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DR info

Clinical trials : 3,685 / Drugs : 1,932 - (DrugBank : 355) / Drug target genes : 263 - Drug target pathways : 237

Multiple sclerosis and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
13	Multiple sclerosis	-
6	Parkinson disease	139.526
2	Amyotrophic lateral sclerosis	116.536
96	Crohn disease	108.041
46	Malignant rheumatoid arthritis	103.510
97	Ulcerative colitis	89.503
156	Rett syndrome	75.295
84	Sarcoidosis	60.899
8	Huntington disease	53.890
86	Pulmonary arterial hypertension	53.159
5	Progressive supranuclear palsy	53.116
70	Spinal stenosis	49.301
49	Systemic lupus erythematosus	46.335
3	Spinal muscular atrophy	45.983
206	Fragile X syndrome	45.299
21	Mitochondrial disease	45.191
51	Scleroderma	44.136
193	Prader-Willi syndrome	42.270
36	Epidermolysis bullosa	41.948
65	Primary immunodeficiency	40.579
18	Spinocerebellar degeneration	39.642
226	Interstitial cystitis with Hunners ulcer	39.631
17	Multiple system atrophy	39.616
85	Idiopathic interstitial pneumonia	39.217
34	Neurofibromatosis	38.953
298	Hereditary pancreatitis	37.764
140	Dorabe syndrome	37.579
144	Lennox-Gastaut syndrome	36.947
299	Cystic fibrosis	36.367
296	Biliary atresia	36.224
90	Retinitis pigmentosa	35.338
107	Juvenile idiopathic arthritis	33.664
11	Myasthenia gravis	32.933
98	Eosinophilic gastro-intestinal disorder	32.204
113	Muscular dystrophy	31.809
158	Tuberous sclerosis	31.348
50	Dermatomyositis	31.214
53	Sjogren syndrome	29.318
155	Acquired aphasia with convulsive disorder	29.000
78	Hypopituitarism	28.783
222	Primary nephrotic syndrome	26.997
231	Alpha-1-antitrypsin deficiency	26.198
63	Idiopathic thrombocytopenic purpura	25.292
60	Aplastic anemia	23.827
145	West syndrome	23.322
58	Hypertrophic cardiomyopathy	22.617
41	Giant cell arteritis	22.589
22	Moyamoya disease	22.573
19	Lysosomal storage disease	22.227
66	IgA nephropathy	21.455
26	HTLV-1-associated myelopathy	21.407
205	Fragile X syndrome related disease	21.319
127	Frontotemporal lobar degeneration	20.484
164	Oculocutaneous albinism	20.480
225	Congenital nephrogenic diabetes insipidus	19.633
28	Systemic amyloidosis	19.622
75	Cushing disease	19.479
271	Ankylosing spondylitis	18.716
285	Fanconi anemia	18.097
162	Pemphigoid	18.045
283	Acquired pure red cell aplasia	18.000
114	Non-dystrophic myotonia syndrome	18.000
230	Alveolar hypoventilation syndrome	18.000
256	Muscle glycogenosis	17.578
272	Fibrodysplasia ossificans progressiva	17.280
284	Diamond-Blackfan anemia	16.594
152	PCDH19 related syndrome	16.000
56	Behcet disease	15.413
228	Bronchiolitis obliterans	15.273
300	IgG4-related disease	15.000
201	Angelman syndrome	14.949
331	Idiopathic multicentric castleman disease	14.761
45	Eosinophilic granulomatosis with Polyangiitis	14.329
203	22q11.2 deletion syndrome	14.000
95	Autoimmune hepatitis	13.626
35	Pemphigus	13.383
61	Autoimmune hemolytic anemia	13.301
38	Stevens-Johnson syndrome	13.116
115	Hereditary periodic paralysis	13.000
154	Epilepsy with continuous spikes and waves during slow sleep	13.000
265	Lipodystrophy	12.836
62	Paroxysmal nocturnal hemoglobinuria	12.420
43	Microscopic polyangiitis	12.117
4	Primary lateral sclerosis	12.020
55	Relapsing polychondritis	12.000
14	Chronic inflammatory demyelinating polyneuropathy	12.000
42	Polyarteritis nodosa	11.491
89	Lymphangioleiomyomatosis	11.106
215	Tetralogy of Fallot	11.053
10	Charcot-Marie-Tooth disease	11.000
40	Takayasu arteritis	10.586
149	Hemiconvulsion hemiplegia epilepsy syndrome	10.091
37	Generalised pustular psoriasis	10.021
224	Purpura nephritis	9.708
44	Wegener granulomatosis	9.579
20	Adrenoleukodystrophy	9.177
39	Toxic epidermal necrolysis	9.125
233	Wolfram syndrome	9.125
227	Osler disease	8.810
81	Congenital adrenal hyperplasia	8.396
160	Congenital ichthyosis	8.180
286	Hereditary sideroblastic anemia	8.000
212	Tricuspid atresia	8.000
93	Primary biliary cholangitis	7.837
254	Porphyria	7.778
64	Thrombotic thrombocytopenic purpura	7.705
236	Pseudohypoparathyroidism	7.417
67	Polycystic kidney disease	7.294
280	Huge arteriovenous malformation with cervicofacial or limb lesion	7.250
102	Rubinstein-Taybi syndrome	7.000
25	Progressive multifocal leukoencephalopathy	7.000
269	Pyogenic arthritis	6.792
94	Primary sclerosing cholangitis	6.560
88	Chronic thromboembolic pulmonary hypertension	6.324
151	Rasmussen encephalitis	6.000
83	Addison disease	6.000
47	Buerger disease	6.000
15	Inclusion body myositis	5.884
288	Autoimmune acquired coagulation factor deficiency	5.723
179	Williams syndrome	5.485
234	Peroxisomal disease (except Adrenoleukodystrophy)	5.414
326	Osteopetrosis	5.196
12	Congenital myasthenic syndrome	5.000
302	Leber hereditary optic neuropathy	5.000
294	Congenital diaphragmatic hernia	5.000
211	Hypoplastic left heart syndrome	5.000
1	Spinal and bulbar muscular atrophy	4.955
274	Osteogenesis Imperfecta	4.675
270	Chronic recurrent multifocal osteomyelitis	4.182
76	Pituitary gonadotropin secretion hyperthyroidism	4.182
168	Ehlers-Danlos syndrome	4.045
169	Menkes disease	4.045
170	Occipital horn syndrome	4.045
87	Pulmonary veno-occlusive disease	4.000
106	Cryopyrin-associated periodic syndrome	4.000
246	Methylmalonic acidemia	3.892
167	Marfan syndrome	3.654
210	Single Ventricle	3.383
157	Sturge-Weber syndrome	3.212
278	Huge lymphatic malformation with cervicofacial lesion	3.212
16	Crow-Fukase syndrome	3.212
118	Myelomeningocele	3.160
187	Kabuki syndrome	3.000
171	Wilson disease	3.000
323	Aromatic L-amino acid decarboxylase deficiency	3.000
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy	2.687
251	Urea cycle disorder	2.258
202	Smith-Magenis syndrome	2.258
71	Idiopathic osteonecrosis of the femoral head	2.258
77	Growth hormone secreting pituitary adenoma	2.000
337	Homocystinuria	2.000
195	Noonan syndrome	2.000
282	Congenital dyserythropoietic anemia	2.000
307	Canavan disease	2.000
139	Congenital cerebral hypomyelination	2.000
120	Hereditary dystonia	2.000
266	Familial mediterranean fever	1.846
159	Xeroderma pigmentosum	1.814
166	Pseudoxanthoma elasticum	1.814
301	Macular dystrophy	1.811
57	Idiopathic dilated cardiomyopathy	1.811
74	Prolactin secreting pituitary adenoma	1.627
218	Alport syndrome	1.517
310	Congenital anomalies syndrome	1.338
229	Autoimmune pulmonary alveolar proteinosis	1.338
172	Hypophosphatasia	1.338
80	Resistance to thyroid hormone	1.338
79	Homozygous familial hypercholesterolemia	1.023
309	Progressive myoclonus epilepsy	1.008
333	Hutchinson-Gilford syndrome	1.008
91	Budd-Chiari syndrome	1.008
238	Vitamin D-resistant rickets	1.008
235	Hypoparathyroidism	1.008
137	Focal cortical dysplasia	1.000
192	Cockayne syndrome	1.000
277	Lymphangiomatosis	1.000
281	Klippel-Trenaunay-Weber syndrome	1.000
111	Congenital myopathy	1.000
108	TNF receptor-associated periodic syndrome	1.000
267	Hyper-IgD syndrome	1.000
99	Chronic intestinal pseudo-obstruction	1.000
317	Trifunctional protein deficiency	1.000
54	Adult still disease	1.000
191	Werner syndrome	1.000
52	Mixed connective tissue disease	1.000
290	Chronic nonspecific multiple ulcers of the small intestine	1.000
220	Rapidly progressive glomerulonephritis	1.000
30	Distal myopathy	1.000