Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 MAPK14 [9] VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
2 MAPK14 [9] VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
3 HLA-DMA [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
4 HLA-DMB [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
5 HLA-DOA [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
6 HLA-DOB [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
7 HLA-DPA1 [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
8 HLA-DPB1 [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
9 HLA-DQA1 [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
10 HLA-DQA2 [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
11 HLA-DQB1 [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
12 HLA-DRA [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
13 HLA-DRB1 [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
14 HLA-DRB3 [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
15 HLA-DRB4 [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
16 HLA-DRB5 [6] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
17 IFNG [5] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D04242 Fontolizumab [1] 46
18 IFNG [5] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D11120 Emapalumab [2] 49, 107
19 IFNGR1 [4] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D00747 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326
20 IFNGR2 [4] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D00747 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326
21 IL2RA [3] Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation D00748 Aldesleukin [6] 2, 35, 49, 65, 96, 97
22 IL2RA [3] Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation D03058 Basiliximab [6] 2, 50, 66, 97, 222, 228
23 IL2RA [3] Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation D03639 Daclizumab [8] 13, 56, 60, 65, 97, 107, 283, 284
24 IL2RB [4] Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation, Transcriptional misregulation in cancer D00748 Aldesleukin [6] 2, 35, 49, 65, 96, 97
25 IL2RG [3] Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation D00748 Aldesleukin [6] 2, 35, 49, 65, 96, 97
26 IL4 [2] Th1 and Th2 cell differentiation, Th17 cell differentiation D03117 Binetrakin [1] 46
27 IL4R [2] Th1 and Th2 cell differentiation, Th17 cell differentiation D10354 Dupilumab [4] 51, 98, 160, 162
28 IL5 [1] Th1 and Th2 cell differentiation D04923 Mepolizumab [4] 44, 45, 98, 162
29 IL5 [1] Th1 and Th2 cell differentiation D08985 Reslizumab [2] 44, 98
30 IL12A [5] Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D09214 Ustekinumab [17] 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
31 IL12B [5] Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D09214 Ustekinumab [17] 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
32 IL13 [1] Th1 and Th2 cell differentiation D08857 Anrukinzumab [1] 97
33 IL13 [1] Th1 and Th2 cell differentiation D09633 Lebrikizumab [1] 85
34 IL13 [1] Th1 and Th2 cell differentiation D09979 Tralokinumab [2] 85, 97
35 JAK1 [5] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D09959 Ruxolitinib [1] 228
36 JAK1 [5] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D09970 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
37 JAK1 [5] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10308 Baricitinib [13] 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325
38 JAK1 [5] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10653 Peficitinib [1] 46
39 JAK1 [5] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10871 Filgotinib [6] 46, 53, 96, 97, 222, 271
40 JAK1 [5] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10944 Itacitinib [5] 46, 51, 60, 97, 228
41 JAK1 [5] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10994 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271
42 JAK2 [4] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D09959 Ruxolitinib [1] 228
43 JAK2 [4] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D09970 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
44 JAK2 [4] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D10308 Baricitinib [13] 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325
45 JAK2 [4] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D10653 Peficitinib [1] 46
46 JAK3 [3] Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral carcinogenesis D09970 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
47 JAK3 [3] Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral carcinogenesis D10653 Peficitinib [1] 46
48 LCK [3] Th1 and Th2 cell differentiation, Th17 cell differentiation, Yersinia infection D03658 Dasatinib [2] 51, 85
49 LCK [3] Th1 and Th2 cell differentiation, Th17 cell differentiation, Yersinia infection D06414 Dasatinib [2] 51, 85
50 NFKB1 [9] Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D01146 Iguratimod [4] 46, 51, 53, 271
51 PPP3CA [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00107 Tacrolimus [34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
52 PPP3CA [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00184 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
53 PPP3CA [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D05480 Pimecrolimus [1] 160
54 PPP3CA [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D08556 Tacrolimus [34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
55 PPP3CA [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D09033 Voclosporin [1] 222
56 PPP3CB [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00107 Tacrolimus [34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
57 PPP3CB [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00184 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
58 PPP3CB [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D05480 Pimecrolimus [1] 160
59 PPP3CB [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D08556 Tacrolimus [34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
60 PPP3CB [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D09033 Voclosporin [1] 222
61 PPP3CC [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00107 Tacrolimus [34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
62 PPP3CC [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00184 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
63 PPP3CC [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D05480 Pimecrolimus [1] 160
64 PPP3CC [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D08556 Tacrolimus [34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
65 PPP3CC [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D09033 Voclosporin [1] 222
66 PPP3R1 [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00107 Tacrolimus [34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
67 PPP3R1 [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00184 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
68 PPP3R1 [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D05480 Pimecrolimus [1] 160
69 PPP3R1 [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D08556 Tacrolimus [34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
70 PPP3R1 [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D09033 Voclosporin [1] 222
71 PPP3R2 [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00107 Tacrolimus [34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
72 PPP3R2 [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00184 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
73 PPP3R2 [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D05480 Pimecrolimus [1] 160
74 PPP3R2 [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D08556 Tacrolimus [34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
75 PPP3R2 [5] Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D09033 Voclosporin [1] 222
76 PRKCQ [3] Vascular smooth muscle contraction, Th1 and Th2 cell differentiation, Th17 cell differentiation D09671 Sotrastaurin [1] 97
77 MAPK11 [9] VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
78 MAPK11 [9] VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
79 MAPK13 [9] VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
80 MAPK13 [9] VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
81 RELA [9] Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D12181 Edasalonexent [1] 113
82 MAPK12 [9] VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
83 MAPK12 [9] VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
84 TYK2 [3] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis D09970 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
85 TYK2 [3] Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis D11817 Deucravacitinib [2] 96, 97
86 CD3D [2] Th1 and Th2 cell differentiation, Th17 cell differentiation D05092 Muromonab [3] 60, 96, 97
87 CD3D [2] Th1 and Th2 cell differentiation, Th17 cell differentiation D06314 Visilizumab [2] 96, 97
88 CD3D [2] Th1 and Th2 cell differentiation, Th17 cell differentiation D08959 Otelixizumab [1] 46
89 CD3E [2] Th1 and Th2 cell differentiation, Th17 cell differentiation D05092 Muromonab [3] 60, 96, 97
90 CD3E [2] Th1 and Th2 cell differentiation, Th17 cell differentiation D06314 Visilizumab [2] 96, 97
91 CD3E [2] Th1 and Th2 cell differentiation, Th17 cell differentiation D08959 Otelixizumab [1] 46
92 CD3E [2] Th1 and Th2 cell differentiation, Th17 cell differentiation D11463 Mosunetuzumab [1] 49
93 CD3G [2] Th1 and Th2 cell differentiation, Th17 cell differentiation D05092 Muromonab [3] 60, 96, 97
94 CD3G [2] Th1 and Th2 cell differentiation, Th17 cell differentiation D06314 Visilizumab [2] 96, 97
95 CD3G [2] Th1 and Th2 cell differentiation, Th17 cell differentiation D08959 Otelixizumab [1] 46