58. 肥大型心筋症 Disease details / Clinical trials / Drug dev / DR info

1,4-benzoxazepin-5(2H)-ONE, 3,4-dihydro-4-(2-pyrimidinylmethyl)-7-[4- (trifluoromethoxy)phenyl]
   Gilead Sciences, Inc.
      2023   Phase 2   EUCTR2019-003958-86-NL   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-FR   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-DK   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2015   Phase 2   EUCTR2013-004429-97-GB   Australia;France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
1,4-benzoxazepin-5(2H)-ONE, 3,4-dihydro-4-(2-pyrimidinylmethyl)-7-[4-(trifluoromethoxy)phenyl]
   Gilead Sciences, Inc.
      2015   Phase 2   EUCTR2013-004429-97-NL   France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2013-004429-97-IT   France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2013-004429-97-GB   Australia;France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride
   University College London (UCL)
      2011   -   EUCTR2011-000038-12-GB   United Kingdom
12-lead ECG
   Mayo Clinic
      2024   -   NCT06290570   United States
4-(pyrimidin-2-ylmethyl)-7-[4- (trifluoromethoxy)phenyl]-3,4-dihydro-1,4-benzoxazepin-5(2H)-ONE
   Gilead Sciences, Inc.
      2023   Phase 2   EUCTR2019-003958-86-NL   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-FR   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-DK   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2015   Phase 2   EUCTR2013-004429-97-GB   Australia;France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
4-(pyrimidin-2-ylmethyl)-7-[4-(trifluoromethoxy)phenyl]-3,4-dihydro-1,4-benzoxazepin-5(2H)-ONE
   Gilead Sciences, Inc.
      2015   Phase 2   EUCTR2013-004429-97-NL   France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2013-004429-97-IT   France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2013-004429-97-GB   Australia;France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
Adenosine
   Duke University
      2017   Phase 4   NCT03249272   United States
Aficamten
   CYTOKINETICS, INC.
      2022   Phase 3   EUCTR2021-003536-92-IT   China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
   Cytokinetics
      2024   Phase 2/Phase 3   NCT06412666   Canada;Italy;Spain;United Kingdom;United States
      2023   Phase 3   NCT06081894   Argentina;Australia;Brazil;Canada;China;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   NCT05767346   Brazil;Canada;China;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Spain;United Kingdom;United States
      2022   Phase 3   NCT05186818   China;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2021   Phase 2/Phase 3   NCT04848506   Canada;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
   Cytokinetics, Inc.
      2023   Phase 2   EUCTR2020-003571-17-PT   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 2   EUCTR2020-003571-17-PL   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 2   EUCTR2020-003571-17-DE   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 2   EUCTR2020-003571-17-CZ   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-003536-92-PT   China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-003536-92-NL   China;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-003536-92-HU   China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-003536-92-ES   China;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-003536-92-DK   China;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 2   EUCTR2020-003571-17-NL   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 2   EUCTR2020-003571-17-HU   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 2   EUCTR2020-003571-17-DK   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
   Cytokinetics, Incorporated
      2022   Phase 3   EUCTR2021-003536-92-PL   China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
   Ji Xing Pharmaceuticals (Shanghai) Co., Ltd.
      2023   Phase 3   NCT06116968   China
AIR venous plethysmography
   University Hospital, Bordeaux
      2019   -   NCT04129905   France
Alcohol septal ablation
   National Heart, Lung, and Blood Institute (NHLBI)
      2002   Phase 2   NCT00035386   United States
   St. Antonius Hospital
      2021   -   NCT04684290   Netherlands
Alivecor kardiamobile 6-lead ECG
   Mayo Clinic
      2024   -   NCT06290570   United States
Amyl nitrite inhalation
   Mayo Clinic
      2021   -   NCT04905173   United States
Antiarrhythmic drugs
   Institute of Cardiology, Warsaw, Poland
      2009   Phase 3   NCT00821353   Poland
Apple smart watch single lead ECG
   Mayo Clinic
      2024   -   NCT06290570   United States
Approved hypertrophic cardiomyopathy drug treatments
   Bristol-Myers Squibb
      2023   -   NCT06372457   United States
Atorvastatin
   University of Calgary
      2007   Phase 3   NCT00317967   Canada
Bisoprolol
   Aarhus University Hospital
      2022   Phase 2   EUCTR2021-006953-77-DK   Denmark
   Morten Steen Kvistholm Jensen
      2022   Phase 4   NCT05569382   Denmark
BNP blood sample test
   University Hospital, Bordeaux
      2019   -   NCT04129905   France
Candesartan
   Charles University, Czech Republic
      2007   Phase 2   NCT00430833   Czech Republic
   The First Affiliated Hospital, Sun Yat-sen University
      2018   Phase 4 study   ChiCTR-IIR-17013661   China
Carnitine
   University Health Network, Toronto
      2013   Phase 4   NCT01904396   Canada
CK-3773274
   CYTOKINETICS, INC.
      2022   Phase 3   EUCTR2021-003536-92-IT   China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2021   Phase 2   EUCTR2020-003571-17-IT   Czech Republic;Denmark;Germany;Hungary;Italy;Netherlands;Poland;Portugal;Spain;United States
      2020   Phase 2   EUCTR2019-002785-12-IT   Italy;Netherlands;Spain;United Kingdom;United States
   Corxel Pharmaceuticals
      2021   Phase 1   NCT04783766   China
   Cytokinetics
      2023   Phase 3   NCT05767346   Brazil;Canada;China;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Spain;United Kingdom;United States
      2020   Phase 2   NCT04219826   Italy;Netherlands;Spain;United States
   Cytokinetics, Inc.
      2023   Phase 2   EUCTR2020-003571-17-PT   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 2   EUCTR2020-003571-17-PL   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 2   EUCTR2020-003571-17-DE   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 2   EUCTR2020-003571-17-CZ   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-003536-92-PT   China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-003536-92-NL   China;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-003536-92-HU   China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-003536-92-ES   China;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-003536-92-DK   China;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 2   EUCTR2020-003571-17-NL   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 2   EUCTR2020-003571-17-HU   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 2   EUCTR2020-003571-17-DK   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2021   Phase 2   EUCTR2020-003571-17-ES   Italy;Spain;United States
      2020   Phase 2   EUCTR2019-002785-12-GB   Italy;Netherlands;Spain;United Kingdom;United States
      2020   Phase 2   EUCTR2019-002785-12-ES   Italy;Netherlands;Spain;United Kingdom;United States
      -   Phase 2   EUCTR2019-002785-12-NL   Italy;Netherlands;Spain;United Kingdom;United States
   Cytokinetics, Incorporated
      2022   Phase 3   EUCTR2021-003536-92-PL   China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
CK-3773274 - granules IN capsule
   Cytokinetics
      2018   Phase 1   NCT03767855   United States
CK-3773274 - tablets
   Cytokinetics
      2018   Phase 1   NCT03767855   United States
Close follow-UP
   RenJi Hospital
      2025   -   NCT06794710   China
CT-G20
   Celltrion
      2020   Phase 1   NCT04418297   Korea, Republic of;Poland;United States
Cufence
   Manchester University NHS Foundation Trust
      2020   Phase 2   EUCTR2020-002242-17-GB   United Kingdom
Cyclosporine A
   National Heart, Lung, and Blood Institute (NHLBI)
      1999   Phase 2   NCT00001965   United States
Diltiazem
   Brigham and Women's Hospital
      2006   Phase 2/Phase 3   NCT00319982   United States
Diovan 160 MG
   National Heart, Lung, and Blood Institute / National Institutes of Health
      2016   Phase 2   EUCTR2015-002283-16-DK   Denmark
Diovan 40 MG
   National Heart, Lung, and Blood Institute / National Institutes of Health
      2016   Phase 2   EUCTR2015-002283-16-DK   Denmark
Diovan 80 MG
   National Heart, Lung, and Blood Institute / National Institutes of Health
      2016   Phase 2   EUCTR2015-002283-16-DK   Denmark
Diuretics, aceis/arbs, beta blockers, positive inotropic drugs, mras, SGLT2I, retinoids
   RenJi Hospital
      2025   -   NCT06794710   China
Dobutamine
   University of Aarhus
      2011   Phase 4   NCT01375335   Denmark
Early rehabilitation guidance
   RenJi Hospital
      2025   -   NCT06794710   China
Echo and myocardial contrast echocardiography perfusion imaging
   Oregon Health and Science University
      2015   -   NCT02560467   United States
Echocardiography
   University Hospital, Bordeaux
      2019   -   NCT04129905   France
EDG-7500
   Edgewise Therapeutics, Inc.
      2024   Phase 2   NCT06347159   United States
Eleclazine
   Gilead Sciences
      2015   Phase 2/Phase 3   NCT02291237   Australia;France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
Eleclazine pink 6 MG tablets
   GILEAD SCIENCES INCORPORATED
      2023   Phase 4   EUCTR2019-003958-86-IT   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
   Gilead Sciences, Inc.
      2023   Phase 2   EUCTR2019-003958-86-NL   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-FR   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-DK   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
Eleclazine white 10 MG tablets
   GILEAD SCIENCES INCORPORATED
      2023   Phase 4   EUCTR2019-003958-86-IT   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
   Gilead Sciences, Inc.
      2023   Phase 2   EUCTR2019-003958-86-NL   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-FR   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-DK   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
Eleclazine white 3 MG tablets
   GILEAD SCIENCES INCORPORATED
      2023   Phase 4   EUCTR2019-003958-86-IT   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
   Gilead Sciences, Inc.
      2023   Phase 2   EUCTR2019-003958-86-NL   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-FR   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-DK   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
Eleclazine white 6 MG tablets
   GILEAD SCIENCES INCORPORATED
      2023   Phase 4   EUCTR2019-003958-86-IT   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
   Gilead Sciences, Inc.
      2023   Phase 2   EUCTR2019-003958-86-NL   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-FR   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-DK   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
Electrocardiogram
   University Hospital, Bordeaux
      2019   -   NCT04129905   France
Empagliflozin 10 MG
   China National Center for Cardiovascular Diseases
      2022   Phase 4   NCT06401343   China
   National Institute of Cardiology, Warsaw, Poland
      2022   Phase 3   NCT05182658   Poland
Enavogliflozin 0.3MG
   Yonsei University
      2024   Phase 4   NCT06580717   Korea, Republic of
Endothelial function biomarkers
   University Hospital, Bordeaux
      2019   -   NCT04129905   France
Entresto
   Novartis Farmacéutica, S.A.
      2020   Phase 2   EUCTR2019-003098-24-ES   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
   Novartis Pharma AG
      2020   Phase 2   EUCTR2019-003098-24-GR   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2020   Phase 2   EUCTR2019-003098-24-GB   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2020   Phase 2   EUCTR2019-003098-24-FI   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2019   Phase 2   EUCTR2019-003098-24-DE   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
   University Hospital Regensburg
      2019   Phase 2   EUCTR2018-004882-15-DE   Germany
Ethanol
   Hiraya Daigo
      2022   -   JPRN-jRCTs031220363   -
Exercise echocardiography
   University Hospital, Bordeaux
      2015   Phase 2   NCT02590809   France
Exercise stress transthoracic echocardiogram
   University of East Anglia
      2017   Phase 1   NCT03251287   United Kingdom
Gadoteric acid
   IC TARGETS AS
      2024   Phase 2   NCT06731738   Norway
Genomic sequencing
   The Cleveland Clinic
      2018   -   NCT03043209   United States
GS-6155 white 6 MG tablets
   GILEAD SCIENCES INCORPORATED
      2023   Phase 4   EUCTR2019-003958-86-IT   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
   Gilead Sciences, Inc.
      2023   Phase 2   EUCTR2019-003958-86-NL   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-FR   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-DK   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
GS-6615 3 MG
   Gilead Sciences, Inc.
      2015   Phase 2   EUCTR2013-004429-97-NL   France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2013-004429-97-IT   France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
GS-6615 3 MG pink
   Gilead Sciences, Inc.
      2015   Phase 2   EUCTR2013-004429-97-GB   Australia;France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
GS-6615 3 MG white
   Gilead Sciences, Inc.
      2015   Phase 2   EUCTR2013-004429-97-GB   Australia;France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
GS-6615 6 MG
   Gilead Sciences, Inc.
      2015   Phase 2   EUCTR2013-004429-97-NL   France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2013-004429-97-IT   France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
GS-6615 6 MG white
   Gilead Sciences, Inc.
      2015   Phase 2   EUCTR2013-004429-97-GB   Australia;France;Germany;Israel;Italy;Netherlands;United Kingdom;United States
GS-6615 pink 6 MG tablets
   GILEAD SCIENCES INCORPORATED
      2023   Phase 4   EUCTR2019-003958-86-IT   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
   Gilead Sciences, Inc.
      2023   Phase 2   EUCTR2019-003958-86-NL   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-FR   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-DK   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
GS-6615 white 10 MG tablets
   GILEAD SCIENCES INCORPORATED
      2023   Phase 4   EUCTR2019-003958-86-IT   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
   Gilead Sciences, Inc.
      2023   Phase 2   EUCTR2019-003958-86-NL   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-FR   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-DK   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
GS-6615 white 3 MG tablets
   GILEAD SCIENCES INCORPORATED
      2023   Phase 4   EUCTR2019-003958-86-IT   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
   Gilead Sciences, Inc.
      2023   Phase 2   EUCTR2019-003958-86-NL   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-FR   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
      2022   Phase 2   EUCTR2019-003958-86-DK   Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;New Zealand;Poland;United Kingdom;United States
Gutron 2,5MG
   CHU de Bordeaux
      2015   -   EUCTR2015-003521-34-FR   France
Gutron 5MG
   CHU de Bordeaux
      2015   -   EUCTR2015-003521-34-FR   France
Holter ECG
   University Hospital, Bordeaux
      2019   -   NCT04129905   France
HRS-1893
   Shandong Suncadia Medicine Co., Ltd.
      2025   Phase 2   NCT06816251   China
      2025   Phase 1   NCT06775834   China
      2024   Phase 2   NCT06516068   China
      2023   Phase 1   NCT05879523   China
HRS-1893 tablet
   Shandong Suncadia Medicine Co., Ltd.
      2024   Phase 1   NCT06354556   China
HS-10511 tablets
   Jiangsu Hansoh Pharmaceutical Co., Ltd.
      2024   Phase 1   NCT06210607   -
IMB-1018972
   Imbria Pharmaceuticals, Inc.
      2021   Phase 2   NCT04826185   United Kingdom;United States
Imukin - 6 flaconi 0.5 ML 100 MCG
   ASSOCIAZIONE LA NOSTRA FAMIGLIA - SEZIONE SCIENTIFICA I.R.C.C.S. E.MEDEA
      2016   Phase 2   EUCTR2015-002432-40-IT   Italy
Insertable cardiac monitor
   Region Gävleborg
      2017   -   NCT03259113   Sweden
Isoptin
   Aarhus University Hospital
      2022   Phase 2   EUCTR2021-006953-77-DK   Denmark
LCZ696
   Novartis Pharmaceuticals
      2020   Phase 2   NCT04164732   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
LCZ696 100 MG
   Novartis Farmacéutica, S.A.
      2020   Phase 2   EUCTR2019-003098-24-ES   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
   Novartis Pharma AG
      2020   Phase 2   EUCTR2019-003098-24-GR   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2020   Phase 2   EUCTR2019-003098-24-GB   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2020   Phase 2   EUCTR2019-003098-24-FI   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2019   Phase 2   EUCTR2019-003098-24-DE   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
LCZ696 200 MG
   Novartis Farmacéutica, S.A.
      2020   Phase 2   EUCTR2019-003098-24-ES   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
   Novartis Pharma AG
      2020   Phase 2   EUCTR2019-003098-24-GR   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2020   Phase 2   EUCTR2019-003098-24-GB   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2020   Phase 2   EUCTR2019-003098-24-FI   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2019   Phase 2   EUCTR2019-003098-24-DE   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
LCZ696 50 MG
   Novartis Farmacéutica, S.A.
      2020   Phase 2   EUCTR2019-003098-24-ES   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
   Novartis Pharma AG
      2020   Phase 2   EUCTR2019-003098-24-GR   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2020   Phase 2   EUCTR2019-003098-24-GB   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2020   Phase 2   EUCTR2019-003098-24-FI   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2019   Phase 2   EUCTR2019-003098-24-DE   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
Lifestyle
   Newcastle University
      2019   Phase 2   NCT03832660   Germany;Italy;Serbia;United Kingdom
   Newcastle-upon-Tyne Hospitals NHS Trust
      2019   Phase 2/Phase 3   NCT05366101   United Kingdom
Losartan
   Henning Bundgaard
      2011   Phase 2   NCT01447654   Denmark
   Massachusetts General Hospital
      2007   Phase 2   NCT01150461   United States
   National Heart, Lung, and Blood Institute (NHLBI)
      1996   -   NCT00001534   United States
Losartan bluefish 50 MG
   Hjertemedicinsk klinik B, 2142, Rigshospitalet
      2011   -   EUCTR2011-001191-19-DK   Denmark
Mangafodipir trisodium
   University of Edinburgh
      2018   -   NCT03607669   United Kingdom
Mangafodipir trisodium injection
   IC TARGETS AS
      2024   Phase 2   NCT06731738   Norway
Mavacamten
   Aronson Ron
      2023   Phase 3   JPRN-jRCT2051220175   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Hungary;India;Israel;Italy;Japan;Korea;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
   Bristol-Myers Squibb
      2024   -   NCT06551129   United States
      2024   -   NCT06549608   Canada
      2024   -   NCT06338202   Canada
      2024   Phase 3   NCT06253221   Australia;Canada;France;Germany;Ireland;Italy;Spain;United Kingdom;United States
      2024   -   NCT06146660   Korea, Republic of
      2024   Phase 4   NCT06112743   Argentina;Australia;Austria;Belgium;Canada;Czechia;Finland;France;Germany;Greece;Hungary;Italy;Poland;Spain;Switzerland;United Kingdom;United States
      2023   -   NCT06372457   United States
      2023   -   NCT05939700   United States
      2022   Phase 3   NCT05582395   Australia;Austria;Belgium;Brazil;Canada;China;Czechia;Denmark;France;Germany;Hungary;India;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   NCT05414175   Japan
      2020   Phase 3   NCT04349072   United States
      2018   Phase 2/Phase 3   NCT03723655   Belgium;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 2   NCT03496168   United States
   Florea Victoria
      2022   Phase 3   JPRN-jRCT2031220178   -
   LianBio LLC
      2022   Phase 3   NCT05174416   China
      2021   Phase 1   NCT05135871   China
   MYOKARDIA, INC.
      2023   Phase 3   EUCTR2021-005329-26-IT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-IT   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-IT   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
   Michael Ayers
      2023   -   NCT06023186   United States
   MyoKardia, Inc.
      2019   Phase 3   EUCTR2018-004039-64-PT   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-PL   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-NL   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-GB   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-ES   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-DK   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-DE   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-CZ   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-BE   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   NCT03470545   Belgium;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 2   NCT03442764   United States
      2018   Phase 3   EUCTR2017-002530-23-PT   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-PL   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-NL   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-GB   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-FR   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-ES   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-DK   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-DE   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-CZ   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-BE   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
   Myokardia, Inc.
      2023   Phase 3   EUCTR2021-005329-26-PT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-PL   Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;India;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-NO   Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;India;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-NL   Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;India;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-HU   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-FR   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-ES   Australia;Austria;Belgium;Brazil;Canada;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-DE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Hungary;India;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-CZ   Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;India;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-005329-26-DK   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Hungary;India;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
   Shanghai Chest Hospital
      2025   -   NCT06856265   -
   The First Affiliated Hospital of Dalian Medical University
      2024   Phase 0   ChiCTR2500095275   China
MEK162
   Array Biopharma, now a wholly owned subsidiary of Pfizer
      2012   Phase 2   NCT01556568   United Kingdom;United States
   Novartis Pharma Services AG
      2012   -   EUCTR2011-003392-10-GB   United Kingdom;United States
Metoprolol
   University Hospital, Motol
      2020   Phase 4   NCT04133532   Czechia
Metoprolol succinate
   Cytokinetics
      2023   Phase 3   NCT05767346   Brazil;Canada;China;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Spain;United Kingdom;United States
   Steen Hvitfeldt Poulsen
      2018   Phase 2   NCT03532802   Denmark
   The First Affiliated Hospital, Sun Yat-sen University
      2018   Phase 4 study   ChiCTR-IIR-17013661   China
Midodrine hydrochloride
   CHU de Bordeaux
      2015   -   EUCTR2015-003521-34-FR   France
MYK-224
   Bristol-Myers Squibb
      2023   Phase 2   NCT05556343   Italy;Poland;Spain;United States
MYK-461
   MYOKARDIA, INC.
      2023   Phase 3   EUCTR2021-005329-26-IT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-IT   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-IT   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
   MyoKardia, Inc.
      2019   Phase 3   EUCTR2018-004039-64-PT   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-PL   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-NL   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-GB   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-ES   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-DK   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-DE   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-CZ   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2019   Phase 3   EUCTR2018-004039-64-BE   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-PT   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-PL   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-NL   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-GB   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-FR   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-ES   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-DK   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-DE   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-CZ   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2018   Phase 3   EUCTR2017-002530-23-BE   Belgium;Czech Republic;Denmark;France;Germany;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2016   Phase 2   NCT02842242   United States
      2014   Phase 1   NCT02329184   United States
   Myokardia, Inc.
      2023   Phase 3   EUCTR2021-005329-26-PT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-PL   Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;India;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-NO   Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;India;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-NL   Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;India;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-HU   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-FR   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-ES   Australia;Austria;Belgium;Brazil;Canada;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-DE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Hungary;India;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 3   EUCTR2021-005329-26-CZ   Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;India;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-005329-26-DK   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Hungary;India;Israel;Italy;Japan;Korea, Republic of;Netherlands;Norway;Poland;Portugal;Spain;United Kingdom;United States
N-acetylcysteine
   The University of Texas Health Science Center, Houston
      2012   Phase 1   NCT01537926   United States
NON-mavacamten symptomatic ohcm therapy
   Bristol-Myers Squibb
      2022   -   NCT05489705   Austria;France;Germany;Puerto Rico;Spain;United Kingdom;United States
Perhexiline
   Flinders University
      2020   Phase 2   NCT04426578   Australia
   Heart Metabolics Limited
      2015   Phase 3   NCT02431221   -
   University Hospital Birmingham
      2006   Phase 2   NCT00500552   United Kingdom
Perindopril arginina
   AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI
      2017   Phase 2   EUCTR2015-004317-24-IT   Italy
Perindopril arginine
   AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI
      2017   Phase 2   EUCTR2015-004317-24-IT   Italy
Perxexiline
   University Hospital of Birmingham Foundation Trust
      2005   -   EUCTR2005-000755-15-GB   United Kingdom
Pexsig
   University Hospital of Birmingham Foundation Trust
      2005   -   EUCTR2005-000755-15-GB   United Kingdom
Phosphorous magnetic resonance spectroscopy
   University of East Anglia
      2017   Phase 1   NCT03251287   United Kingdom
Pirfenidone
   National Heart, Lung, and Blood Institute (NHLBI)
      2001   Phase 2   NCT00011076   United States
Procaptan - 10 MG compresse rivestite CON film 60 compresse IN contenitore PER compresse PP
   AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI
      2017   Phase 2   EUCTR2015-004317-24-IT   Italy
Procaptan - 5 MG compresse rivestite CON film 10 compresse IN contenitore PER compresse PP
   AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI
      2017   Phase 2   EUCTR2015-004317-24-IT   Italy
Pyrazole
   CYTOKINETICS, INC.
      2021   Phase 2   EUCTR2020-003571-17-IT   Czech Republic;Denmark;Germany;Hungary;Italy;Netherlands;Poland;Portugal;Spain;United States
      2020   Phase 2   EUCTR2019-002785-12-IT   Italy;Netherlands;Spain;United Kingdom;United States
   Cytokinetics, Inc.
      2023   Phase 2   EUCTR2020-003571-17-PT   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 2   EUCTR2020-003571-17-PL   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 2   EUCTR2020-003571-17-DE   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2023   Phase 2   EUCTR2020-003571-17-CZ   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-003536-92-PT   China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-003536-92-NL   China;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-003536-92-HU   China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-003536-92-ES   China;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 3   EUCTR2021-003536-92-DK   China;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 2   EUCTR2020-003571-17-NL   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 2   EUCTR2020-003571-17-HU   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2022   Phase 2   EUCTR2020-003571-17-DK   Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
      2021   Phase 2   EUCTR2020-003571-17-ES   Italy;Spain;United States
      2020   Phase 2   EUCTR2019-002785-12-GB   Italy;Netherlands;Spain;United Kingdom;United States
      2020   Phase 2   EUCTR2019-002785-12-ES   Italy;Netherlands;Spain;United Kingdom;United States
      -   Phase 2   EUCTR2019-002785-12-NL   Italy;Netherlands;Spain;United Kingdom;United States
   Cytokinetics, Incorporated
      2022   Phase 3   EUCTR2021-003536-92-PL   China;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Netherlands;Poland;Portugal;Spain;United Kingdom;United States
Radiofrequency ablation
   Shanghai Chest Hospital
      2025   -   NCT06856265   -
Ranexa
   MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A.
      2012   Phase 2   EUCTR2011-004507-20-IT   Germany;Italy;Spain
   Menarini International Operations Luxembourg S.A.
      2012   -   EUCTR2011-004507-20-ES   Germany;Italy;Spain
      2012   -   EUCTR2011-004507-20-DE   Germany;Italy;Spain
Ranolazina ranexa
   OSPEDALE SAN RAFFAELE
      2016   Phase 2   EUCTR2015-004402-42-IT   Italy
Ranolazine
   Duke University
      2012   Phase 4   NCT01721967   United States
   MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A.
      2012   Phase 2   EUCTR2011-004507-20-IT   Germany;Italy;Spain
Ranolazine 1000 MG PR tablets
   Menarini International Operations Luxembourg S.A.
      2012   -   EUCTR2011-004507-20-ES   Germany;Italy;Spain
      2012   -   EUCTR2011-004507-20-DE   Germany;Italy;Spain
Ranolazine 500 MG PR tablets
   Menarini International Operations Luxembourg S.A.
      2012   -   EUCTR2011-004507-20-ES   Germany;Italy;Spain
      2012   -   EUCTR2011-004507-20-DE   Germany;Italy;Spain
Ranolazine 750 MG PR tablets
   Menarini International Operations Luxembourg S.A.
      2012   -   EUCTR2011-004507-20-ES   Germany;Italy;Spain
      2012   -   EUCTR2011-004507-20-DE   Germany;Italy;Spain
Ranolazine PR (prolonged-release) 500 MG 1 tablet BIS IN DIE and 750 MG 1 tablet BIS IN DIE
   IRCCS San Raffaele
      2016   Phase 2   NCT03953989   Italy
Regadenoson
   Duke University
      2017   Phase 4   NCT03249272   United States
RF catheter ablation
   Institute of Cardiology, Warsaw, Poland
      2009   Phase 3   NCT00821353   Poland
Sacubitril valsartan
   Novartis Farmacéutica, S.A.
      2020   Phase 2   EUCTR2019-003098-24-ES   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
   Novartis Pharma AG
      2020   Phase 2   EUCTR2019-003098-24-GR   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2020   Phase 2   EUCTR2019-003098-24-GB   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2020   Phase 2   EUCTR2019-003098-24-FI   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2019   Phase 2   EUCTR2019-003098-24-DE   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
   University Hospital Regensburg
      2019   Phase 2   EUCTR2018-004882-15-DE   Germany
Sacubitril/valsartan
   Newcastle University
      2019   Phase 2   NCT03832660   Germany;Italy;Serbia;United Kingdom
   Newcastle-upon-Tyne Hospitals NHS Trust
      2019   Phase 2/Phase 3   NCT05366101   United Kingdom
   Novartis Farmacéutica, S.A.
      2020   Phase 2   EUCTR2019-003098-24-ES   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
   Novartis Pharma AG
      2020   Phase 2   EUCTR2019-003098-24-GR   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2020   Phase 2   EUCTR2019-003098-24-GB   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2020   Phase 2   EUCTR2019-003098-24-FI   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
      2019   Phase 2   EUCTR2019-003098-24-DE   Finland;Germany;Greece;Korea, Republic of;Spain;United Kingdom;United States
   University Hospital Regensburg
      2019   Phase 2   EUCTR2018-004882-15-DE   Germany
Sodium nitrate
   University of East Anglia
      2017   Phase 1   NCT03251287   United Kingdom
Sotagliflozin
   Lexicon Pharmaceuticals
      2024   Phase 3   NCT06481891   Argentina;Serbia;United Kingdom;United States
   University of Pennsylvania
      2024   Early Phase 1   NCT06433050   United States
Spironolactone
   Tufts Medical Center
      2007   Phase 4   NCT00879060   United States
   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
      2018   Phase 4   NCT02948998   China
Squat-TO-stand maneuver
   Mayo Clinic
      2021   -   NCT04905173   United States
Standard therapy
   Medical University of Warsaw
      2024   Phase 2   NCT06555237   Poland
Surgical septal myectomy
   St. Antonius Hospital
      2021   -   NCT04684290   Netherlands
TN-201
   Tenaya Therapeutics
      2023   Phase 1/Phase 2   NCT05836259   United States
Trametinib tablet
   Medical University of Warsaw
      2024   Phase 2   NCT06555237   Poland
Treatment BX1514M
   University Hospital, Bordeaux
      2015   Phase 2   NCT02590809   France
Trientine
   Manchester University NHS Foundation Trust
      2020   Phase 2   NCT04706429   United Kingdom
      2020   Phase 2   EUCTR2020-002242-17-GB   United Kingdom
Trientine dihydrochloride
   Manchester University NHS Foundation Trust
      2014   Phase 4   EUCTR2014-001577-13-GB   United Kingdom
Triethylinetetramine dihydrochloride
   Manchester University NHS Foundation Trust
      2020   Phase 2   EUCTR2020-002242-17-GB   United Kingdom
Trimetazidine
   University College, London
      2012   Phase 2   NCT01696370   United Kingdom
Trimetazidine dihydrochloride 20MG
   University College London (UCL)
      2011   -   EUCTR2011-000038-12-GB   United Kingdom
Upper member arterial doppler echography with analysis OF FMD
   University Hospital, Bordeaux
      2019   -   NCT04129905   France
USE OF bioanalytical assay TO monitor plasma levels OF perhexiline
   Heart Metabolics Limited
      2016   Phase 2   NCT02862600   United States
Valsalva
   Mayo Clinic
      2021   -   NCT04905173   United States
Valsartan
   Fuwai Hospital, Chinese Academy of Medical Sciences
      2023   Phase 0   ChiCTR2400082062   China
   HealthCore-NERI
      2014   Phase 2   NCT01912534   Canada;United States
   National Heart, Lung, and Blood Institute / National Institutes of Health
      2016   Phase 2   EUCTR2015-002283-16-DK   Denmark
   The First Affiliated Hospital of the Army Medical University
      2023   -   ChiCTR2400088330   China
Vastarel
   VU University Medical Center
      2018   Phase 2   EUCTR2018-000029-29-NL   Netherlands
Vastarel 20MG film coated tablets
   University College London (UCL)
      2011   -   EUCTR2011-000038-12-GB   United Kingdom
Verapamil
   Morten Steen Kvistholm Jensen
      2022   Phase 4   NCT05569382   Denmark
Verapamil hydrochloride
   Aarhus University Hospital
      2022   Phase 2   EUCTR2021-006953-77-DK   Denmark
Verapamil tablet
   Shandong Suncadia Medicine Co., Ltd.
      2024   Phase 1   NCT06354556   China
Walk distance test
   University Hospital, Bordeaux
      2015   Phase 2   NCT02590809   France