| 1 | [PF-07256472] | - | - | - | - | [1] 276 276 💬
|
| 2 | ABSK061 | - | - | - | - | [1] 276 276 💬
|
| 3 | Active BMN 111: Subcutaneous injection of recommended dose of BMN 111 based on weight-band dosing once daily. | - | - | - | - | [1] 276 276 💬
|
| 4 | BGJ398 (also known as BBP-831) | - | - | - | - | [1] 276 276 💬
|
| 5 | BMN 111 | - | - | - | - | [1] 276 276 💬
|
| 6 | BMN 111 administration via vial and syringe | - | - | - | - | [1] 276 276 💬
|
| 7 | BMN 333 | - | - | - | - | [1] 276 276 💬
|
| 8 | C-type natriuretic peptide conjugated to a multi-arm polyethylene glycol carrier molecule through a cleavable linker | [1] Polyethylene glycol Polyethylene glycol | [3] Polyethylene glycol 3350
Polyethylene glycol 3350
,
Macrogol 4000
,
Macrogol 6000
💬
| - | - | [1] 276 276 💬
|
| 9 | C-TYPE NATRIURETIC PEPTIDE CONJUGATED TO MULTI-ARM POLYETHYLENE GLYCOL CARRIER THROUGH A CLEAVABLE LINKER | [1] Polyethylene glycol Polyethylene glycol | [3] Polyethylene glycol 3350
Polyethylene glycol 3350
,
Macrogol 4000
,
Macrogol 6000
💬
| - | - | [1] 276 276 💬
|
| 10 | Combination of Navepegritide and Lonapegsomatropin administered as two separate s.c. injections | [2] Lonapegsomatropin Lonapegsomatropin, Navepegritide | [2] Lonapegsomatropin
Lonapegsomatropin
,
Navepegritide
💬
| [2] GHR GHR, NPR2 💬
| [10] Cytokine-cytokine receptor interaction Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, Hormone signaling, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Purine metabolism, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬 | [1] 276 276 💬
|
| 11 | Combination Product: BMN 111 administration via Injector Pen | - | - | - | - | [1] 276 276 💬
|
| 12 | INFIGRATINIB | [1] Infigratinib Infigratinib | [2] Infigratinib
Infigratinib
,
Infigratinib phosphate
💬
| [3] FGFR1 FGFR1, FGFR2, FGFR3 💬
| [22] Adherens junction Adherens junction, Bladder cancer, Breast cancer, Cadherin signaling, Calcium signaling pathway, Central carbon metabolism in cancer, Endocytosis, Gastric cancer, IgSF CAM signaling, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells, Thermogenesis 💬 | [1] 276 276 💬
|
| 13 | Infigratinib 0.016 mg/kg | [1] Infigratinib Infigratinib | [2] Infigratinib
Infigratinib
,
Infigratinib phosphate
💬
| [3] FGFR1 FGFR1, FGFR2, FGFR3 💬
| [22] Adherens junction Adherens junction, Bladder cancer, Breast cancer, Cadherin signaling, Calcium signaling pathway, Central carbon metabolism in cancer, Endocytosis, Gastric cancer, IgSF CAM signaling, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells, Thermogenesis 💬 | [1] 276 276 💬
|
| 14 | Infigratinib 0.032 mg/kg | [1] Infigratinib Infigratinib | [2] Infigratinib
Infigratinib
,
Infigratinib phosphate
💬
| [3] FGFR1 FGFR1, FGFR2, FGFR3 💬
| [22] Adherens junction Adherens junction, Bladder cancer, Breast cancer, Cadherin signaling, Calcium signaling pathway, Central carbon metabolism in cancer, Endocytosis, Gastric cancer, IgSF CAM signaling, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells, Thermogenesis 💬 | [1] 276 276 💬
|
| 15 | Infigratinib 0.064 mg/kg | [1] Infigratinib Infigratinib | [2] Infigratinib
Infigratinib
,
Infigratinib phosphate
💬
| [3] FGFR1 FGFR1, FGFR2, FGFR3 💬
| [22] Adherens junction Adherens junction, Bladder cancer, Breast cancer, Cadherin signaling, Calcium signaling pathway, Central carbon metabolism in cancer, Endocytosis, Gastric cancer, IgSF CAM signaling, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells, Thermogenesis 💬 | [1] 276 276 💬
|
| 16 | Infigratinib 0.128 mg/kg | [1] Infigratinib Infigratinib | [2] Infigratinib
Infigratinib
,
Infigratinib phosphate
💬
| [3] FGFR1 FGFR1, FGFR2, FGFR3 💬
| [22] Adherens junction Adherens junction, Bladder cancer, Breast cancer, Cadherin signaling, Calcium signaling pathway, Central carbon metabolism in cancer, Endocytosis, Gastric cancer, IgSF CAM signaling, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells, Thermogenesis 💬 | [1] 276 276 💬
|
| 17 | Infigratinib 0.25 mg/kg | [1] Infigratinib Infigratinib | [2] Infigratinib
Infigratinib
,
Infigratinib phosphate
💬
| [3] FGFR1 FGFR1, FGFR2, FGFR3 💬
| [22] Adherens junction Adherens junction, Bladder cancer, Breast cancer, Cadherin signaling, Calcium signaling pathway, Central carbon metabolism in cancer, Endocytosis, Gastric cancer, IgSF CAM signaling, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells, Thermogenesis 💬 | [1] 276 276 💬
|
| 18 | Infigratinib 0.25 mg/kg/day | [1] Infigratinib Infigratinib | [2] Infigratinib
Infigratinib
,
Infigratinib phosphate
💬
| [3] FGFR1 FGFR1, FGFR2, FGFR3 💬
| [22] Adherens junction Adherens junction, Bladder cancer, Breast cancer, Cadherin signaling, Calcium signaling pathway, Central carbon metabolism in cancer, Endocytosis, Gastric cancer, IgSF CAM signaling, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells, Thermogenesis 💬 | [1] 276 276 💬
|
| 19 | Infigratinib is provided as a single dose of minitablets for oral administration | [1] Infigratinib Infigratinib | [2] Infigratinib
Infigratinib
,
Infigratinib phosphate
💬
| [3] FGFR1 FGFR1, FGFR2, FGFR3 💬
| [22] Adherens junction Adherens junction, Bladder cancer, Breast cancer, Cadherin signaling, Calcium signaling pathway, Central carbon metabolism in cancer, Endocytosis, Gastric cancer, IgSF CAM signaling, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells, Thermogenesis 💬 | [1] 276 276 💬
|
| 20 | Infigratinib is provided as sprinkle capsules for daily oral administration | [1] Infigratinib Infigratinib | [2] Infigratinib
Infigratinib
,
Infigratinib phosphate
💬
| [3] FGFR1 FGFR1, FGFR2, FGFR3 💬
| [22] Adherens junction Adherens junction, Bladder cancer, Breast cancer, Cadherin signaling, Calcium signaling pathway, Central carbon metabolism in cancer, Endocytosis, Gastric cancer, IgSF CAM signaling, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells, Thermogenesis 💬 | [1] 276 276 💬
|
| 21 | Infigratinib phosphate | [1] Infigratinib Infigratinib | [2] Infigratinib
Infigratinib
,
Infigratinib phosphate
💬
| [3] FGFR1 FGFR1, FGFR2, FGFR3 💬
| [22] Adherens junction Adherens junction, Bladder cancer, Breast cancer, Cadherin signaling, Calcium signaling pathway, Central carbon metabolism in cancer, Endocytosis, Gastric cancer, IgSF CAM signaling, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells, Thermogenesis 💬 | [1] 276 276 💬
|
| 22 | KK8398 | - | - | - | - | [1] 276 276 💬
|
| 23 | Lonapegsomatropin | [1] Lonapegsomatropin Lonapegsomatropin | [1] Lonapegsomatropin
Lonapegsomatropin
💬
| [1] GHR GHR 💬
| [6] Cytokine-cytokine receptor interaction Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, Hormone signaling, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬 | [1] 276 276 💬
|
| 24 | Modified recombinant human c-type | - | - | - | - | [1] 276 276 💬
|
| 25 | Modified recombinant human C-type natriuretic peptide | - | - | - | - | [1] 276 276 💬
|
| 26 | MODIFIED RHCNP | - | - | - | - | [1] 276 276 💬
|
| 27 | Natriuretic peptide | - | - | - | - | [1] 276 276 💬
|
| 28 | Navepegritide | [1] Navepegritide Navepegritide | [1] Navepegritide
Navepegritide
💬
| [1] NPR2 NPR2 💬
| [5] Hormone signaling Hormone signaling, Oxytocin signaling pathway, Purine metabolism, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬 | [1] 276 276 💬
|
| 29 | Normal Saline | - | - | - | - | [20] 6 6, 13, 17, 22, 36, 46, 49, 60, 70, 71, 79, 94, 96, 97, 210, 211, 226, 276, 296, 299 💬
|
| 30 | Other: Recifercept | [1] Recifercept Recifercept | [1] Recifercept
Recifercept
💬
| [1] FGFR3 FGFR3 💬
| [12] Bladder cancer Bladder cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Endocytosis, MAPK signaling pathway, MicroRNAs in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells 💬 | [1] 276 276 💬
|
| 31 | PF-07256472 | - | - | - | - | [1] 276 276 💬
|
| 32 | Polyethylene glycol | [1] Polyethylene glycol Polyethylene glycol | [3] Polyethylene glycol 3350
Polyethylene glycol 3350
,
Macrogol 4000
,
Macrogol 6000
💬
| - | - | [8] 6 6, 50, 96, 97, 195, 235, 276, 299 💬
|
| 33 | Recifercept | [1] Recifercept Recifercept | [1] Recifercept
Recifercept
💬
| [1] FGFR3 FGFR3 💬
| [12] Bladder cancer Bladder cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Endocytosis, MAPK signaling pathway, MicroRNAs in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells 💬 | [1] 276 276 💬
|
| 34 | Recifercept (proposed INN) | [1] Recifercept Recifercept | [1] Recifercept
Recifercept
💬
| [1] FGFR3 FGFR3 💬
| [12] Bladder cancer Bladder cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Endocytosis, MAPK signaling pathway, MicroRNAs in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells 💬 | [1] 276 276 💬
|
| 35 | Recombinant human growth hormone | - | - | - | - | [4] 77 77, 193, 265, 276 💬
|
| 36 | SAR442501 | - | - | - | - | [1] 276 276 💬
|
| 37 | Somatropin | - | - | - | - | [14] 3 3, 74, 75, 78, 97, 107, 113, 187, 193, 195, 222, 238, 274, 276 💬
|
| 38 | TA-46 | [1] Recifercept Recifercept | [1] Recifercept
Recifercept
💬
| [1] FGFR3 FGFR3 💬
| [12] Bladder cancer Bladder cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Endocytosis, MAPK signaling pathway, MicroRNAs in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells 💬 | [1] 276 276 💬
|
| 39 | TBD | - | - | - | - | [5] 19 19, 86, 90, 276, 299 💬
|
| 40 | TransCon CNP | - | - | - | - | [1] 276 276 💬
|
| 41 | TransCon CNP 3.9 mg CNP-38/vial | - | - | - | - | [1] 276 276 💬
|
| 42 | TransCon CNP 3.9 mg CNP-38/vialProduct Code: TransCon CNPPharmaceutical Form: Powder and solvent for solution for injectionINN or Proposed INN: C-TYPE NATRIURETIC PEPTIDE CONJUGATED TO MULTI-ARM POLYETHYLENE GLYCOL CARRIER THROUGH A CLEAVABLE LINKERCAS Number: 2413551-27-4Current Sponsor code: TransCon CNPOther descriptive name: C-type natriuretic peptide conjugated to a multi-arm polyethylene glycol carrier molecule through a cleavable linkerConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 3.9-Pharmaceutical form of the placebo: Powder and solvent for solution for injectionRoute of administration of the placebo: Subcutaneous use | [1] Polyethylene glycol Polyethylene glycol | [3] Polyethylene glycol 3350
Polyethylene glycol 3350
,
Macrogol 4000
,
Macrogol 6000
💬
| - | - | [1] 276 276 💬
|
| 43 | TYRA-300 0.125 mg/kg | - | - | - | - | [1] 276 276 💬
|
| 44 | TYRA-300 0.25 mg/kg | - | - | - | - | [1] 276 276 💬
|
| 45 | TYRA-300 0.375 mg/kg | - | - | - | - | [1] 276 276 💬
|
| 46 | TYRA-300 0.50 mg/kg | - | - | - | - | [1] 276 276 💬
|
| 47 | Vorsoritide | - | - | - | - | [1] 276 276 💬
|
| 48 | Vosoritide | [1] Vosoritide Vosoritide | [1] Vosoritide
Vosoritide
💬
| [1] NPR2 NPR2 💬
| [5] Hormone signaling Hormone signaling, Oxytocin signaling pathway, Purine metabolism, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬 | [3] 19 19, 195, 276 💬
|
| 49 | Vosoritide Injection [Voxzogo] | [1] Vosoritide Vosoritide | [1] Vosoritide
Vosoritide
💬
| [1] NPR2 NPR2 💬
| [5] Hormone signaling Hormone signaling, Oxytocin signaling pathway, Purine metabolism, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬 | [2] 19 19, 276 💬
|
| 50 | Voxzogo | - | - | - | - | [1] 276 276 💬
|