4. Primary lateral sclerosis Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 7 / Drugs : 20 - (DrugBank : 5) / Drug target genes : 16 - Drug target pathways : 28
Primary lateral sclerosis and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 4 | Primary lateral sclerosis | - |
| 6 | Parkinson disease | 19.000 |
| 2 | Amyotrophic lateral sclerosis | 12.118 |
| 13 | Multiple sclerosis/Neuromyelitis optica | 12.020 |
| 17 | Multiple system atrophy | 11.161 |
| 8 | Huntington disease | 6.975 |
| 206 | Fragile X syndrome | 6.140 |
| 5 | Progressive supranuclear palsy | 5.992 |
| 215 | Tetralogy of Fallot | 5.427 |
| 21 | Mitochondrial disease | 5.170 |
| 90 | Retinitis pigmentosa | 5.133 |
| 3 | Spinal muscular atrophy | 5.068 |
| 70 | Spinal stenosis | 4.909 |
| 46 | Malignant rheumatoid arthritis | 4.494 |
| 78 | Hypopituitarism | 4.211 |
| 309 | Progressive myoclonus epilepsy | 4.000 |
| 113 | Muscular dystrophy | 3.996 |
| 96 | Crohn disease | 3.589 |
| 12 | Congenital myasthenic syndrome | 3.368 |
| 7 | Corticobasal degeneration | 3.363 |
| 127 | Frontotemporal lobar degeneration | 3.353 |
| 11 | Myasthenia gravis | 3.267 |
| 201 | Angelman syndrome | 3.014 |
| 323 | Aromatic L-amino acid decarboxylase deficiency | 3.000 |
| 97 | Ulcerative colitis | 2.795 |
| 203 | 22q11.2 deletion syndrome | 2.632 |
| 164 | Oculocutaneous albinism | 2.619 |
| 74 | Prolactin secreting pituitary adenoma | 2.467 |
| 140 | Dorabe syndrome | 2.408 |
| 156 | Rett syndrome | 2.215 |
| 205 | Fragile X syndrome related disease | 2.053 |
| 14 | Chronic inflammatory demyelinating polyneuropathy | 1.895 |
| 18 | Spinocerebellar degeneration | 1.725 |
| 299 | Cystic fibrosis | 1.508 |
| 254 | Porphyria | 1.507 |
| 85 | Idiopathic interstitial pneumonia | 1.502 |
| 49 | Systemic lupus erythematosus | 1.477 |
| 212 | Tricuspid atresia | 1.421 |
| 118 | Myelomeningocele | 1.421 |
| 169 | Menkes disease | 1.316 |
| 170 | Occipital horn syndrome | 1.316 |
| 280 | Huge arteriovenous malformation with cervicofacial or limb lesion | 1.015 |