Alendronate

( DrugBank: Alendronate / KEGG DRUG: Alendronic acid )

7 diseases

ID	Disease name (Link within this page)	Number of trials
19	Lysosomal storage disease	1
41	Giant cell arteritis	1
46	Malignant rheumatoid arthritis	5
50	Dermatomyositis	1

ID	Disease name (Link within this page)	Number of trials
271	Ankylosing spondylitis	1
274	Osteogenesis Imperfecta	3
299	Cystic fibrosis	3

19. Lysosomal storage disease

Clinical trials : 899 / Drugs : 684 - (DrugBank : 99) / Drug target genes : 51 - Drug target pathways : 182

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00004488 (ClinicalTrials.gov)	October 1998	18/10/1999	Phase II Randomized Study of Alendronate Sodium for Osteopenia in Patients With Gaucher's Disease		Gaucher's Disease;Osteopenia	Drug: alendronate sodium;Drug: calcium carbonate;Drug: cholecalciferol	Children's Hospital Medical Center, Cincinnati	NULL	Completed	18 Years	50 Years	Both	82	Phase 2	United States;Israel

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41. Giant cell arteritis

Clinical trials : 131 / Drugs : 139 - (DrugBank : 36) / Drug target genes : 33 - Drug target pathways : 125

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00138983 (ClinicalTrials.gov)	May 2000	29/8/2005	Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: AlendronateVersus Alfacalci ...	Prevention of Glucocorticoid-Induced Osteoporosis in Patients With Rheumatic Diseases. The STOP-Stud ...	Rheumatoid Arthritis;Polymyalgia Rheumatica;Giant Cell Arteritis;Polymyositis;Wegener’s Granulomatos ...	Drug: Alendronate versus alfacalcidol (1-alpha OH vitamin D)	UMC Utrecht	Dutch Health Care Insurance Board	Completed	18 Years	90 Years	Both	200	Phase 3	Netherlands

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46. Malignant rheumatoid arthritis

Clinical trials : 4,356 / Drugs : 2,567 - (DrugBank : 415) / Drug target genes : 192 - Drug target pathways : 228

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02944799 (ClinicalTrials.gov)	December 2015	27/6/2016	Alendronate Treatment of Osteoporosis in Rheumatoid Arthritis	AlendronateTreatment of Osteoporosis in Rheumatoid Arthritis - Indication and Duration: A Randomized ...	Rheumatoid Arthritis;Osteoporosis	Drug: Placebo;Drug: Alendronate;Drug: Calcium;Drug: Vitamin D	University of Aarhus	NULL	Active, not recruiting	18 Years	N/A	All	69	Phase 2	Denmark
2	EUCTR2015-003638-28-DK (EUCTR)	30/09/2015	28/08/2015	Treatment of osteoporosis in patients with rheumatoid arthritis.	ALOSTRAAlendronate treatment of osteoporosis in rheumatoid arthritis – indication and duration. A ra ...	Rheumatoid arthritis and osteoporosis MedDRA version: 20.0;Level: LLT;Classification code 10031289;T ...	Trade Name: Alendronat Teva INN or Proposed INN: Alendronic Acid Other descriptive name: ALENDRONIC AC ...	Aarhus University Hospital	NULL	Not Recruiting			Female: yes Male: yes	160	Phase 2	Denmark
3	NCT01770106 (ClinicalTrials.gov)	December 2012	3/1/2013	RA Denosumab on Bone Microstructure Study	Comparison of the Effect of Denosumab and Alendronateon Bone Density and Microarchitecture in Rheuma ...	Rheumatoid Arthritis	Drug: Denosumab;Drug: Alendronate	Chinese University of Hong Kong	NULL	Completed	18 Years	80 Years	Female	40	Phase 4	Hong Kong
4	ChiCTR-TRC-09000473	2009-07-20	2009-07-15	Efficacy and safety of Alendronateon Structural Benefit and Inflammation in Rheumatoid Arthritis(RA) ...	Efficacy and safety of Alendronateon Structural Benefit and Inflammation in Rheumatoid Arthritis(RA) ...	Rheumatoid Arthritis	Group B:MTX 7.5-20mg, orally taken once weekly for 48 week;Group A:MTX7.5-20mg, orally taken once we ...	People's Hospital, Peking University	NULL	Completed	18		Both	Group B:160;Group A:160;		China
5	NCT00138983 (ClinicalTrials.gov)	May 2000	29/8/2005	Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: AlendronateVersus Alfacalci ...	Prevention of Glucocorticoid-Induced Osteoporosis in Patients With Rheumatic Diseases. The STOP-Stud ...	Rheumatoid Arthritis;Polymyalgia Rheumatica;Giant Cell Arteritis;Polymyositis;Wegener’s Granulomatos ...	Drug: Alendronate versus alfacalcidol (1-alpha OH vitamin D)	UMC Utrecht	Dutch Health Care Insurance Board	Completed	18 Years	90 Years	Both	200	Phase 3	Netherlands

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50. Dermatomyositis

Clinical trials : 194 / Drugs : 244 - (DrugBank : 89) / Drug target genes : 50 - Drug target pathways : 151

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00138983 (ClinicalTrials.gov)	May 2000	29/8/2005	Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: AlendronateVersus Alfacalci ...	Prevention of Glucocorticoid-Induced Osteoporosis in Patients With Rheumatic Diseases. The STOP-Stud ...	Rheumatoid Arthritis;Polymyalgia Rheumatica;Giant Cell Arteritis;Polymyositis;Wegener’s Granulomatos ...	Drug: Alendronate versus alfacalcidol (1-alpha OH vitamin D)	UMC Utrecht	Dutch Health Care Insurance Board	Completed	18 Years	90 Years	Both	200	Phase 3	Netherlands

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271. Ankylosing spondylitis

Clinical trials : 574 / Drugs : 359 - (DrugBank : 68) / Drug target genes : 41 - Drug target pathways : 146

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01104987 (ClinicalTrials.gov)	October 2009	13/4/2010	Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS)	Treatment With Alendronatein Patients With Ankylosing Spondylitis (AS), an Open Label Prospective Tr ...	Ankylosing Spondylitis;Osteoporosis	Drug: alendronate	Göteborg University	NULL	Completed	18 Years	80 Years	Both	16		Sweden

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274. Osteogenesis Imperfecta

Clinical trials : 91 / Drugs : 101 - (DrugBank : 20) / Drug target genes : 11 - Drug target pathways : 48

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-UMIN000010615	2013/04/30	30/04/2013	Clinical study on efficacy of alendronateinfusion for pediatric osteogenesis imperfecta (including s ...	Clinical study on efficacy of alendronateinfusion for pediatric osteogenesis imperfecta (including s ...	osteogenesis imperfecta	Eighteen micrograms (2 ml)/kg of alendronatewill be infused in 1 hour every 4 weeks. The study durat ...	Tohoku University School of Medicine, Department of Pediatrics	NULL	Complete: follow-up continuing	Not applicable	15years-old	Male and Female	10	Not applicable	Japan
2	NCT02303873 (ClinicalTrials.gov)	March 2007	19/11/2014	Efficacy and Safety of Alendronate in Chinese Children or Adolescents With Osteogenesis Imperfecta	Efficacy and Safety of Alendronatein Chinese Children or Adolescents With Osteogenesis Imperfecta: a ...	Osteogenesis Imperfecta	Drug: Alendronate	Peking Union Medical College Hospital	National Natural Science Foundation of China	Completed	N/A	18 Years	Both	99	Phase 4	NULL
3	NCT00159419 (ClinicalTrials.gov)	August 1999	7/9/2005	Bisphosphonate Therapy for Osteogenesis Imperfecta	Bisphosphonate Therapy for Osteogenesis Imperfecta	Osteogenesis Imperfecta;Osteoporosis;Paget Disease of Bone	Drug: Alendronate;Drug: Pamidronate	Indiana University School of Medicine	NULL	Completed	3 Years	21 Years	All	18	Phase 4	United States

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299. Cystic fibrosis

Clinical trials : 1,695 / Drugs : 1,527 - (DrugBank : 268) / Drug target genes : 111 - Drug target pathways : 174

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00157690 (ClinicalTrials.gov)	December 2003	8/9/2005	Study of Alendronate to Prevent and Treat Osteoporosis in Cystic Fibrosis Patients	A Multicentre, Double-Blind, Randomized Placebo-Controlled Study of 70mg AlendronateOnce Weekly for ...	Cystic Fibrosis;Osteoporosis;Bone Diseases, Metabolic	Drug: Alendronate;Drug: Placebo	McMaster University	Centre hospitalier de l'Université de Montréal (CHUM);London Health Sciences Centre;University of Ca ...	Completed	18 Years	N/A	Both	56	Phase 4	Canada
2	NCT01812551 (ClinicalTrials.gov)	October 2002	14/3/2013	Treatment of Low Bone Density in Cystic Fibrosis.	Osteoporosis in Cystic Fibrosis: Study of Bone Mass and Bone Metabolism, and Prospective Randomized ...	Osteoporosis;Cystic Fibrosis	Drug: Alendronate;Drug: Placebo	Istituto Auxologico Italiano	Fondazione Telethon	Completed	5 Years	30 Years	Both	171	Phase 3	Holy See (Vatican City State);Italy
3	NCT00004489 (ClinicalTrials.gov)	October 1998	18/10/1999	Randomized Study of Alendronate in Adult Patients With Cystic Fibrosis Related Osteoporosis		Osteoporosis;Cystic Fibrosis	Drug: alendronate sodium;Drug: calcium carbonate;Drug: cholecalciferol	University of North Carolina	NULL	Completed	18 Years	45 Years	Both	60	N/A	United States

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