Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1100-mg VX-445 / 50-mg TEZ / 75-mg IVA FDCProduct Code: VX-445/TEZ/IVAPharmaceutical Form: Film-coated tabletINN or Proposed INN: elexacaftorCAS Number: 2216712-66-0Current Sponsor code: VX-445Other descriptive name: VX-445Concentration unit: mg milligram(s)Concentration type: equalConcentration number: 100-INN or Proposed INN: TEZACAFTORCAS Number: 1152311-62-0Current Sponsor code: VX-661Other descriptive name: TEZConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 50-INN or Proposed INN: IVACAFTORCAS Number: 873054-44-5Current Sponsor code: VX-770Other descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 75-Pharmaceutical form of the placebo: Film-coated tabletRoute of administration of the placebo: Oral use----[1] 299 💬
2100mg ELX/50mg TEZ /75mg IVAProduct Code: VX-445/TEZ/IVAPharmaceutical Form: Film-coated tabletINN or Proposed INN: ElexacaftorCAS Number: 2216712-66-0Current Sponsor code: VX-445Other descriptive name: ELXConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 100-INN or Proposed INN: TezacaftorCAS Number: 1152311-62-0Current Sponsor code: VX-661Other descriptive name: TEZConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 50-INN or Proposed INN: IvacaftorCAS Number: 873054-44-5Current Sponsor code: VX-770Other descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 75-Pharmaceutical form of the placebo: TabletRoute of administration of the placebo: Oral useProduct Name: 150mg IVACAFTORProduct Code: VX-770Pharmaceutical Form: Film-coated tabletINN or Proposed INN: IvacaftorCAS Number: 873054-44-5Current Sponsor code: VX-770Other descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 150-Pharmaceutical form of the placebo: Film-coated tabletRoute of administration of the placebo: Oral useProduct Name: 75-mg IVACAFTORProduct Code: VX-770Pharmaceutical Form: Film-coated tabletINN or Proposed INN: IvacaftorCAS Number: 873054-44-5Current Sponsor code: VX-770Other descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 75-Pharmaceutical form of the placebo: Film-coated tabletRoute of administration of the placebo: Oral useProduct Name: 50 mg ELX/25 mg TEZ/37.5 mg IVAProduct Code: VX-445/TEZ/IVAPharmaceutical Form: Film-coated tabletINN or Proposed INN: IvacaftorCAS Number: 873054-44-5Current Sponsor code: VX-----[1] 299 💬
3ELEXACAFTOR[1] Elexacaftor (Elexacaftor)[1] Elexacaftor (Elexacaftor) 💬 [1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
4Elexacaftor / Ivacaftor / Tezacaftor[3] Elexacaftor (Elexacaftor),
Ivacaftor,
Tezacaftor		[3] Ivacaftor ,
Tezacaftor ,
Elexacaftor (Elexacaftor) 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
5Elexacaftor 100 MG / Ivacaftor 75 MG / Tezacaftor 50 MG, 2 tablets each morning + Ivacaftor 150 mg one tablet each evening[3] Elexacaftor (Elexacaftor),
Ivacaftor,
Tezacaftor		[3] Ivacaftor ,
Tezacaftor ,
Elexacaftor (Elexacaftor) 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
6Elexacaftor, Tezacaftor, Ivacaftor[3] Elexacaftor (Elexacaftor),
Ivacaftor,
Tezacaftor		[3] Ivacaftor ,
Tezacaftor ,
Elexacaftor (Elexacaftor) 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
7Elexacaftor-tezacaftor-ivacaftor exposure[3] Elexacaftor (Elexacaftor),
Ivacaftor,
Tezacaftor		[3] Ivacaftor ,
Tezacaftor ,
Elexacaftor (Elexacaftor) 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
8Elexacaftor-tezacaftor-ivacaftor treatment[3] Elexacaftor (Elexacaftor),
Ivacaftor,
Tezacaftor		[3] Ivacaftor ,
Tezacaftor ,
Elexacaftor (Elexacaftor) 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
9Elexacaftor/tezacaftor/ivacaftor[3] Elexacaftor (Elexacaftor),
Ivacaftor,
Tezacaftor		[3] Ivacaftor ,
Tezacaftor ,
Elexacaftor (Elexacaftor) 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
10Ivacaftor or elexacaftor/tezacaftor/ivacaftor[3] Elexacaftor (Elexacaftor),
Ivacaftor,
Tezacaftor		[3] Ivacaftor ,
Tezacaftor ,
Elexacaftor (Elexacaftor) 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
11Treatment with cystic fibrosis transmembrane regulator (CFTR) modualtors Ivacaftor, Lumacaftor-Ivacaftor, Tezacaftor-Ivacaftor, Elexacaftor-Tezacaftor-Ivacaftor, Vanzacaftor-Tezacaftor-Deutivacaftor[6] Deutivacaftor,
Elexacaftor (Elexacaftor),
Ivacaftor,
Lumacaftor,
Tezacaftor,
Vanzacaftor		[7] Ivacaftor ,
Lumacaftor ,
Tezacaftor ,
Deutivacaftor ,
Elexacaftor (Elexacaftor),
Vanzacaftor ,
Vanzacaftor calcium 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬