62. Paroxysmal nocturnal hemoglobinuria Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 380 / Drugs : 240 - (DrugBank : 38) / Drug target genes : 28 - Drug target pathways : 122
Paroxysmal nocturnal hemoglobinuria and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 62 | Paroxysmal nocturnal hemoglobinuria | - |
| 13 | Multiple sclerosis/Neuromyelitis optica | 12.420 |
| 283 | Acquired pure red cell aplasia | 11.624 |
| 285 | Fanconi anemia | 11.511 |
| 49 | Systemic lupus erythematosus | 11.278 |
| 96 | Crohn disease | 11.097 |
| 2 | Amyotrophic lateral sclerosis | 11.088 |
| 60 | Aplastic anemia | 10.889 |
| 46 | Malignant rheumatoid arthritis | 9.686 |
| 284 | Diamond-Blackfan anemia | 9.662 |
| 11 | Myasthenia gravis | 9.478 |
| 61 | Autoimmune hemolytic anemia | 9.326 |
| 222 | Primary nephrotic syndrome | 9.103 |
| 19 | Lysosomal storage disease | 8.981 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 8.963 |
| 65 | Primary immunodeficiency | 8.763 |
| 164 | Oculocutaneous albinism | 8.672 |
| 51 | Scleroderma | 8.617 |
| 36 | Epidermolysis bullosa | 8.117 |
| 286 | Hereditary sideroblastic anemia | 8.000 |
| 53 | Sjogren syndrome | 7.979 |
| 42 | Polyarteritis nodosa | 7.978 |
| 162 | Pemphigoid | 7.508 |
| 66 | IgA nephropathy | 7.408 |
| 40 | Takayasu arteritis | 6.857 |
| 39 | Toxic epidermal necrolysis | 6.649 |
| 28 | Systemic amyloidosis | 6.635 |
| 41 | Giant cell arteritis | 6.349 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 6.349 |
| 85 | Idiopathic interstitial pneumonia | 6.344 |
| 93 | Primary biliary cholangitis | 6.259 |
| 63 | Idiopathic thrombocytopenic purpura | 5.926 |
| 224 | Purpura nephritis | 5.689 |
| 326 | Osteopetrosis | 5.524 |
| 228 | Bronchiolitis obliterans | 5.260 |
| 95 | Autoimmune hepatitis | 5.133 |
| 55 | Relapsing polychondritis | 5.056 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 20 | Adrenoleukodystrophy | 4.848 |
| 50 | Dermatomyositis | 4.821 |
| 38 | Stevens-Johnson syndrome | 4.511 |
| 269 | Pyogenic arthritis | 4.511 |
| 151 | Rasmussen encephalitis | 4.365 |
| 299 | Cystic fibrosis | 4.339 |
| 97 | Ulcerative colitis | 4.181 |
| 160 | Congenital ichthyosis | 4.148 |
| 56 | Behcet disease | 4.148 |
| 6 | Parkinson disease | 4.103 |
| 26 | HTLV-1-associated myelopathy | 4.090 |
| 94 | Primary sclerosing cholangitis | 4.053 |
| 90 | Retinitis pigmentosa | 3.856 |
| 35 | Pemphigus | 3.818 |
| 107 | Juvenile idiopathic arthritis | 3.810 |
| 226 | Interstitial cystitis with Hunners ulcer | 3.667 |
| 43 | Microscopic polyangiitis | 3.551 |
| 64 | Thrombotic thrombocytopenic purpura | 3.321 |
| 44 | Wegener granulomatosis | 2.939 |
| 113 | Muscular dystrophy | 2.887 |
| 274 | Osteogenesis Imperfecta | 2.551 |
| 158 | Tuberous sclerosis | 2.449 |
| 84 | Sarcoidosis | 2.028 |
| 227 | Osler disease | 2.019 |
| 331 | Idiopathic multicentric castleman disease | 1.805 |
| 58 | Hypertrophic cardiomyopathy | 1.587 |
| 109 | Atypical hemolytic uremic syndrome | 1.397 |
| 172 | Hypophosphatasia | 1.397 |
| 256 | Muscle glycogenosis | 1.180 |
| 137 | Focal cortical dysplasia | 1.000 |
| 192 | Cockayne syndrome | 1.000 |
| 277 | Lymphangiomatosis | 1.000 |
| 281 | Klippel-Trenaunay-Weber syndrome | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |