Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 KCNA4 2件: Cortisol synthesis and secretion, Cushing syndrome D04127 Dalfampridine 5件: 3, 4, 6, 13, 14
2 KCNA4 2件: Cortisol synthesis and secretion, Cushing syndrome D10228 Amifampridine 3件: 3, 11, 12
3 KCNC3 1件: Spinocerebellar ataxia D04127 Dalfampridine 5件: 3, 4, 6, 13, 14
4 KCNC3 1件: Spinocerebellar ataxia D10228 Amifampridine 3件: 3, 11, 12
5 KCND2 1件: Serotonergic synapse D04127 Dalfampridine 5件: 3, 4, 6, 13, 14
6 KCND2 1件: Serotonergic synapse D10228 Amifampridine 3件: 3, 11, 12
7 KCND3 1件: Spinocerebellar ataxia D00636 Amiodarone 2件: 28, 127
8 KCND3 1件: Spinocerebellar ataxia D02910 Amiodarone 2件: 28, 127
9 KCND3 1件: Spinocerebellar ataxia D04127 Dalfampridine 5件: 3, 4, 6, 13, 14
10 KCND3 1件: Spinocerebellar ataxia D10228 Amifampridine 3件: 3, 11, 12
11 KCNJ3 10件: Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Dopaminergic synapse, Estrogen signaling pathway, Oxytocin signaling pathway, GnRH secretion, Morphine addiction D00636 Amiodarone 2件: 28, 127
12 KCNJ3 10件: Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Dopaminergic synapse, Estrogen signaling pathway, Oxytocin signaling pathway, GnRH secretion, Morphine addiction D02910 Amiodarone 2件: 28, 127
13 KCNJ5 9件: Circadian entrainment, Retrograde endocannabinoid signaling, Serotonergic synapse, Dopaminergic synapse, Estrogen signaling pathway, Oxytocin signaling pathway, Aldosterone synthesis and secretion, GnRH secretion, Morphine addiction D00636 Amiodarone 2件: 28, 127
14 KCNJ5 9件: Circadian entrainment, Retrograde endocannabinoid signaling, Serotonergic synapse, Dopaminergic synapse, Estrogen signaling pathway, Oxytocin signaling pathway, Aldosterone synthesis and secretion, GnRH secretion, Morphine addiction D02910 Amiodarone 2件: 28, 127
15 KCNJ8 1件: cGMP-PKG signaling pathway D00636 Amiodarone 2件: 28, 127
16 KCNJ8 1件: cGMP-PKG signaling pathway D02910 Amiodarone 2件: 28, 127
17 KCNJ11 3件: Insulin secretion, GnRH secretion, Type II diabetes mellitus D00294 Diazoxide 2件: 13, 193
18 KCNJ11 3件: Insulin secretion, GnRH secretion, Type II diabetes mellitus D00418 Minoxidil 1件: 179
19 KCNJ11 3件: Insulin secretion, GnRH secretion, Type II diabetes mellitus D00594 Repaglinide 3件: 6, 21, 299
20 KCNJ11 3件: Insulin secretion, GnRH secretion, Type II diabetes mellitus D00636 Amiodarone 2件: 28, 127
21 KCNJ11 3件: Insulin secretion, GnRH secretion, Type II diabetes mellitus D02910 Amiodarone 2件: 28, 127
22 KCNJ12 2件: Cholinergic synapse, Oxytocin signaling pathway D00636 Amiodarone 2件: 28, 127
23 KCNJ12 2件: Cholinergic synapse, Oxytocin signaling pathway D02910 Amiodarone 2件: 28, 127
24 KCNQ1 6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D00636 Amiodarone 2件: 28, 127
25 KCNQ1 6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D02910 Amiodarone 2件: 28, 127
26 KCNQ1 6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D09569 Ezogabine 2件: 2, 144
27 KCNQ2 1件: Cholinergic synapse D09569 Ezogabine 2件: 2, 144
28 KCNQ3 1件: Cholinergic synapse D09569 Ezogabine 2件: 2, 144
29 KDR 10件: EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D03218 Axitinib 1件: 34
30 KDR 10件: EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D06272 Sorafenib 2件: 34, 86
31 KDR 10件: EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D06402 Sunitinib 2件: 28, 34
32 KDR 10件: EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D08524 Sorafenib 2件: 34, 86
33 KDR 10件: EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D08552 Sunitinib 2件: 28, 34
34 KDR 10件: EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D08881 Cediranib 1件: 34
35 KDR 10件: EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D10062 Cabozantinib 1件: 34
36 KDR 10件: EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D10481 Nintedanib 5件: 51, 85, 89, 227, 228
37 KDR 10件: EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D11772 Tesevatinib 1件: 67
38 KIT 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D01441 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
39 KIT 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D03658 Dasatinib 2件: 51, 85
40 KIT 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D06272 Sorafenib 2件: 34, 86
41 KIT 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D06402 Sunitinib 2件: 28, 34
42 KIT 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D06414 Dasatinib 2件: 51, 85
43 KIT 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D08066 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
44 KIT 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D08524 Sorafenib 2件: 34, 86
45 KIT 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D08552 Sunitinib 2件: 28, 34
46 KIT 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D08953 Nilotinib 5件: 6, 8, 34, 51, 86
47 KIT 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D10229 Masitinib 6件: 2, 5, 6, 13, 46, 96
48 KIT 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D11270 Pexidartinib 1件: 34
49 KLKB1 1件: Complement and coagulation cascades D10845 Conestat alfa 1件: 61
50 KCNQ5 1件: Cholinergic synapse D09569 Ezogabine 2件: 2, 144
51 KCNQ4 1件: Cholinergic synapse D09569 Ezogabine 2件: 2, 144
52 KEAP1 6件: Ubiquitin mediated proteolysis, Parkinson disease, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis D03846 Dimethyl fumarate 5件: 13, 49, 51, 86, 296