Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 ANGPTL3 💬 1件: Cholesterol metabolism Evinacumab 💬 Evinacumab 1件: 79 💬
2 APOB 💬 4件: Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism, Lipid and atherosclerosis Mipomersen sodium 💬 Mipomersen 1件: 79 💬
3 CETP 💬 1件: Cholesterol metabolism Torcetrapib 💬 Torcetrapib 1件: 79 💬
4 CETP 💬 1件: Cholesterol metabolism Anacetrapib 💬 Anacetrapib 1件: 79 💬
5 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Atorvastatin 💬 Atorvastatin 20件: 13, 22, 46, 49, 51, 58, 63, 67, 79, 84, 88, 93, 96, 97, 160, 225, 265, 271, 297, 299 💬
6 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Rosuvastatin 💬 Rosuvastatin 13件: 6, 18, 46, 49, 51, 56, 65, 79, 94, 96, 97, 271, 299 💬
7 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Atorvastatin calcium 💬 Atorvastatin 20件: 13, 22, 46, 49, 51, 58, 63, 67, 79, 84, 88, 93, 96, 97, 160, 225, 265, 271, 297, 299 💬
8 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Pravastatin 💬 Pravastatin 10件: 13, 46, 49, 67, 79, 96, 164, 210, 265, 333 💬
9 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Simvastatin 💬 Simvastatin 21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
10 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Fluvastatin sodium 💬 Fluvastatin 2件: 79, 222 💬
11 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Lovastatin 💬 Lovastatin 11件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
12 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Fluvastatin 💬 Fluvastatin 2件: 79, 222 💬
13 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Pravastatin sodium 💬 Pravastatin 10件: 13, 46, 49, 67, 79, 96, 164, 210, 265, 333 💬
14 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Rosuvastatin calcium 💬 Rosuvastatin 13件: 6, 18, 46, 49, 51, 56, 65, 79, 94, 96, 97, 271, 299 💬
15 LIPC 💬 2件: Glycerolipid metabolism, Cholesterol metabolism Dextran sulfate sodium 💬 Dextran 3件: 2, 79, 97 💬
16 LPL 💬 4件: Glycerolipid metabolism, PPAR signaling pathway, Cholesterol metabolism, Alzheimer disease Dextran sulfate sodium 💬 Dextran 3件: 2, 79, 97 💬
17 MTTP 💬 1件: Fat digestion and absorption Lomitapide mesylate 💬 Lomitapide 1件: 79 💬
18 MTTP 💬 1件: Fat digestion and absorption Lomitapide 💬 Lomitapide 1件: 79 💬
19 NPC1L1 💬 1件: Fat digestion and absorption Ezetimibe 💬 Ezetimibe 5件: 49, 79, 93, 149, 260 💬
20 NR1C1 💬 10件: PPAR signaling pathway, cAMP signaling pathway, Adipocytokine signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hepatitis C, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy Fenofibrate 💬 Fenofibrate 6件: 8, 79, 93, 94, 97, 265 💬
21 NR3C1 💬 1件: Neuroactive ligand-receptor interaction Prednisone 💬 Prednisone 54件: 2, 11, 13, 14, 18, 19, 26, 28, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 60, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 90, 93, 95, 96, 97, 113, 145, 162, 164, 205, 222, 224, 228, 251, 269, 283, 285, 288, 299, 300, 303, 307, 331 💬
22 PCSK9 💬 1件: Cholesterol metabolism Inclisiran 💬 Inclisiran 1件: 79 💬
23 PCSK9 💬 1件: Cholesterol metabolism Inclisiran sodium 💬 Inclisiran 1件: 79 💬
24 PCSK9 💬 1件: Cholesterol metabolism Evolocumab 💬 Evolocumab 2件: 79, 222 💬
25 PCSK9 💬 1件: Cholesterol metabolism Alirocumab 💬 Alirocumab 1件: 79 💬
26 PCSK9 💬 1件: Cholesterol metabolism Lerodalcibep 💬 Lerodalcibep 1件: 79 💬
27 SERPINC1 💬 1件: Complement and coagulation cascades Heparin calcium 💬 Heparin 10件: 47, 60, 65, 70, 79, 84, 107, 226, 280, 299 💬
28 SERPINC1 💬 1件: Complement and coagulation cascades Heparin sodium 💬 Heparin 10件: 47, 60, 65, 70, 79, 84, 107, 226, 280, 299 💬