| 1 | (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4’- | - | - | - | - | [1]  79 79 💬
 | 
| 2 | 1,2-Dihexadecanoyl-sn-Glycero-3-Phospho-(1-raac-glycerol) | [1]  Glycerin Glycerin | [1]  Glycerin 
                
                    Glycerin
                
             💬
 | - | - | [1]  79 79 💬
 | 
| 3 | AAV directed hLDLR gene therapy | - | - | - | - | [1]  79 79 💬
 | 
| 4 | AAV8.TBG.hLDLR | - | - | - | - | [1]  79 79 💬
 | 
| 5 | Acetate | [1]  Acetate Acetate | - | - | - | [41]  1 1, 2, 6, 10, 13, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 171, 206, 222, 224, 225, 227, 235, 251, 265, 288, 298, 299 💬
 | 
| 6 | AEGR-733 | - | - | - | - | [1]  79 79 💬
 | 
| 7 | AK102 | - | - | - | - | [1]  79 79 💬
 | 
| 8 | AKCEA-ANGPTL3-LRX | - | - | - | - | [2]  79 79, 265 💬
 | 
| 9 | ALIROCUMAB | [1]  Alirocumab Alirocumab | [1]  Alirocumab 
                
                    Alirocumab
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 10 | Alirocumab SAR236553 (REGN727) | [1]  Alirocumab Alirocumab | [1]  Alirocumab 
                
                    Alirocumab
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 11 | ALN-60212 | - | - | - | - | [1]  79 79 💬
 | 
| 12 | ALN-PCSSC | [1]  Inclisiran Inclisiran | [1]  Inclisiran 
                
                    Inclisiran
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 13 | AMG 145 | - | - | - | - | [1]  79 79 💬
 | 
| 14 | AMG145 | - | - | - | - | [1]  79 79 💬
 | 
| 15 | ANACETRAPIB | [1]  Anacetrapib Anacetrapib | [1]  Anacetrapib 
                
                    Anacetrapib
                
             💬
 | [1]  CETP CETP 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 16 | ARO-ANG 3 Injection | - | - | - | - | [1]  79 79 💬
 | 
| 17 | Atorvastatin | [1]  Atorvastatin Atorvastatin | [1]  Atorvastatin 
                
                    Atorvastatin
                
             💬
 | [1]  HMGCR HMGCR 💬
 | [4]  AMPK signaling pathway AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬 | [19]  13 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
 | 
| 18 | Calcium | [2]  Calcium Calcium, Calcium carbonate | [2]  Calcium carbonate 
                
                    Calcium carbonate
                
            , 
                
                    Calcium carbonate
                
             💬
 | - | - | [27]  6 6, 13, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 156, 214, 215, 222, 224, 235, 265, 274, 298, 299 💬
 | 
| 19 | Calcium rosuvastatin | [2]  Calcium Calcium, Rosuvastatin | [1]  Rosuvastatin 
                
                    Rosuvastatin
                
             💬
 | [1]  HMGCR HMGCR 💬
 | [4]  AMPK signaling pathway AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬 | [1]  79 79 💬
 | 
| 20 | CER-001 | - | - | - | - | [1]  79 79 💬
 | 
| 21 | Cholestyramine | [1]  Cholestyramine Cholestyramine | - | - | - | [2]  13 13, 79 💬
 | 
| 22 | Comparator: ezetimibe | [1]  Ezetimibe Ezetimibe | [1]  Ezetimibe 
                
                    Ezetimibe
                
             💬
 | [1]  NPC1L1 NPC1L1 💬
 | [1]  Fat digestion and absorption Fat digestion and absorption 💬 | [2]  79 79, 260 💬
 | 
| 23 | Crestor | [1]  Rosuvastatin Rosuvastatin | [1]  Rosuvastatin 
                
                    Rosuvastatin
                
             💬
 | [1]  HMGCR HMGCR 💬
 | [4]  AMPK signaling pathway AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬 | [3]  49 49, 79, 299 💬
 | 
| 24 | Crestor Film-Coated Tablet | [1]  Rosuvastatin Rosuvastatin | [1]  Rosuvastatin 
                
                    Rosuvastatin
                
             💬
 | [1]  HMGCR HMGCR 💬
 | [4]  AMPK signaling pathway AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬 | [1]  79 79 💬
 | 
| 25 | Crestor Tablets (calcium rosuvastatin) Film-Coated tablets | [2]  Calcium Calcium, Rosuvastatin | [1]  Rosuvastatin 
                
                    Rosuvastatin
                
             💬
 | [1]  HMGCR HMGCR 💬
 | [4]  AMPK signaling pathway AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬 | [1]  79 79 💬
 | 
| 26 | Current lipid-lowering treatment | - | - | - | - | [1]  79 79 💬
 | 
| 27 | DPPG | - | - | - | - | [1]  79 79 💬
 | 
| 28 | EVINACUMAB | [1]  Evinacumab Evinacumab | [1]  Evinacumab 
                
                    Evinacumab
                
             💬
 | [1]  ANGPTL3 ANGPTL3 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 29 | Evinacumab (REGN1500) | [1]  Evinacumab Evinacumab | [1]  Evinacumab 
                
                    Evinacumab
                
             💬
 | [1]  ANGPTL3 ANGPTL3 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 30 | EVOLOCUMAB | [1]  Evolocumab Evolocumab | [1]  Evolocumab 
                
                    Evolocumab
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [2]  79 79, 222 💬
 | 
| 31 | Evolocumab (AMG 145) | [1]  Evolocumab Evolocumab | [1]  Evolocumab 
                
                    Evolocumab
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 32 | Ezetimibe | [1]  Ezetimibe Ezetimibe | [1]  Ezetimibe 
                
                    Ezetimibe
                
             💬
 | [1]  NPC1L1 NPC1L1 💬
 | [1]  Fat digestion and absorption Fat digestion and absorption 💬 | [4]  49 49, 79, 93, 260 💬
 | 
| 33 | Fenofibrate | [1]  Fenofibrate Fenofibrate | [1]  Fenofibrate 
                
                    Fenofibrate
                
             💬
 | [1]  PPARA PPARA 💬
 | [10]  Adipocytokine signaling pathway Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬 | [6]  8 8, 79, 93, 94, 97, 265 💬
 | 
| 34 | Fluvastatin | [1]  Fluvastatin Fluvastatin | [1]  Fluvastatin 
                
                    Fluvastatin
                
             💬
 | [1]  HMGCR HMGCR 💬
 | [4]  AMPK signaling pathway AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬 | [3]  79 79, 218, 222 💬
 | 
| 35 | Gemcabene | [1]  Gemcabene Gemcabene | - | - | - | [2]  79 79, 265 💬
 | 
| 36 | Gene analysis | - | - | - | - | [1]  79 79 💬
 | 
| 37 | Glycerol | [1]  Glycerin Glycerin | [1]  Glycerin 
                
                    Glycerin
                
             💬
 | - | - | [5]  6 6, 13, 79, 316, 317 💬
 | 
| 38 | IBI306 | - | - | - | - | [1]  79 79 💬
 | 
| 39 | Implitapide | [1]  Implitapide Implitapide | - | - | - | [1]  79 79 💬
 | 
| 40 | Inclisiran | [1]  Inclisiran Inclisiran | [1]  Inclisiran 
                
                    Inclisiran
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 41 | Inclisiran Sodium | [1]  Inclisiran Inclisiran | [1]  Inclisiran 
                
                    Inclisiran
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 42 | Inclisiran Sodium for injection | [1]  Inclisiran Inclisiran | [1]  Inclisiran 
                
                    Inclisiran
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 43 | ISIS 301012 | - | - | - | - | [1]  79 79 💬
 | 
| 44 | ISIS 301012 phosphorothioate oligonucleotide | - | - | - | - | [1]  79 79 💬
 | 
| 45 | ISIS 703802 | - | - | - | - | [1]  79 79 💬
 | 
| 46 | JS002 | - | - | - | - | [1]  79 79 💬
 | 
| 47 | KJX839 | - | - | - | - | [1]  79 79 💬
 | 
| 48 | Lapaquistat | [1]  Lapaquistat Lapaquistat | - | - | - | [1]  79 79 💬
 | 
| 49 | Lapaquistat acetate and current lipid-lowering treatment | [2]  Acetate Acetate, Lapaquistat | - | - | - | [1]  79 79 💬
 | 
| 50 | Leqvio | [1]  Inclisiran Inclisiran | [1]  Inclisiran 
                
                    Inclisiran
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 51 | Leqvio 284 mg solution for injection in pre-filled syringe | [1]  Inclisiran Inclisiran | [1]  Inclisiran 
                
                    Inclisiran
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 52 | Lerodalcibep | - | - | - | - | [1]  79 79 💬
 | 
| 53 | LIB003 | - | - | - | - | [1]  79 79 💬
 | 
| 54 | Lojuxta | [1]  Lomitapide Lomitapide | [1]  Lomitapide 
                
                    Lomitapide
                
             💬
 | [1]  MTTP MTTP 💬
 | [1]  Fat digestion and absorption Fat digestion and absorption 💬 | [1]  79 79 💬
 | 
| 55 | Lojuxta 10 mg hard capsules | [1]  Lomitapide Lomitapide | [1]  Lomitapide 
                
                    Lomitapide
                
             💬
 | [1]  MTTP MTTP 💬
 | [1]  Fat digestion and absorption Fat digestion and absorption 💬 | [1]  79 79 💬
 | 
| 56 | Lojuxta 20 mg hard capsules | [1]  Lomitapide Lomitapide | [1]  Lomitapide 
                
                    Lomitapide
                
             💬
 | [1]  MTTP MTTP 💬
 | [1]  Fat digestion and absorption Fat digestion and absorption 💬 | [1]  79 79 💬
 | 
| 57 | Lojuxta 5 mg hard capsules | [1]  Lomitapide Lomitapide | [1]  Lomitapide 
                
                    Lomitapide
                
             💬
 | [1]  MTTP MTTP 💬
 | [1]  Fat digestion and absorption Fat digestion and absorption 💬 | [1]  79 79 💬
 | 
| 58 | LOMITAPIDE | [1]  Lomitapide Lomitapide | [1]  Lomitapide 
                
                    Lomitapide
                
             💬
 | [1]  MTTP MTTP 💬
 | [1]  Fat digestion and absorption Fat digestion and absorption 💬 | [1]  79 79 💬
 | 
| 59 | Lomitapide 2mg hard capsules | [1]  Lomitapide Lomitapide | [1]  Lomitapide 
                
                    Lomitapide
                
             💬
 | [1]  MTTP MTTP 💬
 | [1]  Fat digestion and absorption Fat digestion and absorption 💬 | [1]  79 79 💬
 | 
| 60 | Lovastatin | [1]  Lovastatin Lovastatin | [1]  Lovastatin 
                
                    Lovastatin
                
             💬
 | [1]  HMGCR HMGCR 💬
 | [4]  AMPK signaling pathway AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬 | [11]  6 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
 | 
| 61 | MBX-8025 | - | - | - | - | [3]  79 79, 93, 94 💬
 | 
| 62 | MBX-8025 50 mg (Dose Escalation Period 1) | - | - | - | - | [1]  79 79 💬
 | 
| 63 | MBX-8025 50 mg or 100 mg (Dose Escalation Period 2) | - | - | - | - | [1]  79 79 💬
 | 
| 64 | MBX-8025 50 mg, 100 mg or 200 mg (Dose Escalation Period 3) | - | - | - | - | [1]  79 79 💬
 | 
| 65 | Mipomersen | [1]  Mipomersen Mipomersen | - | - | - | [1]  79 79 💬
 | 
| 66 | MK-0859 | - | - | - | - | [1]  79 79 💬
 | 
| 67 | Nicotinic acid | [1]  Niacin Niacin | [1]  Niacin 
                
                    Niacin
                
             💬
 | - | - | [1]  79 79 💬
 | 
| 68 | Omega-3 | [1]  Omega-3 fatty acids Omega-3 fatty acids | - | - | - | [7]  13 13, 46, 49, 66, 79, 96, 299 💬
 | 
| 69 | Omega-3 fatty acids | [1]  Omega-3 fatty acids Omega-3 fatty acids | - | - | - | [2]  13 13, 79 💬
 | 
| 70 | Phospholipids | [1]  Omega-3 fatty acids Omega-3 fatty acids | - | - | - | [1]  79 79 💬
 | 
| 71 | Placebo | - | - | - | - | [28]  3 3, 5, 6, 11, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276 💬
 | 
| 72 | Praluent | [1]  Alirocumab Alirocumab | [1]  Alirocumab 
                
                    Alirocumab
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 73 | Pravastatin | [1]  Pravastatin Pravastatin | [1]  Pravastatin 
                
                    Pravastatin
                
             💬
 | [1]  HMGCR HMGCR 💬
 | [4]  AMPK signaling pathway AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬 | [9]  13 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
 | 
| 74 | PRD7255830 | - | - | - | - | [1]  79 79 💬
 | 
| 75 | PRD7255977 | - | - | - | - | [1]  79 79 💬
 | 
| 76 | PRD7256003 | - | - | - | - | [1]  79 79 💬
 | 
| 77 | Prednisone | [1]  Prednisone Prednisone | [1]  Prednisone 
                
                    Prednisone
                
             💬
 | [1]  NR3C1 NR3C1 💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction 💬 | [45]  2 2, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331 💬
 | 
| 78 | R727 | - | - | - | - | [1]  79 79 💬
 | 
| 79 | Recombinant Human Apolipoprotein | - | - | - | - | [1]  79 79 💬
 | 
| 80 | Recombinant Human Apolipoprotein A-I | - | - | - | - | [1]  79 79 💬
 | 
| 81 | Recombinant Human Apolipoprotein A-I/Phospholipids Complex | [1]  Omega-3 fatty acids Omega-3 fatty acids | - | - | - | [1]  79 79 💬
 | 
| 82 | Recombinant human apolipoprotein a1 | - | - | - | - | [1]  79 79 💬
 | 
| 83 | REGN1500 | - | - | - | - | [1]  79 79 💬
 | 
| 84 | REGN1500 250 mg SC/15 mg/kg IV/450 mg SC | - | - | - | - | [1]  79 79 💬
 | 
| 85 | REGN7272 | - | - | - | - | [1]  79 79 💬
 | 
| 86 | Repatha | [1]  Evolocumab Evolocumab | [1]  Evolocumab 
                
                    Evolocumab
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 87 | Repatha (evolocumab) | [1]  Evolocumab Evolocumab | [1]  Evolocumab 
                
                    Evolocumab
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 88 | Repatha 140 mg Solution for Injection in Pre-filled Pen | [1]  Evolocumab Evolocumab | [1]  Evolocumab 
                
                    Evolocumab
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 89 | Repatha 140 mg soluzione per iniezione in penna preriempita. | [1]  Evolocumab Evolocumab | [1]  Evolocumab 
                
                    Evolocumab
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 90 | Repatha 420 mg solution for injection in cartridge | [1]  Evolocumab Evolocumab | [1]  Evolocumab 
                
                    Evolocumab
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 91 | Repatha 420 mg soluzione per iniezione in cartuccia | [1]  Evolocumab Evolocumab | [1]  Evolocumab 
                
                    Evolocumab
                
             💬
 | [1]  PCSK9 PCSK9 💬
 | [1]  Cholesterol metabolism Cholesterol metabolism 💬 | [1]  79 79 💬
 | 
| 92 | Rosuvastatin | [1]  Rosuvastatin Rosuvastatin | [1]  Rosuvastatin 
                
                    Rosuvastatin
                
             💬
 | [1]  HMGCR HMGCR 💬
 | [4]  AMPK signaling pathway AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬 | [11]  6 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
 | 
| 93 | Rosuvastatin 20mg | [1]  Rosuvastatin Rosuvastatin | [1]  Rosuvastatin 
                
                    Rosuvastatin
                
             💬
 | [1]  HMGCR HMGCR 💬
 | [4]  AMPK signaling pathway AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬 | [1]  79 79 💬
 | 
| 94 | ROSUVASTATIN CALCIUM | [2]  Calcium Calcium, Rosuvastatin | [1]  Rosuvastatin 
                
                    Rosuvastatin
                
             💬
 | [1]  HMGCR HMGCR 💬
 | [4]  AMPK signaling pathway AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬 | [4]  49 49, 79, 97, 299 💬
 | 
| 95 | SAR236553 | - | - | - | - | [1]  79 79 💬
 | 
| 96 | Sfingomielina | - | - | - | - | [1]  79 79 💬
 | 
| 97 | SHR-1209 | - | - | - | - | [1]  79 79 💬
 | 
| 98 | Simvastatin | [1]  Simvastatin Simvastatin | [1]  Simvastatin 
                
                    Simvastatin
                
             💬
 | [1]  HMGCR HMGCR 💬
 | [4]  AMPK signaling pathway AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬 | [21]  6 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
 | 
| 99 | Single intravenous (IV) dose of human Low Density Lipoprotein Receptor (LDLR) Gene Therapy | - | - | - | - | [1]  79 79 💬
 | 
| 100 | Sphingomyelin | - | - | - | - | [1]  79 79 💬
 | 
| 101 | Standard of Care | - | - | - | - | [8]  6 6, 13, 49, 51, 63, 64, 79, 171 💬
 | 
| 102 | Statins | - | - | - | - | [2]  46 46, 79 💬
 | 
| 103 | TAK-475 | [1]  TAK-475 TAK-475 | - | - | - | [1]  79 79 💬
 | 
| 104 | Whole genome sequencing | - | - | - | - | [3]  6 6, 79, 172 💬
 | 
| 105 | ZD4522 | - | - | - | - | [1]  79 79 💬
 |