Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Shigellosis 💬
1件: BCL2 💬 Obatoclax mesylate 💬 Obatoclax 1件: 60 💬
2 Shigellosis 💬
1件: BCL2 💬 Venetoclax 💬 Venetoclax 2件: 28, 85 💬
3 Shigellosis 💬
1件: C3 💬 Pegcetacoplan 💬 Pegcetacoplan 4件:  2 , 61, 62, 222 💬
4 Shigellosis 💬
1件: CSF2 💬 Otilimab 💬 Otilimab 1件: 46 💬
5 Shigellosis 💬
1件: EGFR 💬 Afatinib 💬 Afatinib 1件: 285 💬
6 Shigellosis 💬
1件: EGFR 💬 Afatinib dimaleate 💬 Afatinib 1件: 285 💬
7 Shigellosis 💬
1件: EGFR 💬 Cetuximab 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
8 Shigellosis 💬
1件: EGFR 💬 Erlotinib hydrochloride 💬 Erlotinib 2件: 94, 160 💬
9 Shigellosis 💬
1件: EGFR 💬 Erlotinib 💬 Erlotinib 2件: 94, 160 💬
10 Shigellosis 💬
1件: EGFR 💬 Gefitinib 💬 Gefitinib 1件: 75 💬
11 Shigellosis 💬
1件: EGFR 💬 Icotinib 💬 Icotinib 1件: 34 💬
12 Shigellosis 💬
1件: EGFR 💬 Lapatinib ditosylate 💬 Lapatinib 3件: 34, 74, 75 💬
13 Shigellosis 💬
1件: EGFR 💬 Lapatinib 💬 Lapatinib 3件: 34, 74, 75 💬
14 Shigellosis 💬
1件: EGFR 💬 Neratinib 💬 Neratinib 1件: 34 💬
15 Shigellosis 💬
1件: EGFR 💬 Neratinib maleate 💬 Neratinib 1件: 34 💬
16 Shigellosis 💬
1件: EGFR 💬 Tesevatinib 💬 Tesevatinib 1件: 67 💬
17 Shigellosis 💬
1件: IFNB 💬 Dazukibart 💬 Dazukibart 1件: 50 💬
18 Shigellosis 💬
1件: IL1B 💬 Canakinumab 💬 Canakinumab 11件: 46, 54, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
19 Shigellosis 💬
1件: IL1B 💬 Gevokizumab 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
20 Shigellosis 💬
1件: IL1B 💬 Lutikizumab 💬 Lutikizumab 3件: 46, 96, 97 💬
21 Shigellosis 💬
1件: IL1B 💬 Rilonacept 💬 Rilonacept 5件: 51, 84, 106, 107, 266 💬
22 Shigellosis 💬
2件: IL1B, TNF 💬 Pirfenidone 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
23 Shigellosis 💬
1件: IL1R1 💬 Anakinra 💬 Anakinra 19件:  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 54, 56, 84, 86, 97, 106, 107, 266, 299 💬
24 Shigellosis 💬
2件: ITGA5, ITGB1 💬 Bexotegrast 💬 Bexotegrast 1件: 94 💬
25 Shigellosis 💬
1件: ITGB1 💬 Carotegrast methyl 💬 Carotegrast methyl 1件: 97 💬
26 Shigellosis 💬
1件: MTOR 💬 Everolimus 💬 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
27 Shigellosis 💬
1件: MTOR 💬 Sirolimus 💬 Sirolimus 46件:  2 ,  6 , 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 97, 98, 137, 157, 158, 192, 193, 222, 227, 256, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
28 Shigellosis 💬
1件: MTOR 💬 Temsirolimus 💬 Temsirolimus 4件: 13, 34, 89, 331 💬
29 Shigellosis 💬
1件: MYL2 💬 Aficamten 💬 Aficamten 1件: 58 💬
30 Shigellosis 💬
1件: NFKB1 💬 Iguratimod 💬 Iguratimod 6件: 46, 49, 51, 53, 271, 300 💬
31 Shigellosis 💬
4件: P38, P38, P38, P38 💬 Neflamapimod 💬 Neflamapimod 1件:  8  💬
32 Shigellosis 💬
4件: P38, P38, P38, P38 💬 Losmapimod 💬 Losmapimod 2件: 113, 222 💬
33 Shigellosis 💬
1件: PIK3C3 💬 Fimepinostat 💬 Fimepinostat 1件: 75 💬
34 Shigellosis 💬
1件: PIK3CA_B_D 💬 Alpelisib 💬 Alpelisib 4件: 138, 278, 279, 280 💬
35 Shigellosis 💬
1件: PIK3CA_B_D 💬 Leniolisib phosphate 💬 Leniolisib 2件: 53, 65 💬
36 Shigellosis 💬
1件: PIK3CA_B_D 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
37 Shigellosis 💬
2件: PIK3CA_B_D, PIK3CA_B_D 💬 Copanlisib 💬 Copanlisib 1件: 121 💬
38 Shigellosis 💬
3件: PIK3CA_B_D, PIK3CA_B_D, PIK3CA_B_D 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
39 Shigellosis 💬
3件: PRKCD, PRKCE, PRKCQ 💬 Sotrastaurin 💬 Sotrastaurin 1件: 97 💬
40 Shigellosis 💬
3件: PRKCD, PRKCE, PRKCQ 💬 Sotrastaurin acetate 💬 Sotrastaurin 1件: 97 💬
41 Shigellosis 💬
1件: RELA 💬 Edasalonexent 💬 Edasalonexent 1件: 113 💬
42 Shigellosis 💬
1件: RIPK1 💬 Eclitasertib 💬 SAR443122 1件: 97 💬
43 Shigellosis 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
44 Shigellosis 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
45 Shigellosis 💬
1件: ROCK2 💬 Belumosudil 💬 Belumosudil 3件: 51, 85, 228 💬
46 Shigellosis 💬
1件: ROCK2 💬 Belumosudil mesylate 💬 Belumosudil 3件: 51, 85, 228 💬
47 Shigellosis 💬
1件: SRC 💬 Bosutinib 💬 Bosutinib 2件:  2 , 67 💬
48 Shigellosis 💬
1件: SRC 💬 Bosutinib hydrate 💬 Bosutinib 2件:  2 , 67 💬
49 Shigellosis 💬
1件: SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
50 Shigellosis 💬
1件: SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
51 Shigellosis 💬
1件: SRC 💬 Saracatinib 💬 Saracatinib 3件:  6 , 89, 272 💬
52 Shigellosis 💬
1件: TNF 💬 Adalimumab 💬 Adalimumab 21件: 19, 37, 38, 40, 41, 46, 55, 56, 84, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
53 Shigellosis 💬
1件: TNF 💬 Certolizumab pegol 💬 Certolizumab pegol 7件: 37, 46, 49, 96, 107, 226, 271 💬
54 Shigellosis 💬
1件: TNF 💬 Etanercept 💬 Etanercept 16件: 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
55 Shigellosis 💬
1件: TNF 💬 Golimumab 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
56 Shigellosis 💬
1件: TNF 💬 Infliximab 💬 Infliximab 25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 164, 269, 270, 271 💬
57 Shigellosis 💬
1件: TNF 💬 Lenalidomide 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
58 Shigellosis 💬
1件: TNF 💬 Ozoralizumab 💬 Ozoralizumab 1件: 46 💬
59 Shigellosis 💬
1件: TNF 💬 Pegsunercept 💬 Pegsunercept 1件: 46 💬
60 Shigellosis 💬
1件: TNF 💬 Pomalidomide 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
61 Shigellosis 💬
1件: TNF 💬 Thalidomide 💬 Thalidomide 21件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬