Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1Abatacept (ABA) + Methotrexate (MTX), double-blind (DB)[2] Abatacept,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Abatacept 💬 		[4] CD80,
CD86,
DHFR,
DHFR2 💬 		[18] Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬[1] 46 💬
2Abatacept + Methotrexate[2] Abatacept,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Abatacept 💬 		[4] CD80,
CD86,
DHFR,
DHFR2 💬 		[18] Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬[1] 46 💬
3Adalimumab with methotrexate[2] Adalimumab,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Adalimumab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
4AZATHIOPRINE or METHOTREXATE[2] Azathioprine,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Azathioprine 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96 💬
5BMS-582949 and Methotrexate[2] BMS-582949,
Methotrexate (Methotrexate Subcutaneous)		[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
6Busulfan/Fludarabine phosphate/Tacrolimus/Methotrexate/G-CSF[6] Busulfan,
Filgrastim,
Fludarabine,
Methotrexate (Methotrexate Subcutaneous),
Phosphate ion,
Tacrolimus		[6] Tacrolimus ,
Methotrexate (Methotrexate),
Busulfan ,
Filgrastim ,
Fludarabine ,
Tacrolimus 💬 		[9] CSF3R,
DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2,
RRM1 💬 		[48] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Drug metabolism - other enzymes, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Glutathione metabolism, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, Nucleotide metabolism, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Purine metabolism, Pyrimidine metabolism, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 60 💬
7Certolizumab Pegol + Methotrexate (MTX)[2] Certolizumab pegol,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Certolizumab pegol 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
8Clobetasol propionate + Methotrexate[3] Clobetasol,
Clobetasol propionate,
Methotrexate (Methotrexate Subcutaneous)		[3] Methotrexate (Methotrexate),
Clobetasol propionate ,
Clobetasol 💬 		[3] DHFR,
DHFR2,
NR3C1 💬 		[6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬[1] 162 💬
9Combination Product: Exercise, and methotrexate[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
10Combination Product: Laser, exercise, and methotrexate[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
11Combination Product: Methotrexate[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
12CP-690,550 + methotrexate[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
13Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids[3] Azathioprine,
Cyclophosphamide,
Methotrexate (Methotrexate Subcutaneous)		[4] Methotrexate (Methotrexate),
Azathioprine ,
Cyclophosphamide ,
Cyclophosphamide 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 44 💬
14Cyclosporin, Methotrexate (GVHD prophylaxis)[2] Cyclosporine,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Cyclosporine 💬 		[7] DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬 		[38] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 326 💬
15DMARDs (methotrexate[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
16Doxorubicin, methotrexate, cyclophosphamide, L-asparaginase[4] Asparaginase Escherichia coli,
Cyclophosphamide,
Doxorubicin,
Methotrexate (Methotrexate Subcutaneous)		[4] Methotrexate (Methotrexate),
Cyclophosphamide ,
Doxorubicin ,
Cyclophosphamide 💬 		[4] DHFR,
DHFR2,
TOP2A,
TOP2B 💬 		[6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Platinum drug resistance 💬[1] 65 💬
17Early immunosuppressants (azathioprine, methotrexate)[2] Azathioprine,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Azathioprine 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96 💬
18Etanercept + Methotrexate[2] Etanercept,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Etanercept 💬 		[4] DHFR,
DHFR2,
LTA,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
19Etanercept , Methotrexate[2] Etanercept,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Etanercept 💬 		[4] DHFR,
DHFR2,
LTA,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
20Etanercept, methotrexate and depomedrone[2] Etanercept,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Etanercept 💬 		[4] DHFR,
DHFR2,
LTA,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
21Etanercept, Methotrexate, Prednisolone[3] Etanercept,
Methotrexate (Methotrexate Subcutaneous),
Prednisolone		[3] Methotrexate (Methotrexate),
Prednisolone ,
Etanercept 💬 		[5] DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬 		[72] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 56 💬
22Immunosuppressive regime (azathioprine, mycophenolate mofetil or methotrexate)[4] Azathioprine,
Methotrexate (Methotrexate Subcutaneous),
Mycophenolate mofetil,
Mycophenolic acid		[4] Methotrexate (Methotrexate),
Azathioprine ,
Mycophenolate mofetil ,
Mycophenolic acid 💬 		[4] DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬 		[8] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, Nucleotide metabolism, One carbon pool by folate, Purine metabolism 💬[1] 49 💬
23Infliximab + methotrexate (MTX)[2] Infliximab,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
24Infliximab plus methotrexate[2] Infliximab,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 107 💬
25Infliximab, methylprednisolone, methotrexate[3] Infliximab,
Methotrexate (Methotrexate Subcutaneous),
Methylprednisolone		[3] Methotrexate (Methotrexate),
Methylprednisolone ,
Infliximab 💬 		[4] DHFR,
DHFR2,
NR3C1,
TNF 💬 		[72] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
26Intrathecal methotrexate[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 13 💬
27Methotrexat[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[4] 13, 46, 50, 96 💬
28Methotrexat 2,5 mg Tabletten medac[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
29Methotrexat HEXAL® 2,5 mg Tabletten[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
30Methotrexat Lachema 2,5mg[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50 💬
31Methotrexat Lachema 2,5mg tbl.[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50 💬
32Methotrexat Lachema 5 inj. sol[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50 💬
33METHOTREXAT Lederle - Tabletten[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
34Methotrexat Lederle 2.5mg tablets[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
35Methotrexate[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
36Methotrexate 'Lederle' 2,5mg tablets[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
37Methotrexate 'Lederle' 2.5mg Tablets[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
38Methotrexate 'Lederle' Tablets[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
39Methotrexate (Metoject® prefilled pen)[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
40Methotrexate (MTX)[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
41Methotrexate (stable dose)[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
42Methotrexate (tapering dose)[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
43Methotrexate + Infliximab[2] Infliximab,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
44Methotrexate + Methylprednisolone[2] Methotrexate (Methotrexate Subcutaneous),
Methylprednisolone		[2] Methotrexate (Methotrexate),
Methylprednisolone 💬 		[3] DHFR,
DHFR2,
NR3C1 💬 		[6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬[1] 46 💬
45METHOTREXATE - 20 MG/0.8 ML SOLUZIONE INIETTABILE 4 SIRINGHE PRERIEMPITE MONOUSO DA 1.25 ML[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96 💬
46Methotrexate - Amneal[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
47Methotrexate - DAVA[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
48Methotrexate - Delay[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
49Methotrexate - etanercept - prednisolone arm[3] Etanercept,
Methotrexate (Methotrexate Subcutaneous),
Prednisolone		[3] Methotrexate (Methotrexate),
Prednisolone ,
Etanercept 💬 		[5] DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬 		[72] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[2] 46, 107 💬
50Methotrexate - Immediate[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
51Methotrexate 10 mg[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
52Methotrexate 10 mg tablets[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
53Methotrexate 2.5 mg[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 44 💬
54METHOTREXATE 2.5 mg tablets[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
55Methotrexate 2.5mg Tablets[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
56Methotrexate 2.5mg Tablets BP[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
57Methotrexate 25 mg[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 44 💬
58Methotrexate 50mg/ml solution for injection, pre-filled syringe[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
59Methotrexate ``Lederle`` 2.5mg tablets[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
60Methotrexate alone[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 107 💬
61Methotrexate and folic acid[2] Folic acid,
Methotrexate (Methotrexate Subcutaneous)		[2] Folic acid ,
Methotrexate (Methotrexate) 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 49 💬
62Methotrexate as methotrexate disodium[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
63Methotrexate bellon[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 97 💬
64Methotrexate bellon 25mg/ml[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 97 💬
65Methotrexate capsules[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
66METHOTREXATE DISODIUM[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[5] 46, 96, 97, 107, 271 💬
67Methotrexate Ebewe[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
68METHOTREXATE HOSPIRA 2,5 mg tablety[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
69METHOTREXATE HOSPIRA 2.5 mg tablety[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
70Methotrexate injection[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 96, 97 💬
71Methotrexate Lachema 5inj. sol[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50 💬
72Methotrexate Lederle 2.5 mg Tablets[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
73Methotrexate Pfizer 2,5 mg tabletter[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
74Methotrexate Placebo[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
75Methotrexate plus ENBREL or ENBREL alone[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
76Methotrexate plus ERB-041 for 12 weeks[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
77Methotrexate plus sulfasalazine[2] Methotrexate (Methotrexate Subcutaneous),
Sulfasalazine		[2] Methotrexate (Methotrexate),
Sulfasalazine 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
78Methotrexate pre-filled pen[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
79Methotrexate prefilled pen[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
80Methotrexate prefilled syringe[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
81METHOTREXATE SODIUM[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 46, 256 💬
82Methotrexate Sodium 2.5mg Tablets[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
83Methotrexate Sodium Tablets 2.5 mg[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
84Methotrexate Sodium Tablets 2.5mg[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
85Methotrexate Tablets[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 40, 46 💬
86Methotrexate tablets 2.5 mg[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
87Methotrexate treatment[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 41, 46 💬
88Methotrexate Wyeth 2,5mg[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50 💬
89Methotrexate Wyeth 2,5mg tbl.[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50 💬
90Methotrexate ® 2.5mg Tablets[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
91Methotrexate(MTX)[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
92Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
93Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol.[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
94Methotrexate(necessary)[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
95METHOTREXATE*100CPR 2,5MG[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
96METHOTREXATE*10MG/1,33ML 4S[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
97METHOTREXATE*15MG/2ML 4SIR[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
98METHOTREXATE*2,5MG 25CPR[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
99METHOTREXATE*20MG/2,66ML 4S[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
100METHOTREXATE*25CPR 2,5MG[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 46, 107 💬
101METHOTREXATE*7,5MG/ML 4SIR.[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
102Methotrexate, Leucovorin and BMS-986142[3] BMS-986142,
Leucovorin,
Methotrexate (Methotrexate Subcutaneous)		[3] Methotrexate (Methotrexate),
Folinic acid ,
Folinic acid calcium salt pentahydrate 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
103Methotrexate,Adalimumab[2] Adalimumab,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Adalimumab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
104Methotrexate-Lachema[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
105Methotrexate-Sulfasalazine-Hydroxychloroquine[3] Hydroxychloroquine,
Methotrexate (Methotrexate Subcutaneous),
Sulfasalazine		[3] Methotrexate (Methotrexate),
Sulfasalazine ,
Hydroxychloroquine 💬 		[2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
106Methotrexate® 2.5 mg tablets[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
107MP-435(dose1) + Methotrexate[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
108Mycophenolate mofetil,methotrexate[3] Methotrexate (Methotrexate Subcutaneous),
Mycophenolate mofetil,
Mycophenolic acid		[3] Methotrexate (Methotrexate),
Mycophenolate mofetil ,
Mycophenolic acid 💬 		[4] DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬 		[8] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, Nucleotide metabolism, One carbon pool by folate, Purine metabolism 💬[3] 42, 43, 45 💬
109Oral methotrexate[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
110Phase 1: Methotrexate[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
111Response to anakinra associated with methotrexate[2] Anakinra,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Anakinra 💬 		[4] DHFR,
DHFR2,
IL1R1,
IL1R2 💬 		[20] Amoebiasis, Antifolate resistance, Biosynthesis of cofactors, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Folate biosynthesis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, Metabolic pathways, NF-kappa B signaling pathway, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[1] 46 💬
112Response to infliximab associated with methotrexate[2] Infliximab,
Methotrexate (Methotrexate Subcutaneous)		[2] Methotrexate (Methotrexate),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
113Stable weekly dose of methotrexate[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
114Tacrolimus with Methotrexate[2] Methotrexate (Methotrexate Subcutaneous),
Tacrolimus		[3] Tacrolimus ,
Methotrexate (Methotrexate),
Tacrolimus 💬 		[7] DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬 		[38] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 46 💬
115TAK-715 and methotrexate[2] Methotrexate (Methotrexate Subcutaneous),
TAK-715		[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
116TAK-783 and methotrexate[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬
117Tasocitinib plus Methotrexate[2] Methotrexate (Methotrexate Subcutaneous),
Tofacitinib		[2] Methotrexate (Methotrexate),
Tofacitinib 💬 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46 💬
118Tocilizumab + methotrexate(MTX)[2] Methotrexate (Methotrexate Subcutaneous),
Tocilizumab		[2] Methotrexate (Methotrexate),
Tocilizumab 💬 		[3] DHFR,
DHFR2,
IL6R 💬 		[17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46 💬
119Tocilizumab plus methotrexate[2] Methotrexate (Methotrexate Subcutaneous),
Tocilizumab		[2] Methotrexate (Methotrexate),
Tocilizumab 💬 		[3] DHFR,
DHFR2,
IL6R 💬 		[17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46 💬
120Tocilizumab+Methotrexate(MTX)[2] Methotrexate (Methotrexate Subcutaneous),
Tocilizumab		[2] Methotrexate (Methotrexate),
Tocilizumab 💬 		[3] DHFR,
DHFR2,
IL6R 💬 		[17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46 💬
121Tofacitinib with methotrexate[2] Methotrexate (Methotrexate Subcutaneous),
Tofacitinib		[2] Methotrexate (Methotrexate),
Tofacitinib 💬 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46 💬
122Tofacitinib without methotrexate[2] Methotrexate (Methotrexate Subcutaneous),
Tofacitinib		[2] Methotrexate (Methotrexate),
Tofacitinib 💬 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46 💬
123Treatment with systemic therapy (methotrexate)[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 162 💬
124Urine samples taken to measure methotrexate and its major metabolite 7-OH-methotrexate level[1] Methotrexate (Methotrexate Subcutaneous)[1] Methotrexate (Methotrexate) 💬 [2] DHFR,
DHFR2 💬 		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46 💬