Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Fluid shear stress and atherosclerosis 💬
 1件: ACVR2A 💬 Sotatercept 💬 Sotatercept 2件: 86, 284 💬
2 Fluid shear stress and atherosclerosis 💬
 2件: ACVR2A, ACVR2B 💬 Bimagrumab 💬 Bimagrumab 1件: 15 💬
3 Fluid shear stress and atherosclerosis 💬
 1件: ACVR2B 💬 Luspatercept 💬 Luspatercept 1件: 60 💬
4 Fluid shear stress and atherosclerosis 💬
 1件: BCL2 💬 Venetoclax 💬 Venetoclax 1件: 28 💬
5 Fluid shear stress and atherosclerosis 💬
 4件: CCL2, IL1A, IL1B, TNF 💬 Pirfenidone 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
6 Fluid shear stress and atherosclerosis 💬
 1件: HMOX1 💬 Stannsoporfin 💬 Stannsoporfin 1件: 254 💬
7 Fluid shear stress and atherosclerosis 💬
 1件: IFNG 💬 Emapalumab 💬 Emapalumab 3件: 49, 65, 107 💬
8 Fluid shear stress and atherosclerosis 💬
 1件: IFNG 💬 Fontolizumab 💬 Fontolizumab 1件: 46 💬
9 Fluid shear stress and atherosclerosis 💬
 1件: IL1A 💬 Bermekimab 💬 Bermekimab 1件: 51 💬
10 Fluid shear stress and atherosclerosis 💬
 2件: IL1A, IL1B 💬 Rilonacept 💬 Rilonacept 4件: 51, 106, 107, 266 💬
11 Fluid shear stress and atherosclerosis 💬
 1件: IL1B 💬 Canakinumab 💬 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
12 Fluid shear stress and atherosclerosis 💬
 1件: IL1B 💬 Gevokizumab 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
13 Fluid shear stress and atherosclerosis 💬
 2件: IL1R1, IL1R2 💬 Anakinra 💬 Anakinra 18件:  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
14 Fluid shear stress and atherosclerosis 💬
 1件: KDR 💬 Axitinib 💬 Axitinib 1件: 34 💬
15 Fluid shear stress and atherosclerosis 💬
 1件: KDR 💬 Cabozantinib 💬 Cabozantinib 1件: 34 💬
16 Fluid shear stress and atherosclerosis 💬
 1件: KDR 💬 Cediranib 💬 Cediranib 1件: 34 💬
17 Fluid shear stress and atherosclerosis 💬
 1件: KDR 💬 Nintedanib 💬 Nintedanib 5件: 51, 85, 89, 227, 228 💬
18 Fluid shear stress and atherosclerosis 💬
 1件: KDR 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬
19 Fluid shear stress and atherosclerosis 💬
 1件: KDR 💬 Sunitinib 💬 Sunitinib 2件: 28, 34 💬
20 Fluid shear stress and atherosclerosis 💬
 1件: KDR 💬 Tesevatinib 💬 Tesevatinib 1件: 67 💬
21 Fluid shear stress and atherosclerosis 💬
 1件: KEAP1 💬 Dimethyl fumarate 💬 Dimethyl fumarate 5件: 13, 49, 51, 86, 296 💬
22 Fluid shear stress and atherosclerosis 💬
 1件: MAP3K5 💬 Selonsertib 💬 Selonsertib 1件: 86 💬
23 Fluid shear stress and atherosclerosis 💬
 4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod 2件: 113, 222 💬
24 Fluid shear stress and atherosclerosis 💬
 4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod 1件:  8  💬
25 Fluid shear stress and atherosclerosis 💬
 1件: NFE2L2 💬 Omaveloxolone 💬 Omaveloxolone 1件: 18 💬
26 Fluid shear stress and atherosclerosis 💬
 1件: NFKB1 💬 Iguratimod 💬 Iguratimod 5件: 46, 51, 53, 271, 300 💬
27 Fluid shear stress and atherosclerosis 💬
 1件: NQO1 💬 Warfarin 💬 Warfarin 11件:  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
28 Fluid shear stress and atherosclerosis 💬
 1件: PIK3CA 💬 Alpelisib 💬 Alpelisib 1件: 138 💬
29 Fluid shear stress and atherosclerosis 💬
 3件: PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
30 Fluid shear stress and atherosclerosis 💬
 1件: PIK3CD 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
31 Fluid shear stress and atherosclerosis 💬
 2件: PRKAA1, PRKAA2 💬 Metformin 💬 Metformin 25件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
32 Fluid shear stress and atherosclerosis 💬
 1件: RELA 💬 Edasalonexent 💬 Edasalonexent 1件: 113 💬
33 Fluid shear stress and atherosclerosis 💬
 1件: SRC 💬 Bosutinib 💬 Bosutinib 2件:  2 , 67 💬
34 Fluid shear stress and atherosclerosis 💬
 1件: SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
35 Fluid shear stress and atherosclerosis 💬
 1件: SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
36 Fluid shear stress and atherosclerosis 💬
 1件: SRC 💬 Saracatinib 💬 Saracatinib 3件:  6 , 89, 272 💬
37 Fluid shear stress and atherosclerosis 💬
 1件: TNF 💬 Adalimumab 💬 Adalimumab 17件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
38 Fluid shear stress and atherosclerosis 💬
 1件: TNF 💬 Certolizumab pegol 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
39 Fluid shear stress and atherosclerosis 💬
 1件: TNF 💬 Etanercept 💬 Etanercept 16件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
40 Fluid shear stress and atherosclerosis 💬
 1件: TNF 💬 Golimumab 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
41 Fluid shear stress and atherosclerosis 💬
 1件: TNF 💬 Infliximab 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
42 Fluid shear stress and atherosclerosis 💬
 1件: TNF 💬 Lenalidomide 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
43 Fluid shear stress and atherosclerosis 💬
 1件: TNF 💬 Ozoralizumab 💬 Ozoralizumab 1件: 46 💬
44 Fluid shear stress and atherosclerosis 💬
 1件: TNF 💬 Pegsunercept 💬 Pegsunercept 1件: 46 💬
45 Fluid shear stress and atherosclerosis 💬
 1件: TNF 💬 Pomalidomide 💬 Pomalidomide 5件: 28, 51, 85, 227, 331 💬
46 Fluid shear stress and atherosclerosis 💬
 1件: TNF 💬 Thalidomide 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
47 Fluid shear stress and atherosclerosis 💬
 1件: VEGFA 💬 Aflibercept 💬 Aflibercept 2件: 90, 166 💬
48 Fluid shear stress and atherosclerosis 💬
 1件: VEGFA 💬 Bevacizumab 💬 Bevacizumab 6件: 13, 34, 85, 87, 227, 280 💬
49 Fluid shear stress and atherosclerosis 💬
 1件: VEGFA 💬 Ranibizumab 💬 Ranibizumab 4件: 34, 166, 227, 301 💬