49. Systemic lupus erythematosus Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 1,227 / Drugs : 752 - (DrugBank : 175) / Drug target genes : 130 - Drug target pathways : 207
Systemic lupus erythematosus and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 49 | Systemic lupus erythematosus | - |
| 46 | Malignant rheumatoid arthritis | 70.556 |
| 13 | Multiple sclerosis | 46.335 |
| 96 | Crohn disease | 40.532 |
| 65 | Primary immunodeficiency | 37.524 |
| 97 | Ulcerative colitis | 34.003 |
| 93 | Primary biliary cholangitis | 30.027 |
| 51 | Scleroderma | 29.731 |
| 56 | Behcet disease | 27.865 |
| 2 | Amyotrophic lateral sclerosis | 26.925 |
| 53 | Sjogren syndrome | 26.180 |
| 60 | Aplastic anemia | 22.307 |
| 50 | Dermatomyositis | 21.711 |
| 42 | Polyarteritis nodosa | 20.882 |
| 66 | IgA nephropathy | 20.839 |
| 85 | Idiopathic interstitial pneumonia | 20.325 |
| 11 | Myasthenia gravis | 20.020 |
| 40 | Takayasu arteritis | 19.869 |
| 41 | Giant cell arteritis | 18.833 |
| 285 | Fanconi anemia | 18.716 |
| 28 | Systemic amyloidosis | 17.943 |
| 107 | Juvenile idiopathic arthritis | 17.094 |
| 222 | Primary nephrotic syndrome | 16.573 |
| 26 | HTLV-1-associated myelopathy | 15.753 |
| 19 | Lysosomal storage disease | 15.449 |
| 271 | Ankylosing spondylitis | 14.940 |
| 113 | Muscular dystrophy | 14.774 |
| 162 | Pemphigoid | 14.770 |
| 283 | Acquired pure red cell aplasia | 14.472 |
| 284 | Diamond-Blackfan anemia | 13.713 |
| 35 | Pemphigus | 13.713 |
| 6 | Parkinson disease | 13.668 |
| 331 | Idiopathic multicentric castleman disease | 12.871 |
| 61 | Autoimmune hemolytic anemia | 12.371 |
| 84 | Sarcoidosis | 12.294 |
| 55 | Relapsing polychondritis | 12.000 |
| 37 | Generalised pustular psoriasis | 11.743 |
| 300 | IgG4-related disease | 11.464 |
| 299 | Cystic fibrosis | 11.365 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 11.278 |
| 160 | Congenital ichthyosis | 11.271 |
| 95 | Autoimmune hepatitis | 10.768 |
| 266 | Familial mediterranean fever | 10.466 |
| 210 | Single Ventricle | 10.220 |
| 44 | Wegener granulomatosis | 9.906 |
| 269 | Pyogenic arthritis | 9.853 |
| 224 | Purpura nephritis | 9.853 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 9.801 |
| 86 | Pulmonary arterial hypertension | 9.600 |
| 20 | Adrenoleukodystrophy | 9.534 |
| 228 | Bronchiolitis obliterans | 8.914 |
| 63 | Idiopathic thrombocytopenic purpura | 8.905 |
| 164 | Oculocutaneous albinism | 8.718 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 8.480 |
| 78 | Hypopituitarism | 8.124 |
| 34 | Neurofibromatosis | 8.004 |
| 286 | Hereditary sideroblastic anemia | 8.000 |
| 64 | Thrombotic thrombocytopenic purpura | 7.894 |
| 326 | Osteopetrosis | 7.894 |
| 39 | Toxic epidermal necrolysis | 7.493 |
| 256 | Muscle glycogenosis | 7.265 |
| 226 | Interstitial cystitis with Hunners ulcer | 6.377 |
| 43 | Microscopic polyangiitis | 6.039 |
| 151 | Rasmussen encephalitis | 6.000 |
| 83 | Addison disease | 6.000 |
| 36 | Epidermolysis bullosa | 5.961 |
| 158 | Tuberous sclerosis | 5.760 |
| 94 | Primary sclerosing cholangitis | 5.679 |
| 25 | Progressive multifocal leukoencephalopathy | 5.188 |
| 16 | Crow-Fukase syndrome | 5.000 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 38 | Stevens-Johnson syndrome | 4.529 |
| 75 | Cushing disease | 4.492 |
| 8 | Huntington disease | 4.300 |
| 270 | Chronic recurrent multifocal osteomyelitis | 4.203 |
| 76 | Pituitary gonadotropin secretion hyperthyroidism | 4.203 |
| 227 | Osler disease | 3.954 |
| 127 | Frontotemporal lobar degeneration | 3.795 |
| 274 | Osteogenesis Imperfecta | 3.715 |
| 206 | Fragile X syndrome | 3.649 |
| 265 | Lipodystrophy | 3.580 |
| 18 | Spinocerebellar degeneration | 3.491 |
| 15 | Inclusion body myositis | 3.416 |
| 17 | Multiple system atrophy | 3.375 |
| 90 | Retinitis pigmentosa | 3.293 |
| 81 | Congenital adrenal hyperplasia | 3.158 |
| 3 | Spinal muscular atrophy | 3.124 |
| 21 | Mitochondrial disease | 2.818 |
| 58 | Hypertrophic cardiomyopathy | 2.778 |
| 251 | Urea cycle disorder | 2.270 |
| 91 | Budd-Chiari syndrome | 2.270 |
| 202 | Smith-Magenis syndrome | 2.270 |
| 205 | Fragile X syndrome related disease | 2.269 |
| 70 | Spinal stenosis | 2.259 |
| 14 | Chronic inflammatory demyelinating polyneuropathy | 2.211 |
| 215 | Tetralogy of Fallot | 2.211 |
| 77 | Growth hormone secreting pituitary adenoma | 2.000 |
| 268 | Nakajo-Nishimura syndrome | 2.000 |
| 325 | Hereditary autoinflammatory syndrome | 2.000 |
| 337 | Homocystinuria | 2.000 |
| 257 | Hepatic glycogenosis | 2.000 |
| 139 | Congenital cerebral hypomyelination | 2.000 |
| 120 | Hereditary dystonia | 2.000 |
| 203 | 22q11.2 deletion syndrome | 1.927 |
| 5 | Progressive supranuclear palsy | 1.858 |
| 278 | Huge lymphatic malformation with cervicofacial lesion | 1.832 |
| 211 | Hypoplastic left heart syndrome | 1.832 |
| 159 | Xeroderma pigmentosum | 1.832 |
| 156 | Rett syndrome | 1.679 |
| 98 | Eosinophilic gastro-intestinal disorder | 1.552 |
| 288 | Autoimmune acquired coagulation factor deficiency | 1.547 |
| 218 | Alport syndrome | 1.539 |
| 4 | Primary lateral sclerosis | 1.477 |
| 225 | Congenital nephrogenic diabetes insipidus | 1.453 |
| 296 | Biliary atresia | 1.452 |
| 171 | Wilson disease | 1.345 |
| 229 | Autoimmune pulmonary alveolar proteinosis | 1.345 |
| 172 | Hypophosphatasia | 1.345 |
| 80 | Resistance to thyroid hormone | 1.345 |
| 88 | Chronic thromboembolic pulmonary hypertension | 1.328 |
| 298 | Hereditary pancreatitis | 1.298 |
| 67 | Polycystic kidney disease | 1.213 |
| 212 | Tricuspid atresia | 1.174 |
| 89 | Lymphangioleiomyomatosis | 1.105 |
| 145 | West syndrome | 1.105 |
| 79 | Homozygous familial hypercholesterolemia | 1.053 |
| 301 | Macular dystrophy | 1.053 |
| 57 | Idiopathic dilated cardiomyopathy | 1.053 |
| 106 | Cryopyrin-associated periodic syndrome | 1.018 |
| 333 | Hutchinson-Gilford syndrome | 1.018 |
| 235 | Hypoparathyroidism | 1.018 |
| 137 | Focal cortical dysplasia | 1.000 |
| 192 | Cockayne syndrome | 1.000 |
| 277 | Lymphangiomatosis | 1.000 |
| 281 | Klippel-Trenaunay-Weber syndrome | 1.000 |
| 111 | Congenital myopathy | 1.000 |
| 54 | Adult still disease | 1.000 |
| 260 | Sitosterolemia | 1.000 |
| 52 | Mixed connective tissue disease | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |