DR info

Clinical trials : 133 / Drugs : 186 - (DrugBank : 67) / Drug target genes : 79 - Drug target pathways : 190

Neurofibromatosis and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
34	Neurofibromatosis	-
13	Multiple sclerosis/Neuromyelitis optica	38.953
46	Malignant rheumatoid arthritis	38.221
2	Amyotrophic lateral sclerosis	32.488
6	Parkinson disease	26.227
331	Idiopathic multicentric castleman disease	23.060
28	Systemic amyloidosis	22.759
51	Scleroderma	22.698
84	Sarcoidosis	21.876
85	Idiopathic interstitial pneumonia	21.476
96	Crohn disease	21.439
5	Progressive supranuclear palsy	18.292
8	Huntington disease	17.365
231	Alpha-1-antitrypsin deficiency	17.199
22	Moyamoya disease	17.017
298	Hereditary pancreatitis	16.713
97	Ulcerative colitis	16.297
152	PCDH19 related syndrome	16.000
65	Primary immunodeficiency	15.896
158	Tuberous sclerosis	15.895
3	Spinal muscular atrophy	15.588
36	Epidermolysis bullosa	15.133
26	HTLV-1-associated myelopathy	15.079
70	Spinal stenosis	14.952
89	Lymphangioleiomyomatosis	14.600
21	Mitochondrial disease	14.360
206	Fragile X syndrome	14.345
193	Prader-Willi syndrome	13.711
18	Spinocerebellar degeneration	12.503
201	Angelman syndrome	12.439
272	Fibrodysplasia ossificans progressiva	12.265
140	Dorabe syndrome	12.039
256	Muscle glycogenosis	12.013
145	West syndrome	11.934
144	Lennox-Gastaut syndrome	11.897
205	Fragile X syndrome related disease	11.299
156	Rett syndrome	11.134
98	Eosinophilic gastrointestinal disease	11.031
86	Pulmonary arterial hypertension	10.792
17	Multiple system atrophy	10.553
155	Acquired aphasia with convulsive disorder	10.147
56	Behcet disease	9.781
296	Biliary atresia	9.434
266	Familial mediterranean fever	8.941
75	Cushing disease	8.700
58	Hypertrophic cardiomyopathy	8.166
49	Systemic lupus erythematosus	8.004
42	Polyarteritis nodosa	7.471
113	Muscular dystrophy	7.263
222	Primary nephrotic syndrome	7.134
102	Rubinstein-Taybi syndrome	7.000
107	Juvenile idiopathic arthritis	6.960
228	Bronchiolitis obliterans	6.299
280	Huge arteriovenous malformation with cervicofacial or limb lesion	6.118
127	Frontotemporal lobar degeneration	5.536
164	Oculocutaneous albinism	5.306
93	Primary biliary cholangitis	5.202
35	Pemphigus	5.172
210	Single Ventricle	4.694
233	Wolfram syndrome	4.659
87	Pulmonary veno-occlusive disease	4.000
226	Interstitial cystitis with Hunners ulcer	3.595
38	Stevens-Johnson syndrome	3.567
90	Retinitis pigmentosa	3.548
227	Osler disease	3.262
11	Myasthenia gravis	3.116
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion	3.000
171	Wilson disease	3.000
323	Aromatic L-amino acid decarboxylase deficiency	3.000
168	Ehlers-Danlos syndrome	2.905
1	Spinal and bulbar muscular atrophy	2.644
162	Pemphigoid	2.497
50	Dermatomyositis	2.444
10	Charcot-Marie-Tooth disease	2.429
215	Tetralogy of Fallot	2.276
333	Hutchinson-Gilford syndrome	2.276
53	Sjogren syndrome	2.251
60	Aplastic anemia	2.119
337	Homocystinuria	2.000
41	Giant cell arteritis	1.929
67	Polycystic kidney disease	1.749
149	Hemiconvulsion hemiplegia epilepsy syndrome	1.673
271	Ankylosing spondylitis	1.662
114	Non-dystrophic myotonia syndrome	1.596
270	Chronic recurrent multifocal osteomyelitis	1.552
88	Chronic thromboembolic pulmonary hypertension	1.358
172	Hypophosphatasia	1.349
25	Progressive multifocal leukoencephalopathy	1.345
118	Myelomeningocele	1.190
212	Tricuspid atresia	1.190
78	Hypopituitarism	1.176
285	Fanconi anemia	1.073
169	Menkes disease	1.069
170	Occipital horn syndrome	1.069
283	Acquired pure red cell aplasia	1.032
45	Eosinophilic granulomatosis with Polyangiitis	1.032
288	Autoimmune acquired coagulation factor deficiency	1.032
106	Cryopyrin-associated periodic syndrome	1.023
251	Urea cycle disorder	1.023
137	Focal cortical dysplasia	1.000
192	Cockayne syndrome	1.000
277	Lymphangiomatosis	1.000
281	Klippel-Trenaunay-Weber syndrome	1.000
108	TNF receptor-associated periodic syndrome	1.000
267	Hyper-IgD syndrome	1.000