Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1BCX7353 + digoxin[1] Digoxin (Digoxinum)[1] Digoxin (Digoxin) 💬 [4] ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4 💬 		[19] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cytoskeleton in muscle cells, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 65 💬
2BMS Drug-drug interaction cocktail (montelukast, flurbiprofen, omeprazole, midazolam, and digoxin)[5] Digoxin (Digoxinum),
Flurbiprofen,
Midazolam,
Montelukast,
Omeprazole		[11] Digoxin (Digoxin),
Flurbiprofen ,
Omeprazole ,
Montelukast sodium ,
Midazolam ,
Midazolam hydrochloride ,
Omeprazole sodium ,
Flurbiprofen sodium ,
Midazolam maleate ,
Omeprazole magnesium ,
Montelukast 💬 		[25] ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4,
ATP4A,
ATP4B,
CYSLTR1,
GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
PTGS1,
PTGS2 💬 		[52] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Arachidonic acid metabolism, Bile secretion, C-type lectin receptor signaling pathway, Cadherin signaling, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Chemical carcinogenesis - DNA adducts, Collecting duct acid secretion, Cytoskeleton in muscle cells, Efferocytosis, Endocrine and other factor-regulated calcium reabsorption, GABAergic synapse, Gastric acid secretion, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Insulin secretion, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MicroRNAs in cancer, Mineral absorption, Morphine addiction, NF-kappa B signaling pathway, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Ovarian steroidogenesis, Oxidative phosphorylation, Oxytocin signaling pathway, Pancreatic secretion, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, Taste transduction, Thyroid hormone signaling pathway, Thyroid hormone synthesis, VEGF signaling pathway, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 46 💬
3Cocktail Substrates (Midazolam Oral Solution, Rosuvastatin Calcium Tablets, and Digoxin Tablets)[4] Calcium,
Digoxin (Digoxinum),
Midazolam,
Rosuvastatin		[6] Digoxin (Digoxin),
Midazolam ,
Midazolam hydrochloride ,
Rosuvastatin calcium ,
Midazolam maleate ,
Rosuvastatin 💬 		[21] ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4,
GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
HMGCR 💬 		[30] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Cadherin signaling, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cytoskeleton in muscle cells, Endocrine and other factor-regulated calcium reabsorption, GABAergic synapse, Gastric acid secretion, Insulin secretion, Mineral absorption, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Taste transduction, Terpenoid backbone biosynthesis, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 67 💬
4Digoxin[1] Digoxin (Digoxinum)[1] Digoxin (Digoxin) 💬 [4] ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4 💬 		[19] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cytoskeleton in muscle cells, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[7] 2, 8, 46, 57, 65, 67, 210 💬
5Digoxin 0.25 mg[1] Digoxin (Digoxinum)[1] Digoxin (Digoxin) 💬 [4] ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4 💬 		[19] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cytoskeleton in muscle cells, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 46 💬
6Digoxin+furosemide+captopril[3] Captopril,
Digoxin (Digoxinum),
Furosemide		[3] Captopril ,
Digoxin (Digoxin),
Furosemide 💬 		[6] ACE,
ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4,
SLC12A2 💬 		[26] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Chagas disease, Coronavirus disease, Cytoskeleton in muscle cells, Diabetic cardiomyopathy, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Hypertrophic cardiomyopathy, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Renin secretion, Renin-angiotensin system, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, Vibrio cholerae infection, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 57 💬
7Montelukast, Flurbiprofen, Midazolam, Digoxin, Pravastatin and BMS-986142[6] BMS-986142,
Digoxin (Digoxinum),
Flurbiprofen,
Midazolam,
Montelukast,
Pravastatin		[10] Digoxin (Digoxin),
Flurbiprofen ,
Montelukast sodium ,
Midazolam ,
Midazolam hydrochloride ,
Pravastatin sodium ,
Flurbiprofen sodium ,
Midazolam maleate ,
Montelukast ,
Pravastatin 💬 		[24] ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4,
CYSLTR1,
GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
HMGCR,
PTGS1,
PTGS2 💬 		[52] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Arachidonic acid metabolism, Bile secretion, C-type lectin receptor signaling pathway, Cadherin signaling, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Chemical carcinogenesis - DNA adducts, Cytoskeleton in muscle cells, Efferocytosis, Endocrine and other factor-regulated calcium reabsorption, GABAergic synapse, Gastric acid secretion, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Insulin secretion, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MicroRNAs in cancer, Mineral absorption, Morphine addiction, NF-kappa B signaling pathway, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Ovarian steroidogenesis, Oxytocin signaling pathway, Pancreatic secretion, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, Taste transduction, Terpenoid backbone biosynthesis, Thyroid hormone signaling pathway, Thyroid hormone synthesis, VEGF signaling pathway, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 46 💬
8PK/PD Model Based Dosing of Digoxin in Infants with Single Ventricle Heart Disease[1] Digoxin (Digoxinum)[1] Digoxin (Digoxin) 💬 [4] ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4 💬 		[19] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cytoskeleton in muscle cells, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 210 💬