34. Neurofibromatosis Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 165 / Drugs : 189 - (DrugBank : 83) / Drug target genes : 93 - Drug target pathways : 209
Neurofibromatosis and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 34 | Neurofibromatosis | - |
| 13 | Multiple sclerosis | 38.953 |
| 46 | Malignant rheumatoid arthritis | 38.221 |
| 2 | Amyotrophic lateral sclerosis | 32.488 |
| 6 | Parkinson disease | 26.227 |
| 331 | Idiopathic multicentric castleman disease | 23.060 |
| 28 | Systemic amyloidosis | 22.759 |
| 51 | Scleroderma | 22.698 |
| 84 | Sarcoidosis | 21.876 |
| 85 | Idiopathic interstitial pneumonia | 21.476 |
| 96 | Crohn disease | 21.439 |
| 5 | Progressive supranuclear palsy | 18.292 |
| 8 | Huntington disease | 17.365 |
| 231 | Alpha-1-antitrypsin deficiency | 17.199 |
| 22 | Moyamoya disease | 17.017 |
| 298 | Hereditary pancreatitis | 16.713 |
| 97 | Ulcerative colitis | 16.297 |
| 152 | PCDH19 related syndrome | 16.000 |
| 65 | Primary immunodeficiency | 15.896 |
| 158 | Tuberous sclerosis | 15.895 |
| 3 | Spinal muscular atrophy | 15.588 |
| 36 | Epidermolysis bullosa | 15.133 |
| 26 | HTLV-1-associated myelopathy | 15.079 |
| 70 | Spinal stenosis | 14.952 |
| 89 | Lymphangioleiomyomatosis | 14.600 |
| 21 | Mitochondrial disease | 14.360 |
| 206 | Fragile X syndrome | 14.345 |
| 193 | Prader-Willi syndrome | 13.711 |
| 18 | Spinocerebellar degeneration | 12.503 |
| 201 | Angelman syndrome | 12.439 |
| 272 | Fibrodysplasia ossificans progressiva | 12.265 |
| 140 | Dorabe syndrome | 12.039 |
| 256 | Muscle glycogenosis | 12.013 |
| 145 | West syndrome | 11.934 |
| 144 | Lennox-Gastaut syndrome | 11.897 |
| 205 | Fragile X syndrome related disease | 11.299 |
| 156 | Rett syndrome | 11.134 |
| 98 | Eosinophilic gastro-intestinal disorder | 11.031 |
| 86 | Pulmonary arterial hypertension | 10.792 |
| 17 | Multiple system atrophy | 10.553 |
| 155 | Acquired aphasia with convulsive disorder | 10.147 |
| 56 | Behcet disease | 9.781 |
| 296 | Biliary atresia | 9.434 |
| 266 | Familial mediterranean fever | 8.941 |
| 75 | Cushing disease | 8.700 |
| 58 | Hypertrophic cardiomyopathy | 8.166 |
| 49 | Systemic lupus erythematosus | 8.004 |
| 42 | Polyarteritis nodosa | 7.471 |
| 113 | Muscular dystrophy | 7.263 |
| 222 | Primary nephrotic syndrome | 7.134 |
| 102 | Rubinstein-Taybi syndrome | 7.000 |
| 107 | Juvenile idiopathic arthritis | 6.960 |
| 228 | Bronchiolitis obliterans | 6.299 |
| 280 | Huge arteriovenous malformation with cervicofacial or limb lesion | 6.118 |
| 127 | Frontotemporal lobar degeneration | 5.536 |
| 164 | Oculocutaneous albinism | 5.306 |
| 93 | Primary biliary cholangitis | 5.202 |
| 35 | Pemphigus | 5.172 |
| 210 | Single Ventricle | 4.694 |
| 233 | Wolfram syndrome | 4.659 |
| 87 | Pulmonary veno-occlusive disease | 4.000 |
| 226 | Interstitial cystitis with Hunners ulcer | 3.595 |
| 38 | Stevens-Johnson syndrome | 3.567 |
| 90 | Retinitis pigmentosa | 3.548 |
| 227 | Osler disease | 3.262 |
| 11 | Myasthenia gravis | 3.116 |
| 279 | Huge venous malformation with cervical, oral and pharyngeal diffuse lesion | 3.000 |
| 171 | Wilson disease | 3.000 |
| 323 | Aromatic L-amino acid decarboxylase deficiency | 3.000 |
| 168 | Ehlers-Danlos syndrome | 2.905 |
| 1 | Spinal and bulbar muscular atrophy | 2.644 |
| 162 | Pemphigoid | 2.497 |
| 50 | Dermatomyositis | 2.444 |
| 10 | Charcot-Marie-Tooth disease | 2.429 |
| 215 | Tetralogy of Fallot | 2.276 |
| 333 | Hutchinson-Gilford syndrome | 2.276 |
| 53 | Sjogren syndrome | 2.251 |
| 60 | Aplastic anemia | 2.119 |
| 337 | Homocystinuria | 2.000 |
| 41 | Giant cell arteritis | 1.929 |
| 67 | Polycystic kidney disease | 1.749 |
| 149 | Hemiconvulsion hemiplegia epilepsy syndrome | 1.673 |
| 271 | Ankylosing spondylitis | 1.662 |
| 114 | Non-dystrophic myotonia syndrome | 1.596 |
| 270 | Chronic recurrent multifocal osteomyelitis | 1.552 |
| 88 | Chronic thromboembolic pulmonary hypertension | 1.358 |
| 172 | Hypophosphatasia | 1.349 |
| 25 | Progressive multifocal leukoencephalopathy | 1.345 |
| 118 | Myelomeningocele | 1.190 |
| 212 | Tricuspid atresia | 1.190 |
| 78 | Hypopituitarism | 1.176 |
| 285 | Fanconi anemia | 1.073 |
| 169 | Menkes disease | 1.069 |
| 170 | Occipital horn syndrome | 1.069 |
| 283 | Acquired pure red cell aplasia | 1.032 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 1.032 |
| 288 | Autoimmune acquired coagulation factor deficiency | 1.032 |
| 106 | Cryopyrin-associated periodic syndrome | 1.023 |
| 251 | Urea cycle disorder | 1.023 |
| 137 | Focal cortical dysplasia | 1.000 |
| 192 | Cockayne syndrome | 1.000 |
| 277 | Lymphangiomatosis | 1.000 |
| 281 | Klippel-Trenaunay-Weber syndrome | 1.000 |
| 108 | TNF receptor-associated periodic syndrome | 1.000 |
| 267 | Hyper-IgD syndrome | 1.000 |