299. Cystic fibrosis Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 1,826 / Drugs : 1,271 - (DrugBank : 246) / Drug target genes : 118 - Drug target pathways : 180
Cystic fibrosis and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 299 | Cystic fibrosis | - |
| 13 | Multiple sclerosis | 36.367 |
| 46 | Malignant rheumatoid arthritis | 33.684 |
| 6 | Parkinson disease | 33.579 |
| 226 | Interstitial cystitis with Hunners ulcer | 27.407 |
| 2 | Amyotrophic lateral sclerosis | 25.195 |
| 63 | Idiopathic thrombocytopenic purpura | 24.470 |
| 96 | Crohn disease | 20.235 |
| 97 | Ulcerative colitis | 20.144 |
| 236 | Pseudohypoparathyroidism | 20.000 |
| 86 | Pulmonary arterial hypertension | 15.562 |
| 65 | Primary immunodeficiency | 15.282 |
| 246 | Methylmalonic acidemia | 15.216 |
| 265 | Lipodystrophy | 13.500 |
| 78 | Hypopituitarism | 12.424 |
| 49 | Systemic lupus erythematosus | 11.365 |
| 51 | Scleroderma | 10.601 |
| 113 | Muscular dystrophy | 10.433 |
| 107 | Juvenile idiopathic arthritis | 10.256 |
| 21 | Mitochondrial disease | 9.921 |
| 225 | Congenital nephrogenic diabetes insipidus | 8.672 |
| 50 | Dermatomyositis | 7.965 |
| 19 | Lysosomal storage disease | 7.957 |
| 8 | Huntington disease | 7.937 |
| 53 | Sjogren syndrome | 7.334 |
| 20 | Adrenoleukodystrophy | 7.227 |
| 162 | Pemphigoid | 7.115 |
| 224 | Purpura nephritis | 7.014 |
| 271 | Ankylosing spondylitis | 6.974 |
| 56 | Behcet disease | 6.692 |
| 58 | Hypertrophic cardiomyopathy | 6.299 |
| 90 | Retinitis pigmentosa | 6.218 |
| 164 | Oculocutaneous albinism | 6.058 |
| 39 | Toxic epidermal necrolysis | 6.000 |
| 158 | Tuberous sclerosis | 5.935 |
| 95 | Autoimmune hepatitis | 5.757 |
| 285 | Fanconi anemia | 5.700 |
| 74 | Prolactin secreting pituitary adenoma | 5.432 |
| 64 | Thrombotic thrombocytopenic purpura | 5.432 |
| 75 | Cushing disease | 5.406 |
| 98 | Eosinophilic gastro-intestinal disorder | 5.324 |
| 84 | Sarcoidosis | 5.268 |
| 60 | Aplastic anemia | 5.239 |
| 66 | IgA nephropathy | 5.100 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 294 | Congenital diaphragmatic hernia | 5.000 |
| 274 | Osteogenesis Imperfecta | 4.857 |
| 26 | HTLV-1-associated myelopathy | 4.816 |
| 210 | Single Ventricle | 4.608 |
| 41 | Giant cell arteritis | 4.507 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 4.339 |
| 326 | Osteopetrosis | 4.333 |
| 93 | Primary biliary cholangitis | 4.321 |
| 85 | Idiopathic interstitial pneumonia | 4.261 |
| 151 | Rasmussen encephalitis | 4.210 |
| 222 | Primary nephrotic syndrome | 4.156 |
| 179 | Williams syndrome | 4.125 |
| 67 | Polycystic kidney disease | 4.080 |
| 227 | Osler disease | 4.035 |
| 160 | Congenital ichthyosis | 3.926 |
| 228 | Bronchiolitis obliterans | 3.756 |
| 17 | Multiple system atrophy | 3.566 |
| 5 | Progressive supranuclear palsy | 3.438 |
| 28 | Systemic amyloidosis | 3.409 |
| 298 | Hereditary pancreatitis | 3.282 |
| 206 | Fragile X syndrome | 3.244 |
| 286 | Hereditary sideroblastic anemia | 3.223 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 3.188 |
| 156 | Rett syndrome | 3.136 |
| 283 | Acquired pure red cell aplasia | 3.034 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 3.034 |
| 11 | Myasthenia gravis | 3.032 |
| 301 | Macular dystrophy | 2.894 |
| 7 | Corticobasal degeneration | 2.894 |
| 36 | Epidermolysis bullosa | 2.870 |
| 76 | Pituitary gonadotropin secretion hyperthyroidism | 2.722 |
| 38 | Stevens-Johnson syndrome | 2.625 |
| 269 | Pyogenic arthritis | 2.625 |
| 284 | Diamond-Blackfan anemia | 2.575 |
| 296 | Biliary atresia | 2.475 |
| 251 | Urea cycle disorder | 2.273 |
| 309 | Progressive myoclonus epilepsy | 2.273 |
| 55 | Relapsing polychondritis | 2.235 |
| 94 | Primary sclerosing cholangitis | 2.151 |
| 254 | Porphyria | 2.151 |
| 77 | Growth hormone secreting pituitary adenoma | 2.000 |
| 337 | Homocystinuria | 2.000 |
| 195 | Noonan syndrome | 2.000 |
| 263 | Cerebrotendinous xanthomatosis | 2.000 |
| 282 | Congenital dyserythropoietic anemia | 2.000 |
| 120 | Hereditary dystonia | 2.000 |
| 70 | Spinal stenosis | 1.956 |
| 61 | Autoimmune hemolytic anemia | 1.725 |
| 40 | Takayasu arteritis | 1.725 |
| 42 | Polyarteritis nodosa | 1.673 |
| 127 | Frontotemporal lobar degeneration | 1.646 |
| 288 | Autoimmune acquired coagulation factor deficiency | 1.577 |
| 15 | Inclusion body myositis | 1.561 |
| 233 | Wolfram syndrome | 1.561 |
| 218 | Alport syndrome | 1.547 |
| 83 | Addison disease | 1.547 |
| 124 | Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy | 1.547 |
| 18 | Spinocerebellar degeneration | 1.520 |
| 4 | Primary lateral sclerosis | 1.508 |
| 140 | Dorabe syndrome | 1.457 |
| 37 | Generalised pustular psoriasis | 1.445 |
| 81 | Congenital adrenal hyperplasia | 1.444 |
| 187 | Kabuki syndrome | 1.347 |
| 171 | Wilson disease | 1.347 |
| 310 | Congenital anomalies syndrome | 1.347 |
| 229 | Autoimmune pulmonary alveolar proteinosis | 1.347 |
| 88 | Chronic thromboembolic pulmonary hypertension | 1.346 |
| 201 | Angelman syndrome | 1.338 |
| 168 | Ehlers-Danlos syndrome | 1.062 |
| 79 | Homozygous familial hypercholesterolemia | 1.062 |
| 256 | Muscle glycogenosis | 1.025 |
| 106 | Cryopyrin-associated periodic syndrome | 1.021 |
| 333 | Hutchinson-Gilford syndrome | 1.021 |
| 238 | Vitamin D-resistant rickets | 1.021 |
| 72 | Pituitary ADH secretion disorder | 1.021 |
| 235 | Hypoparathyroidism | 1.021 |
| 71 | Idiopathic osteonecrosis of the femoral head | 1.021 |
| 3 | Spinal muscular atrophy | 1.012 |
| 232 | Carney complex | 1.000 |
| 111 | Congenital myopathy | 1.000 |
| 317 | Trifunctional protein deficiency | 1.000 |
| 191 | Werner syndrome | 1.000 |
| 290 | Chronic nonspecific multiple ulcers of the small intestine | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |