MODAFINIL

( DrugBank: Modafinil / KEGG DRUG: Modafinil )

4 diseases

ID	Disease name (Link within this page)	Number of trials
6	Parkinson disease	6
13	Multiple sclerosis/Neuromyelitis optica	5

ID	Disease name (Link within this page)	Number of trials
49	Systemic lupus erythematosus	1
93	Primary biliary cholangitis	1

6. Parkinson disease

Clinical trials : 2,307 / Drugs : 2,007 - (DrugBank : 349) / Drug target genes : 188 - Drug target pathways : 199

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Showing 1 to 6 of 6 trials

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2017-004475-31-CZ (EUCTR)	09/05/2018	09/05/2018	Safety and efficacy study of two THN102 doses in subjects with excessive daytime sleepiness associat ...	Randomised, double-blind, placebo-controlled, complete 3-way cross-over phase IIa trial to investiga ...	Excessive daytime sleepiness associated with Parkinson’s disease MedDRA version: 20.0;Level: SOC;Cla ...	Product Name: Flecainide acetate Product Code: THN02 INN or Proposed INN: Flecainidum Other descriptive ...	Theranexus S.A.	NULL	Not Recruiting			Female: yes Male: yes	60	Phase 2	France;United States;Hungary;Czech Republic;Germany
2	EUCTR2017-004475-31-HU (EUCTR)	17/04/2018	09/02/2018	Safety and efficacy study of two THN102 doses in subjects with excessive daytime sleepiness associat ...	Randomised, double-blind, placebo-controlled, complete 3-way cross-over phase IIa trial to investiga ...	Excessive daytime sleepiness associated with Parkinson’s disease MedDRA version: 20.0;Level: SOC;Cla ...	Product Name: Flecainide acetate Product Code: THN02 INN or Proposed INN: Flecainidum Other descriptive ...	Theranexus S.A.	NULL	Not Recruiting			Female: yes Male: yes	60	Phase 2	Czech Republic;Hungary;United States;France;Germany
3	NCT03083132 (ClinicalTrials.gov)	June 13, 2017	7/3/2017	Modafinil for Freezing of Gait (FOG) in Parkinson's Disease (PD)	Modafinil as a Novel Therapy for the Treatment of Freezing of Gait in Parkinson's Disease	Parkinson Disease	Drug: modafinil 50mg;Drug: Placebo oral capsule	University of Arkansas	NULL	Completed	50 Years	90 Years	All	23	Early Phase 1	United States
4	NCT02857244 (ClinicalTrials.gov)	November 2016	25/7/2016	A Multidisciplinary Approach to Manage Gait Difficulty in Parkinson Patients	A Multidisciplinary Approach to Manage Gait Difficulty in Parkinson Patients	Parkinson's Disease	Drug: Duloxetine;Drug: Donepezil;Drug: Modafinil	University of Chicago	NULL	Withdrawn	18 Years	100 Years	All	0	Phase 2	United States
5	JPRN-UMIN000019676	2015/11/10	10/11/2015	The double blind, placebo controlled trial of modafinilfor excessive daytime sleepiness in Parkinson ...	The double blind, placebo controlled trial of modafinilfor excessive daytime sleepiness in Parkinson ...	Parkinson's disease	taking modafinil(200 mg/day) after breakfast for 4 weeks, wash out for 2 weeks, taking matching plac ...	Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine	NULL	Complete: follow-up complete	20years-old	100years-old	Male and Female	20	Not selected	Japan
6	NCT00393562 (ClinicalTrials.gov)	March 2006	26/10/2006	Comparison of Modafiniland Methylphenidate in Treatment of Excessive Daytime Sleepiness in Patients ...	Comparison of Modafiniland Methylphenidate in Treatment of Excessive Daytime Sleepiness in Patients ...	Parkinson's Disease	Drug: modafinil;Drug: methylphenidate	Department of Veterans Affairs	NULL	Withdrawn	50 Years	80 Years	Both	0	N/A	United States

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13. Multiple sclerosis/Neuromyelitis optica

Clinical trials : 3,340 / Drugs : 2,163 - (DrugBank : 383) / Drug target genes : 241 - Drug target pathways : 238

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Showing 1 to 5 of 5 trials

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03621761 (ClinicalTrials.gov)	November 15, 2018	3/8/2018	Cognitive Behavioral Therapy, Modafinil, or Both for Multiple Sclerosis Fatigue	A Randomized Controlled Trial of Telephone-delivered Cognitive Behavioral-therapy, Modafinil, and Co ...	Multiple Sclerosis	Behavioral: Telephone-based Cognitive Behavioral Therapy;Drug: Modafinil	University of Michigan	University of Washington;Patient-Centered Outcomes Research Institute;National Multiple Sclerosis So ...	Completed	18 Years	N/A	All	343	Phase 4	United States
2	NCT03185065 (ClinicalTrials.gov)	October 4, 2017	9/6/2017	Treatment of Fatigue With Methylphenidate, Modafinil and Amantadine in Multiple Sclerosis	Treatment of Fatigue With Methylphenidate, Modafinil and Amantadine in Multiple Sclerosis	Fatigue in Multiple Sclerosis	Drug: Amantadine;Drug: Modafinil;Drug: Methylphenidate;Drug: Placebos	Johns Hopkins University	Patient-Centered Outcomes Research Institute	Completed	18 Years	N/A	All	141	Phase 3	United States
3	EUCTR2012-003418-15-AT (EUCTR)	23/10/2012	09/11/2012	Methylphenidate modified release as treatment of MS-associated fatigue.	Methylphenidate modified release as treatment option of MS-associated fatigue. A single-center rando ...	Fatigue is a very common symptom in multiple sclerosis. Its management comprises nonpharmacologic ap ...	Trade Name: Ritalin LA 20mg capsules Product Name: Methylphenidate modified release 20 mg INN or Propo ...	Medizinische Universität Wien	NULL	Not Recruiting			Female: yes Male: yes	96	Phase 2	Austria
4	NCT00142402 (ClinicalTrials.gov)	June 2003	1/9/2005	Modafinil in Multiple Sclerosis	Modafinil for Improving New Learning and Memory in Multiple Sclerosis	Multiple Sclerosis	Drug: Modafinil	Kessler Foundation	National Multiple Sclerosis Society	Completed	18 Years	60 Years	Both	20	N/A	United States
5	NCT00210301 (ClinicalTrials.gov)	January 2003	13/9/2005	Combination Therapy (Provigil + Avonex) to Treat Cognitive Problems in MS	Combination Therapy (Provigil + Avonex) in the Treatment of Attention Problems in Patients With Rela ...	Relapsing-Remitting Multiple Sclerosis	Drug: Provigil (modafinil)	Institute for Clinical Research	NULL	Recruiting	20 Years	65 Years	Both	60	N/A	United States

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49. Systemic lupus erythematosus

Clinical trials : 993 / Drugs : 702 - (DrugBank : 184) / Drug target genes : 116 - Drug target pathways : 200

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00297284 (ClinicalTrials.gov)	February 2006	24/2/2006	Memory and Attention Problems in Lupus: New Treatment Trial With Modafinil	Pilot and Feasibility Study of Modafinil Treatment to Improve Cognitive Efficiency in SLE Patients	Systemic Lupus Erythematosus	Drug: Modafinil	Hospital for Special Surgery, New York	NULL	Terminated	18 Years	60 Years	Both	20	N/A	United States

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93. Primary biliary cholangitis

Clinical trials : 298 / Drugs : 252 - (DrugBank : 59) / Drug target genes : 35 - Drug target pathways : 115

trials per page:

Showing 1 to 1 of 1 trials

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00943176 (ClinicalTrials.gov)	June 2009	17/7/2009	Modafinil in the Treatment of Fatigue in Patients With Primary Biliary Cirrhosis (PBC)	Modafinil in the Treatment of Fatigue in Patients With Primary Biliary Cirrhosis	Fatigue;Primary Biliary Cirrhosis	Drug: Modafinil	Mayo Clinic	American College of Gastroenterology	Completed	21 Years	75 Years	Both	40	Phase 1	United States

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