127. Frontotemporal lobar degeneration Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 137 / Drugs : 175 - (DrugBank : 35) / Drug target genes : 44 - Drug target pathways : 112
Frontotemporal lobar degeneration and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 127 | Frontotemporal lobar degeneration | - |
| 6 | Parkinson disease | 28.239 |
| 2 | Amyotrophic lateral sclerosis | 20.967 |
| 13 | Multiple sclerosis/Neuromyelitis optica | 20.484 |
| 46 | Malignant rheumatoid arthritis | 13.277 |
| 85 | Idiopathic interstitial pneumonia | 12.020 |
| 5 | Progressive supranuclear palsy | 11.941 |
| 86 | Pulmonary arterial hypertension | 10.920 |
| 28 | Systemic amyloidosis | 10.800 |
| 8 | Huntington disease | 10.221 |
| 256 | Muscle glycogenosis | 10.161 |
| 113 | Muscular dystrophy | 10.042 |
| 70 | Spinal stenosis | 8.727 |
| 3 | Spinal muscular atrophy | 8.278 |
| 96 | Crohn disease | 8.214 |
| 17 | Multiple system atrophy | 7.930 |
| 233 | Wolfram syndrome | 7.732 |
| 97 | Ulcerative colitis | 7.474 |
| 206 | Fragile X syndrome | 7.259 |
| 102 | Rubinstein-Taybi syndrome | 7.000 |
| 156 | Rett syndrome | 5.706 |
| 58 | Hypertrophic cardiomyopathy | 5.700 |
| 34 | Neurofibromatosis | 5.536 |
| 215 | Tetralogy of Fallot | 5.513 |
| 331 | Idiopathic multicentric castleman disease | 4.919 |
| 65 | Primary immunodeficiency | 4.720 |
| 168 | Ehlers-Danlos syndrome | 4.300 |
| 49 | Systemic lupus erythematosus | 3.795 |
| 222 | Primary nephrotic syndrome | 3.730 |
| 89 | Lymphangioleiomyomatosis | 3.496 |
| 4 | Primary lateral sclerosis | 3.353 |
| 90 | Retinitis pigmentosa | 3.306 |
| 193 | Prader-Willi syndrome | 3.256 |
| 226 | Interstitial cystitis with Hunners ulcer | 3.006 |
| 26 | HTLV-1-associated myelopathy | 2.947 |
| 38 | Stevens-Johnson syndrome | 2.940 |
| 1 | Spinal and bulbar muscular atrophy | 2.812 |
| 78 | Hypopituitarism | 2.764 |
| 11 | Myasthenia gravis | 2.738 |
| 149 | Hemiconvulsion hemiplegia epilepsy syndrome | 2.700 |
| 10 | Charcot-Marie-Tooth disease | 2.614 |
| 51 | Scleroderma | 2.581 |
| 67 | Polycystic kidney disease | 2.289 |
| 84 | Sarcoidosis | 2.224 |
| 118 | Myelomeningocele | 2.200 |
| 203 | 22q11.2 deletion syndrome | 2.188 |
| 205 | Fragile X syndrome related disease | 2.124 |
| 18 | Spinocerebellar degeneration | 2.123 |
| 21 | Mitochondrial disease | 2.085 |
| 140 | Dorabe syndrome | 2.067 |
| 144 | Lennox-Gastaut syndrome | 2.050 |
| 36 | Epidermolysis bullosa | 2.050 |
| 77 | Growth hormone secreting pituitary adenoma | 2.000 |
| 57 | Idiopathic dilated cardiomyopathy | 2.000 |
| 169 | Menkes disease | 2.000 |
| 170 | Occipital horn syndrome | 2.000 |
| 53 | Sjogren syndrome | 1.960 |
| 114 | Non-dystrophic myotonia syndrome | 1.840 |
| 288 | Autoimmune acquired coagulation factor deficiency | 1.840 |
| 299 | Cystic fibrosis | 1.646 |
| 107 | Juvenile idiopathic arthritis | 1.488 |
| 298 | Hereditary pancreatitis | 1.477 |
| 280 | Huge arteriovenous malformation with cervicofacial or limb lesion | 1.429 |
| 285 | Fanconi anemia | 1.354 |
| 158 | Tuberous sclerosis | 1.250 |
| 231 | Alpha-1-antitrypsin deficiency | 1.250 |
| 283 | Acquired pure red cell aplasia | 1.200 |
| 179 | Williams syndrome | 1.150 |
| 60 | Aplastic anemia | 1.146 |
| 137 | Focal cortical dysplasia | 1.000 |
| 192 | Cockayne syndrome | 1.000 |
| 277 | Lymphangiomatosis | 1.000 |
| 281 | Klippel-Trenaunay-Weber syndrome | 1.000 |
| 52 | Mixed connective tissue disease | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |