Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: ALK 💬 Brigatinib 💬 Brigatinib 1件: 34 💬
2 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: ALK 💬 Crizotinib 💬 Crizotinib 2件:  2 , 34 💬
3 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: CD28 💬 Acazicolcept 💬 Acazicolcept 1件: 49 💬
4 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 3件: CD3D, CD3E, CD3G 💬 Blinatumomab 💬 Blinatumomab 3件: 11, 46, 49 💬
5 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 3件: CD3D, CD3E, CD3G 💬 Muromonab-CD3 💬 Muromonab 3件: 60, 96, 97 💬
6 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 3件: CD3D, CD3E, CD3G 💬 Otelixizumab 💬 Otelixizumab 1件: 46 💬
7 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 3件: CD3D, CD3E, CD3G 💬 Visilizumab 💬 Visilizumab 2件: 96, 97 💬
8 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 4件: CD3D, CD3E, CD3G, CD4 💬 Anti-human thymocyte immunoglobulin, rabbit 💬 Antithymocyte immunoglobulin (rabbit) 13件: 13, 36, 49, 51, 60, 62, 65, 96, 283, 284, 285, 286, 326 💬
9 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: CD3E 💬 Elranatamab 💬 Elranatamab 1件: 28 💬
10 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: CD3E 💬 Imvotamab 💬 Imvotamab 2件: 46, 49 💬
11 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: CD3E 💬 Mosunetuzumab 💬 Mosunetuzumab 1件: 49 💬
12 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: CD3E 💬 Talquetamab 💬 Talquetamab 1件: 28 💬
13 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: CD3E 💬 Teclistamab 💬 Teclistamab 1件: 28 💬
14 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: CD4 💬 Zanolimumab 💬 Zanolimumab 1件: 46 💬
15 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: EGFR 💬 Afatinib 💬 Afatinib 1件: 285 💬
16 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: EGFR 💬 Afatinib dimaleate 💬 Afatinib 1件: 285 💬
17 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: EGFR 💬 Cetuximab 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
18 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: EGFR 💬 Erlotinib hydrochloride 💬 Erlotinib 2件: 94, 160 💬
19 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: EGFR 💬 Erlotinib 💬 Erlotinib 2件: 94, 160 💬
20 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: EGFR 💬 Gefitinib 💬 Gefitinib 1件: 75 💬
21 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: EGFR 💬 Icotinib 💬 Icotinib 1件: 34 💬
22 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: EGFR 💬 Lapatinib ditosylate 💬 Lapatinib 3件: 34, 74, 75 💬
23 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: EGFR 💬 Lapatinib 💬 Lapatinib 3件: 34, 74, 75 💬
24 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: EGFR 💬 Neratinib 💬 Neratinib 1件: 34 💬
25 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: EGFR 💬 Neratinib maleate 💬 Neratinib 1件: 34 💬
26 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: EGFR 💬 Tesevatinib 💬 Tesevatinib 1件: 67 💬
27 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: IFNG 💬 Emapalumab 💬 Emapalumab 5件: 49, 54, 60, 65, 107 💬
28 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: IFNG 💬 Fontolizumab 💬 Fontolizumab 1件: 46 💬
29 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
30 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: JAK1 💬 Abrocitinib 💬 Abrocitinib 2件: 39, 84 💬
31 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: JAK1 💬 Filgotinib 💬 Filgotinib 10件: 46, 53, 56, 96, 97, 107, 222, 271, 300, 331 💬
32 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: JAK1 💬 Itacitinib 💬 Itacitinib 4件: 46, 51, 97, 228 💬
33 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: JAK1 💬 Itacitinib adipate 💬 Itacitinib 4件: 46, 51, 97, 228 💬
34 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: JAK1 💬 Upadacitinib 💬 Upadacitinib 10件: 40, 41, 46, 49, 53, 55, 96, 97, 107, 271 💬
35 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: JAK1 💬 Upadacitinib tartrate 💬 Upadacitinib 10件: 40, 41, 46, 49, 53, 55, 96, 97, 107, 271 💬
36 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: JAK1 💬 Upadacitinib hydrate 💬 Upadacitinib 10件: 40, 41, 46, 49, 53, 55, 96, 97, 107, 271 💬
37 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: JAK1, JAK2 💬 Baricitinib 💬 Baricitinib 21件:  2 , 13, 40, 41, 46, 49, 50, 51, 53, 54, 84, 93, 107, 135, 162, 265, 268, 269, 300, 325, 345 💬
38 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: JAK1, JAK2 💬 Delgocitinib 💬 Delgocitinib 1件: 50 💬
39 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: JAK1, JAK2 💬 Filgotinib maleate 💬 Filgotinib 10件: 46, 53, 56, 96, 97, 107, 222, 271, 300, 331 💬
40 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: JAK1, JAK2 💬 Gusacitinib 💬 Gusacitinib 1件: 49 💬
41 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: JAK1, JAK2 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
42 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: JAK1, JAK2 💬 Ruxolitinib 💬 Ruxolitinib 6件: 13, 15, 50, 60, 65, 228 💬
43 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: JAK1, JAK2 💬 Ruxolitinib phosphate 💬 Ruxolitinib 6件: 13, 15, 50, 60, 65, 228 💬
44 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: JAK1, JAK2 💬 Tofacitinib citrate 💬 Tofacitinib 22件:  2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬
45 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: JAK1, JAK2 💬 Tofacitinib 💬 Tofacitinib 22件:  2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬
46 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: JAK2 💬 Pacritinib 💬 Pacritinib 1件: 331 💬
47 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: LCK 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
48 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: LCK 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
49 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
50 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
51 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: MAP2K1, MAP2K2 💬 Cobimetinib fumarate 💬 Cobimetinib 1件: 280 💬
52 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 4件: 34, 278, 279, 280 💬
53 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
54 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: MAP2K1, MAP2K2 💬 Selumetinib sulfate 💬 Selumetinib 1件: 34 💬
55 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
56 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: MAP2K1, MAP2K2 💬 Trametinib dimethyl sulfoxide 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
57 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: MTOR 💬 Everolimus 💬 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
58 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: MTOR 💬 Sirolimus 💬 Sirolimus 46件:  2 ,  6 , 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 97, 98, 137, 157, 158, 192, 193, 222, 227, 256, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
59 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: MTOR 💬 Temsirolimus 💬 Temsirolimus 4件: 13, 34, 89, 331 💬
60 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: NFKB1 💬 Iguratimod 💬 Iguratimod 6件: 46, 49, 51, 53, 271, 300 💬
61 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 4件: P38, P38, P38, P38 💬 Losmapimod 💬 Losmapimod 2件: 113, 222 💬
62 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 4件: P38, P38, P38, P38 💬 Neflamapimod 💬 Neflamapimod 1件:  8  💬
63 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: PDCD1 💬 Nivolumab 💬 Nivolumab 12件: 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159 💬
64 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: PDCD1 💬 Pembrolizumab 💬 Pembrolizumab 2件: 25, 285 💬
65 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: PDCD1 💬 Peresolimab 💬 Peresolimab 1件: 46 💬
66 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: PDCD1 💬 Rosnilimab 💬 Rosnilimab 2件: 46, 97 💬
67 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: PDL1 💬 Atezolizumab 💬 Atezolizumab 1件: 85 💬
68 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: PDL1 💬 Durvalumab 💬 Durvalumab 1件: 85 💬
69 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: PIK3CA_B_D 💬 Alpelisib 💬 Alpelisib 4件: 138, 278, 279, 280 💬
70 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: PIK3CA_B_D 💬 Leniolisib phosphate 💬 Leniolisib 2件: 53, 65 💬
71 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: PIK3CA_B_D 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
72 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: PIK3CA_B_D, PIK3CA_B_D 💬 Copanlisib 💬 Copanlisib 1件: 121 💬
73 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 3件: PIK3CA_B_D, PIK3CA_B_D, PIK3CA_B_D 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
74 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Cyclosporine 💬 Cyclosporine 42件: 11, 19, 20, 26, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 54, 55, 56, 58, 60, 61, 62, 63, 64, 65, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
75 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Pimecrolimus 💬 Pimecrolimus 1件: 160 💬
76 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus 33件:  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
77 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus 33件:  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
78 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Voclosporin 💬 Voclosporin 2件: 49, 222 💬
79 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: PRKCQ 💬 Sotrastaurin 💬 Sotrastaurin 1件: 97 💬
80 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: PRKCQ 💬 Sotrastaurin acetate 💬 Sotrastaurin 1件: 97 💬
81 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: RAF1 💬 Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
82 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: RAF1 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬
83 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: RELA 💬 Edasalonexent 💬 Edasalonexent 1件: 113 💬
84 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 1件: TLR9 💬 Cobitolimod 💬 Cobitolimod 1件: 97 💬