KEGG DRUG

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No.	Drug (Description in trials)	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY	Disease ID
1	150-mg IVACAFTOR (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
2	150mg IVACAFTOR (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
3	75-mg IVACAFTOR (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
4	CF patients with a G551D mutation and treated with Ivacaftor (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
5	Deuterated Ivacaftor (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
6	Elexacaftor-tezacaftor-ivacaftor exposure (Synonym: Kalydeco (TN))	[3] Elexacaftor, Ivacaftor (Synonym: Kalydeco), Tezacaftor	[3] D09916 (Name: Kalydeco (TN)), D11041 , D11507	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
7	Elexacaftor/tezacaftor/ivacaftor (Synonym: Kalydeco (TN))	[3] Elexacaftor, Ivacaftor (Synonym: Kalydeco), Tezacaftor	[3] D09916 (Name: Kalydeco (TN)), D11041 , D11507	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
8	IVACAFTOR (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
9	Ivacaftor (proposed INN) (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
10	Ivacaftor 125mg tablet (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
11	Ivacaftor 150 mg (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
12	Ivacaftor 150 mg or 250 mg (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
13	Ivacaftor 25 mg/75 mg (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
14	IVACAFTOR 59,5mg (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
15	IVACAFTOR 59.5mg (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
16	Ivacaftor 75 mg (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
17	Ivacaftor 75 mg/150 mg (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
18	IVACAFTOR 75mg (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
19	Ivacaftor Exposed (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
20	Ivacaftor or elexacaftor/tezacaftor/ivacaftor (Synonym: Kalydeco (TN))	[3] Elexacaftor, Ivacaftor (Synonym: Kalydeco), Tezacaftor	[3] D09916 (Name: Kalydeco (TN)), D11041 , D11507	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
21	Ivacaftor+lumacaftor (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Lumacaftor	[2] D09916 (Name: Kalydeco (TN)), D10134	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
22	Ivacaftor/Ataluren (Synonym: Kalydeco (TN))	[2] Ataluren, Ivacaftor (Synonym: Kalydeco)	[2] D09323 , D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
23	Ivacaftor/Kalydeco	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
24	Ivacaftor/Trikafta (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
25	Kalydeco	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
26	Kalydeco 150 mg film-c	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
27	Kalydeco 150 mg film-coated tablets	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
28	Kalydeco 150mg	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
29	Lumacaftor / ivacaftor (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Lumacaftor	[2] D09916 (Name: Kalydeco (TN)), D10134	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
30	Lumacaftor plus Ivacaftor (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Lumacaftor	[2] D09916 (Name: Kalydeco (TN)), D10134	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
31	Lumacaftor Plus Ivacaftor Combination (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Lumacaftor	[2] D09916 (Name: Kalydeco (TN)), D10134	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
32	Lumacaftor, Ivacaftor Drug Combination (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Lumacaftor	[2] D09916 (Name: Kalydeco (TN)), D10134	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
33	Lumacaftor-ivacaftor (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Lumacaftor	[2] D09916 (Name: Kalydeco (TN)), D10134	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
34	Lumacaftor-Ivacaftor treatment (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Lumacaftor	[2] D09916 (Name: Kalydeco (TN)), D10134	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
35	Lumacaftor/Ivacaftor (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Lumacaftor	[2] D09916 (Name: Kalydeco (TN)), D10134	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
36	Lumacaftor/ivacaftor 100mg/125mg tablets (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Lumacaftor	[2] D09916 (Name: Kalydeco (TN)), D10134	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
37	Lumacaftor/ivacaftor 200mg/125mg (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Lumacaftor	[2] D09916 (Name: Kalydeco (TN)), D10134	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
38	Lumacaftor/ivacaftor 200mg/125mg tablets (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Lumacaftor	[2] D09916 (Name: Kalydeco (TN)), D10134	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
39	Lumacaftor/ivacaftor 200mg/83mg tablet (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Lumacaftor	[2] D09916 (Name: Kalydeco (TN)), D10134	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
40	Orkambi: contains lumacaftor and ivacaftor (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Lumacaftor	[2] D09916 (Name: Kalydeco (TN)), D10134	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
41	Tezacaftor/Ivacaftor (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Tezacaftor	[2] D09916 (Name: Kalydeco (TN)), D11041	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
42	Tezacaftor/Ivacaftor + Ivacaftor (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Tezacaftor	[2] D09916 (Name: Kalydeco (TN)), D11041	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
43	Tezacaftor/Ivacaftor 100mg/150mg (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Tezacaftor	[2] D09916 (Name: Kalydeco (TN)), D11041	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
44	Tezacaftor/Ivacaftor/100mg/150mg (Synonym: Kalydeco (TN))	[2] Ivacaftor (Synonym: Kalydeco), Tezacaftor	[2] D09916 (Name: Kalydeco (TN)), D11041	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
45	Treatment with cystic fibrosis transmembrane regulator (CFTR) modualtors Ivacaftor, Lumacaftor-Ivacaftor, Tezacaftor-Ivacaftor, Elexacaftor-Tezacaftor-Ivacaftor (Synonym: Kalydeco (TN))	[4] Elexacaftor, Ivacaftor (Synonym: Kalydeco), Lumacaftor, Tezacaftor	[4] D09916 (Name: Kalydeco (TN)), D10134 , D11041 , D11507	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
46	VX-659/Tezacaftor/Ivacaftor (Synonym: Kalydeco (TN))	[3] Ivacaftor (Synonym: Kalydeco), Tezacaftor, VX-659	[2] D09916 (Name: Kalydeco (TN)), D11041	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
47	VX-661 Plus Ivacaftor Combination (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
48	VX-661/Ivacaftor (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
49	VX-661/ivacaftor (VX-770) 100mg/150 mg (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
50	VX-661/ivacaftor 100 mg/ 150 mg (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
51	VX-661/ivacaftor 100mg/150 mg (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
52	VX-661/ivacaftor 100mg/150mg (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299
53	VX-661/ivacaftor 50 mg/ 75 mg (Synonym: Kalydeco (TN))	[1] Ivacaftor (Synonym: Kalydeco)	[1] D09916 (Name: Kalydeco (TN))	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299