60. Aplastic anemia Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 357 / Drugs : 477 - (DrugBank : 94) / Drug target genes : 57 - Drug target pathways : 184
Aplastic anemia and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 60 | Aplastic anemia | - |
| 46 | Malignant rheumatoid arthritis | 27.190 |
| 285 | Fanconi anemia | 24.679 |
| 65 | Primary immunodeficiency | 24.286 |
| 13 | Multiple sclerosis/Neuromyelitis optica | 23.827 |
| 49 | Systemic lupus erythematosus | 22.307 |
| 96 | Crohn disease | 20.222 |
| 284 | Diamond-Blackfan anemia | 17.581 |
| 19 | Lysosomal storage disease | 13.696 |
| 283 | Acquired pure red cell aplasia | 13.393 |
| 53 | Sjogren syndrome | 13.333 |
| 164 | Oculocutaneous albinism | 13.160 |
| 97 | Ulcerative colitis | 13.136 |
| 51 | Scleroderma | 12.451 |
| 11 | Myasthenia gravis | 11.829 |
| 41 | Giant cell arteritis | 10.898 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 10.889 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 10.507 |
| 55 | Relapsing polychondritis | 10.323 |
| 40 | Takayasu arteritis | 9.893 |
| 326 | Osteopetrosis | 9.857 |
| 63 | Idiopathic thrombocytopenic purpura | 9.617 |
| 85 | Idiopathic interstitial pneumonia | 9.584 |
| 28 | Systemic amyloidosis | 9.487 |
| 50 | Dermatomyositis | 9.397 |
| 107 | Juvenile idiopathic arthritis | 9.143 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 8.730 |
| 162 | Pemphigoid | 8.626 |
| 228 | Bronchiolitis obliterans | 8.626 |
| 42 | Polyarteritis nodosa | 8.512 |
| 64 | Thrombotic thrombocytopenic purpura | 8.463 |
| 93 | Primary biliary cholangitis | 8.400 |
| 20 | Adrenoleukodystrophy | 8.104 |
| 35 | Pemphigus | 8.104 |
| 286 | Hereditary sideroblastic anemia | 8.000 |
| 222 | Primary nephrotic syndrome | 7.728 |
| 95 | Autoimmune hepatitis | 7.581 |
| 61 | Autoimmune hemolytic anemia | 7.543 |
| 56 | Behcet disease | 7.265 |
| 2 | Amyotrophic lateral sclerosis | 7.017 |
| 66 | IgA nephropathy | 6.367 |
| 39 | Toxic epidermal necrolysis | 6.234 |
| 38 | Stevens-Johnson syndrome | 6.171 |
| 224 | Purpura nephritis | 6.171 |
| 151 | Rasmussen encephalitis | 6.000 |
| 36 | Epidermolysis bullosa | 5.528 |
| 84 | Sarcoidosis | 5.447 |
| 299 | Cystic fibrosis | 5.239 |
| 113 | Muscular dystrophy | 5.172 |
| 271 | Ankylosing spondylitis | 5.059 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 300 | IgG4-related disease | 4.978 |
| 269 | Pyogenic arthritis | 4.978 |
| 44 | Wegener granulomatosis | 4.959 |
| 331 | Idiopathic multicentric castleman disease | 4.839 |
| 6 | Parkinson disease | 4.645 |
| 160 | Congenital ichthyosis | 4.402 |
| 26 | HTLV-1-associated myelopathy | 4.386 |
| 226 | Interstitial cystitis with Hunners ulcer | 4.276 |
| 43 | Microscopic polyangiitis | 4.083 |
| 158 | Tuberous sclerosis | 3.747 |
| 274 | Osteogenesis Imperfecta | 3.061 |
| 227 | Osler disease | 2.942 |
| 270 | Chronic recurrent multifocal osteomyelitis | 2.794 |
| 83 | Addison disease | 2.794 |
| 94 | Primary sclerosing cholangitis | 2.481 |
| 34 | Neurofibromatosis | 2.119 |
| 77 | Growth hormone secreting pituitary adenoma | 2.000 |
| 16 | Crow-Fukase syndrome | 1.886 |
| 256 | Muscle glycogenosis | 1.853 |
| 76 | Pituitary gonadotropin secretion hyperthyroidism | 1.607 |
| 81 | Congenital adrenal hyperplasia | 1.587 |
| 14 | Chronic inflammatory demyelinating polyneuropathy | 1.587 |
| 86 | Pulmonary arterial hypertension | 1.575 |
| 58 | Hypertrophic cardiomyopathy | 1.500 |
| 90 | Retinitis pigmentosa | 1.487 |
| 229 | Autoimmune pulmonary alveolar proteinosis | 1.365 |
| 172 | Hypophosphatasia | 1.365 |
| 127 | Frontotemporal lobar degeneration | 1.146 |
| 235 | Hypoparathyroidism | 1.048 |
| 137 | Focal cortical dysplasia | 1.000 |
| 192 | Cockayne syndrome | 1.000 |
| 277 | Lymphangiomatosis | 1.000 |
| 281 | Klippel-Trenaunay-Weber syndrome | 1.000 |
| 317 | Trifunctional protein deficiency | 1.000 |
| 52 | Mixed connective tissue disease | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |