| 1 | 100-mg VX-445 / 50-mg TEZ / 75-mg IVA FDCProduct Code: VX-445/TEZ/IVAPharmaceutical Form: Film-coated tabletINN or Proposed INN: elexacaftorCAS Number: 2216712-66-0Current Sponsor code: VX-445Other descriptive name: VX-445Concentration unit: mg milligram(s)Concentration type: equalConcentration number: 100-INN or Proposed INN: TEZACAFTORCAS Number: 1152311-62-0Current Sponsor code: VX-661Other descriptive name: TEZConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 50-INN or Proposed INN: IVACAFTORCAS Number: 873054-44-5Current Sponsor code: VX-770Other descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 75-Pharmaceutical form of the placebo: Film-coated tabletRoute of administration of the placebo: Oral use | - | - | - | - | [1] 299 299 💬
|
| 2 | 100mg ELX/50mg TEZ /75mg IVAProduct Code: VX-445/TEZ/IVAPharmaceutical Form: Film-coated tabletINN or Proposed INN: ElexacaftorCAS Number: 2216712-66-0Current Sponsor code: VX-445Other descriptive name: ELXConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 100-INN or Proposed INN: TezacaftorCAS Number: 1152311-62-0Current Sponsor code: VX-661Other descriptive name: TEZConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 50-INN or Proposed INN: IvacaftorCAS Number: 873054-44-5Current Sponsor code: VX-770Other descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 75-Pharmaceutical form of the placebo: TabletRoute of administration of the placebo: Oral useProduct Name: 150mg IVACAFTORProduct Code: VX-770Pharmaceutical Form: Film-coated tabletINN or Proposed INN: IvacaftorCAS Number: 873054-44-5Current Sponsor code: VX-770Other descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 150-Pharmaceutical form of the placebo: Film-coated tabletRoute of administration of the placebo: Oral useProduct Name: 75-mg IVACAFTORProduct Code: VX-770Pharmaceutical Form: Film-coated tabletINN or Proposed INN: IvacaftorCAS Number: 873054-44-5Current Sponsor code: VX-770Other descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 75-Pharmaceutical form of the placebo: Film-coated tabletRoute of administration of the placebo: Oral useProduct Name: 50 mg ELX/25 mg TEZ/37.5 mg IVAProduct Code: VX-445/TEZ/IVAPharmaceutical Form: Film-coated tabletINN or Proposed INN: IvacaftorCAS Number: 873054-44-5Current Sponsor code: VX- | - | - | - | - | [1] 299 299 💬
|
| 3 | 150-mg IVACAFTOR | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 4 | 150mg IVACAFTOR | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 5 | 75-mg IVACAFTOR | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 6 | CF patients with a G551D mutation and treated with Ivacaftor | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 7 | Deuterated Ivacaftor | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 8 | Elexacaftor / Ivacaftor / Tezacaftor | [3] Elexacaftor Elexacaftor, Ivacaftor (Ivacaftor), Tezacaftor | [3] Ivacaftor
Ivacaftor
(Ivacaftor),
Tezacaftor
,
Elexacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 9 | Elexacaftor 100 MG / Ivacaftor 75 MG / Tezacaftor 50 MG, 2 tablets each morning + Ivacaftor 150 mg one tablet each evening | [3] Elexacaftor Elexacaftor, Ivacaftor (Ivacaftor), Tezacaftor | [3] Ivacaftor
Ivacaftor
(Ivacaftor),
Tezacaftor
,
Elexacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 10 | Elexacaftor, Tezacaftor, Ivacaftor | [3] Elexacaftor Elexacaftor, Ivacaftor (Ivacaftor), Tezacaftor | [3] Ivacaftor
Ivacaftor
(Ivacaftor),
Tezacaftor
,
Elexacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 11 | Elexacaftor-tezacaftor-ivacaftor exposure | [3] Elexacaftor Elexacaftor, Ivacaftor (Ivacaftor), Tezacaftor | [3] Ivacaftor
Ivacaftor
(Ivacaftor),
Tezacaftor
,
Elexacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 12 | Elexacaftor-tezacaftor-ivacaftor treatment | [3] Elexacaftor Elexacaftor, Ivacaftor (Ivacaftor), Tezacaftor | [3] Ivacaftor
Ivacaftor
(Ivacaftor),
Tezacaftor
,
Elexacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 13 | Elexacaftor/tezacaftor/ivacaftor | [3] Elexacaftor Elexacaftor, Ivacaftor (Ivacaftor), Tezacaftor | [3] Ivacaftor
Ivacaftor
(Ivacaftor),
Tezacaftor
,
Elexacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 14 | Ivacaftor | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [3] 298 298, 299, 340 💬
|
| 15 | Ivacaftor (proposed INN) | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 16 | Ivacaftor 125mg tablet | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 17 | Ivacaftor 150 mg | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 18 | Ivacaftor 150 MG (milligrams) | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [2] 298 298, 299 💬
|
| 19 | Ivacaftor 150 mg or 250 mg | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 20 | Ivacaftor 25 mg/75 mg | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 21 | IVACAFTOR 59,5mg | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 22 | IVACAFTOR 59.5mg | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 23 | Ivacaftor 75 mg | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 24 | Ivacaftor 75 mg/150 mg | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 25 | IVACAFTOR 75mg | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 26 | Ivacaftor and Symdeko | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 27 | Ivacaftor Exposed | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 28 | Ivacaftor or elexacaftor/tezacaftor/ivacaftor | [3] Elexacaftor Elexacaftor, Ivacaftor (Ivacaftor), Tezacaftor | [3] Ivacaftor
Ivacaftor
(Ivacaftor),
Tezacaftor
,
Elexacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 29 | Ivacaftor+lumacaftor | [2] Ivacaftor Ivacaftor (Ivacaftor), Lumacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Lumacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 30 | Ivacaftor/Ataluren | [2] Ataluren Ataluren, Ivacaftor (Ivacaftor) | [2] Ataluren
Ataluren
,
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 31 | Ivacaftor/Kalydeco | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 32 | Lumacaftor / ivacaftor | [2] Ivacaftor Ivacaftor (Ivacaftor), Lumacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Lumacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 33 | Lumacaftor plus Ivacaftor | [2] Ivacaftor Ivacaftor (Ivacaftor), Lumacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Lumacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 34 | Lumacaftor Plus Ivacaftor Combination | [2] Ivacaftor Ivacaftor (Ivacaftor), Lumacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Lumacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 35 | Lumacaftor, Ivacaftor Drug Combination | [2] Ivacaftor Ivacaftor (Ivacaftor), Lumacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Lumacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 36 | Lumacaftor-ivacaftor | [2] Ivacaftor Ivacaftor (Ivacaftor), Lumacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Lumacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 37 | Lumacaftor-Ivacaftor treatment | [2] Ivacaftor Ivacaftor (Ivacaftor), Lumacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Lumacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 38 | Lumacaftor/Ivacaftor | [2] Ivacaftor Ivacaftor (Ivacaftor), Lumacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Lumacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 39 | Lumacaftor/ivacaftor 100mg/125mg tablets | [2] Ivacaftor Ivacaftor (Ivacaftor), Lumacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Lumacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 40 | Lumacaftor/ivacaftor 200mg/125mg | [2] Ivacaftor Ivacaftor (Ivacaftor), Lumacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Lumacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 41 | Lumacaftor/ivacaftor 200mg/125mg tablets | [2] Ivacaftor Ivacaftor (Ivacaftor), Lumacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Lumacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 42 | Lumacaftor/ivacaftor 200mg/83mg tablet | [2] Ivacaftor Ivacaftor (Ivacaftor), Lumacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Lumacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 43 | Orkambi: contains lumacaftor and ivacaftor | [2] Ivacaftor Ivacaftor (Ivacaftor), Lumacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Lumacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 44 | Symkevi 100mg/150mg Film-coated tabletsProduct Code: VX-661 / VX-770Pharmaceutical Form: Film-coated tabletINN or Proposed INN: TEZACAFTORCAS Number: 1152311-62-0Current Sponsor code: VX-661Other descriptive name: TEZConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 100-INN or Proposed INN: IVACAFTORCAS Number: 873054-44-5Current Sponsor code: VX-770Other descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 150-Pharmaceutical form of the placebo: Film-coated tabletRoute of administration of the placebo: Oral useTrade Name: Kalydeco 150 mg film-coated tabletsProduct Code: VX-770Pharmaceutical Form: Film-coated tabletINN or Proposed INN: IVACAFTORCAS Number: 873054-44-5Current Sponsor code: IvacaftorOther descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 150-Pharmaceutical f | - | - | - | - | [1] 299 299 💬
|
| 45 | Tezacaftor/Ivacaftor | [2] Ivacaftor Ivacaftor (Ivacaftor), Tezacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Tezacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 46 | Tezacaftor/Ivacaftor + Ivacaftor | [2] Ivacaftor Ivacaftor (Ivacaftor), Tezacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Tezacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 47 | Tezacaftor/Ivacaftor 100mg/150mg | [2] Ivacaftor Ivacaftor (Ivacaftor), Tezacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Tezacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 48 | Tezacaftor/Ivacaftor/100mg/150mg | [2] Ivacaftor Ivacaftor (Ivacaftor), Tezacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Tezacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 49 | Treatment with cystic fibrosis transmembrane regulator (CFTR) modualtors Ivacaftor, Lumacaftor-Ivacaftor, Tezacaftor-Ivacaftor, Elexacaftor-Tezacaftor-Ivacaftor, Vanzacaftor-Tezacaftor-Deutivacaftor | [6] Deutivacaftor Deutivacaftor (D9-Ivacaftor), Elexacaftor, Ivacaftor (Ivacaftor), Lumacaftor, Tezacaftor, Vanzacaftor | [7] Ivacaftor
Ivacaftor
(Ivacaftor),
Lumacaftor
,
Tezacaftor
,
Deutivacaftor
,
Elexacaftor
,
Vanzacaftor
,
Vanzacaftor calcium
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 50 | VX-659/Tezacaftor/Ivacaftor | [2] Ivacaftor Ivacaftor (Ivacaftor), Tezacaftor | [2] Ivacaftor
Ivacaftor
(Ivacaftor),
Tezacaftor
💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 51 | VX-661 Plus Ivacaftor Combination | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 52 | VX-661/Ivacaftor | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 53 | VX-661/ivacaftor (VX-770) 100mg/150 mg | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 54 | VX-661/ivacaftor 100 mg/ 150 mg | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 55 | VX-661/ivacaftor 100mg/150 mg | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 56 | VX-661/ivacaftor 100mg/150mg | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|
| 57 | VX-661/ivacaftor 50 mg/ 75 mg | [1] Ivacaftor Ivacaftor (Ivacaftor) | [1] Ivacaftor
Ivacaftor
(Ivacaftor) 💬
| [1] CFTR CFTR 💬
| [9] ABC transporters ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬 | [1] 299 299 💬
|