Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1ACETYLSALICYLIC ACID[1] Acetylsalicylic acid[1] Aspirin 💬 [2] PTGS1,
PTGS2 💬 		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Efferocytosis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[5] 13, 46, 51, 62, 210 💬
2ACT-064992----[5] 51, 85, 86, 88, 210 💬
3Administration of an ACE-inhibitor or not----[1] 210 💬
4Aesculus Hippocastanum / Horse Chestnut[1] Horse chestnut[1] Horse chestnut 💬 --[1] 210 💬
5Ambrisentan[1] Ambrisentan[1] Ambrisentan 💬 [1] EDNRA 💬 [7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[10] 51, 66, 84, 85, 86, 88, 210, 211, 218, 222 💬
6Arginine[1] Arginine[3] Arginine hydrochloride ,
Arginine ,
Arginine hydrochloride 💬 		--[16] 2, 21, 46, 57, 58, 67, 72, 96, 97, 98, 113, 210, 223, 225, 251, 299 💬
7Aspirin[1] Acetylsalicylic acid[1] Aspirin 💬 [2] PTGS1,
PTGS2 💬 		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Efferocytosis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[10] 22, 34, 48, 49, 51, 63, 86, 158, 210, 231 💬
8Autologous Tissue-Engineered Vascular Graft----[1] 210 💬
9BAY 59-7939----[2] 48, 210 💬
10Bosentan[1] Bosentan[2] Bosentan ,
Bosentan 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
11Carvedilol[1] Carvedilol[2] Carvedilol ,
Carvedilol phosphate 💬 		[5] ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
ADRB2 💬 		[15] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[7] 6, 46, 57, 58, 86, 113, 210 💬
12Colchicine[1] Colchicine[1] Colchicine 💬 [9] TUBB,
TUBB1,
TUBB2A,
TUBB2B,
TUBB3,
TUBB4A,
TUBB4B,
TUBB6,
TUBB8 💬 		[12] Alzheimer disease, Amyotrophic lateral sclerosis, Gap junction, Huntington disease, IgSF CAM signaling, Motor proteins, Parkinson disease, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Phagocytosis, Prion disease, Salmonella infection 💬[9] 2, 42, 46, 50, 56, 93, 97, 210, 266 💬
13Dapagliflozin[1] Dapagliflozin[1] Dapagliflozin 💬 --[16] 6, 19, 28, 40, 41, 49, 57, 66, 67, 86, 88, 97, 210, 215, 218, 222 💬
14Dapagliflozin tablet[1] Dapagliflozin[1] Dapagliflozin 💬 --[1] 210 💬
15Diagnostic Test: Blood draw for hematocrit and heart failure biomarkers----[1] 210 💬
16Diagnostic Test: Cardiac Magnetic Resonance Imaging----[1] 210 💬
17Diagnostic Test: Cardiopulmonary exercise test----[1] 210 💬
18Diagnostic Test: Exhalomics----[1] 210 💬
19Diagnostic Test: Quality of life questionnaire----[1] 210 💬
20Digoxin[1] Digoxin[1] Digoxin 💬 [4] ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4 💬 		[19] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cytoskeleton in muscle cells, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[7] 2, 8, 46, 57, 65, 67, 210 💬
21Enalapril[1] Enalapril[2] Enalapril maleate ,
Enalapril 💬 		[1] ACE 💬 [6] Chagas disease, Coronavirus disease, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[10] 13, 19, 46, 57, 66, 113, 210, 222, 223, 279 💬
22Eplerenone[1] Eplerenone[1] Eplerenone 💬 [1] NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption 💬[5] 57, 75, 113, 210, 215 💬
23Genetic: Autologous cardiac stem cells (JRM-001)----[2] 210, 211 💬
24Genetic: Cardiac progenitor cell infusion----[2] 210, 211 💬
25Horse chestnut[1] Horse chestnut[1] Horse chestnut 💬 --[1] 210 💬
26IPSC-CL----[1] 210 💬
27JNJ-39039039----[1] 210 💬
28Liothyronine[1] Liothyronine[2] Liothyronine sodium ,
Liothyronine 💬 		[2] THRA,
THRB 💬 		[3] Hormone signaling, Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway 💬[3] 13, 210, 212 💬
29Liothyronine I 131[1] Liothyronine[2] Liothyronine sodium ,
Liothyronine 💬 		[2] THRA,
THRB 💬 		[3] Hormone signaling, Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway 💬[2] 210, 212 💬
30Macitentan[1] Macitentan[1] Macitentan 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 51, 85, 86, 88, 210 💬
31MPC----[2] 210, 211 💬
32MysildecardPharmaceutical Form: CapsulePharmaceutical form of the placebo: CapsuleRoute of administration of the placebo: Oral use----[1] 210 💬
33Nitric Oxide[1] Nitric Oxide[1] Nitric oxide 💬 --[12] 46, 51, 85, 86, 88, 97, 98, 210, 251, 294, 299, 340 💬
34Normal Saline----[20] 6, 13, 17, 22, 36, 46, 49, 60, 70, 71, 79, 94, 96, 97, 210, 211, 226, 276, 296, 299 💬
35ODSH at 0.125 mg/kg/h----[1] 210 💬
36ODSH at 0.250 mg/kg/h----[1] 210 💬
37ODSH at 0.375 mg/kg/h----[1] 210 💬
38Opsumit®----[3] 86, 88, 210 💬
39Other: Collecting discarded blood samples----[1] 210 💬
40Other: Human Milk Derived Fortifier----[1] 210 💬
41Other: Human/Bovine Milk----[1] 210 💬
42Other: Research Blood Sampling----[1] 210 💬
43PK/PD Model Based Dosing of Digoxin in Infants with Single Ventricle Heart Disease[1] Digoxin[1] Digoxin 💬 [4] ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4 💬 		[19] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cytoskeleton in muscle cells, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 210 💬
44Pravastatin[1] Pravastatin[2] Pravastatin sodium ,
Pravastatin 💬 		[1] HMGCR 💬 [3] AMPK signaling pathway, Bile secretion, Terpenoid backbone biosynthesis 💬[11] 13, 46, 49, 67, 79, 96, 164, 210, 222, 265, 333 💬
45Pravastatin 20 mg oral tablet (ages <13 years), or 40 mg oral tablet (=14 years)[1] Pravastatin[2] Pravastatin sodium ,
Pravastatin 💬 		[1] HMGCR 💬 [3] AMPK signaling pathway, Bile secretion, Terpenoid backbone biosynthesis 💬[1] 210 💬
46Rexlemestrocel-L[1] Rexlemestrocel-L---[2] 210, 211 💬
47Rivaroxaban[1] Rivaroxaban[1] Rivaroxaban 💬 [1] F10 💬 [1] Complement and coagulation cascades 💬[10] 46, 48, 49, 56, 58, 75, 91, 210, 222, 271 💬
48Sacubitril[1] Sacubitril[1] Sacubitril 💬 [1] MME 💬 [4] Alzheimer disease, Hematopoietic cell lineage, Protein digestion and absorption, Renin-angiotensin system 💬[4] 28, 58, 210, 222 💬
49Sacubitril / Valsartan Oral Tablet [Entresto][2] Sacubitril,
Valsartan		[2] Valsartan ,
Sacubitril 💬 		[2] AGTR1,
MME 💬 		[20] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hematopoietic cell lineage, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Protein digestion and absorption, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 210 💬
50SCRM001_TEVG----[1] 210 💬
51SGLT2 inhibitors----[3] 208, 210, 215 💬
52Sildenafil[1] Sildenafil[2] Sildenafil citrate ,
Sildenafil 💬 		[1] PDE5A 💬 [2] Purine metabolism, cGMP-PKG signaling pathway 💬[17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
53Sildenafil 10mg oral tablet (participants <20kg), or 20mg oral tablet (participants =20kg)[1] Sildenafil[2] Sildenafil citrate ,
Sildenafil 💬 		[1] PDE5A 💬 [2] Purine metabolism, cGMP-PKG signaling pathway 💬[1] 210 💬
54Sildenafil by injection[1] Sildenafil[2] Sildenafil citrate ,
Sildenafil 💬 		[1] PDE5A 💬 [2] Purine metabolism, cGMP-PKG signaling pathway 💬[1] 210 💬
55Spironolactone[1] Spironolactone[1] Spironolactone 💬 [1] NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption 💬[12] 46, 57, 58, 67, 86, 113, 210, 214, 218, 222, 223, 225 💬
56Spironolactone (drug)[1] Spironolactone[1] Spironolactone 💬 [1] NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption 💬[1] 210 💬
57Sugar pill----[9] 5, 6, 49, 67, 70, 86, 120, 206, 210 💬
58Tadalafil[1] Tadalafil[1] Tadalafil 💬 [1] PDE5A 💬 [2] Purine metabolism, cGMP-PKG signaling pathway 💬[8] 6, 51, 75, 77, 84, 86, 113, 210 💬
59Tadalafil Citrate[1] Tadalafil[1] Tadalafil 💬 [1] PDE5A 💬 [2] Purine metabolism, cGMP-PKG signaling pathway 💬[1] 210 💬
60Tracleer----[8] 13, 51, 84, 85, 86, 88, 210, 211 💬
61Treprostinil[1] Treprostinil[3] Treprostinil ,
Treprostinil monosodium salt ,
Treprostinil diolamine 💬 		[1] PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[6] 51, 84, 85, 86, 88, 210 💬
62Udenafil[1] Udenafil[1] Udenafil 💬 [1] PDE5A 💬 [2] Purine metabolism, cGMP-PKG signaling pathway 💬[2] 86, 210 💬
63Valsartan[1] Valsartan[1] Valsartan 💬 [1] AGTR1 💬 [17] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[11] 28, 57, 58, 66, 75, 86, 210, 218, 222, 223, 224 💬
64Vasopressin[1] Vasopressin[1] Vasopressin 💬 [3] AVPR1A,
AVPR1B,
AVPR2 💬 		[6] Calcium signaling pathway, Hormone signaling, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vascular smooth muscle contraction, Vasopressin-regulated water reabsorption 💬[2] 210, 225 💬
65Vasopressin, Arginine[2] Arginine,
Vasopressin		[4] Vasopressin ,
Arginine hydrochloride ,
Arginine ,
Arginine hydrochloride 💬 		[3] AVPR1A,
AVPR1B,
AVPR2 💬 		[6] Calcium signaling pathway, Hormone signaling, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vascular smooth muscle contraction, Vasopressin-regulated water reabsorption 💬[1] 210 💬
66Vitamin C----[5] 49, 206, 210, 211, 212 💬
67XARELTO----[3] 48, 49, 210 💬