Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1Abatacept (ABA) + Methotrexate (MTX), double-blind (DB)
(D02115)		[2] Abatacept,
Methotrexate		[3] Methotrexate ,
Methotrexate sodium (D02115),
Abatacept 💬 		[4] CD80,
CD86,
DHFR,
DHFR2 💬 		[17] Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecule (CAM) interaction, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, IgSF CAM signaling, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬[1] 46 💬
2Adalimumab with methotrexate
(D02115)		[2] Adalimumab,
Methotrexate		[3] Methotrexate ,
Methotrexate sodium (D02115),
Adalimumab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
3AZATHIOPRINE or METHOTREXATE
(D02115)		[2] Azathioprine,
Methotrexate		[4] Methotrexate ,
Azathioprine ,
Methotrexate sodium (D02115),
Azathioprine sodium 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 96 💬
4BMS-582949 and Methotrexate
(D02115)		[2] BMS-582949,
Methotrexate		[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
5Busulfan/Fludarabine phosphate/Tacrolimus/Methotrexate/G-CSF
(D02115)		[4] Busulfan,
Fludarabine,
Methotrexate,
Tacrolimus		[7] Tacrolimus ,
Methotrexate ,
Busulfan ,
Fludarabine phosphate ,
Methotrexate sodium (D02115),
Fludarabine ,
Tacrolimus 💬 		[8] DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2,
RRM1 💬 		[40] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Drug metabolism - other enzymes, Folate biosynthesis, Folate transport and metabolism, Glucagon signaling pathway, Glutamatergic synapse, Glutathione metabolism, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Purine metabolism, Pyrimidine metabolism, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 60 💬
6Certolizumab Pegol + Methotrexate (MTX)
(D02115)		[2] Certolizumab pegol,
Methotrexate		[3] Methotrexate ,
Methotrexate sodium (D02115),
Certolizumab pegol 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
7Clobetasol propionate + Methotrexate
(D02115)		[3] Clobetasol,
Clobetasol propionate,
Methotrexate		[4] Methotrexate ,
Clobetasol propionate ,
Methotrexate sodium (D02115),
Clobetasol 💬 		[3] DHFR,
DHFR2,
NR3C1 💬 		[4] Folate biosynthesis, Folate transport and metabolism, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬[1] 162 💬
8Combination Product: Exercise, and methotrexate
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
9Combination Product: Laser, exercise, and methotrexate
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
10Combination Product: Methotrexate
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
11CP-690,550 + methotrexate
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
12Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids
(D02115)		[3] Azathioprine,
Cyclophosphamide,
Methotrexate		[6] Methotrexate ,
Azathioprine ,
Cyclophosphamide ,
Methotrexate sodium (D02115),
Azathioprine sodium ,
Cyclophosphamide 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 44 💬
13Cyclosporin, Methotrexate (GVHD prophylaxis)
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 326 💬
14DMARDs (methotrexate
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
15Doxorubicin, methotrexate, cyclophosphamide, L-asparaginase
(D02115)		[3] Cyclophosphamide,
Doxorubicin,
Methotrexate		[6] Methotrexate ,
Cyclophosphamide ,
Doxorubicin hydrochloride ,
Methotrexate sodium (D02115),
Doxorubicin ,
Cyclophosphamide 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 65 💬
16Early immunosuppressants (azathioprine, methotrexate)
(D02115)		[2] Azathioprine,
Methotrexate		[4] Methotrexate ,
Azathioprine ,
Methotrexate sodium (D02115),
Azathioprine sodium 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 96 💬
17Etanercept + Methotrexate
(D02115)		[2] Etanercept,
Methotrexate		[3] Methotrexate ,
Etanercept ,
Methotrexate sodium (D02115) 💬 		[4] DHFR,
DHFR2,
LTA,
TNF 💬 		[69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
18Etanercept , Methotrexate
(D02115)		[2] Etanercept,
Methotrexate		[3] Methotrexate ,
Etanercept ,
Methotrexate sodium (D02115) 💬 		[4] DHFR,
DHFR2,
LTA,
TNF 💬 		[69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
19Etanercept, methotrexate and depomedrone
(D02115)		[2] Etanercept,
Methotrexate		[3] Methotrexate ,
Etanercept ,
Methotrexate sodium (D02115) 💬 		[4] DHFR,
DHFR2,
LTA,
TNF 💬 		[69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
20Etanercept, Methotrexate, Prednisolone
(D02115)		[3] Etanercept,
Methotrexate,
Prednisolone		[4] Methotrexate ,
Prednisolone ,
Etanercept ,
Methotrexate sodium (D02115) 💬 		[5] DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬 		[70] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 56 💬
21Immunosuppressive regime (azathioprine, mycophenolate mofetil or methotrexate)
(D02115)		[3] Azathioprine,
Methotrexate,
Mycophenolate mofetil		[6] Methotrexate ,
Azathioprine ,
Mycophenolate mofetil ,
Methotrexate sodium (D02115),
Azathioprine sodium ,
Mycophenolate mofetil hydrochloride 💬 		[4] DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬 		[5] Drug metabolism - other enzymes, Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate, Purine metabolism 💬[1] 49 💬
22Infliximab + methotrexate (MTX)
(D02115)		[2] Infliximab,
Methotrexate		[3] Methotrexate ,
Methotrexate sodium (D02115),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
23Infliximab plus methotrexate
(D02115)		[2] Infliximab,
Methotrexate		[3] Methotrexate ,
Methotrexate sodium (D02115),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 107 💬
24Infliximab, methylprednisolone, methotrexate
(D02115)		[3] Infliximab,
Methotrexate,
Methylprednisolone		[5] Methotrexate ,
Methylprednisolone ,
Methylprednisolone acetate ,
Methotrexate sodium (D02115),
Infliximab 💬 		[4] DHFR,
DHFR2,
NR3C1,
TNF 💬 		[70] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
25Inj. Methotrexate 25mg/week
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
26Intrathecal methotrexate
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 13 💬
27JAK inhibitor(tofacitinib/upadacitinib) as advised by the rheumatologist as add on to 25 mg methotrexate
(D02115)		[3] Methotrexate,
Tofacitinib,
Upadacitinib		[7] Methotrexate ,
Methotrexate sodium (D02115),
Tofacitinib citrate ,
Tofacitinib ,
Upadacitinib ,
Upadacitinib tartrate ,
Upadacitinib hydrate 💬 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease, Efferocytosis, Epstein-Barr virus infection, Folate biosynthesis, Folate transport and metabolism, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Hormone signaling, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46 💬
28Leflunomide plus Methotrexate
(D02115)		[2] Leflunomide,
Methotrexate		[3] Methotrexate ,
Leflunomide ,
Methotrexate sodium (D02115) 💬 		[3] DHFR,
DHFR2,
DHODH 💬 		[4] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate, Pyrimidine metabolism 💬[1] 107 💬
29METHOTREXATE
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[41] 11, 13, 14, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 54, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 223, 240, 256, 270, 271, 284, 285, 286, 326, 331 💬
30Methotrexate 'Lederle' 2,5mg tablets
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
31Methotrexate 'Lederle' 2.5mg Tablets
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
32Methotrexate 'Lederle' Tablets
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
33Methotrexate (Metoject® prefilled pen)
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
34Methotrexate (MTX)
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[2] 46, 55 💬
35Methotrexate (stable dose)
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
36Methotrexate (tapering dose)
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
37Methotrexate + Infliximab
(D02115)		[2] Infliximab,
Methotrexate		[3] Methotrexate ,
Methotrexate sodium (D02115),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
38Methotrexate + Methylprednisolone
(D02115)		[2] Methotrexate,
Methylprednisolone		[4] Methotrexate ,
Methylprednisolone ,
Methylprednisolone acetate ,
Methotrexate sodium (D02115) 💬 		[3] DHFR,
DHFR2,
NR3C1 💬 		[4] Folate biosynthesis, Folate transport and metabolism, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬[1] 46 💬
39Methotrexate + targeted therapy administration
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
40METHOTREXATE - 20 MG/0.8 ML SOLUZIONE INIETTABILE 4 SIRINGHE PRERIEMPITE MONOUSO DA 1.25 ML
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 96 💬
41Methotrexate - Amneal
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
42Methotrexate - DAVA
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
43Methotrexate - Delay
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
44Methotrexate - etanercept - prednisolone arm
(D02115)		[3] Etanercept,
Methotrexate,
Prednisolone		[4] Methotrexate ,
Prednisolone ,
Etanercept ,
Methotrexate sodium (D02115) 💬 		[5] DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬 		[70] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[2] 46, 107 💬
45Methotrexate - Immediate
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
46Methotrexate 10 mg
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
47Methotrexate 10 mg tablets
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
48Methotrexate 2.5 mg
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 44 💬
49METHOTREXATE 2.5 mg tablets
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
50Methotrexate 2.5mg Tablets
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
51Methotrexate 2.5mg Tablets BP
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
52Methotrexate 25 mg
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 44 💬
53Methotrexate 50mg/ml solution for injection, pre-filled syringe
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
54Methotrexate ``Lederle`` 2.5mg tablets
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
55Methotrexate alone
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 107 💬
56Methotrexate and folic acid
(D02115)		[2] Folic acid,
Methotrexate		[4] Folic acid ,
Methotrexate ,
Methotrexate sodium (D02115),
Folate sodium 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 49 💬
57Methotrexate as methotrexate disodium
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
58Methotrexate bellon
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 97 💬
59Methotrexate bellon 25mg/ml
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 97 💬
60Methotrexate capsules
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
61Methotrexate Combined With Tofacitinib
(D02115)		[2] Methotrexate,
Tofacitinib		[4] Methotrexate ,
Methotrexate sodium (D02115),
Tofacitinib citrate ,
Tofacitinib 💬 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease, Efferocytosis, Epstein-Barr virus infection, Folate biosynthesis, Folate transport and metabolism, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Hormone signaling, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46 💬
62METHOTREXATE DISODIUM
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[5] 46, 96, 97, 107, 271 💬
63Methotrexate Ebewe
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
64METHOTREXATE HOSPIRA 2,5 mg tablety
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
65METHOTREXATE HOSPIRA 2.5 mg tablety
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
66Methotrexate injection
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[2] 96, 97 💬
67Methotrexate Lachema 5inj. sol
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 50 💬
68Methotrexate Lederle 2.5 mg Tablets
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
69Methotrexate Monotherapy
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 107 💬
70Methotrexate or leflunomide + sulfasalazine + hydroxychloroquine administration
(D02115)		[4] Hydroxychloroquine,
Leflunomide,
Methotrexate,
Sulfasalazine		[6] Methotrexate ,
Sulfasalazine ,
Leflunomide ,
Hydroxychloroquine sulfate ,
Methotrexate sodium (D02115),
Hydroxychloroquine 💬 		[3] DHFR,
DHFR2,
DHODH 💬 		[4] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate, Pyrimidine metabolism 💬[1] 46 💬
71Methotrexate Pfizer 2,5 mg tabletter
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
72Methotrexate ph. Eur.
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 14 💬
73Methotrexate plus ENBREL or ENBREL alone
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
74Methotrexate plus ERB-041 for 12 weeks
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
75Methotrexate plus sulfasalazine
(D02115)		[2] Methotrexate,
Sulfasalazine		[3] Methotrexate ,
Sulfasalazine ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
76Methotrexate pre-filled pen
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
77Methotrexate prefilled pen
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[2] 46, 107 💬
78Methotrexate prefilled syringe
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
79METHOTREXATE SODIUM
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[2] 46, 256 💬
80Methotrexate Sodium 2.5mg Tablets
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
81Methotrexate Sodium Tablets 2.5 mg
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
82Methotrexate Sodium Tablets 2.5mg
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
83Methotrexate Tablets
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[2] 40, 46 💬
84Methotrexate tablets 2.5 mg
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
85Methotrexate treatment
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[2] 41, 46 💬
86Methotrexate Wyeth 2,5mg
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 50 💬
87Methotrexate Wyeth 2,5mg tbl.
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 50 💬
88Methotrexate ® 2.5mg Tablets
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
89Methotrexate(MTX)
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
90Methotrexate(necessary)
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
91METHOTREXATE*100CPR 2,5MG
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
92METHOTREXATE*10MG/1,33ML 4S
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
93METHOTREXATE*15MG/2ML 4SIR
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
94METHOTREXATE*2,5MG 25CPR
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
95METHOTREXATE*20MG/2,66ML 4S
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
96METHOTREXATE*25CPR 2,5MG
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[2] 46, 107 💬
97METHOTREXATE*7,5MG/ML 4SIR.
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
98Methotrexate, Leucovorin and BMS-986142
(D02115)		[3] BMS-986142,
Leucovorin,
Methotrexate		[5] Methotrexate ,
Leucovorin calcium ,
Methotrexate sodium (D02115),
Folinic acid ,
Folinic acid calcium salt pentahydrate 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
99Methotrexate-Lachema
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
100Methotrexate-Sulfasalazine-Hydroxychloroquine
(D02115)		[3] Hydroxychloroquine,
Methotrexate,
Sulfasalazine		[5] Methotrexate ,
Sulfasalazine ,
Hydroxychloroquine sulfate ,
Methotrexate sodium (D02115),
Hydroxychloroquine 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
101Methotrexate® 2.5 mg tablets
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
102Modified Zhiwang Decoction Combined with methotrexate
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
103MP-435(dose1) + Methotrexate
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
104Mycophenolate mofetil,methotrexate
(D02115)		[2] Methotrexate,
Mycophenolate mofetil		[4] Methotrexate ,
Mycophenolate mofetil ,
Methotrexate sodium (D02115),
Mycophenolate mofetil hydrochloride 💬 		[4] DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬 		[5] Drug metabolism - other enzymes, Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate, Purine metabolism 💬[3] 42, 43, 45 💬
105Oral methotrexate
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
106Other: Methotrexate therapy
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
107Phase 1: Methotrexate
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
108Response to anakinra associated with methotrexate
(D02115)		[2] Anakinra,
Methotrexate		[3] Methotrexate ,
Methotrexate sodium (D02115),
Anakinra 💬 		[4] DHFR,
DHFR2,
IL1R1,
IL1R2 💬 		[18] Amoebiasis, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, NF-kappa B signaling pathway, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[1] 46 💬
109Response to infliximab associated with methotrexate
(D02115)		[2] Infliximab,
Methotrexate		[3] Methotrexate ,
Methotrexate sodium (D02115),
Infliximab 💬 		[3] DHFR,
DHFR2,
TNF 💬 		[69] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46 💬
110Stable weekly dose of methotrexate
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
111Tab. Methotrexate 25mg/week
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
112Tacrolimus with Methotrexate
(D02115)		[2] Methotrexate,
Tacrolimus		[4] Tacrolimus ,
Methotrexate ,
Methotrexate sodium (D02115),
Tacrolimus 💬 		[7] DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬 		[36] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Folate transport and metabolism, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 46 💬
113TAK-715 and methotrexate
(D02115)		[2] Methotrexate,
TAK-715		[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
114TAK-783 and methotrexate
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬
115Tasocitinib plus Methotrexate
(D02115)		[2] Methotrexate,
Tofacitinib		[4] Methotrexate ,
Methotrexate sodium (D02115),
Tofacitinib citrate ,
Tofacitinib 💬 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease, Efferocytosis, Epstein-Barr virus infection, Folate biosynthesis, Folate transport and metabolism, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Hormone signaling, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46 💬
116To see the efficacy of Upadacitinib, Methotrexate versus Tofacitinib, Methotrexate in moderate to severe Rheumatoid arthritis
(D02115)		[3] Methotrexate,
Tofacitinib,
Upadacitinib		[7] Methotrexate ,
Methotrexate sodium (D02115),
Tofacitinib citrate ,
Tofacitinib ,
Upadacitinib ,
Upadacitinib tartrate ,
Upadacitinib hydrate 💬 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease, Efferocytosis, Epstein-Barr virus infection, Folate biosynthesis, Folate transport and metabolism, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Hormone signaling, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46 💬
117Tocilizumab + methotrexate(MTX)
(D02115)		[2] Methotrexate,
Tocilizumab		[3] Methotrexate ,
Methotrexate sodium (D02115),
Tocilizumab 💬 		[3] DHFR,
DHFR2,
IL6R 💬 		[14] Coronavirus disease, Cytokine-cytokine receptor interaction, Folate biosynthesis, Folate transport and metabolism, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46 💬
118Tocilizumab plus methotrexate
(D02115)		[2] Methotrexate,
Tocilizumab		[3] Methotrexate ,
Methotrexate sodium (D02115),
Tocilizumab 💬 		[3] DHFR,
DHFR2,
IL6R 💬 		[14] Coronavirus disease, Cytokine-cytokine receptor interaction, Folate biosynthesis, Folate transport and metabolism, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46 💬
119Tocilizumab+Methotrexate(MTX)
(D02115)		[2] Methotrexate,
Tocilizumab		[3] Methotrexate ,
Methotrexate sodium (D02115),
Tocilizumab 💬 		[3] DHFR,
DHFR2,
IL6R 💬 		[14] Coronavirus disease, Cytokine-cytokine receptor interaction, Folate biosynthesis, Folate transport and metabolism, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46 💬
120Tofacitinib with methotrexate
(D02115)		[2] Methotrexate,
Tofacitinib		[4] Methotrexate ,
Methotrexate sodium (D02115),
Tofacitinib citrate ,
Tofacitinib 💬 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease, Efferocytosis, Epstein-Barr virus infection, Folate biosynthesis, Folate transport and metabolism, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Hormone signaling, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46 💬
121Tofacitinib without methotrexate
(D02115)		[2] Methotrexate,
Tofacitinib		[4] Methotrexate ,
Methotrexate sodium (D02115),
Tofacitinib citrate ,
Tofacitinib 💬 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease, Efferocytosis, Epstein-Barr virus infection, Folate biosynthesis, Folate transport and metabolism, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Hormone signaling, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46 💬
122Treatment with systemic therapy (methotrexate)
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 162 💬
123Urine samples taken to measure methotrexate and its major metabolite 7-OH-methotrexate level
(D02115)		[1] Methotrexate[2] Methotrexate ,
Methotrexate sodium (D02115) 💬 		[2] DHFR,
DHFR2 💬 		[3] Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬[1] 46 💬