Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1Abatacept (ABA) + Methotrexate (MTX), double-blind (DB)[2] Abatacept,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Abatacept 💬 		[4] CD80,
CD86,
DHFR,
DHFR2 💬 		[18] Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬[1] 46 💬
2Abatacept + Methotrexate[2] Abatacept,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Abatacept 💬 		[4] CD80,
CD86,
DHFR,
DHFR2 💬 		[18] Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬[1] 46 💬
3Adalimumab with methotrexate[2] Adalimumab,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Adalimumab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
4AZATHIOPRINE or METHOTREXATE[2] Azathioprine,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Azathioprine 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96 💬
5BMS-582949 and Methotrexate[2] BMS-582949,
Methotrexate (Methotrexate Sodium Injection USP)		[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
6Busulfan/Fludarabine phosphate/Tacrolimus/Methotrexate/G-CSF[6] Busulfan,
Filgrastim,
Fludarabine,
Methotrexate (Methotrexate Sodium Injection USP),
Phosphate ion,
Tacrolimus		[6] Tacrolimus ,
Methotrexate (Methotrexate),
Busulfan ,
Filgrastim ,
Fludarabine ,
Tacrolimus 💬 		[9] CSF3R,
DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2,
RRM1 💬 		[48] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Drug metabolism - other enzymes, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Glutathione metabolism, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, Nucleotide metabolism, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Purine metabolism, Pyrimidine metabolism, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 60 💬
7Certolizumab Pegol + Methotrexate (MTX)[2] Certolizumab pegol,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Certolizumab pegol 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
8Clobetasol propionate + Methotrexate[3] Clobetasol,
Clobetasol propionate,
Methotrexate (Methotrexate Sodium Injection USP)		[3] Methotrexate (Methotrexate),
Clobetasol propionate ,
Clobetasol 💬 		[3] DHFR,
DHFR2,
NR3C1 💬 		[6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬[1] 162 💬
9Combination Product: Exercise, and methotrexate[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
10Combination Product: Laser, exercise, and methotrexate[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
11Combination Product: Methotrexate[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
12CP-690,550 + methotrexate[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
13Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids[3] Azathioprine,
Cyclophosphamide,
Methotrexate (Methotrexate Sodium Injection USP)		[4] Methotrexate (Methotrexate),
Azathioprine ,
Cyclophosphamide ,
Cyclophosphamide 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 44 💬
14Cyclosporin, Methotrexate (GVHD prophylaxis)[2] Cyclosporine,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Cyclosporine 💬 		[7] DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬 		[38] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 326 💬
15DMARDs (methotrexate[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
16Doxorubicin, methotrexate, cyclophosphamide, L-asparaginase[4] Asparaginase Escherichia coli,
Cyclophosphamide,
Doxorubicin,
Methotrexate (Methotrexate Sodium Injection USP)		[4] Methotrexate (Methotrexate),
Cyclophosphamide ,
Doxorubicin ,
Cyclophosphamide 💬 		[4] DHFR,
DHFR2,
TOP2A,
TOP2B 💬 		[6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Platinum drug resistance 💬[1] 65 💬
17Early immunosuppressants (azathioprine, methotrexate)[2] Azathioprine,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Azathioprine 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96 💬
18Etanercept + Methotrexate[2] Etanercept,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Etanercept 💬 		[4] DHFR,
DHFR2,
LTA,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
19Etanercept , Methotrexate[2] Etanercept,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Etanercept 💬 		[4] DHFR,
DHFR2,
LTA,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
20Etanercept, methotrexate and depomedrone[2] Etanercept,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Etanercept 💬 		[4] DHFR,
DHFR2,
LTA,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
21Etanercept, Methotrexate, Prednisolone[3] Etanercept,
Methotrexate (Methotrexate Sodium Injection USP),
Prednisolone		[3] Methotrexate (Methotrexate),
Prednisolone ,
Etanercept 💬 		[5] DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬 		[72] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 56 💬
22Immunosuppressive regime (azathioprine, mycophenolate mofetil or methotrexate)[4] Azathioprine,
Methotrexate (Methotrexate Sodium Injection USP),
Mycophenolate mofetil,
Mycophenolic acid		[4] Methotrexate (Methotrexate),
Azathioprine ,
Mycophenolate mofetil ,
Mycophenolic acid 💬 		[4] DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬 		[8] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, Nucleotide metabolism, One carbon pool by folate, Purine metabolism 💬[1] 49 💬
23Infliximab + methotrexate (MTX)[2] Infliximab,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
24Infliximab plus methotrexate[2] Infliximab,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 107 💬
25Infliximab, methylprednisolone, methotrexate[3] Infliximab,
Methotrexate (Methotrexate Sodium Injection USP),
Methylprednisolone		[3] Methotrexate (Methotrexate),
Methylprednisolone ,
Infliximab 💬 		[4] DHFR,
DHFR2,
NR3C1,
TNF 💬 		[72] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
26Intrathecal methotrexate[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 13 💬
27Methotrexate[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
28Methotrexate 'Lederle' 2,5mg tablets[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
29Methotrexate 'Lederle' 2.5mg Tablets[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
30Methotrexate 'Lederle' Tablets[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
31Methotrexate (Metoject® prefilled pen)[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
32Methotrexate (MTX)[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
33Methotrexate (stable dose)[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
34Methotrexate (tapering dose)[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
35Methotrexate + Infliximab[2] Infliximab,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
36Methotrexate + Methylprednisolone[2] Methotrexate (Methotrexate Sodium Injection USP),
Methylprednisolone		[2] Methotrexate (Methotrexate),
Methylprednisolone 💬 		[3] DHFR,
DHFR2,
NR3C1 💬 		[6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬[1] 46 💬
37METHOTREXATE - 20 MG/0.8 ML SOLUZIONE INIETTABILE 4 SIRINGHE PRERIEMPITE MONOUSO DA 1.25 ML[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96 💬
38Methotrexate - Amneal[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
39Methotrexate - DAVA[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
40Methotrexate - Delay[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
41Methotrexate - etanercept - prednisolone arm[3] Etanercept,
Methotrexate (Methotrexate Sodium Injection USP),
Prednisolone		[3] Methotrexate (Methotrexate),
Prednisolone ,
Etanercept 💬 		[5] DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬 		[72] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[2] 46, 107 💬
42Methotrexate - Immediate[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
43Methotrexate 10 mg[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
44Methotrexate 10 mg tablets[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
45Methotrexate 2.5 mg[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 44 💬
46METHOTREXATE 2.5 mg tablets[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
47Methotrexate 2.5mg Tablets[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
48Methotrexate 2.5mg Tablets BP[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
49Methotrexate 25 mg[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 44 💬
50Methotrexate 50mg/ml solution for injection, pre-filled syringe[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
51Methotrexate ``Lederle`` 2.5mg tablets[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
52Methotrexate alone[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 107 💬
53Methotrexate and folic acid[2] Folic acid,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Folic acid ,
Methotrexate (Methotrexate) 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 49 💬
54Methotrexate as methotrexate disodium[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
55Methotrexate bellon[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 97 💬
56Methotrexate bellon 25mg/ml[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 97 💬
57Methotrexate capsules[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
58METHOTREXATE DISODIUM[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[5] 46, 96, 97, 107, 271 💬
59Methotrexate Ebewe[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
60METHOTREXATE HOSPIRA 2,5 mg tablety[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
61METHOTREXATE HOSPIRA 2.5 mg tablety[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
62Methotrexate injection[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 96, 97 💬
63Methotrexate Lachema 5inj. sol[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50 💬
64Methotrexate Lederle 2.5 mg Tablets[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
65Methotrexate Pfizer 2,5 mg tabletter[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
66Methotrexate Placebo[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
67Methotrexate plus ENBREL or ENBREL alone[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
68Methotrexate plus ERB-041 for 12 weeks[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
69Methotrexate plus sulfasalazine[2] Methotrexate (Methotrexate Sodium Injection USP),
Sulfasalazine		[2] Methotrexate (Methotrexate),
Sulfasalazine 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
70Methotrexate pre-filled pen[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
71Methotrexate prefilled pen[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
72Methotrexate prefilled syringe[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
73METHOTREXATE SODIUM[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 46, 256 💬
74Methotrexate Sodium 2.5mg Tablets[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
75Methotrexate Sodium Tablets 2.5 mg[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
76Methotrexate Sodium Tablets 2.5mg[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
77Methotrexate Tablets[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 40, 46 💬
78Methotrexate tablets 2.5 mg[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
79Methotrexate treatment[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 41, 46 💬
80Methotrexate Wyeth 2,5mg[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50 💬
81Methotrexate Wyeth 2,5mg tbl.[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50 💬
82Methotrexate ® 2.5mg Tablets[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
83Methotrexate(MTX)[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
84Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
85Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol.[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
86Methotrexate(necessary)[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
87METHOTREXATE*100CPR 2,5MG[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
88METHOTREXATE*10MG/1,33ML 4S[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
89METHOTREXATE*15MG/2ML 4SIR[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
90METHOTREXATE*2,5MG 25CPR[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
91METHOTREXATE*20MG/2,66ML 4S[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
92METHOTREXATE*25CPR 2,5MG[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 46, 107 💬
93METHOTREXATE*7,5MG/ML 4SIR.[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
94Methotrexate, Leucovorin and BMS-986142[3] BMS-986142,
Leucovorin,
Methotrexate (Methotrexate Sodium Injection USP)		[3] Methotrexate (Methotrexate),
Folinic acid ,
Folinic acid calcium salt pentahydrate 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
95Methotrexate,Adalimumab[2] Adalimumab,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Adalimumab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
96Methotrexate-Lachema[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
97Methotrexate-Sulfasalazine-Hydroxychloroquine[3] Hydroxychloroquine,
Methotrexate (Methotrexate Sodium Injection USP),
Sulfasalazine		[3] Methotrexate (Methotrexate),
Sulfasalazine ,
Hydroxychloroquine 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
98Methotrexate® 2.5 mg tablets[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
99MP-435(dose1) + Methotrexate[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
100Mycophenolate mofetil,methotrexate[3] Methotrexate (Methotrexate Sodium Injection USP),
Mycophenolate mofetil,
Mycophenolic acid		[3] Methotrexate (Methotrexate),
Mycophenolate mofetil ,
Mycophenolic acid 💬 		[4] DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬 		[8] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, Nucleotide metabolism, One carbon pool by folate, Purine metabolism 💬[3] 42, 43, 45 💬
101Oral methotrexate[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
102Phase 1: Methotrexate[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
103Response to anakinra associated with methotrexate[2] Anakinra,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Anakinra 💬 		[4] DHFR,
DHFR2,
IL1R1,
IL1R2 💬 		[20] Amoebiasis, Antifolate resistance, Biosynthesis of cofactors, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Folate biosynthesis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, Metabolic pathways, NF-kappa B signaling pathway, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[1] 46 💬
104Response to infliximab associated with methotrexate[2] Infliximab,
Methotrexate (Methotrexate Sodium Injection USP)		[2] Methotrexate (Methotrexate),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
105Stable weekly dose of methotrexate[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
106Tacrolimus with Methotrexate[2] Methotrexate (Methotrexate Sodium Injection USP),
Tacrolimus		[3] Tacrolimus ,
Methotrexate (Methotrexate),
Tacrolimus 💬 		[7] DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬 		[38] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 46 💬
107TAK-715 and methotrexate[2] Methotrexate (Methotrexate Sodium Injection USP),
TAK-715		[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
108TAK-783 and methotrexate[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
109Tasocitinib plus Methotrexate[2] Methotrexate (Methotrexate Sodium Injection USP),
Tofacitinib		[2] Methotrexate (Methotrexate),
Tofacitinib 💬 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46 💬
110Tocilizumab + methotrexate(MTX)[2] Methotrexate (Methotrexate Sodium Injection USP),
Tocilizumab		[2] Methotrexate (Methotrexate),
Tocilizumab 💬 		[3] DHFR,
DHFR2,
IL6R 💬 		[17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46 💬
111Tocilizumab plus methotrexate[2] Methotrexate (Methotrexate Sodium Injection USP),
Tocilizumab		[2] Methotrexate (Methotrexate),
Tocilizumab 💬 		[3] DHFR,
DHFR2,
IL6R 💬 		[17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46 💬
112Tocilizumab+Methotrexate(MTX)[2] Methotrexate (Methotrexate Sodium Injection USP),
Tocilizumab		[2] Methotrexate (Methotrexate),
Tocilizumab 💬 		[3] DHFR,
DHFR2,
IL6R 💬 		[17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46 💬
113Tofacitinib with methotrexate[2] Methotrexate (Methotrexate Sodium Injection USP),
Tofacitinib		[2] Methotrexate (Methotrexate),
Tofacitinib 💬 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46 💬
114Tofacitinib without methotrexate[2] Methotrexate (Methotrexate Sodium Injection USP),
Tofacitinib		[2] Methotrexate (Methotrexate),
Tofacitinib 💬 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46 💬
115Treatment with systemic therapy (methotrexate)[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 162 💬
116Urine samples taken to measure methotrexate and its major metabolite 7-OH-methotrexate level[1] Methotrexate (Methotrexate Sodium Injection USP)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬