Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Chagas disease 💬
1件: ACE 💬 Benazepril hydrochloride 💬 Benazepril 4件: 49, 57, 218, 224 💬
2 Chagas disease 💬
1件: ACE 💬 Benazepril 💬 Benazepril 4件: 49, 57, 218, 224 💬
3 Chagas disease 💬
1件: ACE 💬 Captopril 💬 Captopril 7件: 17, 46, 86, 96, 97, 107, 271 💬
4 Chagas disease 💬
1件: ACE 💬 Cilazapril 💬 Cilazapril 1件: 66 💬
5 Chagas disease 💬
1件: ACE 💬 Cilazapril 💬 Cilazapril 1件: 66 💬
6 Chagas disease 💬
1件: ACE 💬 Enalapril maleate 💬 Enalapril 8件: 13, 19, 46, 66, 113, 210, 222, 279 💬
7 Chagas disease 💬
1件: ACE 💬 Enalapril 💬 Enalapril 8件: 13, 19, 46, 66, 113, 210, 222, 279 💬
8 Chagas disease 💬
1件: ACE 💬 Imidapril hydrochloride 💬 Imidapril 1件: 67 💬
9 Chagas disease 💬
1件: ACE 💬 Imidapril 💬 Imidapril 1件: 67 💬
10 Chagas disease 💬
1件: ACE 💬 Lisinopril 💬 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222 💬
11 Chagas disease 💬
1件: ACE 💬 Lisinopril 💬 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222 💬
12 Chagas disease 💬
1件: ACE 💬 Moexipril hydrochloride 💬 Moexipril 1件: 93 💬
13 Chagas disease 💬
1件: ACE 💬 Moexipril 💬 Moexipril 1件: 93 💬
14 Chagas disease 💬
1件: ACE 💬 Perindopril erbumine 💬 Perindopril 4件: 58, 113, 167, 222 💬
15 Chagas disease 💬
1件: ACE 💬 Perindopril 💬 Perindopril 4件: 58, 113, 167, 222 💬
16 Chagas disease 💬
1件: ACE 💬 Perindopril arginine 💬 Perindopril 4件: 58, 113, 167, 222 💬
17 Chagas disease 💬
1件: ACE 💬 Ramipril 💬 Ramipril 7件: 46, 49, 66, 67, 113, 218, 257 💬
18 Chagas disease 💬
1件: BDKRB2 💬 Deucrictibant 💬 Deucrictibant 1件: 65 💬
19 Chagas disease 💬
1件: BDKRB2 💬 Icatibant acetate 💬 Icatibant 1件: 65 💬
20 Chagas disease 💬
1件: C3 💬 Pegcetacoplan 💬 Pegcetacoplan 4件:  2 , 61, 62, 222 💬
21 Chagas disease 💬
5件: CCL2, IL10, IL1B, IL6, TNF 💬 Pirfenidone 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
22 Chagas disease 💬
3件: CD3D, CD3E, CD3G 💬 Anti-human thymocyte immunoglobulin, rabbit 💬 Antithymocyte immunoglobulin (rabbit) 13件: 13, 36, 49, 51, 60, 62, 65, 96, 283, 284, 285, 286, 326 💬
23 Chagas disease 💬
3件: CD3D, CD3E, CD3G 💬 Blinatumomab 💬 Blinatumomab 3件: 11, 46, 49 💬
24 Chagas disease 💬
3件: CD3D, CD3E, CD3G 💬 Muromonab-CD3 💬 Muromonab 3件: 60, 96, 97 💬
25 Chagas disease 💬
3件: CD3D, CD3E, CD3G 💬 Otelixizumab 💬 Otelixizumab 1件: 46 💬
26 Chagas disease 💬
3件: CD3D, CD3E, CD3G 💬 Visilizumab 💬 Visilizumab 2件: 96, 97 💬
27 Chagas disease 💬
1件: CD3E 💬 Elranatamab 💬 Elranatamab 1件: 28 💬
28 Chagas disease 💬
1件: CD3E 💬 Imvotamab 💬 Imvotamab 2件: 46, 49 💬
29 Chagas disease 💬
1件: CD3E 💬 Mosunetuzumab 💬 Mosunetuzumab 1件: 49 💬
30 Chagas disease 💬
1件: CD3E 💬 Talquetamab 💬 Talquetamab 1件: 28 💬
31 Chagas disease 💬
1件: CD3E 💬 Teclistamab 💬 Teclistamab 1件: 28 💬
32 Chagas disease 💬
1件: IFNB 💬 Dazukibart 💬 Dazukibart 1件: 50 💬
33 Chagas disease 💬
1件: IFNG 💬 Emapalumab 💬 Emapalumab 5件: 49, 54, 60, 65, 107 💬
34 Chagas disease 💬
1件: IFNG 💬 Fontolizumab 💬 Fontolizumab 1件: 46 💬
35 Chagas disease 💬
2件: IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
36 Chagas disease 💬
2件: IL12A, IL12B 💬 Ustekinumab 💬 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
37 Chagas disease 💬
1件: IL1B 💬 Canakinumab 💬 Canakinumab 11件: 46, 54, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
38 Chagas disease 💬
1件: IL1B 💬 Gevokizumab 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
39 Chagas disease 💬
1件: IL1B 💬 Lutikizumab 💬 Lutikizumab 3件: 46, 96, 97 💬
40 Chagas disease 💬
1件: IL1B 💬 Rilonacept 💬 Rilonacept 5件: 51, 84, 106, 107, 266 💬
41 Chagas disease 💬
1件: IL6 💬 Olokizumab 💬 Olokizumab 2件: 46, 96 💬
42 Chagas disease 💬
1件: IL6 💬 Siltuximab 💬 Siltuximab 2件: 28, 331 💬
43 Chagas disease 💬
1件: IL6 💬 Sirukumab 💬 Sirukumab 2件: 41, 46 💬
44 Chagas disease 💬
2件: IL6, TNF 💬 Pomalidomide 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
45 Chagas disease 💬
1件: NFKB1 💬 Iguratimod 💬 Iguratimod 6件: 46, 49, 51, 53, 271, 300 💬
46 Chagas disease 💬
1件: NOS2 💬 Tilarginine acetate 💬 Tilarginine 1件: 67 💬
47 Chagas disease 💬
4件: P38, P38, P38, P38 💬 Neflamapimod 💬 Neflamapimod 1件:  8  💬
48 Chagas disease 💬
4件: P38, P38, P38, P38 💬 Losmapimod 💬 Losmapimod 2件: 113, 222 💬
49 Chagas disease 💬
1件: PIK3CA_B_D 💬 Alpelisib 💬 Alpelisib 4件: 138, 278, 279, 280 💬
50 Chagas disease 💬
1件: PIK3CA_B_D 💬 Leniolisib phosphate 💬 Leniolisib 2件: 53, 65 💬
51 Chagas disease 💬
1件: PIK3CA_B_D 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
52 Chagas disease 💬
2件: PIK3CA_B_D, PIK3CA_B_D 💬 Copanlisib 💬 Copanlisib 1件: 121 💬
53 Chagas disease 💬
3件: PIK3CA_B_D, PIK3CA_B_D, PIK3CA_B_D 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
54 Chagas disease 💬
1件: RELA 💬 Edasalonexent 💬 Edasalonexent 1件: 113 💬
55 Chagas disease 💬
3件: TGFB1, TGFB2, TGFB3 💬 Fresolimumab 💬 Fresolimumab 4件: 51, 85, 222, 274 💬
56 Chagas disease 💬
1件: TLR9 💬 Cobitolimod 💬 Cobitolimod 1件: 97 💬
57 Chagas disease 💬
1件: TNF 💬 Adalimumab 💬 Adalimumab 21件: 19, 37, 38, 40, 41, 46, 55, 56, 84, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
58 Chagas disease 💬
1件: TNF 💬 Certolizumab pegol 💬 Certolizumab pegol 7件: 37, 46, 49, 96, 107, 226, 271 💬
59 Chagas disease 💬
1件: TNF 💬 Etanercept 💬 Etanercept 16件: 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
60 Chagas disease 💬
1件: TNF 💬 Golimumab 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
61 Chagas disease 💬
1件: TNF 💬 Infliximab 💬 Infliximab 25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 164, 269, 270, 271 💬
62 Chagas disease 💬
1件: TNF 💬 Lenalidomide 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
63 Chagas disease 💬
1件: TNF 💬 Ozoralizumab 💬 Ozoralizumab 1件: 46 💬
64 Chagas disease 💬
1件: TNF 💬 Pegsunercept 💬 Pegsunercept 1件: 46 💬
65 Chagas disease 💬
1件: TNF 💬 Thalidomide 💬 Thalidomide 21件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬