11. Myasthenia gravis Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 525 / Drugs : 355 - (DrugBank : 80) / Drug target genes : 75 - Drug target pathways : 139
Myasthenia gravis and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 11 | Myasthenia gravis | - |
| 13 | Multiple sclerosis/Neuromyelitis optica | 32.933 |
| 46 | Malignant rheumatoid arthritis | 31.738 |
| 96 | Crohn disease | 24.516 |
| 49 | Systemic lupus erythematosus | 20.020 |
| 65 | Primary immunodeficiency | 18.194 |
| 51 | Scleroderma | 17.548 |
| 6 | Parkinson disease | 15.366 |
| 53 | Sjogren syndrome | 15.253 |
| 107 | Juvenile idiopathic arthritis | 14.323 |
| 40 | Takayasu arteritis | 12.288 |
| 28 | Systemic amyloidosis | 12.256 |
| 44 | Wegener granulomatosis | 12.143 |
| 283 | Acquired pure red cell aplasia | 11.857 |
| 60 | Aplastic anemia | 11.829 |
| 284 | Diamond-Blackfan anemia | 11.818 |
| 164 | Oculocutaneous albinism | 10.541 |
| 55 | Relapsing polychondritis | 10.307 |
| 300 | IgG4-related disease | 10.240 |
| 2 | Amyotrophic lateral sclerosis | 10.181 |
| 50 | Dermatomyositis | 10.169 |
| 285 | Fanconi anemia | 10.000 |
| 61 | Autoimmune hemolytic anemia | 9.756 |
| 162 | Pemphigoid | 9.545 |
| 41 | Giant cell arteritis | 9.545 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 9.478 |
| 113 | Muscular dystrophy | 9.470 |
| 222 | Primary nephrotic syndrome | 9.370 |
| 93 | Primary biliary cholangitis | 9.286 |
| 85 | Idiopathic interstitial pneumonia | 9.164 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 9.067 |
| 169 | Menkes disease | 9.000 |
| 170 | Occipital horn syndrome | 9.000 |
| 256 | Muscle glycogenosis | 8.711 |
| 14 | Chronic inflammatory demyelinating polyneuropathy | 8.704 |
| 271 | Ankylosing spondylitis | 8.659 |
| 42 | Polyarteritis nodosa | 8.378 |
| 286 | Hereditary sideroblastic anemia | 8.000 |
| 97 | Ulcerative colitis | 7.680 |
| 95 | Autoimmune hepatitis | 7.501 |
| 226 | Interstitial cystitis with Hunners ulcer | 7.344 |
| 66 | IgA nephropathy | 7.189 |
| 19 | Lysosomal storage disease | 7.174 |
| 43 | Microscopic polyangiitis | 6.429 |
| 228 | Bronchiolitis obliterans | 6.400 |
| 118 | Myelomeningocele | 6.261 |
| 224 | Purpura nephritis | 6.120 |
| 269 | Pyogenic arthritis | 6.120 |
| 22 | Moyamoya disease | 5.954 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 5.807 |
| 35 | Pemphigus | 5.758 |
| 70 | Spinal stenosis | 5.576 |
| 288 | Autoimmune acquired coagulation factor deficiency | 5.400 |
| 84 | Sarcoidosis | 5.221 |
| 26 | HTLV-1-associated myelopathy | 5.095 |
| 12 | Congenital myasthenic syndrome | 5.000 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 5 | Progressive supranuclear palsy | 4.825 |
| 64 | Thrombotic thrombocytopenic purpura | 4.711 |
| 326 | Osteopetrosis | 4.711 |
| 58 | Hypertrophic cardiomyopathy | 4.594 |
| 158 | Tuberous sclerosis | 4.444 |
| 56 | Behcet disease | 4.383 |
| 57 | Idiopathic dilated cardiomyopathy | 4.267 |
| 151 | Rasmussen encephalitis | 4.259 |
| 331 | Idiopathic multicentric castleman disease | 3.890 |
| 38 | Stevens-Johnson syndrome | 3.847 |
| 20 | Adrenoleukodystrophy | 3.814 |
| 36 | Epidermolysis bullosa | 3.810 |
| 227 | Osler disease | 3.710 |
| 39 | Toxic epidermal necrolysis | 3.636 |
| 86 | Pulmonary arterial hypertension | 3.603 |
| 17 | Multiple system atrophy | 3.497 |
| 160 | Congenital ichthyosis | 3.388 |
| 4 | Primary lateral sclerosis | 3.267 |
| 90 | Retinitis pigmentosa | 3.122 |
| 34 | Neurofibromatosis | 3.116 |
| 299 | Cystic fibrosis | 3.032 |
| 274 | Osteogenesis Imperfecta | 3.029 |
| 280 | Huge arteriovenous malformation with cervicofacial or limb lesion | 3.029 |
| 3 | Spinal muscular atrophy | 3.023 |
| 323 | Aromatic L-amino acid decarboxylase deficiency | 3.000 |
| 206 | Fragile X syndrome | 3.000 |
| 127 | Frontotemporal lobar degeneration | 2.738 |
| 63 | Idiopathic thrombocytopenic purpura | 2.592 |
| 296 | Biliary atresia | 2.592 |
| 215 | Tetralogy of Fallot | 2.533 |
| 210 | Single Ventricle | 2.382 |
| 251 | Urea cycle disorder | 2.300 |
| 8 | Huntington disease | 2.049 |
| 78 | Hypopituitarism | 2.029 |
| 268 | Nakajo-Nishimura syndrome | 2.000 |
| 325 | Hereditary autoinflammatory syndrome | 2.000 |
| 337 | Homocystinuria | 2.000 |
| 278 | Huge lymphatic malformation with cervicofacial lesion | 1.880 |
| 16 | Crow-Fukase syndrome | 1.880 |
| 94 | Primary sclerosing cholangitis | 1.725 |
| 270 | Chronic recurrent multifocal osteomyelitis | 1.600 |
| 25 | Progressive multifocal leukoencephalopathy | 1.400 |
| 172 | Hypophosphatasia | 1.363 |
| 212 | Tricuspid atresia | 1.250 |
| 254 | Porphyria | 1.123 |
| 167 | Marfan syndrome | 1.040 |
| 21 | Mitochondrial disease | 1.028 |
| 111 | Congenital myopathy | 1.000 |
| 54 | Adult still disease | 1.000 |
| 52 | Mixed connective tissue disease | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |