51. Scleroderma Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 639 / Drugs : 551 - (DrugBank : 157) / Drug target genes : 135 - Drug target pathways : 222
Scleroderma and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 51 | Scleroderma | - |
| 46 | Malignant rheumatoid arthritis | 49.603 |
| 85 | Idiopathic interstitial pneumonia | 45.016 |
| 13 | Multiple sclerosis | 44.136 |
| 49 | Systemic lupus erythematosus | 29.731 |
| 96 | Crohn disease | 29.342 |
| 28 | Systemic amyloidosis | 26.066 |
| 65 | Primary immunodeficiency | 25.644 |
| 50 | Dermatomyositis | 24.354 |
| 42 | Polyarteritis nodosa | 24.251 |
| 2 | Amyotrophic lateral sclerosis | 24.006 |
| 97 | Ulcerative colitis | 23.361 |
| 84 | Sarcoidosis | 23.344 |
| 228 | Bronchiolitis obliterans | 23.264 |
| 34 | Neurofibromatosis | 22.698 |
| 86 | Pulmonary arterial hypertension | 22.363 |
| 93 | Primary biliary cholangitis | 20.853 |
| 107 | Juvenile idiopathic arthritis | 20.677 |
| 6 | Parkinson disease | 20.573 |
| 41 | Giant cell arteritis | 20.280 |
| 56 | Behcet disease | 19.051 |
| 53 | Sjogren syndrome | 18.809 |
| 222 | Primary nephrotic syndrome | 18.802 |
| 11 | Myasthenia gravis | 17.548 |
| 271 | Ankylosing spondylitis | 17.402 |
| 226 | Interstitial cystitis with Hunners ulcer | 17.211 |
| 58 | Hypertrophic cardiomyopathy | 16.825 |
| 162 | Pemphigoid | 16.094 |
| 164 | Oculocutaneous albinism | 15.747 |
| 40 | Takayasu arteritis | 15.207 |
| 285 | Fanconi anemia | 14.513 |
| 283 | Acquired pure red cell aplasia | 14.474 |
| 331 | Idiopathic multicentric castleman disease | 14.159 |
| 284 | Diamond-Blackfan anemia | 13.718 |
| 38 | Stevens-Johnson syndrome | 13.182 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 12.832 |
| 44 | Wegener granulomatosis | 12.730 |
| 60 | Aplastic anemia | 12.451 |
| 35 | Pemphigus | 12.254 |
| 55 | Relapsing polychondritis | 12.000 |
| 256 | Muscle glycogenosis | 11.654 |
| 36 | Epidermolysis bullosa | 11.230 |
| 26 | HTLV-1-associated myelopathy | 11.097 |
| 70 | Spinal stenosis | 11.065 |
| 299 | Cystic fibrosis | 10.601 |
| 227 | Osler disease | 10.475 |
| 266 | Familial mediterranean fever | 10.468 |
| 89 | Lymphangioleiomyomatosis | 10.404 |
| 113 | Muscular dystrophy | 9.988 |
| 300 | IgG4-related disease | 9.855 |
| 298 | Hereditary pancreatitis | 9.751 |
| 66 | IgA nephropathy | 9.572 |
| 43 | Microscopic polyangiitis | 8.872 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 8.617 |
| 269 | Pyogenic arthritis | 8.352 |
| 224 | Purpura nephritis | 8.352 |
| 210 | Single Ventricle | 8.089 |
| 95 | Autoimmune hepatitis | 8.048 |
| 286 | Hereditary sideroblastic anemia | 8.000 |
| 88 | Chronic thromboembolic pulmonary hypertension | 7.897 |
| 19 | Lysosomal storage disease | 7.547 |
| 61 | Autoimmune hemolytic anemia | 7.478 |
| 63 | Idiopathic thrombocytopenic purpura | 7.149 |
| 160 | Congenital ichthyosis | 7.139 |
| 20 | Adrenoleukodystrophy | 7.125 |
| 274 | Osteogenesis Imperfecta | 6.042 |
| 151 | Rasmussen encephalitis | 6.000 |
| 10 | Charcot-Marie-Tooth disease | 5.973 |
| 39 | Toxic epidermal necrolysis | 5.973 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 5.522 |
| 64 | Thrombotic thrombocytopenic purpura | 5.376 |
| 326 | Osteopetrosis | 5.376 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 294 | Congenital diaphragmatic hernia | 5.000 |
| 8 | Huntington disease | 4.314 |
| 47 | Buerger disease | 4.204 |
| 158 | Tuberous sclerosis | 4.191 |
| 168 | Ehlers-Danlos syndrome | 4.106 |
| 67 | Polycystic kidney disease | 3.945 |
| 90 | Retinitis pigmentosa | 3.901 |
| 1 | Spinal and bulbar muscular atrophy | 3.727 |
| 94 | Primary sclerosing cholangitis | 3.696 |
| 140 | Dorabe syndrome | 3.346 |
| 16 | Crow-Fukase syndrome | 3.228 |
| 211 | Hypoplastic left heart syndrome | 3.228 |
| 193 | Prader-Willi syndrome | 3.212 |
| 225 | Congenital nephrogenic diabetes insipidus | 3.202 |
| 156 | Rett syndrome | 2.946 |
| 265 | Lipodystrophy | 2.854 |
| 231 | Alpha-1-antitrypsin deficiency | 2.847 |
| 21 | Mitochondrial disease | 2.824 |
| 144 | Lennox-Gastaut syndrome | 2.745 |
| 124 | Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy | 2.714 |
| 127 | Frontotemporal lobar degeneration | 2.581 |
| 78 | Hypopituitarism | 2.411 |
| 87 | Pulmonary veno-occlusive disease | 2.270 |
| 251 | Urea cycle disorder | 2.270 |
| 81 | Congenital adrenal hyperplasia | 2.212 |
| 288 | Autoimmune acquired coagulation factor deficiency | 2.212 |
| 98 | Eosinophilic gastro-intestinal disorder | 2.017 |
| 268 | Nakajo-Nishimura syndrome | 2.000 |
| 325 | Hereditary autoinflammatory syndrome | 2.000 |
| 337 | Homocystinuria | 2.000 |
| 282 | Congenital dyserythropoietic anemia | 2.000 |
| 280 | Huge arteriovenous malformation with cervicofacial or limb lesion | 1.928 |
| 7 | Corticobasal degeneration | 1.856 |
| 276 | Achondroplasia | 1.832 |
| 167 | Marfan syndrome | 1.685 |
| 272 | Fibrodysplasia ossificans progressiva | 1.630 |
| 114 | Non-dystrophic myotonia syndrome | 1.549 |
| 15 | Inclusion body myositis | 1.545 |
| 270 | Chronic recurrent multifocal osteomyelitis | 1.540 |
| 218 | Alport syndrome | 1.540 |
| 310 | Congenital anomalies syndrome | 1.345 |
| 172 | Hypophosphatasia | 1.345 |
| 25 | Progressive multifocal leukoencephalopathy | 1.331 |
| 75 | Cushing disease | 1.175 |
| 212 | Tricuspid atresia | 1.175 |
| 5 | Progressive supranuclear palsy | 1.141 |
| 74 | Prolactin secreting pituitary adenoma | 1.106 |
| 296 | Biliary atresia | 1.076 |
| 79 | Homozygous familial hypercholesterolemia | 1.053 |
| 106 | Cryopyrin-associated periodic syndrome | 1.018 |
| 235 | Hypoparathyroidism | 1.018 |
| 71 | Idiopathic osteonecrosis of the femoral head | 1.018 |
| 137 | Focal cortical dysplasia | 1.000 |
| 192 | Cockayne syndrome | 1.000 |
| 277 | Lymphangiomatosis | 1.000 |
| 281 | Klippel-Trenaunay-Weber syndrome | 1.000 |
| 232 | Carney complex | 1.000 |
| 108 | TNF receptor-associated periodic syndrome | 1.000 |
| 267 | Hyper-IgD syndrome | 1.000 |
| 99 | Chronic intestinal pseudo-obstruction | 1.000 |
| 317 | Trifunctional protein deficiency | 1.000 |
| 54 | Adult still disease | 1.000 |
| 52 | Mixed connective tissue disease | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |