DR info

Clinical trials : 90 / Drugs : 87 - (DrugBank : 30) / Drug target genes : 39 - Drug target pathways : 88

Frontotemporal lobar degeneration and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
127	Frontotemporal lobar degeneration	-
6	Parkinson disease	28.239
2	Amyotrophic lateral sclerosis	20.967
13	Multiple sclerosis/Neuromyelitis optica	20.484
46	Malignant rheumatoid arthritis	13.277
85	Idiopathic interstitial pneumonia	12.020
5	Progressive supranuclear palsy	11.941
86	Pulmonary arterial hypertension	10.920
28	Systemic amyloidosis	10.800
8	Huntington disease	10.221
256	Muscle glycogenosis	10.161
113	Muscular dystrophy	10.042
70	Spinal stenosis	8.727
3	Spinal muscular atrophy	8.278
96	Crohn disease	8.214
17	Multiple system atrophy	7.930
233	Wolfram syndrome	7.732
97	Ulcerative colitis	7.474
206	Fragile X syndrome	7.259
102	Rubinstein-Taybi syndrome	7.000
156	Rett syndrome	5.706
58	Hypertrophic cardiomyopathy	5.700
34	Neurofibromatosis	5.536
215	Tetralogy of Fallot	5.513
331	Idiopathic multicentric castleman disease	4.919
65	Primary immunodeficiency	4.720
168	Ehlers-Danlos syndrome	4.300
49	Systemic lupus erythematosus	3.795
222	Primary nephrotic syndrome	3.730
89	Lymphangioleiomyomatosis	3.496
4	Primary lateral sclerosis	3.353
90	Retinitis pigmentosa	3.306
193	Prader-Willi syndrome	3.256
226	Interstitial cystitis with Hunners ulcer	3.006
26	HTLV-1-associated myelopathy	2.947
38	Stevens-Johnson syndrome	2.940
1	Spinal and bulbar muscular atrophy	2.812
78	Hypopituitarism	2.764
11	Myasthenia gravis	2.738
149	Hemiconvulsion hemiplegia epilepsy syndrome	2.700
10	Charcot-Marie-Tooth disease	2.614
51	Scleroderma	2.581
67	Polycystic kidney disease	2.289
84	Sarcoidosis	2.224
118	Myelomeningocele	2.200
203	22q11.2 deletion syndrome	2.188
205	Fragile X syndrome related disease	2.124
18	Spinocerebellar degeneration	2.123
21	Mitochondrial disease	2.085
140	Dorabe syndrome	2.067
144	Lennox-Gastaut syndrome	2.050
36	Epidermolysis bullosa	2.050
77	Growth hormone secreting pituitary adenoma	2.000
57	Idiopathic dilated cardiomyopathy	2.000
169	Menkes disease	2.000
170	Occipital horn syndrome	2.000
53	Sjogren syndrome	1.960
114	Non-dystrophic myotonia syndrome	1.840
288	Autoimmune acquired coagulation factor deficiency	1.840
299	Cystic fibrosis	1.646
107	Juvenile idiopathic arthritis	1.488
298	Hereditary pancreatitis	1.477
280	Huge arteriovenous malformation with cervicofacial or limb lesion	1.429
285	Fanconi anemia	1.354
158	Tuberous sclerosis	1.250
231	Alpha-1-antitrypsin deficiency	1.250
283	Acquired pure red cell aplasia	1.200
179	Williams syndrome	1.150
60	Aplastic anemia	1.146
137	Focal cortical dysplasia	1.000
192	Cockayne syndrome	1.000
277	Lymphangiomatosis	1.000
281	Klippel-Trenaunay-Weber syndrome	1.000
52	Mixed connective tissue disease	1.000
220	Rapidly progressive glomerulonephritis	1.000
30	Distal myopathy	1.000