Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1Bosentan[1] Bosentan (Bosentan monohydrate)[2] Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
2Bosentan (Tracleer)[1] Bosentan (Bosentan monohydrate)[2] Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 51 💬
3Bosentan 125 mg[1] Bosentan (Bosentan monohydrate)[2] Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 51 💬
4Bosentan 62.5 mg[1] Bosentan (Bosentan monohydrate)[2] Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 51 💬
5Bosentan administration[1] Bosentan (Bosentan monohydrate)[2] Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
6Bosentan and dapagliflozin[2] Bosentan (Bosentan monohydrate),
Dapagliflozin		[3] Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan),
Dapagliflozin 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 40, 41 💬
7Bosentan Dispersible Tablets[1] Bosentan (Bosentan monohydrate)[2] Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
8Bosentan group[1] Bosentan (Bosentan monohydrate)[2] Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 51 💬
9Bosentan monohydrat[1] Bosentan (Bosentan monohydrate)[2] Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
10BOSENTAN MONOHYDRATE[1] Bosentan (Bosentan monohydrate)[2] Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 51, 84, 86, 88 💬
11BOSENTAN MYLAN[1] Bosentan (Bosentan monohydrate)[2] Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 41 💬
12Bosentan, Ambrisentan[2] Ambrisentan,
Bosentan (Bosentan monohydrate)		[3] Bosentan (Bosentan, Bosentan hydrate),
Ambrisentan ,
Bosentan (Bosentan) 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
13Duo-Therapy with Sildenafil + Bosentan[2] Bosentan (Bosentan monohydrate),
Sildenafil		[4] Bosentan (Bosentan, Bosentan hydrate),
Sildenafil citrate ,
Bosentan (Bosentan),
Sildenafil 💬 		[3] EDNRA,
EDNRB,
PDE5A 💬 		[10] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
14ERA and PDE-5I (Sildenafil, Tadalafil, Bosentan, Macitentan)[4] Bosentan (Bosentan monohydrate),
Macitentan,
Sildenafil,
Tadalafil		[6] Bosentan (Bosentan, Bosentan hydrate),
Tadalafil ,
Sildenafil citrate ,
Bosentan (Bosentan),
Sildenafil ,
Macitentan 💬 		[3] EDNRA,
EDNRB,
PDE5A 💬 		[10] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
15NIRS after bosentan administration[1] Bosentan (Bosentan monohydrate)[2] Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 13 💬
16Other: Switch from Ambrisentan to Bosentan[2] Ambrisentan,
Bosentan (Bosentan monohydrate)		[3] Bosentan (Bosentan, Bosentan hydrate),
Ambrisentan ,
Bosentan (Bosentan) 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
17Sildenafil 20mg and Bosentan 62.5mg[2] Bosentan (Bosentan monohydrate),
Sildenafil		[4] Bosentan (Bosentan, Bosentan hydrate),
Sildenafil citrate ,
Bosentan (Bosentan),
Sildenafil 💬 		[3] EDNRA,
EDNRB,
PDE5A 💬 		[10] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 51, 86 💬
18Sildenafil singly or in association with Bosentan[2] Bosentan (Bosentan monohydrate),
Sildenafil		[4] Bosentan (Bosentan, Bosentan hydrate),
Sildenafil citrate ,
Bosentan (Bosentan),
Sildenafil 💬 		[3] EDNRA,
EDNRB,
PDE5A 💬 		[10] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
19TCD after bosentan administration[1] Bosentan (Bosentan monohydrate)[2] Bosentan (Bosentan, Bosentan hydrate),
Bosentan (Bosentan) 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 13 💬