LX3305

( DrugBank: - / KEGG DRUG: - )

2 diseases

ID	Disease name (Link within this page)	Number of trials
46	Malignant rheumatoid arthritis	6

ID	Disease name (Link within this page)	Number of trials
161	Familial benign chronic pemphigus	1

46. Malignant rheumatoid arthritis

Clinical trials : 4,356 / Drugs : 2,567 - (DrugBank : 415) / Drug target genes : 192 - Drug target pathways : 228

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01417052 (ClinicalTrials.gov)	September 2011	12/8/2011	A Study to Determine the Safety and Efficacy of LX3305 in Subjects With Active Rheumatoid Arthritis	A Phase 1, Single-Center, Randomized, Double-Blind, Placebo-Controlled, Dose Escalation Study to Det ...	Rheumatoid Arthritis	Drug: 50 mg LX3305QD;Drug: 100 mg LX3305QD;Drug: 150 mg LX3305QD;Drug: 200 mg LX3305QD;Drug: 250 mg ...	Lexicon Pharmaceuticals	NULL	Completed	18 Years	75 Years	Both	10	Phase 1	United States
2	EUCTR2009-012705-19-CZ (EUCTR)	16/10/2009	17/07/2009	A Phase 2, Multi-center, Randomized, Double-blind, Placebo-controlled, Multiple-dose Study to Determ ...	A Phase 2, Multi-center, Randomized, Double-blind, Placebo-controlled, Multiple-dose Study to Determ ...	Rheumatoid Arthritis (RA) MedDRA version: 12.0;Level: LLT;Classification code 10039073;Term:	Product Name: LX3305Dihydrate Product Code: LX3305 INN or Proposed INN: None as of yet Other descriptiv ...	Lexicon Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	200	Phase 2	Hungary;Czech Republic;Bulgaria
3	EUCTR2009-012705-19-BG (EUCTR)	29/09/2009	06/10/2009	A Phase 2, Multi-center, Randomized, Double-blind, Placebo-controlled, Multiple-dose Study to Determ ...	A Phase 2, Multi-center, Randomized, Double-blind, Placebo-controlled, Multiple-dose Study to Determ ...	Rheumatoid Arthritis (RA) MedDRA version: 12.0;Level: LLT;Classification code 10039073;Term:	Product Name: LX3305Dihydrate Product Code: LX3305 INN or Proposed INN: None as of yet Other descriptiv ...	Lexicon Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	104	Phase 2	Hungary;Czech Republic;Bulgaria
4	EUCTR2009-012705-19-HU (EUCTR)	17/08/2009	16/07/2009	A Phase 2, Multi-center, Randomized, Double-blind, Placebo-controlled, Multiple-dose Study to Determ ...	A Phase 2, Multi-center, Randomized, Double-blind, Placebo-controlled, Multiple-dose Study to Determ ...	Rheumatoid Arthritis (RA) MedDRA version: 12.0;Level: LLT;Classification code 10039073;Term:	Product Name: LX3305Dihydrate Product Code: LX3305 INN or Proposed INN: None as of yet Other descriptiv ...	Lexicon Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	104	Phase 2	Hungary;Czech Republic;Bulgaria
5	NCT00903383 (ClinicalTrials.gov)	July 2009	14/5/2009	Study of LX3305 in Subjects With Active Rheumatoid Arthritis on Stable Methotrexate	A Phase 2, Multi-center, Randomized, Double Blind, Placebo-controlled, Multiple-dose Study to Determ ...	Rheumatoid Arthritis	Drug: LX3305 low dose;Drug: LX3305 mid dose;Drug: LX3305 high dose;Drug: Placebo	Lexicon Pharmaceuticals	NULL	Completed	18 Years	75 Years	All	208	Phase 2	United States;Bulgaria;Czech Republic;Hungary;Poland;Serbia
6	NCT00847886 (ClinicalTrials.gov)	February 2009	17/2/2009	Study of LX3305 and Methotrexate in Subjects With Stable Rheumatoid Arthritis	A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Study to Determine the Pharm ...	Rheumatoid Arthritis	Drug: LX3305;Drug: LX3305 Placebo;Drug: Methotrexate	Lexicon Pharmaceuticals	NULL	Completed	18 Years	N/A	All	15	Phase 1	United States

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161. Familial benign chronic pemphigus

Clinical trials : 5 / Drugs : 9 - (DrugBank : 4) / Drug target genes : 2 - Drug target pathways : 24

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2018-000373-80-FR (EUCTR)	24/05/2018	13/03/2018	A Phase 1/2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm Study of the Safety and Effi ...	A Phase 1/2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm Study of the Safety and Effi ...	Darier’s Disease or Hailey-Hailey Disease MedDRA version: 20.0;Level: LLT;Classification code 100118 ...	Product Name: LX3305250 mg capsule Product Code: LX3305 INN or Proposed INN: None Other descriptive nam ...	Dermecular Therapeutics, Inc.	NULL	Not Recruiting			Female: yes Male: yes	40	Phase 1;Phase 2	France

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