7. 大脳皮質基底核変性症 Disease details / Clinical trials / Drug dev / DR info
臨床試験数 : 25 / 薬物数 : 39 - (DrugBank : 15) / 標的遺伝子数 : 9 - 標的パスウェイ数 : 41
薬物、開発者(Primary Sponsor)、臨床試験情報(症例登録開始年(Enrollment year)、フェーズ、ID、実施国)
11C-PIB
Nagoya City Rehabilitation Agency
2019 - JPRN-UMIN000036956 Japan
2019 - JPRN-UMIN000036908 Japan
11C-raclopride
Nagoya City Rehabilitation Agency
2019 - JPRN-UMIN000036952 Japan
13c6 leucine
Washington University School of Medicine
2017 - NCT03545126 United States
18F-AV-1451
Skåne University Hospital, Region Skåne
2014 Phase 2 EUCTR2014-000422-38-SE Sweden
18F-FDG
Nagoya City Rehabilitation Agency
2019 - JPRN-UMIN000036908 Japan
18F-RO6958948
Skåne University Hospital
2017 Phase 2 EUCTR2017-000094-36-SE Sweden
ABBV-8e12
AbbVie
2018 - NCT03744546 -
AL-108
University of California, San Francisco
2010 Phase 1 NCT01056965 United States
ANTI-parkinson medication
Beth Israel Deaconess Medical Center
2016 - NCT02994719 United States
Apomorphine
Fondation Ophtalmologique Adolphe de Rothschild
2018 - NCT04786158 France
BIIB092
University of California, San Francisco
2018 Phase 1 NCT03658135 United States
Botulinum toxin type A
Merz Pharmaceuticals GmbH
2014 Phase 3 EUCTR2012-005539-10-DE Germany;Poland;United States
Brain PET scan
Avid Radiopharmaceuticals
2014 Phase 1 NCT02167594 United States
Davunetide
University of California, San Francisco
2010 Phase 1 NCT01056965 United States
Deep brain stimulation
Beth Israel Deaconess Medical Center
2016 - NCT02994719 United States
Dopamine
Juntendo University school of Medicine Department of Diagnosis, Prevention and Treatment of Dementia
2014 - JPRN-UMIN000014098 Japan
Elecsys (roche) abeta42, ttau and ptau
Skane University Hospital
2017 - NCT03174938 Sweden
F-18
Skåne University Hospital
2017 Phase 2 EUCTR2017-000094-36-SE Sweden
Fasudil
Woolsey Pharmaceuticals
2021 Phase 2 NCT04734379 United States
FDG-PET
Itoh Yoshiaki
2019 - JPRN-jRCTs051180214 -
Flortaucipir F18
Avid Radiopharmaceuticals
2014 Phase 1 NCT02167594 United States
Flutemetamol
Itoh Yoshiaki
2019 - JPRN-jRCTs051180214 -
Skåne University Hospital
2017 Phase 2 EUCTR2017-000094-36-SE Sweden
Flutemetamol F18 injection
Skane University Hospital
2017 - NCT03174938 Sweden
Glycerol phenylbutyrate
Klinikum rechts der Isar der Technischen Universität München
2023 Phase 2 EUCTR2022-002988-30-DE Germany
Injection
Kagawa University
2021 - JPRN-UMIN000043737 Japan
Merz Pharmaceuticals GmbH
2014 Phase 3 EUCTR2012-005539-10-DE Germany;Poland;United States
Skåne University Hospital
2017 Phase 2 EUCTR2017-000094-36-SE Sweden
Skåne University Hospital, Region Skåne
2014 Phase 2 EUCTR2014-000422-38-SE Sweden
Lithium
Westat
2008 Phase 1/Phase 2 NCT00703677 United Kingdom;United States
Lumipulse (fujirebio) abeta42, ttau and ptau
Skane University Hospital
2017 - NCT03174938 Sweden
Nicotinamide riboside
Haukeland University Hospital
2024 Phase 2 NCT06162013 Norway
NT 101
Merz Pharmaceuticals GmbH
2014 Phase 3 EUCTR2012-005539-10-DE Germany;Poland;United States
PET/CT
Kagawa University
2021 - JPRN-UMIN000043737 Japan
Ravicti
Klinikum rechts der Isar der Technischen Universität München
2023 Phase 2 EUCTR2022-002988-30-DE Germany
Ravicti 1.1 G/ML
Technical University of Munich
2023 Phase 2 NCT05983588 Germany
THK-5351
Kagawa University
2021 - JPRN-UMIN000043737 Japan
Nagoya University Department of Neurology
2015 - JPRN-UMIN000018496 Japan
THK5351
Nagoya City Rehabilitation Agency
2019 - JPRN-UMIN000036956 Japan
Tohoku University
2017 - JPRN-UMIN000021819 Japan
TPI 287 2 MG/M2
University of California, San Francisco
2014 Phase 1 NCT02133846 United States
TPI-287 20 MG/M2
University of California, San Francisco
2014 Phase 1 NCT02133846 United States
TPI-287 6.3 MG/M2
University of California, San Francisco
2014 Phase 1 NCT02133846 United States
Vizamyl
Skåne University Hospital
2017 Phase 2 EUCTR2017-000094-36-SE Sweden
Xeomin
Merz Pharmaceuticals GmbH
2014 Phase 3 EUCTR2012-005539-10-DE Germany;Poland;United States
Nagoya City Rehabilitation Agency
2019 - JPRN-UMIN000036956 Japan
2019 - JPRN-UMIN000036908 Japan
11C-raclopride
Nagoya City Rehabilitation Agency
2019 - JPRN-UMIN000036952 Japan
13c6 leucine
Washington University School of Medicine
2017 - NCT03545126 United States
18F-AV-1451
Skåne University Hospital, Region Skåne
2014 Phase 2 EUCTR2014-000422-38-SE Sweden
18F-FDG
Nagoya City Rehabilitation Agency
2019 - JPRN-UMIN000036908 Japan
18F-RO6958948
Skåne University Hospital
2017 Phase 2 EUCTR2017-000094-36-SE Sweden
ABBV-8e12
AbbVie
2018 - NCT03744546 -
AL-108
University of California, San Francisco
2010 Phase 1 NCT01056965 United States
ANTI-parkinson medication
Beth Israel Deaconess Medical Center
2016 - NCT02994719 United States
Apomorphine
Fondation Ophtalmologique Adolphe de Rothschild
2018 - NCT04786158 France
BIIB092
University of California, San Francisco
2018 Phase 1 NCT03658135 United States
Botulinum toxin type A
Merz Pharmaceuticals GmbH
2014 Phase 3 EUCTR2012-005539-10-DE Germany;Poland;United States
Brain PET scan
Avid Radiopharmaceuticals
2014 Phase 1 NCT02167594 United States
Davunetide
University of California, San Francisco
2010 Phase 1 NCT01056965 United States
Deep brain stimulation
Beth Israel Deaconess Medical Center
2016 - NCT02994719 United States
Dopamine
Juntendo University school of Medicine Department of Diagnosis, Prevention and Treatment of Dementia
2014 - JPRN-UMIN000014098 Japan
Elecsys (roche) abeta42, ttau and ptau
Skane University Hospital
2017 - NCT03174938 Sweden
F-18
Skåne University Hospital
2017 Phase 2 EUCTR2017-000094-36-SE Sweden
Fasudil
Woolsey Pharmaceuticals
2021 Phase 2 NCT04734379 United States
FDG-PET
Itoh Yoshiaki
2019 - JPRN-jRCTs051180214 -
Flortaucipir F18
Avid Radiopharmaceuticals
2014 Phase 1 NCT02167594 United States
Flutemetamol
Itoh Yoshiaki
2019 - JPRN-jRCTs051180214 -
Skåne University Hospital
2017 Phase 2 EUCTR2017-000094-36-SE Sweden
Flutemetamol F18 injection
Skane University Hospital
2017 - NCT03174938 Sweden
Glycerol phenylbutyrate
Klinikum rechts der Isar der Technischen Universität München
2023 Phase 2 EUCTR2022-002988-30-DE Germany
Injection
Kagawa University
2021 - JPRN-UMIN000043737 Japan
Merz Pharmaceuticals GmbH
2014 Phase 3 EUCTR2012-005539-10-DE Germany;Poland;United States
Skåne University Hospital
2017 Phase 2 EUCTR2017-000094-36-SE Sweden
Skåne University Hospital, Region Skåne
2014 Phase 2 EUCTR2014-000422-38-SE Sweden
Lithium
Westat
2008 Phase 1/Phase 2 NCT00703677 United Kingdom;United States
Lumipulse (fujirebio) abeta42, ttau and ptau
Skane University Hospital
2017 - NCT03174938 Sweden
Nicotinamide riboside
Haukeland University Hospital
2024 Phase 2 NCT06162013 Norway
NT 101
Merz Pharmaceuticals GmbH
2014 Phase 3 EUCTR2012-005539-10-DE Germany;Poland;United States
PET/CT
Kagawa University
2021 - JPRN-UMIN000043737 Japan
Ravicti
Klinikum rechts der Isar der Technischen Universität München
2023 Phase 2 EUCTR2022-002988-30-DE Germany
Ravicti 1.1 G/ML
Technical University of Munich
2023 Phase 2 NCT05983588 Germany
THK-5351
Kagawa University
2021 - JPRN-UMIN000043737 Japan
Nagoya University Department of Neurology
2015 - JPRN-UMIN000018496 Japan
THK5351
Nagoya City Rehabilitation Agency
2019 - JPRN-UMIN000036956 Japan
Tohoku University
2017 - JPRN-UMIN000021819 Japan
TPI 287 2 MG/M2
University of California, San Francisco
2014 Phase 1 NCT02133846 United States
TPI-287 20 MG/M2
University of California, San Francisco
2014 Phase 1 NCT02133846 United States
TPI-287 6.3 MG/M2
University of California, San Francisco
2014 Phase 1 NCT02133846 United States
Vizamyl
Skåne University Hospital
2017 Phase 2 EUCTR2017-000094-36-SE Sweden
Xeomin
Merz Pharmaceuticals GmbH
2014 Phase 3 EUCTR2012-005539-10-DE Germany;Poland;United States