Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1100-mg VX-445 / 50-mg TEZ / 75-mg IVA FDCProduct Code: VX-445/TEZ/IVAPharmaceutical Form: Film-coated tabletINN or Proposed INN: elexacaftorCAS Number: 2216712-66-0Current Sponsor code: VX-445Other descriptive name: VX-445Concentration unit: mg milligram(s)Concentration type: equalConcentration number: 100-INN or Proposed INN: TEZACAFTORCAS Number: 1152311-62-0Current Sponsor code: VX-661Other descriptive name: TEZConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 50-INN or Proposed INN: IVACAFTORCAS Number: 873054-44-5Current Sponsor code: VX-770Other descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 75-Pharmaceutical form of the placebo: Film-coated tabletRoute of administration of the placebo: Oral use----[1] 299 💬
2100mg ELX/50mg TEZ /75mg IVAProduct Code: VX-445/TEZ/IVAPharmaceutical Form: Film-coated tabletINN or Proposed INN: ElexacaftorCAS Number: 2216712-66-0Current Sponsor code: VX-445Other descriptive name: ELXConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 100-INN or Proposed INN: TezacaftorCAS Number: 1152311-62-0Current Sponsor code: VX-661Other descriptive name: TEZConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 50-INN or Proposed INN: IvacaftorCAS Number: 873054-44-5Current Sponsor code: VX-770Other descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 75-Pharmaceutical form of the placebo: TabletRoute of administration of the placebo: Oral useProduct Name: 150mg IVACAFTORProduct Code: VX-770Pharmaceutical Form: Film-coated tabletINN or Proposed INN: IvacaftorCAS Number: 873054-44-5Current Sponsor code: VX-770Other descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 150-Pharmaceutical form of the placebo: Film-coated tabletRoute of administration of the placebo: Oral useProduct Name: 75-mg IVACAFTORProduct Code: VX-770Pharmaceutical Form: Film-coated tabletINN or Proposed INN: IvacaftorCAS Number: 873054-44-5Current Sponsor code: VX-770Other descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 75-Pharmaceutical form of the placebo: Film-coated tabletRoute of administration of the placebo: Oral useProduct Name: 50 mg ELX/25 mg TEZ/37.5 mg IVAProduct Code: VX-445/TEZ/IVAPharmaceutical Form: Film-coated tabletINN or Proposed INN: IvacaftorCAS Number: 873054-44-5Current Sponsor code: VX-----[1] 299 💬
3Elexacaftor / Ivacaftor / Tezacaftor[3] Elexacaftor,
Ivacaftor,
Tezacaftor (Tezacaftor)		[3] Ivacaftor ,
Tezacaftor (Tezacaftor),
Elexacaftor 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
4Elexacaftor 100 MG / Ivacaftor 75 MG / Tezacaftor 50 MG, 2 tablets each morning + Ivacaftor 150 mg one tablet each evening[3] Elexacaftor,
Ivacaftor,
Tezacaftor (Tezacaftor)		[3] Ivacaftor ,
Tezacaftor (Tezacaftor),
Elexacaftor 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
5Elexacaftor, Tezacaftor, Ivacaftor[3] Elexacaftor,
Ivacaftor,
Tezacaftor (Tezacaftor)		[3] Ivacaftor ,
Tezacaftor (Tezacaftor),
Elexacaftor 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
6Elexacaftor-tezacaftor-ivacaftor exposure[3] Elexacaftor,
Ivacaftor,
Tezacaftor (Tezacaftor)		[3] Ivacaftor ,
Tezacaftor (Tezacaftor),
Elexacaftor 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
7Elexacaftor-tezacaftor-ivacaftor treatment[3] Elexacaftor,
Ivacaftor,
Tezacaftor (Tezacaftor)		[3] Ivacaftor ,
Tezacaftor (Tezacaftor),
Elexacaftor 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
8Elexacaftor/tezacaftor/ivacaftor[3] Elexacaftor,
Ivacaftor,
Tezacaftor (Tezacaftor)		[3] Ivacaftor ,
Tezacaftor (Tezacaftor),
Elexacaftor 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
9Ivacaftor or elexacaftor/tezacaftor/ivacaftor[3] Elexacaftor,
Ivacaftor,
Tezacaftor (Tezacaftor)		[3] Ivacaftor ,
Tezacaftor (Tezacaftor),
Elexacaftor 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
10Symkevi 100mg/150mg Film-coated tabletsProduct Code: VX-661 / VX-770Pharmaceutical Form: Film-coated tabletINN or Proposed INN: TEZACAFTORCAS Number: 1152311-62-0Current Sponsor code: VX-661Other descriptive name: TEZConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 100-INN or Proposed INN: IVACAFTORCAS Number: 873054-44-5Current Sponsor code: VX-770Other descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 150-Pharmaceutical form of the placebo: Film-coated tabletRoute of administration of the placebo: Oral useTrade Name: Kalydeco 150 mg film-coated tabletsProduct Code: VX-770Pharmaceutical Form: Film-coated tabletINN or Proposed INN: IVACAFTORCAS Number: 873054-44-5Current Sponsor code: IvacaftorOther descriptive name: IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 150-Pharmaceutical f----[1] 299 💬
11TEZACAFTOR[1] Tezacaftor (Tezacaftor)[1] Tezacaftor (Tezacaftor) 💬 [1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
12Tezacaftor (TEZ)[1] Tezacaftor (Tezacaftor)[1] Tezacaftor (Tezacaftor) 💬 [1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
13Tezacaftor/Ivacaftor[2] Ivacaftor,
Tezacaftor (Tezacaftor)		[2] Ivacaftor ,
Tezacaftor (Tezacaftor) 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
14Tezacaftor/Ivacaftor + Ivacaftor[2] Ivacaftor,
Tezacaftor (Tezacaftor)		[2] Ivacaftor ,
Tezacaftor (Tezacaftor) 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
15Tezacaftor/Ivacaftor 100mg/150mg[2] Ivacaftor,
Tezacaftor (Tezacaftor)		[2] Ivacaftor ,
Tezacaftor (Tezacaftor) 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
16Tezacaftor/Ivacaftor/100mg/150mg[2] Ivacaftor,
Tezacaftor (Tezacaftor)		[2] Ivacaftor ,
Tezacaftor (Tezacaftor) 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
17Treatment with cystic fibrosis transmembrane regulator (CFTR) modualtors Ivacaftor, Lumacaftor-Ivacaftor, Tezacaftor-Ivacaftor, Elexacaftor-Tezacaftor-Ivacaftor, Vanzacaftor-Tezacaftor-Deutivacaftor[6] Deutivacaftor,
Elexacaftor,
Ivacaftor,
Lumacaftor,
Tezacaftor (Tezacaftor),
Vanzacaftor		[7] Ivacaftor ,
Lumacaftor ,
Tezacaftor (Tezacaftor),
Deutivacaftor ,
Elexacaftor ,
Vanzacaftor ,
Vanzacaftor calcium 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
18VX-121/tezacaftor/deutivacaftor[2] Deutivacaftor,
Tezacaftor (Tezacaftor)		[2] Tezacaftor (Tezacaftor),
Deutivacaftor 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
19VX-121/tezacaftor/deutivacaftorProduct Code: VX-121/TEZ/D-IVAPharmaceutical Form: Film-coated tabletINN or Proposed INN: VX-121CAS Number: 2374124-50-0Current Sponsor code: VX-121Other descriptive name: VX-121Concentration unit: mg milligram(s)Concentration type: equalConcentration number: 10-INN or Proposed INN: tezacaftorCAS Number: 1152311-62-0Current Sponsor code: VX-661Concentration unit: mg milligram(s)Concentration type: equalConcentration number: 50-INN or Proposed INN: deutivacaftorCAS Number: 1413431-07-8Current Sponsor code: VX-561Other descriptive name: D-IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 125-Product Name: VX-121/tezacaftor/deutivacaftorProduct Code: VX-121/TEZ/D-IVAPharmaceutical Form: Film-coated tabletINN or Proposed INN: VX-121CAS Number: 2374124-50-0Current Sponsor code: VX-121Other descriptive name: VX-121Concentration unit: mg milligram(s)Concentration type: equalConcentration number: 4-INN or Proposed INN: tezacaftorCAS Number: 1152311-62-0Current Sponsor code: VX-661Concentration unit: mg milligram(s)Concentration type: equalConcentration number: 20-INN or Proposed INN: deutivacaftorCAS Number: 1413431-07-8Current Sponsor code: VX-561Other descriptive name: D-IVAConcentration unit: mg milligram(s)Concentration type: equalConcentration number: 50-Product Name: VX-121/tezacaftor/deutivacaftorProduct Code: VX-121/TEZ/D-IVAPharmaceutical Form: Film-coated tabletINN or Proposed INN: VX-121CAS Number: 2374124-50-0Current Sponsor code: VX-121Other descriptive name: VX-121Concentration unit: mg milligram(s)Concentration type: equalConcentration number: 4-INN or Proposed INN: tezacaftorCAS Number: 1152311-62-0Current Sponsor code: VX-[1] Tezacaftor (Tezacaftor)[1] Tezacaftor (Tezacaftor) 💬 [1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
20VX-659/Tezacaftor/Ivacaftor[2] Ivacaftor,
Tezacaftor (Tezacaftor)		[2] Ivacaftor ,
Tezacaftor (Tezacaftor) 💬 		[1] CFTR 💬 [9] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Phagocytosis, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬