65. Primary immunodeficiency Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 866 / Drugs : 858 - (DrugBank : 122) / Drug target genes : 108 - Drug target pathways : 232
Primary immunodeficiency and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 65 | Primary immunodeficiency | - |
| 46 | Malignant rheumatoid arthritis | 46.486 |
| 13 | Multiple sclerosis/Neuromyelitis optica | 40.579 |
| 49 | Systemic lupus erythematosus | 37.524 |
| 2 | Amyotrophic lateral sclerosis | 34.238 |
| 96 | Crohn disease | 29.669 |
| 85 | Idiopathic interstitial pneumonia | 26.756 |
| 51 | Scleroderma | 25.644 |
| 93 | Primary biliary cholangitis | 25.630 |
| 60 | Aplastic anemia | 24.286 |
| 285 | Fanconi anemia | 21.991 |
| 331 | Idiopathic multicentric castleman disease | 21.505 |
| 56 | Behcet disease | 20.864 |
| 107 | Juvenile idiopathic arthritis | 20.306 |
| 26 | HTLV-1-associated myelopathy | 20.161 |
| 97 | Ulcerative colitis | 19.838 |
| 53 | Sjogren syndrome | 19.708 |
| 42 | Polyarteritis nodosa | 19.443 |
| 284 | Diamond-Blackfan anemia | 18.586 |
| 11 | Myasthenia gravis | 18.194 |
| 222 | Primary nephrotic syndrome | 16.466 |
| 41 | Giant cell arteritis | 16.459 |
| 34 | Neurofibromatosis | 15.896 |
| 299 | Cystic fibrosis | 15.282 |
| 50 | Dermatomyositis | 15.200 |
| 6 | Parkinson disease | 14.888 |
| 28 | Systemic amyloidosis | 14.795 |
| 19 | Lysosomal storage disease | 14.478 |
| 40 | Takayasu arteritis | 13.968 |
| 283 | Acquired pure red cell aplasia | 12.917 |
| 162 | Pemphigoid | 12.641 |
| 326 | Osteopetrosis | 12.522 |
| 35 | Pemphigus | 12.412 |
| 164 | Oculocutaneous albinism | 12.387 |
| 271 | Ankylosing spondylitis | 12.033 |
| 256 | Muscle glycogenosis | 11.961 |
| 113 | Muscular dystrophy | 11.576 |
| 228 | Bronchiolitis obliterans | 10.314 |
| 55 | Relapsing polychondritis | 10.195 |
| 269 | Pyogenic arthritis | 9.920 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 9.910 |
| 266 | Familial mediterranean fever | 8.931 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 8.763 |
| 20 | Adrenoleukodystrophy | 8.450 |
| 86 | Pulmonary arterial hypertension | 8.281 |
| 84 | Sarcoidosis | 8.238 |
| 95 | Autoimmune hepatitis | 8.168 |
| 286 | Hereditary sideroblastic anemia | 8.000 |
| 64 | Thrombotic thrombocytopenic purpura | 7.983 |
| 61 | Autoimmune hemolytic anemia | 7.661 |
| 44 | Wegener granulomatosis | 7.543 |
| 233 | Wolfram syndrome | 7.527 |
| 63 | Idiopathic thrombocytopenic purpura | 7.522 |
| 160 | Congenital ichthyosis | 7.245 |
| 90 | Retinitis pigmentosa | 7.140 |
| 300 | IgG4-related disease | 7.037 |
| 102 | Rubinstein-Taybi syndrome | 7.000 |
| 66 | IgA nephropathy | 6.907 |
| 226 | Interstitial cystitis with Hunners ulcer | 6.874 |
| 58 | Hypertrophic cardiomyopathy | 6.406 |
| 274 | Osteogenesis Imperfecta | 6.107 |
| 39 | Toxic epidermal necrolysis | 6.012 |
| 151 | Rasmussen encephalitis | 6.000 |
| 38 | Stevens-Johnson syndrome | 5.760 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 5.570 |
| 158 | Tuberous sclerosis | 5.166 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 36 | Epidermolysis bullosa | 4.829 |
| 127 | Frontotemporal lobar degeneration | 4.720 |
| 210 | Single Ventricle | 4.664 |
| 3 | Spinal muscular atrophy | 4.606 |
| 224 | Purpura nephritis | 4.599 |
| 37 | Generalised pustular psoriasis | 4.545 |
| 265 | Lipodystrophy | 4.530 |
| 78 | Hypopituitarism | 4.436 |
| 89 | Lymphangioleiomyomatosis | 4.403 |
| 83 | Addison disease | 4.213 |
| 76 | Pituitary gonadotropin secretion hyperthyroidism | 4.213 |
| 5 | Progressive supranuclear palsy | 4.102 |
| 227 | Osler disease | 4.070 |
| 235 | Hypoparathyroidism | 4.000 |
| 71 | Idiopathic osteonecrosis of the femoral head | 4.000 |
| 43 | Microscopic polyangiitis | 3.772 |
| 323 | Aromatic L-amino acid decarboxylase deficiency | 3.000 |
| 94 | Primary sclerosing cholangitis | 2.923 |
| 270 | Chronic recurrent multifocal osteomyelitis | 2.726 |
| 21 | Mitochondrial disease | 2.451 |
| 15 | Inclusion body myositis | 2.424 |
| 251 | Urea cycle disorder | 2.275 |
| 215 | Tetralogy of Fallot | 2.267 |
| 206 | Fragile X syndrome | 2.250 |
| 81 | Congenital adrenal hyperplasia | 2.245 |
| 98 | Eosinophilic gastro-intestinal disorder | 2.133 |
| 77 | Growth hormone secreting pituitary adenoma | 2.000 |
| 268 | Nakajo-Nishimura syndrome | 2.000 |
| 325 | Hereditary autoinflammatory syndrome | 2.000 |
| 337 | Homocystinuria | 2.000 |
| 282 | Congenital dyserythropoietic anemia | 2.000 |
| 280 | Huge arteriovenous malformation with cervicofacial or limb lesion | 1.964 |
| 301 | Macular dystrophy | 1.877 |
| 16 | Crow-Fukase syndrome | 1.840 |
| 298 | Hereditary pancreatitis | 1.811 |
| 149 | Hemiconvulsion hemiplegia epilepsy syndrome | 1.667 |
| 70 | Spinal stenosis | 1.595 |
| 288 | Autoimmune acquired coagulation factor deficiency | 1.590 |
| 18 | Spinocerebellar degeneration | 1.549 |
| 225 | Congenital nephrogenic diabetes insipidus | 1.520 |
| 14 | Chronic inflammatory demyelinating polyneuropathy | 1.452 |
| 8 | Huntington disease | 1.405 |
| 229 | Autoimmune pulmonary alveolar proteinosis | 1.348 |
| 172 | Hypophosphatasia | 1.348 |
| 75 | Cushing disease | 1.273 |
| 118 | Myelomeningocele | 1.188 |
| 212 | Tricuspid atresia | 1.188 |
| 74 | Prolactin secreting pituitary adenoma | 1.133 |
| 22 | Moyamoya disease | 1.121 |
| 169 | Menkes disease | 1.067 |
| 170 | Occipital horn syndrome | 1.067 |
| 106 | Cryopyrin-associated periodic syndrome | 1.022 |
| 238 | Vitamin D-resistant rickets | 1.022 |
| 137 | Focal cortical dysplasia | 1.000 |
| 192 | Cockayne syndrome | 1.000 |
| 277 | Lymphangiomatosis | 1.000 |
| 281 | Klippel-Trenaunay-Weber syndrome | 1.000 |
| 232 | Carney complex | 1.000 |
| 191 | Werner syndrome | 1.000 |
| 68 | Ossification of the ligamentum flavum | 1.000 |
| 52 | Mixed connective tissue disease | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |