107. Juvenile idiopathic arthritis Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 500 / Drugs : 338 - (DrugBank : 52) / Drug target genes : 65 - Drug target pathways : 157
Juvenile idiopathic arthritis and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 107 | Juvenile idiopathic arthritis | - |
| 46 | Malignant rheumatoid arthritis | 42.012 |
| 13 | Multiple sclerosis/Neuromyelitis optica | 33.664 |
| 97 | Ulcerative colitis | 33.351 |
| 96 | Crohn disease | 27.297 |
| 50 | Dermatomyositis | 22.615 |
| 271 | Ankylosing spondylitis | 21.244 |
| 51 | Scleroderma | 20.677 |
| 6 | Parkinson disease | 20.545 |
| 65 | Primary immunodeficiency | 20.306 |
| 53 | Sjogren syndrome | 17.920 |
| 2 | Amyotrophic lateral sclerosis | 17.181 |
| 84 | Sarcoidosis | 17.122 |
| 49 | Systemic lupus erythematosus | 17.094 |
| 113 | Muscular dystrophy | 15.173 |
| 41 | Giant cell arteritis | 15.152 |
| 56 | Behcet disease | 14.530 |
| 11 | Myasthenia gravis | 14.323 |
| 226 | Interstitial cystitis with Hunners ulcer | 13.671 |
| 162 | Pemphigoid | 12.650 |
| 38 | Stevens-Johnson syndrome | 11.700 |
| 40 | Takayasu arteritis | 10.731 |
| 55 | Relapsing polychondritis | 10.277 |
| 299 | Cystic fibrosis | 10.256 |
| 222 | Primary nephrotic syndrome | 9.704 |
| 60 | Aplastic anemia | 9.143 |
| 269 | Pyogenic arthritis | 8.687 |
| 58 | Hypertrophic cardiomyopathy | 8.615 |
| 28 | Systemic amyloidosis | 8.505 |
| 19 | Lysosomal storage disease | 8.377 |
| 228 | Bronchiolitis obliterans | 8.110 |
| 93 | Primary biliary cholangitis | 7.862 |
| 284 | Diamond-Blackfan anemia | 7.804 |
| 256 | Muscle glycogenosis | 7.339 |
| 224 | Purpura nephritis | 7.308 |
| 164 | Oculocutaneous albinism | 6.978 |
| 34 | Neurofibromatosis | 6.960 |
| 285 | Fanconi anemia | 6.462 |
| 286 | Hereditary sideroblastic anemia | 6.243 |
| 95 | Autoimmune hepatitis | 6.174 |
| 39 | Toxic epidermal necrolysis | 6.154 |
| 270 | Chronic recurrent multifocal osteomyelitis | 6.000 |
| 151 | Rasmussen encephalitis | 6.000 |
| 231 | Alpha-1-antitrypsin deficiency | 5.934 |
| 66 | IgA nephropathy | 5.934 |
| 86 | Pulmonary arterial hypertension | 5.928 |
| 44 | Wegener granulomatosis | 5.769 |
| 298 | Hereditary pancreatitis | 5.642 |
| 8 | Huntington disease | 5.474 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 5.279 |
| 160 | Congenital ichthyosis | 5.279 |
| 283 | Acquired pure red cell aplasia | 5.279 |
| 63 | Idiopathic thrombocytopenic purpura | 5.231 |
| 36 | Epidermolysis bullosa | 5.030 |
| 42 | Polyarteritis nodosa | 5.030 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 300 | IgG4-related disease | 4.841 |
| 326 | Osteopetrosis | 4.615 |
| 85 | Idiopathic interstitial pneumonia | 4.530 |
| 78 | Hypopituitarism | 4.495 |
| 70 | Spinal stenosis | 4.448 |
| 21 | Mitochondrial disease | 4.357 |
| 168 | Ehlers-Danlos syndrome | 4.231 |
| 106 | Cryopyrin-associated periodic syndrome | 4.000 |
| 274 | Osteogenesis Imperfecta | 3.971 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 3.810 |
| 35 | Pemphigus | 3.692 |
| 323 | Aromatic L-amino acid decarboxylase deficiency | 3.000 |
| 90 | Retinitis pigmentosa | 2.925 |
| 20 | Adrenoleukodystrophy | 2.870 |
| 158 | Tuberous sclerosis | 2.778 |
| 1 | Spinal and bulbar muscular atrophy | 2.740 |
| 64 | Thrombotic thrombocytopenic purpura | 2.683 |
| 26 | HTLV-1-associated myelopathy | 2.656 |
| 61 | Autoimmune hemolytic anemia | 2.638 |
| 265 | Lipodystrophy | 2.573 |
| 10 | Charcot-Marie-Tooth disease | 2.535 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 2.364 |
| 251 | Urea cycle disorder | 2.293 |
| 43 | Microscopic polyangiitis | 2.095 |
| 266 | Familial mediterranean fever | 2.095 |
| 280 | Huge arteriovenous malformation with cervicofacial or limb lesion | 2.095 |
| 227 | Osler disease | 2.077 |
| 268 | Nakajo-Nishimura syndrome | 2.000 |
| 325 | Hereditary autoinflammatory syndrome | 2.000 |
| 337 | Homocystinuria | 2.000 |
| 257 | Hepatic glycogenosis | 2.000 |
| 282 | Congenital dyserythropoietic anemia | 2.000 |
| 193 | Prader-Willi syndrome | 1.774 |
| 114 | Non-dystrophic myotonia syndrome | 1.736 |
| 288 | Autoimmune acquired coagulation factor deficiency | 1.736 |
| 15 | Inclusion body myositis | 1.650 |
| 236 | Pseudohypoparathyroidism | 1.611 |
| 37 | Generalised pustular psoriasis | 1.611 |
| 127 | Frontotemporal lobar degeneration | 1.488 |
| 98 | Eosinophilic gastro-intestinal disorder | 1.469 |
| 172 | Hypophosphatasia | 1.359 |
| 22 | Moyamoya disease | 1.288 |
| 118 | Myelomeningocele | 1.233 |
| 212 | Tricuspid atresia | 1.233 |
| 331 | Idiopathic multicentric castleman disease | 1.210 |
| 5 | Progressive supranuclear palsy | 1.182 |
| 246 | Methylmalonic acidemia | 1.176 |
| 169 | Menkes disease | 1.115 |
| 170 | Occipital horn syndrome | 1.115 |
| 254 | Porphyria | 1.085 |
| 238 | Vitamin D-resistant rickets | 1.038 |
| 235 | Hypoparathyroidism | 1.038 |
| 71 | Idiopathic osteonecrosis of the femoral head | 1.038 |
| 108 | TNF receptor-associated periodic syndrome | 1.000 |
| 267 | Hyper-IgD syndrome | 1.000 |
| 317 | Trifunctional protein deficiency | 1.000 |
| 54 | Adult still disease | 1.000 |
| 191 | Werner syndrome | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |