2件: 97, 298 💬
71 Morphine addiction 💬
1件: OPRM1 💬 Pethidine 💬 Meperidine 2件: 97, 298 💬
72 Morphine addiction 💬
1件: OPRM1 💬 Methadone hydrochloride 💬 Methadone 1件: 60 💬
73 Morphine addiction 💬
1件: OPRM1 💬 Methadone 💬 Methadone 1件: 60 💬
74 Morphine addiction 💬
1件: OPRM1 💬 Morphine sulfate 💬 Morphine 6件: 36, 46, 70, 85, 86, 298 💬
75 Morphine addiction 💬
1件: OPRM1 💬 Morphine hydrochloride hydrate 💬 Morphine 6件: 36, 46, 70, 85, 86, 298 💬
76 Morphine addiction 💬
1件: OPRM1 💬 Morphine 💬 Morphine 6件: 36, 46, 70, 85, 86, 298 💬
77 Morphine addiction 💬
1件: OPRM1 💬 Morphine tartrate 💬 Morphine 6件: 36, 46, 70, 85, 86, 298 💬
78 Morphine addiction 💬
1件: OPRM1 💬 Nalbuphine hydrochloride 💬 Nalbuphine 1件: 85 💬
79 Morphine addiction 💬
1件: OPRM1 💬 Nalbuphine 💬 Nalbuphine 1件: 85 💬
80 Morphine addiction 💬
1件: OPRM1 💬 Nalmefene hydrochloride 💬 Nalmefene 2件:  6 , 93 💬
81 Morphine addiction 💬
1件: OPRM1 💬 Nalmefene 💬 Nalmefene 2件:  6 , 93 💬
82 Morphine addiction 💬
1件: OPRM1 💬 Nalmefene hydrochloride hydrate 💬 Nalmefene 2件:  6 , 93 💬
83 Morphine addiction 💬
1件: OPRM1 💬 Naloxone hydrochloride 💬 Naloxone 2件:  6 , 226 💬
84 Morphine addiction 💬
1件: OPRM1 💬 Naloxone 💬 Naloxone 2件:  6 , 226 💬
85 Morphine addiction 💬
1件: OPRM1 💬 Naloxone hydrochloride dihydrate 💬 Naloxone 2件:  6 , 226 💬
86 Morphine addiction 💬
1件: OPRM1 💬 Naltrexone hydrochloride 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
87 Morphine addiction 💬
1件: OPRM1 💬 Naltrexone 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
88 Morphine addiction 💬
1件: OPRM1 💬 Oxycodone hydrochloride 💬 Oxycodone 6件:  6 , 46, 70, 226, 231, 298 💬
89 Morphine addiction 💬
1件: OPRM1 💬 Oxycodone terephthalate 💬 Oxycodone 6件:  6 , 46, 70, 226, 231, 298 💬
90 Morphine addiction 💬
1件: OPRM1 💬 Oxycodone 💬 Oxycodone 6件:  6 , 46, 70, 226, 231, 298 💬
91 Morphine addiction 💬
1件: OPRM1 💬 Remifentanil hydrochloride 💬 Remifentanil 3件:  6 , 22, 70 💬
92 Morphine addiction 💬
1件: OPRM1 💬 Remifentanil 💬 Remifentanil 3件:  6 , 22, 70 💬
93 Morphine addiction 💬
1件: OPRM1 💬 Sufentanil citrate 💬 Sufentanil 4件: 11, 22, 70, 280 💬
94 Morphine addiction 💬
1件: OPRM1 💬 Sufentanil 💬 Sufentanil 4件: 11, 22, 70, 280 💬
95 Morphine addiction 💬
1件: OPRM1 💬 Tramadol hydrochloride 💬 Tramadol 4件: 46, 70, 226, 271 💬
96 Morphine addiction 💬
1件: OPRM1 💬 Tramadol 💬 Tramadol 4件: 46, 70, 226, 271 💬
97 Morphine addiction 💬
1件: OPRM1 💬 Trimebutine maleate 💬 Trimebutine 1件: 51 💬
98 Morphine addiction 💬
1件: OPRM1 💬 Trimebutine 💬 Trimebutine 1件: 51 💬
99 Morphine addiction 💬
16件: PDE1, PDE1, PDE1, PDE10, PDE11, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4, PDE7, PDE7, PDE8, PDE8 💬 Flavoxate 💬 Flavoxate 1件: 226 💬
100 Morphine addiction 💬
16件: PDE1, PDE1, PDE1, PDE10, PDE11, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4, PDE7, PDE7, PDE8, PDE8 💬 Flavoxate hydrochloride 💬 Flavoxate 1件: 226 💬
101 Morphine addiction 💬
16件: PDE1, PDE1, PDE1, PDE10, PDE11, PDE2A, PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4, PDE7, PDE7, PDE8, PDE8 💬 Bucladesine 💬 Bucladesine 1件: 246 💬
102 Morphine addiction 💬
2件: PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol 5件:  6 , 46, 51, 70, 124 💬
103 Morphine addiction 💬
2件: PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan 1件:  2  💬
104 Morphine addiction 💬
2件: PDE3A, PDE3B 💬 Milrinone 💬 Milrinone 1件: 294 💬
105 Morphine addiction 💬
2件: PDE3A, PDE3B 💬 Milrinone lactate 💬 Milrinone 1件: 294 💬
106 Morphine addiction 💬
6件: PDE3A, PDE3B, PDE4, PDE4, PDE4, PDE4 💬 Ibudilast 💬 Ibudilast 2件:  2 , 13 💬
107 Morphine addiction 💬
1件: PDE4 💬 Dipyridamole 💬 Dipyridamole 5件: 46, 51, 66, 96, 224 💬
108 Morphine addiction 💬
1件: PDE4 💬 Zatolmilast 💬 Zatolmilast 1件: 206 💬
109 Morphine addiction 💬
4件: PDE4, PDE4, PDE4, PDE4 💬 Rolipram 💬 Rolipram 2件:  8 , 13 💬
110 Morphine addiction 💬
4件: PDE4, PDE4, PDE4, PDE4 💬 Apremilast 💬 Apremilast 8件: 36, 46, 50, 56, 97, 107, 162, 271 💬
111 Morphine addiction 💬
4件: PDE4, PDE4, PDE4, PDE4 💬 Roflumilast 💬 Roflumilast 4件: 84, 97, 206, 299 💬
112 Morphine addiction 💬
1件: PRKCB 💬 Enzastaurin hydrochloride 💬 Enzastaurin 1件: 168 💬
113 Morphine addiction 💬
1件: PRKCB 💬 Enzastaurin 💬 Enzastaurin 1件: 168 💬