58. Hypertrophic cardiomyopathy Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 227 / Drugs : 219 - (DrugBank : 49) / Drug target genes : 51 - Drug target pathways : 190
Hypertrophic cardiomyopathy and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 58 | Hypertrophic cardiomyopathy | - |
| 13 | Multiple sclerosis/Neuromyelitis optica | 22.617 |
| 46 | Malignant rheumatoid arthritis | 20.574 |
| 6 | Parkinson disease | 19.292 |
| 51 | Scleroderma | 16.825 |
| 86 | Pulmonary arterial hypertension | 16.016 |
| 96 | Crohn disease | 15.928 |
| 97 | Ulcerative colitis | 12.948 |
| 113 | Muscular dystrophy | 12.288 |
| 222 | Primary nephrotic syndrome | 12.158 |
| 2 | Amyotrophic lateral sclerosis | 10.630 |
| 226 | Interstitial cystitis with Hunners ulcer | 9.914 |
| 85 | Idiopathic interstitial pneumonia | 9.724 |
| 28 | Systemic amyloidosis | 8.849 |
| 38 | Stevens-Johnson syndrome | 8.739 |
| 107 | Juvenile idiopathic arthritis | 8.615 |
| 34 | Neurofibromatosis | 8.166 |
| 50 | Dermatomyositis | 7.910 |
| 164 | Oculocutaneous albinism | 7.145 |
| 70 | Spinal stenosis | 7.031 |
| 84 | Sarcoidosis | 6.574 |
| 65 | Primary immunodeficiency | 6.406 |
| 299 | Cystic fibrosis | 6.299 |
| 151 | Rasmussen encephalitis | 6.000 |
| 298 | Hereditary pancreatitis | 5.846 |
| 67 | Polycystic kidney disease | 5.842 |
| 127 | Frontotemporal lobar degeneration | 5.700 |
| 168 | Ehlers-Danlos syndrome | 5.671 |
| 228 | Bronchiolitis obliterans | 5.347 |
| 167 | Marfan syndrome | 5.206 |
| 90 | Retinitis pigmentosa | 5.204 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 256 | Muscle glycogenosis | 4.637 |
| 11 | Myasthenia gravis | 4.594 |
| 36 | Epidermolysis bullosa | 4.424 |
| 57 | Idiopathic dilated cardiomyopathy | 4.250 |
| 53 | Sjogren syndrome | 4.217 |
| 269 | Pyogenic arthritis | 3.811 |
| 224 | Purpura nephritis | 3.811 |
| 227 | Osler disease | 3.652 |
| 193 | Prader-Willi syndrome | 3.636 |
| 39 | Toxic epidermal necrolysis | 3.614 |
| 66 | IgA nephropathy | 3.568 |
| 158 | Tuberous sclerosis | 3.568 |
| 26 | HTLV-1-associated myelopathy | 3.419 |
| 272 | Fibrodysplasia ossificans progressiva | 3.385 |
| 55 | Relapsing polychondritis | 3.375 |
| 160 | Congenital ichthyosis | 3.346 |
| 286 | Hereditary sideroblastic anemia | 3.320 |
| 5 | Progressive supranuclear palsy | 3.301 |
| 156 | Rett syndrome | 3.111 |
| 140 | Dorabe syndrome | 3.059 |
| 144 | Lennox-Gastaut syndrome | 3.031 |
| 210 | Single Ventricle | 3.000 |
| 41 | Giant cell arteritis | 2.949 |
| 56 | Behcet disease | 2.815 |
| 218 | Alport syndrome | 2.778 |
| 49 | Systemic lupus erythematosus | 2.778 |
| 1 | Spinal and bulbar muscular atrophy | 2.760 |
| 10 | Charcot-Marie-Tooth disease | 2.557 |
| 63 | Idiopathic thrombocytopenic purpura | 2.519 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 2.500 |
| 215 | Tetralogy of Fallot | 2.500 |
| 225 | Congenital nephrogenic diabetes insipidus | 2.416 |
| 95 | Autoimmune hepatitis | 2.408 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 2.387 |
| 81 | Congenital adrenal hyperplasia | 2.387 |
| 162 | Pemphigoid | 2.289 |
| 231 | Alpha-1-antitrypsin deficiency | 2.217 |
| 93 | Primary biliary cholangitis | 2.217 |
| 17 | Multiple system atrophy | 2.208 |
| 284 | Diamond-Blackfan anemia | 2.182 |
| 20 | Adrenoleukodystrophy | 2.182 |
| 274 | Osteogenesis Imperfecta | 2.121 |
| 280 | Huge arteriovenous malformation with cervicofacial or limb lesion | 2.121 |
| 19 | Lysosomal storage disease | 2.106 |
| 40 | Takayasu arteritis | 2.010 |
| 337 | Homocystinuria | 2.000 |
| 8 | Huntington disease | 1.968 |
| 169 | Menkes disease | 1.963 |
| 170 | Occipital horn syndrome | 1.963 |
| 42 | Polyarteritis nodosa | 1.962 |
| 64 | Thrombotic thrombocytopenic purpura | 1.921 |
| 326 | Osteopetrosis | 1.921 |
| 22 | Moyamoya disease | 1.875 |
| 149 | Hemiconvulsion hemiplegia epilepsy syndrome | 1.838 |
| 285 | Fanconi anemia | 1.800 |
| 114 | Non-dystrophic myotonia syndrome | 1.765 |
| 283 | Acquired pure red cell aplasia | 1.765 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 1.587 |
| 60 | Aplastic anemia | 1.500 |
| 88 | Chronic thromboembolic pulmonary hypertension | 1.462 |
| 61 | Autoimmune hemolytic anemia | 1.417 |
| 102 | Rubinstein-Taybi syndrome | 1.393 |
| 89 | Lymphangioleiomyomatosis | 1.350 |
| 206 | Fragile X syndrome | 1.333 |
| 331 | Idiopathic multicentric castleman disease | 1.243 |
| 118 | Myelomeningocele | 1.242 |
| 288 | Autoimmune acquired coagulation factor deficiency | 1.148 |
| 271 | Ankylosing spondylitis | 1.067 |
| 106 | Cryopyrin-associated periodic syndrome | 1.042 |
| 251 | Urea cycle disorder | 1.042 |
| 108 | TNF receptor-associated periodic syndrome | 1.000 |
| 267 | Hyper-IgD syndrome | 1.000 |