Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank 薬物名（臨床試験情報から抽出） KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1 Adenosine 1件: Adenosine1件: Adenosine 💬 4件: ADORA1,
ADORA2A,
ADORA2B,
ADORA3 💬 		13件: Alcoholism, Calcium signaling pathway, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 13, 58, 65 💬
2 Aficamten 1件: Aficamten1件: Aficamten 💬 5件: MYH6_7,
MYH6_7,
MYL2,
MYL3,
MYL4 💬 		17件: Adherens junction, Adrenergic signaling in cardiomyocytes, Apelin signaling pathway, Cardiac muscle contraction, Cytoskeleton in muscle cells, Dilated cardiomyopathy, Focal adhesion, Hypertrophic cardiomyopathy, Leukocyte transendothelial migration, Motor proteins, Regulation of actin cytoskeleton, Salmonella infection, Shigellosis, Thyroid hormone signaling pathway, Tight junction, Viral myocarditis, cGMP-PKG signaling pathway 💬1件: 58 💬
3 Amyl Nitrite 0件: 1件: Amyl nitrite 💬 3件: GUCY1A,
GUCY1A,
GUCY1B 💬 		10件: Circadian entrainment, Gap junction, Long-term depression, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬1件: 58 💬
4 Apple 0件: ---2件: 58, 70 💬
5 Atorvastatin 2件: Atorvastatin; Atorvastatin calcium2件: Atorvastatin calcium ,
Atorvastatin 💬 		1件: HMGCR 💬 3件: AMPK signaling pathway, Bile secretion, Terpenoid backbone biosynthesis 💬20件: 13, 22, 46, 49, 51, 58, 63, 67, 79, 84, 88, 93, 96, 97, 160, 225, 265, 271, 297, 299 💬
6 Bisoprolol 2件: Bisoprolol; Bisoprolol fumarate2件: Bisoprolol fumarate ,
Bisoprolol 💬 		1件: ADRB1 💬 13件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 58, 67, 86, 113 💬
7 Candesartan 1件: Candesartan1件: Candesartan 💬 1件: AGTR1 💬 17件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬2件: 58, 67 💬
8 Cyclosporine 6件: Ciclosporin; Ciclosporina; Ciclosporine; Cyclosporin; Cyclosporin A; Cyclosporine1件: Cyclosporine 💬 5件: PPP3C,
PPP3C,
PPP3C,
PPP3R,
PPP3R 💬 		33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬42件: 11, 19, 20, 26, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 54, 55, 56, 58, 60, 61, 62, 63, 64, 65, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
9 Diltiazem 2件: Diltiazem; Diltiazem hydrochloride3件: Diltiazem hydrochloride ,
Diltiazem malate ,
Diltiazem 💬 		4件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬 		37件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 51, 58, 86, 88 💬
10 Dobutamine 2件: Dobutamin; Dobutamine3件: Dobutamine hydrochloride ,
Dobutamine ,
Dobutamine tartrate 💬 		1件: ADRB1 💬 13件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 57, 58, 86, 215 💬
11 Eleclazine 1件: Eleclazine1件: Eleclazine 💬 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬 		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 58 💬
12 Empagliflozin 1件: Empagliflozin1件: Empagliflozin 💬 --13件: 46, 58, 65, 67, 72, 77, 86, 96, 97, 113, 257, 298, 299 💬
13 Enavogliflozin 0件: 1件: Enavogliflozin 💬 --1件: 58 💬
14 Ethanol 2件: Alcohol; Ethanol3件: Alcohol ,
Isopropanol and methylated alcohol ,
Ethanol 💬 		--7件: 13, 46, 58, 97, 279, 280, 285 💬
15 Gadoteric acid 1件: Gadoteric acid2件: Gadoterate meglumine ,
Gadoteric acid 💬 		--2件: 13, 58 💬
16 Levocarnitine 3件: Carnitine; L-carnitine; Levocarnitine2件: Levocarnitine chloride ,
Levocarnitine 💬 		--11件: 2, 3, 13, 46, 53, 58, 86, 96, 97, 240, 265 💬
17 Losartan 2件: Losartan; Losartan potassium2件: Losartan potassium ,
Losartan 💬 		1件: AGTR1 💬 17件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
18 Mangafodipir 2件: Mangafodipir; Mangafodipir trisodium2件: Mangafodipir trisodium ,
Mangafodipir 💬 		--2件: 13, 58 💬
19 Mavacamten 2件: Mavacamten; MYK-4611件: Mavacamten 💬 1件: MYH6_7 💬 9件: Adrenergic signaling in cardiomyocytes, Cardiac muscle contraction, Cytoskeleton in muscle cells, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Motor proteins, Thyroid hormone signaling pathway, Viral myocarditis, cGMP-PKG signaling pathway 💬1件: 58 💬
20 Medical air 1件: Medical AIR1件: Air, medical 💬 --6件: 58, 85, 86, 97, 193, 299 💬
21 Metoprolol 2件: Metoprolol; Metoprolol succinate4件: Metoprolol tartrate ,
Metoprolol succinate ,
Metoprolol ,
Metoprolol fumarate 💬 		1件: ADRB1 💬 13件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬6件: 17, 57, 58, 113, 193, 226 💬
22 Midodrine 2件: Midodrine; Midodrine hydrochloride2件: Midodrine hydrochloride ,
Midodrine 💬 		3件: ADRA1A,
ADRA1B,
ADRA1D 💬 		9件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬3件: 6, 17, 58 💬
23 Nesiritide 0件: 1件: Nesiritide 💬 1件: NPR1 💬 10件: Aldosterone synthesis and secretion, Hormone signaling, Oxytocin signaling pathway, Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 58 💬
24 Perhexiline 1件: Perhexiline2件: Perhexiline maleate ,
Perhexiline 💬 		8件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S,
CPT1A,
CPT1B,
CPT1C,
CPT2 💬 		47件: AMPK signaling pathway, Adipocytokine signaling pathway, Adrenergic signaling in cardiomyocytes, Alcoholic liver disease, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Dilated cardiomyopathy, Dopaminergic synapse, Efferocytosis, Fatty acid degradation, GABAergic synapse, Glucagon signaling pathway, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin resistance, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, PPAR signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Thermogenesis, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 58, 272 💬
25 Perindopril 2件: Perindopril; Perindopril arginine3件: Perindopril erbumine ,
Perindopril ,
Perindopril arginine 💬 		1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬4件: 58, 113, 167, 222 💬
26 Phosphorus 1件: Phosphorus---2件: 58, 238 💬
27 Pirfenidone 1件: Pirfenidone1件: Pirfenidone 💬 6件: CCL2,
IL10,
IL1A,
IL1B,
IL6,
TNF 💬 		83件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, Autoimmune thyroid disease, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemokine signaling pathway, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Dilated cardiomyopathy, Efferocytosis, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Graft-versus-host disease, HIF-1 signaling pathway, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Inflammatory mediator regulation of TRP channels, Influenza A, Insulin resistance, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Measles, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Staphylococcus aureus infection, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
28 Pyrazole 2件: 1H-pyrazol; Pyrazole---3件: 2, 58, 75 💬
29 Ranolazine 1件: Ranolazine2件: Ranolazine ,
Ranolazine hydrochloride 💬 		--7件: 2, 58, 86, 96, 97, 113, 114 💬
30 Regadenoson 1件: Regadenoson2件: Regadenoson ,
Regadenoson 💬 		1件: ADORA2A 💬 8件: Alcoholism, Calcium signaling pathway, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway 💬1件: 58 💬
31 Sacubitril 1件: Sacubitril1件: Sacubitril 💬 1件: MME 💬 4件: Alzheimer disease, Hematopoietic cell lineage, Protein digestion and absorption, Renin-angiotensin system 💬3件: 58, 210, 222 💬
32 Sodium nitrate 1件: Sodium nitrate---2件: 58, 113 💬
33 Sotagliflozin 1件: Sotagliflozin1件: Sotagliflozin 💬 1件: SLC5A1 💬 3件: Bile secretion, Carbohydrate digestion and absorption, Mineral absorption 💬2件: 58, 84 💬
34 Spironolactone 1件: Spironolactone1件: Spironolactone 💬 1件: NR3C2 💬 1件: Aldosterone-regulated sodium reabsorption 💬8件: 46, 58, 67, 86, 113, 210, 218, 225 💬
35 TN-201 1件: TN-201---1件: 58 💬
36 Trametinib 1件: Trametinib2件: Trametinib ,
Trametinib dimethyl sulfoxide 💬 		2件: MAP2K1,
MAP2K2 💬 		88件: Acute myeloid leukemia, Alcoholism, Alzheimer disease, Apelin signaling pathway, Apoptosis, Autophagy - animal, B cell receptor signaling pathway, Bladder cancer, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Choline metabolism in cancer, Cholinergic synapse, Chronic myeloid leukemia, Colorectal cancer, Cushing syndrome, Efferocytosis, Endometrial cancer, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Influenza A, Insulin signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-small cell lung cancer, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Renal cell carcinoma, Salmonella infection, Serotonergic synapse, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid cancer, Thyroid hormone signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway, Vascular smooth muscle contraction, Yersinia infection, cAMP signaling pathway, cGMP-PKG signaling pathway, mTOR signaling pathway 💬6件: 2, 34, 58, 195, 279, 280 💬
37 Triethylenetetramine 2件: Trientine; Trientine tetrahydrochloride2件: Trientine hydrochloride ,
Trientine tetrahydrochloride 💬 		--2件: 58, 171 💬
38 Trimetazidine 2件: Trimetazidine; Trimetazidine dihydrochloride2件: Trimetazidine hydrochloride ,
Trimetazidine 💬 		--3件: 2, 58, 86 💬
39 Valsartan 1件: Valsartan1件: Valsartan 💬 1件: AGTR1 💬 17件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬8件: 57, 58, 66, 75, 86, 210, 222, 224 💬
40 Verapamil 2件: Verapamil; Verapamil hydrochloride2件: Verapamil hydrochloride ,
Verapamil 💬 		4件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬 		37件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 58, 96, 140, 167 💬