96. Crohn disease Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 2,888 / Drugs : 1,678 - (DrugBank : 247) / Drug target genes : 193 - Drug target pathways : 234
Crohn disease and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 96 | Crohn disease | - |
| 13 | Multiple sclerosis/Neuromyelitis optica | 108.041 |
| 46 | Malignant rheumatoid arthritis | 95.936 |
| 97 | Ulcerative colitis | 91.853 |
| 2 | Amyotrophic lateral sclerosis | 75.223 |
| 6 | Parkinson disease | 60.766 |
| 156 | Rett syndrome | 47.218 |
| 49 | Systemic lupus erythematosus | 40.532 |
| 70 | Spinal stenosis | 40.060 |
| 21 | Mitochondrial disease | 38.649 |
| 84 | Sarcoidosis | 33.784 |
| 8 | Huntington disease | 33.306 |
| 36 | Epidermolysis bullosa | 31.399 |
| 226 | Interstitial cystitis with Hunners ulcer | 31.172 |
| 298 | Hereditary pancreatitis | 31.090 |
| 113 | Muscular dystrophy | 30.186 |
| 65 | Primary immunodeficiency | 29.669 |
| 51 | Scleroderma | 29.342 |
| 50 | Dermatomyositis | 28.929 |
| 158 | Tuberous sclerosis | 28.111 |
| 22 | Moyamoya disease | 28.000 |
| 107 | Juvenile idiopathic arthritis | 27.297 |
| 11 | Myasthenia gravis | 24.516 |
| 17 | Multiple system atrophy | 24.407 |
| 206 | Fragile X syndrome | 23.956 |
| 53 | Sjogren syndrome | 23.645 |
| 19 | Lysosomal storage disease | 23.620 |
| 231 | Alpha-1-antitrypsin deficiency | 23.333 |
| 75 | Cushing disease | 22.933 |
| 98 | Eosinophilic gastro-intestinal disorder | 21.977 |
| 271 | Ankylosing spondylitis | 21.977 |
| 34 | Neurofibromatosis | 21.439 |
| 40 | Takayasu arteritis | 21.412 |
| 193 | Prader-Willi syndrome | 21.086 |
| 5 | Progressive supranuclear palsy | 21.066 |
| 78 | Hypopituitarism | 20.820 |
| 299 | Cystic fibrosis | 20.235 |
| 60 | Aplastic anemia | 20.222 |
| 85 | Idiopathic interstitial pneumonia | 19.882 |
| 41 | Giant cell arteritis | 19.841 |
| 205 | Fragile X syndrome related disease | 19.706 |
| 18 | Spinocerebellar degeneration | 19.185 |
| 162 | Pemphigoid | 18.390 |
| 93 | Primary biliary cholangitis | 17.535 |
| 95 | Autoimmune hepatitis | 17.154 |
| 140 | Dorabe syndrome | 17.086 |
| 144 | Lennox-Gastaut syndrome | 16.826 |
| 86 | Pulmonary arterial hypertension | 16.101 |
| 152 | PCDH19-related syndrome | 16.000 |
| 272 | Fibrodysplasia ossificans progressiva | 15.934 |
| 58 | Hypertrophic cardiomyopathy | 15.928 |
| 3 | Spinal muscular atrophy | 15.883 |
| 285 | Fanconi anemia | 15.488 |
| 56 | Behcet disease | 14.565 |
| 265 | Lipodystrophy | 14.463 |
| 296 | Biliary atresia | 14.400 |
| 63 | Idiopathic thrombocytopenic purpura | 14.400 |
| 283 | Acquired pure red cell aplasia | 14.392 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 14.392 |
| 145 | West syndrome | 14.007 |
| 66 | IgA nephropathy | 13.650 |
| 28 | Systemic amyloidosis | 13.610 |
| 284 | Diamond-Blackfan anemia | 13.527 |
| 222 | Primary nephrotic syndrome | 12.441 |
| 201 | Angelman syndrome | 12.052 |
| 35 | Pemphigus | 12.052 |
| 38 | Stevens-Johnson syndrome | 11.401 |
| 256 | Muscle glycogenosis | 11.260 |
| 44 | Wegener granulomatosis | 11.097 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 11.097 |
| 164 | Oculocutaneous albinism | 10.437 |
| 42 | Polyarteritis nodosa | 10.432 |
| 55 | Relapsing polychondritis | 10.143 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 10.143 |
| 269 | Pyogenic arthritis | 9.771 |
| 224 | Purpura nephritis | 9.771 |
| 215 | Tetralogy of Fallot | 9.668 |
| 160 | Congenital ichthyosis | 9.668 |
| 155 | Acquired aphasia with convulsive disorder | 9.511 |
| 20 | Adrenoleukodystrophy | 9.333 |
| 168 | Ehlers-Danlos syndrome | 9.000 |
| 57 | Idiopathic dilated cardiomyopathy | 9.000 |
| 169 | Menkes disease | 9.000 |
| 170 | Occipital horn syndrome | 9.000 |
| 127 | Frontotemporal lobar degeneration | 8.214 |
| 167 | Marfan syndrome | 8.148 |
| 286 | Hereditary sideroblastic anemia | 8.000 |
| 94 | Primary sclerosing cholangitis | 7.895 |
| 326 | Osteopetrosis | 7.788 |
| 228 | Bronchiolitis obliterans | 7.549 |
| 280 | Huge arteriovenous malformation with cervicofacial or limb lesion | 7.313 |
| 43 | Microscopic polyangiitis | 7.313 |
| 61 | Autoimmune hemolytic anemia | 7.243 |
| 288 | Autoimmune acquired coagulation factor deficiency | 7.002 |
| 300 | IgG4-related disease | 6.865 |
| 236 | Pseudohypoparathyroidism | 6.374 |
| 118 | Myelomeningocele | 6.161 |
| 151 | Rasmussen encephalitis | 6.000 |
| 274 | Osteogenesis Imperfecta | 5.958 |
| 10 | Charcot-Marie-Tooth disease | 5.922 |
| 39 | Toxic epidermal necrolysis | 5.922 |
| 67 | Polycystic kidney disease | 5.895 |
| 227 | Osler disease | 5.637 |
| 90 | Retinitis pigmentosa | 5.521 |
| 64 | Thrombotic thrombocytopenic purpura | 5.273 |
| 25 | Progressive multifocal leukoencephalopathy | 5.173 |
| 157 | Sturge-Weber syndrome | 5.000 |
| 278 | Huge lymphatic malformation with cervicofacial lesion | 5.000 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 294 | Congenital diaphragmatic hernia | 5.000 |
| 1 | Spinal and bulbar muscular atrophy | 4.987 |
| 26 | HTLV-1-associated myelopathy | 4.376 |
| 37 | Generalised pustular psoriasis | 4.315 |
| 81 | Congenital adrenal hyperplasia | 4.205 |
| 83 | Addison disease | 4.191 |
| 246 | Methylmalonic acidemia | 3.966 |
| 4 | Primary lateral sclerosis | 3.589 |
| 210 | Single Ventricle | 3.534 |
| 171 | Wilson disease | 3.000 |
| 310 | Congenital anomalies syndrome | 3.000 |
| 229 | Autoimmune pulmonary alveolar proteinosis | 3.000 |
| 323 | Aromatic L-amino acid decarboxylase deficiency | 3.000 |
| 270 | Chronic recurrent multifocal osteomyelitis | 2.698 |
| 218 | Alport syndrome | 2.698 |
| 76 | Pituitary gonadotropin secretion hyperthyroidism | 2.698 |
| 15 | Inclusion body myositis | 2.354 |
| 251 | Urea cycle disorder | 2.263 |
| 91 | Budd-Chiari syndrome | 2.263 |
| 71 | Idiopathic osteonecrosis of the femoral head | 2.263 |
| 212 | Tricuspid atresia | 2.048 |
| 88 | Chronic thromboembolic pulmonary hypertension | 2.015 |
| 268 | Nakajo-Nishimura syndrome | 2.000 |
| 325 | Hereditary autoinflammatory syndrome | 2.000 |
| 337 | Homocystinuria | 2.000 |
| 195 | Noonan syndrome | 2.000 |
| 263 | Cerebrotendinous xanthomatosis | 2.000 |
| 257 | Hepatic glycogenosis | 2.000 |
| 282 | Congenital dyserythropoietic anemia | 2.000 |
| 203 | 22q11.2 deletion syndrome | 1.881 |
| 16 | Crow-Fukase syndrome | 1.821 |
| 211 | Hypoplastic left heart syndrome | 1.821 |
| 159 | Xeroderma pigmentosum | 1.821 |
| 331 | Idiopathic multicentric castleman disease | 1.806 |
| 89 | Lymphangioleiomyomatosis | 1.500 |
| 114 | Non-dystrophic myotonia syndrome | 1.496 |
| 14 | Chronic inflammatory demyelinating polyneuropathy | 1.397 |
| 225 | Congenital nephrogenic diabetes insipidus | 1.371 |
| 172 | Hypophosphatasia | 1.341 |
| 74 | Prolactin secreting pituitary adenoma | 1.071 |
| 179 | Williams syndrome | 1.036 |
| 333 | Hutchinson-Gilford syndrome | 1.012 |
| 238 | Vitamin D-resistant rickets | 1.012 |
| 235 | Hypoparathyroidism | 1.012 |
| 137 | Focal cortical dysplasia | 1.000 |
| 192 | Cockayne syndrome | 1.000 |
| 277 | Lymphangiomatosis | 1.000 |
| 281 | Klippel-Trenaunay-Weber syndrome | 1.000 |
| 232 | Carney complex | 1.000 |
| 111 | Congenital myopathy | 1.000 |
| 99 | Chronic intestinal pseudo-obstruction | 1.000 |
| 191 | Werner syndrome | 1.000 |
| 52 | Mixed connective tissue disease | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |