79. 家族性高コレステロール血症（ホモ接合体） Disease details / Clinical trials / Drug dev / DR info

AAV directed hldlr gene therapy
   Regenxbio Inc.
      2016   Phase 1/Phase 2   NCT02651675   Canada;Italy;Netherlands;United States
AAV8.TBG.hldlr
   REGENXBIO Inc.
      2020   Phase 2   EUCTR2019-004496-39-NL   Canada;Italy;Netherlands;United States
      2017   Phase 1;Phase 2   EUCTR2016-001446-25-IT   Canada;Italy;Netherlands;United States
   University of Pennsylvania
      2017   Phase 1;Phase 2   EUCTR2016-001446-25-NL   Canada;Italy;Netherlands;United States
AEGR-733
   AEGERION PHARMACEUTICALS
      2011   -   EUCTR2010-023742-79-IT   Italy
   Aegerion Pharmaceuticals
      2009   -   EUCTR2008-007058-36-IT   Italy
   Aegerion Pharmaceuticals Inc.
      2016   Phase 3   EUCTR2014-003806-33-GR   Austria;Canada;Germany;Greece;Israel;Italy;Turkey
   Aegerion Pharmaceuticals, Inc.
      2007   Phase 3   NCT00730236   Canada;Italy;South Africa;United States
AK102
   Akeso
      2019   Phase 2   NCT03933293   China
Akcea-angptl3-LRX
   Akcea Therapeutics
      2018   Phase 2   NCT03455777   Canada
Alirocumab
   REGENERON PHARMACEUTICALS, INC.
      2019   Phase 3   EUCTR2017-003170-13-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United Kingdom;United States
      2018   Phase 3   EUCTR2017-001388-19-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
      2017   Phase 3   EUCTR2017-000351-95-IT   Austria;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States
   Regeneron Pharmaceuticals
      2017   Phase 3   NCT03156621   Austria;Canada;Czechia;France;Germany;Greece;Italy;Japan;South Africa;Taiwan;Turkey;Ukraine;United States
   Regeneron Pharmaceuticals Inc.
      2018   Phase 3   EUCTR2017-001388-19-GR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Turkey;Ukraine;United States
      2018   Phase 3   EUCTR2017-001388-19-DE   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
      2018   Phase 3   EUCTR2017-001388-19-AT   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
      -   Phase 3   EUCTR2017-001388-19-FR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
      -   Phase 3   EUCTR2017-001388-19-CZ   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
   Regeneron Pharmaceuticals, Inc.
      2019   Phase 3   EUCTR2017-003170-13-GR   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States
      2019   Phase 3   EUCTR2017-003170-13-AT   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States
      2018   Phase 3   EUCTR2017-003170-13-CZ   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States
      2017   Phase 3   EUCTR2017-000351-95-GR   Austria;Canada;Czech Republic;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States
      2017   Phase 3   EUCTR2017-000351-95-FR   Austria;Belgium;Bulgaria;Canada;Croatia;Czech Republic;Denmark;France;Germany;Greece;Israel;Italy;Netherlands;Poland;Portugal;Serbia;Slovenia;South Africa;Spain;Sweden;Tunisia;Turkey;Ukraine;United Kingdom;United States
      2017   Phase 3   EUCTR2017-000351-95-DE   Austria;Canada;Czech Republic;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States
      2017   Phase 3   EUCTR2017-000351-95-AT   Austria;Canada;Czech Republic;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States
      -   Phase 3   EUCTR2017-003170-13-FR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States
      -   Phase 3   EUCTR2017-000351-95-CZ   Austria;Belgium;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Israel;Italy;Netherlands;Poland;Portugal;Serbia;Slovenia;South Africa;Spain;Sweden;Tunisia;Turkey;Ukraine;United Kingdom;United States
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
   Sanofi-Aventis Recherche & Développement
      2018   Phase 3   EUCTR2017-002297-39-SI   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-NO   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-NL   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-IT   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-FR   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-ES   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-DK   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-BG   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-AT   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
ALN-60212
   The Medicines Company
      2017   Phase 2   EUCTR2016-003376-49-NL   Netherlands;South Africa;United States
ALN-pcssc
   The Medicines Company
      2017   Phase 2   EUCTR2016-003376-49-NL   Netherlands;South Africa;United States
      2016   Phase 2   NCT02963311   Netherlands;South Africa;United States
AMG 145
   AMGEN INC.
      2016   Phase 3   EUCTR2015-002276-25-IT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
   Amgen Europe B.V.
      2019   Phase 3   EUCTR2015-002276-25-SI   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States
   Amgen Inc
      2019   Phase 3   EUCTR2015-002276-25-PT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      2019   Phase 3   EUCTR2015-002276-25-PL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States
      2017   Phase 3   EUCTR2015-002276-25-NL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      2017   Phase 3   EUCTR2015-002276-25-ES   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Romania;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-HU   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-GR   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-DE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-CZ   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-BE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-AT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-NL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States
      2013   Phase 2   EUCTR2011-005400-15-IT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Malaysia;Netherlands;New Zealand;Norway;Poland;South Africa;Spain;Turkey;United Kingdom;United States
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-GB   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States
      2013   Phase 2   EUCTR2011-005400-15-ES   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Malaysia;Netherlands;New Zealand;Norway;Poland;South Africa;Spain;Turkey;United Kingdom;United States
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States
      2013   -   EUCTR2011-005400-15-AT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Malaysia;New Zealand;Norway;Poland;South Africa;Spain;Turkey;United Kingdom;United States
      2013   -   EUCTR2011-005399-40-NL   Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States
      2013   -   EUCTR2011-005399-40-IT   Austria;Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States
      2013   -   EUCTR2011-005399-40-ES   Austria;Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Malaysia;New Zealand;South Africa;Spain;Turkey;United States
      2013   Phase 2;Phase 3   EUCTR2011-005399-40-CZ   Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States
      2012   Phase 2   EUCTR2011-005400-15-GR   Belgium;Canada;Czech Republic;Greece;Italy;Netherlands;South Africa;Spain;United Kingdom;United States
      2012   Phase 2;Phase 3   EUCTR2011-005400-15-BE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States
      2012   Phase 2;Phase 3   EUCTR2011-005399-40-BE   Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States
      -   Phase 3   EUCTR2015-002276-25-NO   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      -   Phase 3   EUCTR2015-002276-25-GB   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Turkey;United Kingdom
      -   -   EUCTR2011-005399-40-Outside-EU/EEA   Brazil;Canada;Hong Kong;Lebanon;Malaysia;New Zealand;South Africa;Turkey;United States
AMG145
   AMGEN INC.
      2016   Phase 3   EUCTR2015-002276-25-IT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
   Amgen Inc
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-NL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-GB   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States
      2012   Phase 2;Phase 3   EUCTR2011-005400-15-BE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States
Anacetrapib
   Merck Sharp & Dohme Corp.
      2013   Phase 3   NCT01841684   Canada;Germany;Israel;Italy;Norway;United Kingdom;United States
   Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc
      2013   Phase 3   EUCTR2012-002434-37-IT   Brazil;Canada;Czech Republic;Israel;Italy;Malaysia;Norway;South Africa;United Kingdom;United States
ARO-ANG 3 injection
   Arrowhead Pharmaceuticals
      2022   Phase 2   NCT05217667   Australia;Canada;South Africa;United States
Atorvastatin
   Organon and Co
      2000   Phase 3   NCT03885921   -
      2000   Phase 3   NCT03884452   -
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
AZD4522
   AstraZeneca AB
      2010   -   EUCTR2009-016492-29-NL   Belgium;Canada;Netherlands;Norway;United States
      2010   Phase 3   EUCTR2009-016492-29-BE   Belgium;Netherlands
      2010   -   EUCTR2009-016492-29-AT   Austria;Belgium;Netherlands
      -   -   EUCTR2009-016492-29-Outside-EU/EEA   Belgium;Canada;Netherlands;Norway;United States
BMS356384
   Karo Bio AB
      2011   -   EUCTR2011-001483-21-SE   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
      2011   -   EUCTR2011-001483-21-GB   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
      2011   -   EUCTR2011-001483-21-ES   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
      2011   Phase 3   EUCTR2011-001483-21-DK   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
      2011   -   EUCTR2011-001483-21-CZ   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
      2011   -   EUCTR2011-001483-21-AT   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
CER-001
   CERENIS THERAPEUTICS SA
      2012   -   EUCTR2011-003998-28-IT   Canada;Italy;Netherlands;United Kingdom;United States
   Cerenis Therapeutics
      2012   -   EUCTR2011-003998-28-NL   Canada;France;Italy;Netherlands;United Kingdom;United States
      2012   Phase 2   EUCTR2011-003998-28-GB   Canada;Italy;Netherlands;United Kingdom;United States
   Cerenis Therapeutics, SA
      2011   Phase 2   NCT01412034   Canada;Italy;Netherlands;United Kingdom;United States
Cholestagel
   Genzyme Europe BV
      2007   -   EUCTR2007-000582-37-SE   France;Germany;Sweden;United Kingdom
      2007   Phase 4   EUCTR2007-000582-37-GB   France;Germany;Sweden;United Kingdom
      2007   Phase 4   EUCTR2007-000582-37-FR   France;Germany;Sweden;United Kingdom
      2007   -   EUCTR2007-000582-37-DE   France;Germany;Sweden;United Kingdom
Cholestyramine
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
Colesevelam hydrochloride
   Genzyme Europe BV
      2007   -   EUCTR2007-000582-37-SE   France;Germany;Sweden;United Kingdom
      2007   Phase 4   EUCTR2007-000582-37-GB   France;Germany;Sweden;United Kingdom
      2007   Phase 4   EUCTR2007-000582-37-FR   France;Germany;Sweden;United Kingdom
      2007   -   EUCTR2007-000582-37-DE   France;Germany;Sweden;United Kingdom
Colesevelam hydrochloride FILM-coated tablets
   Genzyme, a Sanofi Company
      2007   Phase 4   NCT00655265   France;Germany;Netherlands;Sweden;United Kingdom
Crestor
   AstraZeneca AB
      2010   -   EUCTR2009-016492-29-NL   Belgium;Canada;Netherlands;Norway;United States
      2010   Phase 3   EUCTR2009-016492-29-BE   Belgium;Netherlands
      2010   -   EUCTR2009-016492-29-AT   Austria;Belgium;Netherlands
      -   -   EUCTR2009-016492-29-Outside-EU/EEA   Belgium;Canada;Netherlands;Norway;United States
Crestor FILM-coated tablet
   AstraZeneca AB
      2015   Phase 3   EUCTR2014-004746-99-DK   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States
      2015   Phase 3   EUCTR2014-004746-99-BE   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States
      -   Phase 3   EUCTR2014-004746-99-SE   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States
Crestor tablets (calcium rosuvastatin) FILM-coated tablets
   AstraZeneca AB
      2014   -   EUCTR2014-000972-24-SE   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States
      2014   -   EUCTR2014-000972-24-NL   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States
      2014   -   EUCTR2014-000972-24-DK   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States
      2014   -   EUCTR2014-000972-24-DE   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States
      2014   Phase 3   EUCTR2014-000972-24-BE   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States
Dextran sulfate adsorption
   Laval University
      2013   -   NCT02286596   Canada
Dppg
   Cerenis Therapeutics
      2012   Phase 2   EUCTR2011-003998-28-GB   Canada;Italy;Netherlands;United Kingdom;United States
Eprotirome
   Karo Bio AB
      2011   Phase 3   NCT01410383   Sweden
      2011   -   EUCTR2011-001483-21-SE   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
      2011   -   EUCTR2011-001483-21-GB   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
      2011   -   EUCTR2011-001483-21-ES   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
      2011   Phase 3   EUCTR2011-001483-21-DK   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
      2011   -   EUCTR2011-001483-21-CZ   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
      2011   -   EUCTR2011-001483-21-AT   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
Evinacumab
   Daniel Gaudet
      2023   Phase 3   NCT05611528   Canada
   Makino Hisashi
      2023   Phase 3   JPRN-jRCT2051220184   -
   REGENERON PHARMACEUTICALS, INC.
      2019   Phase 3   EUCTR2017-003170-13-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United Kingdom;United States
      2018   Phase 3   EUCTR2017-001388-19-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
   Regeneron Pharmaceuticals
      2024   -   NCT06500598   -
      2020   Phase 3   NCT04233918   Australia;Austria;Netherlands;Taiwan;Ukraine;United States
      2018   Phase 3   NCT03409744   Australia;Austria;Canada;Czechia;France;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United States
      2018   Phase 3   NCT03399786   Australia;Austria;Canada;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Turkey;Ukraine;United States
   Regeneron Pharmaceuticals Inc.
      2018   Phase 3   EUCTR2017-001388-19-GR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Turkey;Ukraine;United States
      2018   Phase 3   EUCTR2017-001388-19-DE   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
      2018   Phase 3   EUCTR2017-001388-19-AT   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
      -   Phase 3   EUCTR2017-001388-19-FR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
      -   Phase 3   EUCTR2017-001388-19-CZ   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
   Regeneron Pharmaceuticals, Inc.
      2020   Phase 1;Phase 3   EUCTR2019-001931-30-NL   Australia;Austria;Netherlands;Taiwan;United States
      2020   Phase 1;Phase 3   EUCTR2019-001931-30-AT   Australia;Austria;Netherlands;Taiwan;United States
      2019   Phase 3   JPRN-jRCT2080224823   Africa;Europe;Japan;North America;Oceania
      2019   Phase 3   EUCTR2017-003170-13-NO   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States
      2019   Phase 3   EUCTR2017-003170-13-GR   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States
      2019   Phase 3   EUCTR2017-003170-13-GB   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States
      2019   Phase 3   EUCTR2017-003170-13-AT   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States
      2018   Phase 3   EUCTR2017-003170-13-NL   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States
      2018   Phase 3   EUCTR2017-003170-13-CZ   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States
      2016   Phase 2   EUCTR2016-000411-32-NL   Canada;Netherlands;United States
      -   Phase 3   EUCTR2017-003170-13-FR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States
   Regeneron Pharmaceuticals, Inc.(ICCC: PAREXEL International)
      2018   -   JPRN-jRCT2080224038   Africa;Europe;Japan;North America;Oceania
Evolocumab
   AMGEN INC.
      2016   Phase 3   EUCTR2015-002276-25-IT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
   Amgen
      2018   Phase 4   NCT03403374   India
      2016   Phase 3   NCT02624869   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czechia;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;United States
      2012   Phase 2/Phase 3   NCT01588496   Belgium;Canada;Czech Republic;Czechia;France;Hong Kong;Italy;Lebanon;Netherlands;New Zealand;South Africa;Spain;United States
   Amgen Europe B.V.
      2019   Phase 3   EUCTR2015-002276-25-SI   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States
   Amgen Inc
      2019   Phase 3   EUCTR2015-002276-25-PT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      2019   Phase 3   EUCTR2015-002276-25-PL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States
      2017   Phase 3   EUCTR2015-002276-25-NL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      2017   Phase 3   EUCTR2015-002276-25-ES   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Romania;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-HU   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-GR   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-DE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-CZ   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-BE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-AT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States
      -   Phase 3   EUCTR2015-002276-25-NO   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      -   Phase 3   EUCTR2015-002276-25-GB   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Turkey;United Kingdom
      -   -   EUCTR2011-005399-40-Outside-EU/EEA   Brazil;Canada;Hong Kong;Lebanon;Malaysia;New Zealand;South Africa;Turkey;United States
   Kanazawa University Hospital
      2016   -   JPRN-UMIN000022603   Japan
   LIB Therapeutics LLC
      2019   Phase 3   NCT04034485   India;Israel;Norway;South Africa;Turkey;United States
   LIB Therapeutics, LLC
      2020   Phase 3   EUCTR2019-003611-62-NO   Israel;Norway;South Africa;Turkey;United States
Ezetimibe
   Akeso
      2019   Phase 2   NCT03933293   China
   Organon and Co
      2006   -   NCT00704535   Philippines
      2002   Phase 3   NCT00092833   United States
      2000   Phase 3   NCT03885921   -
      2000   Phase 3   NCT03884452   -
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
Fenofibrate
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
Fish OIL capsule
   The University of Western Australia
      2012   -   NCT01577056   Australia
Fluvastatin
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
Gemcabene
   NeuroBo Pharmaceuticals Inc.
      2016   Phase 2   NCT02722408   Canada;Israel;United States
Gene analysis
   Central South University
      2001   -   NCT01878604   China
Glycerol
   CERENIS THERAPEUTICS SA
      2012   -   EUCTR2011-003998-28-IT   Canada;Italy;Netherlands;United Kingdom;United States
   Cerenis Therapeutics
      2012   -   EUCTR2011-003998-28-NL   Canada;France;Italy;Netherlands;United Kingdom;United States
      2012   Phase 2   EUCTR2011-003998-28-GB   Canada;Italy;Netherlands;United Kingdom;United States
Heparin-induced extracorporeal LDL precipitation
   Laval University
      2013   -   NCT02286596   Canada
Historical data OF lipid-lowering drug administration
   Central South University
      2001   -   NCT01878604   China
Historical data OF plasma lipids, xanthoma changes
   Central South University
      2001   -   NCT01878604   China
HMG coenzyme reductase
   The University of Western Australia
      2012   -   NCT01577056   Australia
IBI306
   Innovent Biologics (Suzhou) Co. Ltd.
      2019   Phase 2/Phase 3   NCT04031742   China
   Shenzhen People's Hospital
      2019   Phase 2/Phase 3   NCT04948008   China
Implitapide
   Medical Research Laboratories International
      2003   Phase 2   NCT00079846   Canada;Israel;Netherlands;Norway;United States
Inclisiran
   Novartis Pharmaceuticals
      2025   Phase 3   NCT06597006   China;Malaysia;Taiwan;United States
      2024   -   NCT06275724   Japan
      2023   Phase 3   NCT05682378   Argentina;Brazil;Canada;Czechia;France;Germany;Greece;Hungary;Israel;Italy;Jordan;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovakia;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2021   Phase 3   NCT04659863   Canada;France;Greece;Lebanon;Malaysia;Netherlands;Slovenia;Switzerland;Turkey;United States;Vietnam
Inclisiran sodium
   NOVARTIS PHARMA AG
      2023   Phase 3   EUCTR2022-002316-23-IT   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;United Kingdom;United States
   Novartis Pharma AG
      2023   Phase 3   EUCTR2022-002316-23-SI   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2023   Phase 3   EUCTR2022-002316-23-PL   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2023   Phase 3   EUCTR2022-002316-23-NL   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2023   Phase 3   EUCTR2022-002316-23-DE   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2022   Phase 3   EUCTR2022-002316-23-NO   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2022   Phase 3   EUCTR2022-002316-23-HU   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2021   Phase 3   EUCTR2020-002755-38-NL   Canada;France;Greece;Lebanon;Malaysia;Netherlands;Slovenia;Turkey;United States
      2021   Phase 3   EUCTR2020-002755-38-GR   Canada;France;Greece;Lebanon;Malaysia;Netherlands;Slovenia;Turkey;United States
      2021   Phase 3   EUCTR2020-002755-38-FR   Canada;France;Greece;Lebanon;Netherlands;Serbia;Slovenia;Switzerland;Türkiye;United States
      2020   Phase 3   EUCTR2020-002755-38-SI   Canada;France;Germany;Greece;Italy;Lebanon;Netherlands;Serbia;Slovenia;South Africa;Switzerland;Türkiye;United States;Viet Nam
      -   Phase 3   EUCTR2022-002316-23-GR   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      -   Phase 3   EUCTR2022-002316-23-FR   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
   Novartis Pharmaceuticals
      2019   Phase 3   NCT03814187   Canada;Czechia;Denmark;Germany;Hungary;Netherlands;Poland;South Africa;Spain;Sweden;Ukraine;United Kingdom;United States
Inclisiran sodium FOR injection
   Novartis Pharmaceuticals
      2019   Phase 3   NCT03851705   Czechia;Hong Kong;Israel;Russian Federation;Serbia;South Africa;Taiwan;Turkey;Ukraine
Isis 301012
   Kastle Therapeutics, LLC
      2006   Phase 2   NCT00280995   Netherlands;United States
Isis 301012 phosphorothioate oligonucleotide
   Genzyme Europe B.V.
      2007   Phase 3   EUCTR2005-003449-15-GB   United Kingdom
Isis 703802
   Ionis Pharmaceuticals, Inc.
      2016   Phase 1;Phase 2   EUCTR2015-004003-23-IT   Canada;Italy;Netherlands
JS002
   Shanghai Junshi Bioscience Co., Ltd.
      2020   Phase 2   NCT04515927   China
KB2115
   Karo Bio AB
      2011   -   EUCTR2011-001483-21-SE   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
      2011   -   EUCTR2011-001483-21-GB   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
      2011   -   EUCTR2011-001483-21-ES   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
      2011   Phase 3   EUCTR2011-001483-21-DK   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
      2011   -   EUCTR2011-001483-21-CZ   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
      2011   -   EUCTR2011-001483-21-AT   Austria;Czech Republic;Denmark;India;Israel;Netherlands;Norway;Russian Federation;South Africa;Spain;Sweden;United Kingdom
KJX839
   NOVARTIS PHARMA AG
      2023   Phase 3   EUCTR2022-002316-23-IT   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;United Kingdom;United States
   Novartis Pharma AG
      2023   Phase 3   EUCTR2022-002316-23-SI   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2023   Phase 3   EUCTR2022-002316-23-PL   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2023   Phase 3   EUCTR2022-002316-23-NL   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2023   Phase 3   EUCTR2022-002316-23-DE   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2022   Phase 3   EUCTR2022-002316-23-NO   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2022   Phase 3   EUCTR2022-002316-23-HU   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2021   Phase 3   EUCTR2020-002755-38-NL   Canada;France;Greece;Lebanon;Malaysia;Netherlands;Slovenia;Turkey;United States
      2021   Phase 3   EUCTR2020-002755-38-GR   Canada;France;Greece;Lebanon;Malaysia;Netherlands;Slovenia;Turkey;United States
      2021   Phase 3   EUCTR2020-002755-38-FR   Canada;France;Greece;Lebanon;Netherlands;Serbia;Slovenia;Switzerland;Türkiye;United States
      2020   Phase 3   EUCTR2020-002755-38-SI   Canada;France;Germany;Greece;Italy;Lebanon;Netherlands;Serbia;Slovenia;South Africa;Switzerland;Türkiye;United States;Viet Nam
      -   Phase 3   EUCTR2022-002316-23-GR   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      -   Phase 3   EUCTR2022-002316-23-FR   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
Lapaquistat acetate and current lipid-lowering treatment
   Takeda
      2005   Phase 3   NCT00263081   Canada;France;Israel;Poland;United Kingdom;United States
Leqvio 284 MG solution FOR injection IN PRE-filled syringe
   NOVARTIS PHARMA AG
      2023   Phase 3   EUCTR2022-002316-23-IT   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;United Kingdom;United States
   Novartis Pharma AG
      2023   Phase 3   EUCTR2022-002316-23-SI   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2023   Phase 3   EUCTR2022-002316-23-PL   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2023   Phase 3   EUCTR2022-002316-23-NL   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2023   Phase 3   EUCTR2022-002316-23-DE   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2022   Phase 3   EUCTR2022-002316-23-NO   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2022   Phase 3   EUCTR2022-002316-23-HU   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      2021   Phase 3   EUCTR2020-002755-38-NL   Canada;France;Greece;Lebanon;Malaysia;Netherlands;Slovenia;Turkey;United States
      2021   Phase 3   EUCTR2020-002755-38-GR   Canada;France;Greece;Lebanon;Malaysia;Netherlands;Slovenia;Turkey;United States
      2020   Phase 3   EUCTR2020-002755-38-SI   Canada;France;Germany;Greece;Italy;Lebanon;Netherlands;Serbia;Slovenia;South Africa;Switzerland;Türkiye;United States;Viet Nam
      -   Phase 3   EUCTR2022-002316-23-GR   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
      -   Phase 3   EUCTR2022-002316-23-FR   Brazil;Canada;France;Germany;Greece;Hungary;Israel;Italy;Lebanon;Malaysia;Netherlands;Norway;Poland;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States
Lerodalcibep
   LIB Therapeutics LLC
      2019   Phase 3   NCT04034485   India;Israel;Norway;South Africa;Turkey;United States
   LIB Therapeutics, LLC
      2022   Phase 3   EUCTR2020-004394-49-FR   Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States
      2022   Phase 3   EUCTR2020-004394-49-ES   Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States
      2022   Phase 3   EUCTR2020-004394-49-DE   Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Türkiye;United Kingdom;United States
      2021   Phase 3   EUCTR2020-004394-49-NO   Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States
LIB003
   LIB Therapeutics, LLC
      2022   Phase 3   EUCTR2020-004394-49-FR   Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States
      2022   Phase 3   EUCTR2020-004394-49-ES   Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States
      2022   Phase 3   EUCTR2020-004394-49-DE   Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Türkiye;United Kingdom;United States
      2021   Phase 3   EUCTR2020-004394-49-NO   Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States
      2020   Phase 3   EUCTR2019-003611-62-NO   Israel;Norway;South Africa;Turkey;United States
Lojuxta 10 MG hard capsules
   Amryt Pharmaceuticals DAC
      2020   Phase 3   EUCTR2019-002278-30-IT   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey
      2020   Phase 3   EUCTR2019-002278-30-DE   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia
Lojuxta 20 MG hard capsules
   Amryt Pharmaceuticals DAC
      2020   Phase 3   EUCTR2019-002278-30-IT   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey
      2020   Phase 3   EUCTR2019-002278-30-DE   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia
Lojuxta 5 MG hard capsules
   Amryt Pharmaceuticals DAC
      2020   Phase 3   EUCTR2019-002278-30-IT   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey
      2020   Phase 3   EUCTR2019-002278-30-DE   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia
Lomitapide
   AEGERION PHARMACEUTICALS
      2011   -   EUCTR2010-023742-79-IT   Italy
   Aegerion Pharmaceuticals Inc.
      2016   Phase 3   EUCTR2014-003806-33-GR   Austria;Canada;Germany;Greece;Israel;Italy;Turkey
   Aegerion Pharmaceuticals, Inc.
      2016   Phase 3   NCT02765841   -
      2015   -   NCT02399852   -
      2014   Phase 3   NCT02173158   Japan
      2009   Phase 3   NCT00943306   Canada;Italy;South Africa;United States
      2003   Phase 2   NCT01556906   United States
   Amryt Pharma
      2020   Phase 3   NCT04681170   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia
      2014   -   NCT02135705   Argentina;Canada;France;Greece;Italy;Netherlands;United Kingdom;United States
Lomitapide 2MG hard capsules
   Amryt Pharmaceuticals DAC
      2020   Phase 3   EUCTR2019-002278-30-IT   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey
      2020   Phase 3   EUCTR2019-002278-30-DE   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia
Lovastatin
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
Maintenance OF specific diet
   AstraZeneca
      2002   Phase 3   NCT00654602   -
MBX-8025
   CymaBay Therapeutics, Inc.
      2015   Phase 2   NCT02472535   Canada;France;Netherlands;Norway
      2015   Phase 2   EUCTR2014-004856-68-NO   France;Netherlands;Norway
      2015   -   EUCTR2014-004856-68-NL   France;Netherlands;Norway
      2015   Phase 2   EUCTR2014-004856-68-FR   France;Netherlands;Norway
Mipomersen
   Kastle Therapeutics, LLC
      2007   Phase 3   NCT00607373   Brazil;Canada;Netherlands;Singapore;South Africa;Taiwan;United Kingdom;United States
MK-0859
   Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc
      2013   Phase 3   EUCTR2012-002434-37-IT   Brazil;Canada;Czech Republic;Israel;Italy;Malaysia;Norway;South Africa;United Kingdom;United States
      2013   Phase 3   EUCTR2012-002434-37-GB   Australia;Canada;Czech Republic;Israel;Italy;Malaysia;Norway;South Africa;United Kingdom;United States
      2013   -   EUCTR2012-002434-37-CZ   Australia;Canada;Czech Republic;Israel;Malaysia;Norway;South Africa;United Kingdom;United States
      2012   -   EUCTR2012-002434-37-NO   Australia;Canada;Czech Republic;Israel;Malaysia;Norway;South Africa;United Kingdom;United States
NGGT006
   First Affiliated Hospital Xi'an Jiaotong University
      2023   Early Phase 1   NCT06125847   China
Nicotinic acid
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
Omega-3 fatty acids
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
Praluent
   REGENERON PHARMACEUTICALS, INC.
      2019   Phase 3   EUCTR2017-003170-13-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United Kingdom;United States
      2018   Phase 3   EUCTR2017-001388-19-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
      2017   Phase 3   EUCTR2017-000351-95-IT   Austria;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States
   Regeneron Pharmaceuticals Inc.
      2018   Phase 3   EUCTR2017-001388-19-GR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Turkey;Ukraine;United States
      2018   Phase 3   EUCTR2017-001388-19-DE   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
      2018   Phase 3   EUCTR2017-001388-19-AT   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
      -   Phase 3   EUCTR2017-001388-19-FR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
      -   Phase 3   EUCTR2017-001388-19-CZ   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
   Regeneron Pharmaceuticals, Inc.
      2019   Phase 3   EUCTR2017-003170-13-GR   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States
      2019   Phase 3   EUCTR2017-003170-13-AT   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States
      2018   Phase 3   EUCTR2017-003170-13-CZ   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States
      2017   Phase 3   EUCTR2017-000351-95-GR   Austria;Canada;Czech Republic;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States
      2017   Phase 3   EUCTR2017-000351-95-FR   Austria;Belgium;Bulgaria;Canada;Croatia;Czech Republic;Denmark;France;Germany;Greece;Israel;Italy;Netherlands;Poland;Portugal;Serbia;Slovenia;South Africa;Spain;Sweden;Tunisia;Turkey;Ukraine;United Kingdom;United States
      2017   Phase 3   EUCTR2017-000351-95-DE   Austria;Canada;Czech Republic;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States
      2017   Phase 3   EUCTR2017-000351-95-AT   Austria;Canada;Czech Republic;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States
      -   Phase 3   EUCTR2017-003170-13-FR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States
      -   Phase 3   EUCTR2017-000351-95-CZ   Austria;Belgium;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Israel;Italy;Netherlands;Poland;Portugal;Serbia;Slovenia;South Africa;Spain;Sweden;Tunisia;Turkey;Ukraine;United Kingdom;United States
   Sanofi-Aventis Recherche & Développement
      2018   Phase 3   EUCTR2017-002297-39-DK   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
Pravastatin
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
Prednisone
   REGENXBIO Inc.
      2017   Phase 1;Phase 2   EUCTR2016-001446-25-IT   Canada;Italy;Netherlands;United States
Probucol
   Chinese University of Hong Kong
      2013   Phase 1 study   ChiCTR-ONC-13003008   China
R727
   REGENERON PHARMACEUTICALS, INC.
      2017   Phase 3   EUCTR2017-000351-95-IT   Austria;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States
Rapeseed OIL
   Medical University of Vienna
      2009   -   NCT00924339   Austria
Recombinant human apolipoprotein
   CERENIS THERAPEUTICS SA
      2012   -   EUCTR2011-003998-28-IT   Canada;Italy;Netherlands;United Kingdom;United States
Recombinant human apolipoprotein A-I/phospholipids complex
   Cerenis Therapeutics
      2012   -   EUCTR2011-003998-28-NL   Canada;France;Italy;Netherlands;United Kingdom;United States
      2012   Phase 2   EUCTR2011-003998-28-GB   Canada;Italy;Netherlands;United Kingdom;United States
Recombinant human apolipoprotein A1
   Cerenis Therapeutics
      2012   Phase 2   EUCTR2011-003998-28-GB   Canada;Italy;Netherlands;United Kingdom;United States
REGN1500
   REGENERON PHARMACEUTICALS, INC.
      2019   Phase 3   EUCTR2017-003170-13-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United Kingdom;United States
      2018   Phase 3   EUCTR2017-001388-19-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
   Regeneron Pharmaceuticals Inc.
      2018   Phase 3   EUCTR2017-001388-19-GR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Turkey;Ukraine;United States
      2018   Phase 3   EUCTR2017-001388-19-DE   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
      2018   Phase 3   EUCTR2017-001388-19-AT   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
      -   Phase 3   EUCTR2017-001388-19-FR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
      -   Phase 3   EUCTR2017-001388-19-CZ   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States
   Regeneron Pharmaceuticals, Inc.
      2020   Phase 1;Phase 3   EUCTR2019-001931-30-NL   Australia;Austria;Netherlands;Taiwan;United States
      2020   Phase 1;Phase 3   EUCTR2019-001931-30-AT   Australia;Austria;Netherlands;Taiwan;United States
      2019   Phase 3   EUCTR2017-003170-13-NO   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States
      2019   Phase 3   EUCTR2017-003170-13-GR   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States
      2019   Phase 3   EUCTR2017-003170-13-GB   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States
      2019   Phase 3   EUCTR2017-003170-13-AT   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States
      2018   Phase 3   EUCTR2017-003170-13-NL   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States
      2018   Phase 3   EUCTR2017-003170-13-CZ   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States
      2016   Phase 2   EUCTR2016-000411-32-NL   Canada;Netherlands;United States
      -   Phase 3   EUCTR2017-003170-13-FR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States
REGN1500 250 MG SC/15 MG/KG IV/450 MG SC
   Regeneron Pharmaceuticals
      2015   Phase 2   NCT02265952   Canada;Netherlands;United States
Repatha 140 MG solution FOR injection IN PRE-filled PEN
   Amgen Europe B.V.
      2019   Phase 3   EUCTR2015-002276-25-SI   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States
   Amgen Inc
      2019   Phase 3   EUCTR2015-002276-25-PT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      2019   Phase 3   EUCTR2015-002276-25-PL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States
      2017   Phase 3   EUCTR2015-002276-25-NL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      2017   Phase 3   EUCTR2015-002276-25-ES   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Romania;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-HU   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-GR   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-DE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-CZ   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-BE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-AT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States
      -   Phase 3   EUCTR2015-002276-25-NO   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      -   Phase 3   EUCTR2015-002276-25-GB   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Turkey;United Kingdom
Repatha 420 MG solution FOR injection IN cartridge
   Amgen Europe B.V.
      2019   Phase 3   EUCTR2015-002276-25-SI   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States
   Amgen Inc
      2019   Phase 3   EUCTR2015-002276-25-PT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      2019   Phase 3   EUCTR2015-002276-25-PL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States
      2017   Phase 3   EUCTR2015-002276-25-NL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-CZ   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-BE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      2016   Phase 3   EUCTR2015-002276-25-AT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
      -   Phase 3   EUCTR2015-002276-25-NO   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom
      -   Phase 3   EUCTR2015-002276-25-GB   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Turkey;United Kingdom
Repatha 420 MG soluzione PER iniezione IN cartuccia
   AMGEN INC.
      2016   Phase 3   EUCTR2015-002276-25-IT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom
Rosuvastatin
   AstraZeneca
      2002   Phase 3   NCT00654602   -
      2002   Phase 3   NCT00654446   -
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
Rosuvastatin 20MG
   AstraZeneca
      2015   Phase 3   NCT02434497   Belgium;Canada;Denmark;Israel;Malaysia;Taiwan
      2014   Phase 3   NCT02226198   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States
Rosuvastatin calcium
   AstraZeneca
      2010   Phase 3   NCT01078675   Austria;Belgium;Canada;Netherlands;Norway;United States
   AstraZeneca AB
      2015   Phase 3   EUCTR2014-004746-99-DK   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States
      2015   Phase 3   EUCTR2014-004746-99-BE   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States
      2010   -   EUCTR2009-016492-29-NL   Belgium;Canada;Netherlands;Norway;United States
      2010   Phase 3   EUCTR2009-016492-29-BE   Belgium;Netherlands
      2010   -   EUCTR2009-016492-29-AT   Austria;Belgium;Netherlands
      -   Phase 3   EUCTR2014-004746-99-SE   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States
      -   -   EUCTR2009-016492-29-Outside-EU/EEA   Belgium;Canada;Netherlands;Norway;United States
SAR236553
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
   Sanofi-Aventis Recherche & Développement
      2018   Phase 3   EUCTR2017-002297-39-SI   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-NO   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-NL   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-IT   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-FR   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-ES   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-DK   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-BG   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
      2018   Phase 3   EUCTR2017-002297-39-AT   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
Sfingomielina
   CERENIS THERAPEUTICS SA
      2012   -   EUCTR2011-003998-28-IT   Canada;Italy;Netherlands;United Kingdom;United States
SHR-1209
   Jiangsu HengRui Medicine Co., Ltd.
      2020   Phase 2   NCT04455581   -
SHR-1918
   Beijing Suncadia Pharmaceuticals Co., Ltd
      2025   Phase 3   NCT06723652   China
      2023   Phase 2   NCT06009393   -
Simvastatin
   AstraZeneca
      2002   Phase 3   NCT00654446   -
   Organon and Co
      2000   Phase 3   NCT03885921   -
      2000   Phase 3   NCT03884452   -
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States
Single intravenous (IV) dose OF human LOW density lipoprotein receptor (ldlr) gene therapy
   REGENXBIO Inc.
      2019   -   NCT04080050   Canada;Italy;Netherlands;United States
SOY protein diet
   Medical University of Vienna
      2009   -   NCT00924339   Austria
Sphingomyelin
   Cerenis Therapeutics
      2012   -   EUCTR2011-003998-28-NL   Canada;France;Italy;Netherlands;United Kingdom;United States
      2012   Phase 2   EUCTR2011-003998-28-GB   Canada;Italy;Netherlands;United Kingdom;United States
Statins
   Akeso
      2019   Phase 2   NCT03933293   China
TAK-475
   Takeda Europe R&D Centre Ltd
      2006   -   EUCTR2005-003626-26-GB   United Kingdom
Torcetrapib/atorvastatin
   Pfizer
      2005   Phase 3   NCT00134511   Canada;South Africa;United States
VSA003
   Visirna Therapeutics HK Limited
      2024   Phase 3   NCT06712771   -
Whole genome sequencing
   Nantes University Hospital
      2017   -   NCT03234127   France
ZD4522
   AstraZeneca AB
      2015   Phase 3   EUCTR2014-004746-99-DK   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States
      2015   Phase 3   EUCTR2014-004746-99-BE   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States
      2014   -   EUCTR2014-000972-24-SE   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States
      2014   -   EUCTR2014-000972-24-NL   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States
      2014   -   EUCTR2014-000972-24-DK   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States
      2014   -   EUCTR2014-000972-24-DE   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States
      2014   Phase 3   EUCTR2014-000972-24-BE   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States
      -   Phase 3   EUCTR2014-004746-99-SE   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States