Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1ACT-064992 (macitentan)
(Opsumit)		[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 85 💬
2ERA and PDE-5I (Sildenafil, Tadalafil, Bosentan, Macitentan)
(Opsumit)		[4] Bosentan,
Macitentan (Opsumit),
Sildenafil,
Tadalafil		[5] Bosentan ,
Tadalafil ,
Bosentan ,
Sildenafil ,
Macitentan (Opsumit) 💬 		[3] EDNRA,
EDNRB,
PDE5A 💬 		[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
3FDC macitentan/tadalafil
(Opsumit)		[2] Macitentan (Opsumit),
Tadalafil		[2] Tadalafil ,
Macitentan (Opsumit) 💬 		[3] EDNRA,
EDNRB,
PDE5A 💬 		[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
4MACITENTAN
(Opsumit)		[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 51, 85, 86, 88, 210 💬
5Macitentan (ACT-064992)
(Opsumit)		[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
6Macitentan 10 mg
(Opsumit)		[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 51, 86, 88 💬
7Macitentan 10 mg tablet, once daily.
(Opsumit)		[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
8Macitentan 10mg
(Opsumit)		[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 51, 88 💬
9Macitentan 3 mg
(Opsumit)		[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 51 💬
10Macitentan 37.5 mg
(Opsumit)		[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
11Macitentan 3mg
(Opsumit)		[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 51 💬
12Macitentan 75 mg
(Opsumit)		[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
13MACITENTAN COMPRESSE
(Opsumit)		[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 86, 88 💬
14Macitentan Group
(Opsumit)		[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
15MACITENTAN TABLETS
(Opsumit)		[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 86, 88 💬
16Observational study with patients treated with Tracleer, Ventavis, Veletri, Opsumit and/or Uptravi[4] Epoprostenol,
Iloprost,
Macitentan (Opsumit),
Selexipag		[4] Epoprostenol ,
Iloprost ,
Selexipag ,
Macitentan (Opsumit) 💬 		[3] EDNRA,
EDNRB,
PTGIR 💬 		[10] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Platelet activation, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
17Opsumit[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 86, 88, 210 💬
18Opsumit (macitentan)[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
19Opsumit 10 Mg Tablet----[1] 51 💬
20Opsumit®[1] Macitentan (Opsumit)[1] Macitentan (Opsumit) 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 86, 88, 210 💬