296. 胆道閉鎖症 Disease details / Clinical trials / Drug dev / DR info

A4250
   ALBIREO AB
      2020   Phase 3   EUCTR2019-003807-37-IT   Australia;Belgium;Canada;China;Denmark;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Turkey;United Kingdom;United States
   Albireo AB
      2020   Phase 3   EUCTR2019-003807-37-NL   Australia;Belgium;Canada;China;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Turkey;United Kingdom;United States
      2020   Phase 3   EUCTR2019-003807-37-HU   Australia;Belgium;Canada;China;Denmark;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Turkey;United Kingdom;United States
      2020   Phase 3   EUCTR2019-003807-37-GB   Australia;Belgium;Canada;China;Denmark;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Turkey;United Kingdom;United States
      2020   Phase 3   EUCTR2019-003807-37-FR   Australia;Belgium;Canada;China;Denmark;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Turkey;United Kingdom;United States
      2020   Phase 3   EUCTR2019-003807-37-BE   Australia;Belgium;Canada;China;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Turkey;United Kingdom;United States
      -   Phase 3   EUCTR2019-003807-37-PL   Australia;Belgium;Canada;China;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Turkey;United Kingdom;United States
      -   Phase 3   EUCTR2019-003807-37-DE   Australia;Belgium;Canada;China;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Türkiye;United Kingdom;United States
Acetic acid
   Children's Hospital of Chongqing Medical University
      2023   -   ChiCTR2300076705   China
Acido obeticolico
   INTERCEPT PHARMACEUTICALS INC.
      2022   Phase 2   EUCTR2014-004693-42-IT   Belgium;Finland;France;Germany;Israel;Italy;Netherlands;Poland;Spain;United Kingdom
Ammonia
   Children's Hospital Affiliated to Zhejiang University Medical College
      2021   -   ChiCTR2100044533   China
Basic treatment: sulperazone + ursodeoxycholic acid + compound glycyrrhizin + methylprednisolone + vitamin AD , D , E , K + imipenem or meropenem
   Children's Hospital of Fudan University
      2023   -   NCT05925309   China
Belimumab
   Guangzhou Women and Children Medical Center
      2021   Phase 4   ChiCTR2100046985   China
Bezafibrate
   Terui Keita
      2021   Phase 2   JPRN-jRCTs031210066   -
Bicarbonate ringer'S solution
   Tongji Hospital
      2020   -   NCT04506021   -
Cefoperazone
   Children's Hospital of Fudan University
      2016   -   ChiCTR-IPR-16008609   China
Corticosteroids
   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
      2005   -   NCT00294684   United States
Desflurane
   Tianjin First Central Hospital
      2023   Phase 4   NCT05783518   China
Desflurane anesthetics
   Yonsei University
      2011   -   NCT01443572   Korea, Republic of
Dexamethasone
   The First Affiliated Hospital of Sun Yat Sen University
      2007   -   ChiCTR-TNRC-09000331   China
Dimethyl fumarate
   Children's Hospital of Fudan University
      2020   Phase 4   ChiCTR2000035667   China
Eicosapentaenoic acid
   Sumida Wataru
      2016   -   JPRN-jRCTs041180088   -
Filgrastim
   Holterman, Ai-Xuan, M.D.
      2023   Phase 2   NCT04373941   Pakistan;United States;Vietnam
Folic acid
   Guangzhou Women and Children Medical Center
      2022   Phase 4   ChiCTR2200063603   China
      2021   Phase 0   ChiCTR2100050992   China
Gelatine
   The First Affiliated Hospital of Sun Yat-sen University
      2023   Phase 4   ChiCTR2300071162   China
Granulocyte colony-stimulating factor
   Holterman, Ai-Xuan, M.D.
      2018   Early Phase 1   NCT03395028   United States;Vietnam
   National Liver Institute, Egypt
      2024   -   NCT06708572   Egypt
High MCT formula
   Tongji Hospital
      2025   -   NCT06764082   -
Human albumin
   The First Affiliated Hospital of Sun Yat-sen University
      2023   Phase 4   ChiCTR2300071162   China
ICG pulsion
   University Medical Centre Groningen
      2010   -   EUCTR2009-014886-21-NL   Netherlands
ICG-pulsion 25MG
   University Medical Centre Groningen
      2010   -   EUCTR2009-014886-21-NL   Netherlands
Indocyanine green
   Juntendo University School of Medicine
      2017   Phase 2   JPRN-UMIN000027972   Japan
   Nagoya University Graduate School of Medicine
      2019   -   JPRN-UMIN000028549   Japan
Lactated ringer
   RenJi Hospital
      2018   -   NCT03563378   China
Lactobacillus casei
   National Taiwan University Hospital
      2003   -   NCT00166868   Taiwan
Ligustrazine
   The First Affiliated Hospital of Sun Yat Sen University
      2007   -   ChiCTR-TNRC-09000331   China
LUM001
   Mirum Pharmaceuticals Inc.
      -   Phase 2   EUCTR2019-002755-42-PL   Australia;Belgium;Canada;France;Poland;Spain;United Kingdom;United States
Magnesium gluconate
   National Center for Research Resources (NCRR)
      2000   -   NCT00007033   United States
Magnesium sulfate
   National Center for Research Resources (NCRR)
      2000   -   NCT00007033   United States
Maralixibat
   Mirum Pharmaceuticals, Inc.
      2021   Phase 2   NCT04524390   China;Germany;Hong Kong;Italy;Poland;Singapore;Taiwan;United Kingdom;United States;Vietnam
Maralixibat (formely SHP625 or LUM001)
   Mirum Pharmaceuticals Inc.
      2020   Phase 2   EUCTR2019-002755-42-BE   Australia;Belgium;Canada;France;Poland;Spain;United Kingdom;United States
Maralixibat chloride
   Mirum Pharmaceuticals Inc.
      2021   Phase 2   EUCTR2020-000974-22-IT   Canada;France;Germany;Italy;Poland;United Kingdom;United States
      2021   Phase 2   EUCTR2020-000974-22-DE   China;France;Germany;Hong Kong;Italy;Mexico;Poland;Singapore;Taiwan;United Kingdom;United States;Viet Nam
      2020   Phase 2   EUCTR2020-000974-22-FR   Canada;France;Germany;Italy;Poland;United Kingdom;United States
      -   Phase 2   EUCTR2019-002755-42-PL   Australia;Belgium;Canada;France;Poland;Spain;United Kingdom;United States
      -   Phase 2   EUCTR2020-000974-22-PL   China;France;Germany;Hong Kong;Italy;Mexico;Poland;Singapore;Taiwan;United Kingdom;United States;Viet Nam
      -   Phase 2   EUCTR2020-000974-22-GB   Canada;France;Germany;Italy;Poland;United Kingdom;United States
Maralixibat cloruro
   Mirum Pharmaceuticals Inc.
      2021   Phase 2   EUCTR2020-000974-22-IT   Canada;France;Germany;Italy;Poland;United Kingdom;United States
Meloxicam
   Yonsei University
      2009   Phase 4   NCT02298218   -
Methylprednisolone
   The First Affiliated Hospital of Sun Yat Sen University
      2007   -   ChiCTR-TNRC-09000331   China
N-acetyl cysteine
   Baylor College of Medicine
      2018   Phase 2   NCT03499249   United States
N-acetylcysteine
   Guangzhou Women and Children Medical Center
      2020   Phase 4   ChiCTR2000040505   China
   Sanjiv Harpavat
      2024   Phase 1   NCT06260566   -
Neomycin
   National Taiwan University Hospital
      2003   -   NCT00166868   Taiwan
Norepinephrine bitartrate
   Kasr El Aini Hospital
      2022   Phase 3   NCT05521152   Egypt
Normal oral intake OF THE traditional formula
   Tongji Hospital
      2025   -   NCT06764082   -
Normal saline
   RenJi Hospital
      2018   -   NCT03563378   China
Obeticholic acid
   Intercept Pharmaceuticals, Inc.
      2022   Phase 2   EUCTR2014-004693-42-FR   Belgium;Finland;France;Germany;Netherlands;Poland;United Kingdom
      2022   Phase 2   EUCTR2014-004693-42-BE   Belgium;Finland;France;Germany;Italy;Netherlands;Poland;Spain;United Kingdom
      2018   Phase 2   EUCTR2014-004693-42-FI   Belgium;Finland;Germany;Italy;Netherlands;United Kingdom;United States
      2016   -   EUCTR2014-004693-42-NL   Canada;Germany;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2014-004693-42-GB   Belgium;Finland;Germany;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2014-004693-42-DE   Belgium;Finland;France;Germany;Italy;Netherlands;Poland;Spain;United Kingdom;United States
OCA
   Intercept Pharmaceuticals
      2024   Phase 2/Phase 3   NCT06121375   Australia;Canada;Hong Kong;Malaysia;New Zealand;Singapore
OCA 0.1 MG
   INTERCEPT PHARMACEUTICALS INC.
      2022   Phase 2   EUCTR2014-004693-42-IT   Belgium;Finland;France;Germany;Israel;Italy;Netherlands;Poland;Spain;United Kingdom
   Intercept Pharmaceuticals, Inc.
      2022   Phase 2   EUCTR2014-004693-42-FR   Belgium;Finland;France;Germany;Netherlands;Poland;United Kingdom
      2022   Phase 2   EUCTR2014-004693-42-BE   Belgium;Finland;France;Germany;Italy;Netherlands;Poland;Spain;United Kingdom
      2018   Phase 2   EUCTR2014-004693-42-FI   Belgium;Finland;Germany;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2014-004693-42-GB   Belgium;Finland;Germany;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2014-004693-42-DE   Belgium;Finland;France;Germany;Italy;Netherlands;Poland;Spain;United Kingdom;United States
OCA 0.1MG
   Intercept Pharmaceuticals
      2015   Phase 2   NCT05321524   Belgium;France;Germany;Israel;Italy;Netherlands;Poland;Spain;United Kingdom
OCA 1.5MG
   INTERCEPT PHARMACEUTICALS INC.
      2022   Phase 2   EUCTR2014-004693-42-IT   Belgium;Finland;France;Germany;Israel;Italy;Netherlands;Poland;Spain;United Kingdom
   Intercept Pharmaceuticals
      2015   Phase 2   NCT05321524   Belgium;France;Germany;Israel;Italy;Netherlands;Poland;Spain;United Kingdom
   Intercept Pharmaceuticals, Inc.
      2022   Phase 2   EUCTR2014-004693-42-FR   Belgium;Finland;France;Germany;Netherlands;Poland;United Kingdom
      2022   Phase 2   EUCTR2014-004693-42-BE   Belgium;Finland;France;Germany;Italy;Netherlands;Poland;Spain;United Kingdom
      2018   Phase 2   EUCTR2014-004693-42-FI   Belgium;Finland;Germany;Italy;Netherlands;United Kingdom;United States
      2016   -   EUCTR2014-004693-42-NL   Canada;Germany;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2014-004693-42-GB   Belgium;Finland;Germany;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2014-004693-42-DE   Belgium;Finland;France;Germany;Italy;Netherlands;Poland;Spain;United Kingdom;United States
OCA 5MG
   INTERCEPT PHARMACEUTICALS INC.
      2022   Phase 2   EUCTR2014-004693-42-IT   Belgium;Finland;France;Germany;Israel;Italy;Netherlands;Poland;Spain;United Kingdom
   Intercept Pharmaceuticals
      2015   Phase 2   NCT05321524   Belgium;France;Germany;Israel;Italy;Netherlands;Poland;Spain;United Kingdom
   Intercept Pharmaceuticals, Inc.
      2022   Phase 2   EUCTR2014-004693-42-FR   Belgium;Finland;France;Germany;Netherlands;Poland;United Kingdom
      2022   Phase 2   EUCTR2014-004693-42-BE   Belgium;Finland;France;Germany;Italy;Netherlands;Poland;Spain;United Kingdom
      2018   Phase 2   EUCTR2014-004693-42-FI   Belgium;Finland;Germany;Italy;Netherlands;United Kingdom;United States
      2016   -   EUCTR2014-004693-42-NL   Canada;Germany;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2014-004693-42-GB   Belgium;Finland;Germany;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2014-004693-42-DE   Belgium;Finland;France;Germany;Italy;Netherlands;Poland;Spain;United Kingdom;United States
Ocaliva
   INTERCEPT PHARMACEUTICALS INC.
      2022   Phase 2   EUCTR2014-004693-42-IT   Belgium;Finland;France;Germany;Israel;Italy;Netherlands;Poland;Spain;United Kingdom
   Intercept Pharmaceuticals, Inc.
      2022   Phase 2   EUCTR2014-004693-42-FR   Belgium;Finland;France;Germany;Netherlands;Poland;United Kingdom
      2022   Phase 2   EUCTR2014-004693-42-BE   Belgium;Finland;France;Germany;Italy;Netherlands;Poland;Spain;United Kingdom
      2018   Phase 2   EUCTR2014-004693-42-FI   Belgium;Finland;Germany;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2014-004693-42-GB   Belgium;Finland;Germany;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2014-004693-42-DE   Belgium;Finland;France;Germany;Italy;Netherlands;Poland;Spain;United Kingdom;United States
Odevixibat
   ALBIREO AB
      2020   Phase 3   EUCTR2019-003807-37-IT   Australia;Belgium;Canada;China;Denmark;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Turkey;United Kingdom;United States
   Albireo AB
      2020   Phase 3   EUCTR2019-003807-37-NL   Australia;Belgium;Canada;China;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Turkey;United Kingdom;United States
      2020   Phase 3   EUCTR2019-003807-37-HU   Australia;Belgium;Canada;China;Denmark;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Turkey;United Kingdom;United States
      2020   Phase 3   EUCTR2019-003807-37-GB   Australia;Belgium;Canada;China;Denmark;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Turkey;United Kingdom;United States
      2020   Phase 3   EUCTR2019-003807-37-FR   Australia;Belgium;Canada;China;Denmark;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Turkey;United Kingdom;United States
      2020   Phase 3   EUCTR2019-003807-37-BE   Australia;Belgium;Canada;China;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Turkey;United Kingdom;United States
      -   Phase 3   EUCTR2019-003807-37-PL   Australia;Belgium;Canada;China;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Turkey;United Kingdom;United States
      -   Phase 3   EUCTR2019-003807-37-DE   Australia;Belgium;Canada;China;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Türkiye;United Kingdom;United States
   Albireo, an Ipsen Company
      2022   Phase 3   NCT05426733   Australia;Canada;China;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Turkey;United States
      2020   Phase 3   NCT04336722   Australia;Belgium;Canada;China;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Netherlands;New Zealand;Poland;Spain;Taiwan;Turkey;United Kingdom;United States
Oral vancomycin
   Sacramento Pediatric Gastroenterology
      2010   Phase 1   NCT02137668   United States
Other crystalloid
   Tongji Hospital
      2020   -   NCT04506021   -
Pentoxifylline
   Baylor College of Medicine
      2013   Phase 2   NCT01774487   United States
Prednisolone
   King's College Hospital NHS Trust
      2000   Phase 3   NCT00539565   United Kingdom
Propanolol
   Institute of Liver and Biliary Sciences, India
      2020   -   NCT04494763   India
Prophylactic oral antibiotics: compound sulfamethoxazole tablet (SMZ/TMP) + cefaclor
   Children's Hospital of Fudan University
      2023   -   NCT05925309   China
Propofol
   Children's Hospital of Chongqing Medical University
      2025   -   ChiCTR2500102658   China
   Tianjin First Center Hospital
      2018   -   ChiCTR1800015778   China
   Tianjin First Central Hospital
      2023   Phase 4   NCT05783518   China
      2018   -   ChiCTR-IOR-17013585   China
Rifaximin
   Tianjin First Center Hospital
      2019   Phase 0   ChiCTR1900023843   China
Rituximab
   Guangzhou Women and Children Medical Center
      2020   Phase 4   ChiCTR2000031738   China
Rocuronium
   Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
      2016   -   ChiCTR-OOC-16008707   China
Sevoflurane
   Children's Hospital of Fudan University
      2012   -   NCT02471209   -
   Tianjin First Central Hospital
      2018   -   ChiCTR-IOR-17013585   China
Sevoflurane anesthetics
   Yonsei University
      2011   -   NCT01443572   Korea, Republic of
Stem cell
   Necmi Kadioglu Hospital
      2024   -   NCT06564740   Turkey
Udca
   Children's Hospital of Fudan University
      2018   -   ChiCTR1800015250   China
Umbilical cord derived mesenchymal stem cell (UC -MSC) transplantation
   Vinmec Research Institute of Stem Cell and Gene Technology
      2019   Phase 1/Phase 2   NCT04522869   Vietnam
Vancomycin
   Stanford University
      2007   Phase 1   NCT01322386   -
VO4CX
   University Medical Centre Groningen
      2010   -   EUCTR2009-014886-21-NL   Netherlands