36. Epidermolysis bullosa Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 183 / Drugs : 159 - (DrugBank : 51) / Drug target genes : 69 - Drug target pathways : 147
Epidermolysis bullosa and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 36 | Epidermolysis bullosa | - |
| 13 | Multiple sclerosis | 41.948 |
| 46 | Malignant rheumatoid arthritis | 38.959 |
| 96 | Crohn disease | 31.399 |
| 6 | Parkinson disease | 31.194 |
| 2 | Amyotrophic lateral sclerosis | 27.035 |
| 97 | Ulcerative colitis | 24.711 |
| 298 | Hereditary pancreatitis | 23.640 |
| 158 | Tuberous sclerosis | 21.501 |
| 231 | Alpha-1-antitrypsin deficiency | 20.152 |
| 70 | Spinal stenosis | 19.837 |
| 84 | Sarcoidosis | 17.666 |
| 193 | Prader-Willi syndrome | 17.517 |
| 140 | Dorabe syndrome | 16.644 |
| 144 | Lennox-Gastaut syndrome | 16.524 |
| 152 | PCDH19 related syndrome | 16.000 |
| 34 | Neurofibromatosis | 15.133 |
| 156 | Rett syndrome | 14.441 |
| 145 | West syndrome | 14.204 |
| 8 | Huntington disease | 14.138 |
| 201 | Angelman syndrome | 13.061 |
| 98 | Eosinophilic gastro-intestinal disorder | 12.758 |
| 205 | Fragile X syndrome related disease | 12.121 |
| 17 | Multiple system atrophy | 12.044 |
| 75 | Cushing disease | 11.982 |
| 272 | Fibrodysplasia ossificans progressiva | 11.856 |
| 22 | Moyamoya disease | 11.382 |
| 51 | Scleroderma | 11.230 |
| 155 | Acquired aphasia with convulsive disorder | 11.170 |
| 296 | Biliary atresia | 11.167 |
| 18 | Spinocerebellar degeneration | 11.167 |
| 206 | Fragile X syndrome | 10.408 |
| 38 | Stevens-Johnson syndrome | 10.188 |
| 53 | Sjogren syndrome | 9.329 |
| 21 | Mitochondrial disease | 8.893 |
| 5 | Progressive supranuclear palsy | 8.802 |
| 19 | Lysosomal storage disease | 8.633 |
| 3 | Spinal muscular atrophy | 8.477 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 8.117 |
| 226 | Interstitial cystitis with Hunners ulcer | 7.918 |
| 283 | Acquired pure red cell aplasia | 7.683 |
| 85 | Idiopathic interstitial pneumonia | 6.966 |
| 28 | Systemic amyloidosis | 6.957 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 6.463 |
| 113 | Muscular dystrophy | 6.373 |
| 39 | Toxic epidermal necrolysis | 6.174 |
| 49 | Systemic lupus erythematosus | 5.961 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 5.769 |
| 284 | Diamond-Blackfan anemia | 5.659 |
| 285 | Fanconi anemia | 5.597 |
| 60 | Aplastic anemia | 5.528 |
| 61 | Autoimmune hemolytic anemia | 5.224 |
| 66 | IgA nephropathy | 5.150 |
| 95 | Autoimmune hepatitis | 5.133 |
| 42 | Polyarteritis nodosa | 5.102 |
| 107 | Juvenile idiopathic arthritis | 5.030 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 224 | Purpura nephritis | 4.876 |
| 65 | Primary immunodeficiency | 4.829 |
| 286 | Hereditary sideroblastic anemia | 4.684 |
| 20 | Adrenoleukodystrophy | 4.659 |
| 162 | Pemphigoid | 4.453 |
| 228 | Bronchiolitis obliterans | 4.453 |
| 41 | Giant cell arteritis | 4.453 |
| 58 | Hypertrophic cardiomyopathy | 4.424 |
| 164 | Oculocutaneous albinism | 4.382 |
| 160 | Congenital ichthyosis | 4.281 |
| 151 | Rasmussen encephalitis | 4.252 |
| 168 | Ehlers-Danlos syndrome | 4.245 |
| 11 | Myasthenia gravis | 3.810 |
| 326 | Osteopetrosis | 3.625 |
| 10 | Charcot-Marie-Tooth disease | 3.607 |
| 40 | Takayasu arteritis | 3.448 |
| 55 | Relapsing polychondritis | 3.367 |
| 222 | Primary nephrotic syndrome | 3.346 |
| 63 | Idiopathic thrombocytopenic purpura | 3.122 |
| 256 | Muscle glycogenosis | 3.034 |
| 274 | Osteogenesis Imperfecta | 2.991 |
| 299 | Cystic fibrosis | 2.870 |
| 269 | Pyogenic arthritis | 2.841 |
| 86 | Pulmonary arterial hypertension | 2.837 |
| 93 | Primary biliary cholangitis | 2.836 |
| 1 | Spinal and bulbar muscular atrophy | 2.755 |
| 64 | Thrombotic thrombocytopenic purpura | 2.709 |
| 50 | Dermatomyositis | 2.422 |
| 94 | Primary sclerosing cholangitis | 2.397 |
| 56 | Behcet disease | 2.167 |
| 227 | Osler disease | 2.108 |
| 26 | HTLV-1-associated myelopathy | 2.105 |
| 127 | Frontotemporal lobar degeneration | 2.050 |
| 157 | Sturge-Weber syndrome | 1.873 |
| 90 | Retinitis pigmentosa | 1.857 |
| 114 | Non-dystrophic myotonia syndrome | 1.757 |
| 35 | Pemphigus | 1.531 |
| 271 | Ankylosing spondylitis | 1.505 |
| 43 | Microscopic polyangiitis | 1.376 |
| 37 | Generalised pustular psoriasis | 1.061 |
| 44 | Wegener granulomatosis | 1.026 |
| 137 | Focal cortical dysplasia | 1.000 |
| 192 | Cockayne syndrome | 1.000 |
| 277 | Lymphangiomatosis | 1.000 |
| 281 | Klippel-Trenaunay-Weber syndrome | 1.000 |
| 52 | Mixed connective tissue disease | 1.000 |