Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1150-mg IVACAFTOR
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
2150mg IVACAFTOR
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
375-mg IVACAFTOR
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
4CF patients with a G551D mutation and treated with Ivacaftor
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
5Deuterated Ivacaftor
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
6Elexacaftor / Ivacaftor / Tezacaftor
(Kalydeco)		[3] Elexacaftor,
Ivacaftor (Kalydeco),
Tezacaftor		[3] Ivacaftor (Kalydeco),
Tezacaftor ,
Elexacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
7Elexacaftor 100 MG / Ivacaftor 75 MG / Tezacaftor 50 MG, 2 tablets each morning + Ivacaftor 150 mg one tablet each evening
(Kalydeco)		[3] Elexacaftor,
Ivacaftor (Kalydeco),
Tezacaftor		[3] Ivacaftor (Kalydeco),
Tezacaftor ,
Elexacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
8Elexacaftor-tezacaftor-ivacaftor exposure
(Kalydeco)		[3] Elexacaftor,
Ivacaftor (Kalydeco),
Tezacaftor		[3] Ivacaftor (Kalydeco),
Tezacaftor ,
Elexacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
9Elexacaftor/tezacaftor/ivacaftor
(Kalydeco)		[3] Elexacaftor,
Ivacaftor (Kalydeco),
Tezacaftor		[3] Ivacaftor (Kalydeco),
Tezacaftor ,
Elexacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
10IVACAFTOR
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
11Ivacaftor (proposed INN)
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
12Ivacaftor 125mg tablet
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
13Ivacaftor 150 mg
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
14Ivacaftor 150 mg or 250 mg
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
15Ivacaftor 25 mg/75 mg
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
16IVACAFTOR 59,5mg
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
17IVACAFTOR 59.5mg
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
18Ivacaftor 75 mg
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
19Ivacaftor 75 mg/150 mg
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
20IVACAFTOR 75mg
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
21Ivacaftor Exposed
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
22Ivacaftor or elexacaftor/tezacaftor/ivacaftor
(Kalydeco)		[3] Elexacaftor,
Ivacaftor (Kalydeco),
Tezacaftor		[3] Ivacaftor (Kalydeco),
Tezacaftor ,
Elexacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
23Ivacaftor+lumacaftor
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Lumacaftor		[2] Ivacaftor (Kalydeco),
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
24Ivacaftor/Ataluren
(Kalydeco)		[2] Ataluren,
Ivacaftor (Kalydeco)		[2] Ataluren ,
Ivacaftor (Kalydeco) 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
25Ivacaftor/Kalydeco[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
26Ivacaftor/Trikafta
(Kalydeco)		[3] Elexacaftor,
Ivacaftor (Kalydeco),
Tezacaftor		[3] Ivacaftor (Kalydeco),
Tezacaftor ,
Elexacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
27Kalydeco[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
28Kalydeco 150 mg film-c[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
29Kalydeco 150 mg film-coated tablets[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
30Kalydeco 150mg[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
31Lumacaftor / ivacaftor
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Lumacaftor		[2] Ivacaftor (Kalydeco),
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
32Lumacaftor plus Ivacaftor
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Lumacaftor		[2] Ivacaftor (Kalydeco),
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
33Lumacaftor Plus Ivacaftor Combination
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Lumacaftor		[2] Ivacaftor (Kalydeco),
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
34Lumacaftor, Ivacaftor Drug Combination
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Lumacaftor		[2] Ivacaftor (Kalydeco),
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
35Lumacaftor-ivacaftor
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Lumacaftor		[2] Ivacaftor (Kalydeco),
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
36Lumacaftor-Ivacaftor treatment
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Lumacaftor		[2] Ivacaftor (Kalydeco),
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
37Lumacaftor/Ivacaftor
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Lumacaftor		[2] Ivacaftor (Kalydeco),
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
38Lumacaftor/ivacaftor 100mg/125mg tablets
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Lumacaftor		[2] Ivacaftor (Kalydeco),
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
39Lumacaftor/ivacaftor 200mg/125mg
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Lumacaftor		[2] Ivacaftor (Kalydeco),
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
40Lumacaftor/ivacaftor 200mg/125mg tablets
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Lumacaftor		[2] Ivacaftor (Kalydeco),
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
41Lumacaftor/ivacaftor 200mg/83mg tablet
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Lumacaftor		[2] Ivacaftor (Kalydeco),
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
42Orkambi: contains lumacaftor and ivacaftor
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Lumacaftor		[2] Ivacaftor (Kalydeco),
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
43Tezacaftor/Ivacaftor
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Tezacaftor		[2] Ivacaftor (Kalydeco),
Tezacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
44Tezacaftor/Ivacaftor + Ivacaftor
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Tezacaftor		[2] Ivacaftor (Kalydeco),
Tezacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
45Tezacaftor/Ivacaftor 100mg/150mg
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Tezacaftor		[2] Ivacaftor (Kalydeco),
Tezacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
46Tezacaftor/Ivacaftor/100mg/150mg
(Kalydeco)		[2] Ivacaftor (Kalydeco),
Tezacaftor		[2] Ivacaftor (Kalydeco),
Tezacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
47Treatment with cystic fibrosis transmembrane regulator (CFTR) modualtors Ivacaftor, Lumacaftor-Ivacaftor, Tezacaftor-Ivacaftor, Elexacaftor-Tezacaftor-Ivacaftor
(Kalydeco)		[4] Elexacaftor,
Ivacaftor (Kalydeco),
Lumacaftor,
Tezacaftor		[4] Ivacaftor (Kalydeco),
Lumacaftor ,
Tezacaftor ,
Elexacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
48VX-659/Tezacaftor/Ivacaftor
(Kalydeco)		[3] Ivacaftor (Kalydeco),
Tezacaftor,
VX-659		[2] Ivacaftor (Kalydeco),
Tezacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
49VX-661 Plus Ivacaftor Combination
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
50VX-661/Ivacaftor
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
51VX-661/ivacaftor (VX-770) 100mg/150 mg
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
52VX-661/ivacaftor 100 mg/ 150 mg
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
53VX-661/ivacaftor 100mg/150 mg
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
54VX-661/ivacaftor 100mg/150mg
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
55VX-661/ivacaftor 50 mg/ 75 mg
(Kalydeco)		[1] Ivacaftor (Kalydeco)[1] Ivacaftor (Kalydeco) 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬