Drug Description in Trials / DrugBank / KEGG DRUG

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No.

Drug (Description in trials)

DrugBank

KEGG DRUG

KEGG GENES

KEGG PATHWAY

Disease ID

1

(RS)-baclofen
(D00241)

[1] Baclofen (D00241) 💬

[2] GABBR1,
GABBR2 💬

[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬

[1] 10 💬

2

(RS)-baclofen, naltrexone hydrochloride and D-sorbitol
(D00241)

[3] Baclofen,
Naltrexone,
Sorbitol

[3] Sorbitol solution ,
Baclofen (D00241),
Naltrexone 💬

Name	Other Names
Sorbitol solution	Sorbitol solution (USP) D-Sorbitol (JP18) Sorbitol (NF) Sorbitol 3% in plastic container (TN)
Baclofen	Baclofen (JP18/USP/INN) Kemstro (TN) Lioresal (TN) FLEQSUVY GABLOFEN LYVISPAH OZOBAX
Naltrexone	Naltrexone (USAN/INN) Vivitrol (TN)

[5] GABBR1,
GABBR2,
OPRD1,
OPRK1,
OPRM1 💬

Name	Full Name
GABBR1	gamma-aminobutyric acid type B receptor subunit 1
GABBR2	gamma-aminobutyric acid type B receptor subunit 2
OPRD1	opioid receptor delta 1
OPRK1	opioid receptor kappa 1
OPRM1	opioid receptor mu 1

[9] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, Taste transduction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬

[1] 10 💬

3

AERT, (R)-Baclofen
(D00241)

[1] Baclofen (D00241) 💬

[2] GABBR1,
GABBR2 💬

[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬

[1] 13 💬

4

BACLOFEN
(D00241)

[1] Baclofen (D00241) 💬

[2] GABBR1,
GABBR2 💬

[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬

[8] 2, 10, 13, 18, 65, 70, 149, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
10	Charcot-Marie-Tooth disease
13	Multiple sclerosis/Neuromyelitis optica
18	Spinocerebellar degeneration
65	Primary immunodeficiency
70	Spinal stenosis
149	Hemiconvulsion hemiplegia epilepsy syndrome
206	Fragile X syndrome

5

Baclofen (baclofen Tab. 10mg) treatment
(D00241)

[1] Baclofen (D00241) 💬

[2] GABBR1,
GABBR2 💬

[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬

[1] 70 💬

6

Baclofen 20 mg
(D00241)

[1] Baclofen (D00241) 💬

[2] GABBR1,
GABBR2 💬

[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬

[1] 13 💬

7

Baclofen ER Capsules (GRS) 10 mg
(D00241)

[1] Baclofen (D00241) 💬

[2] GABBR1,
GABBR2 💬

[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬

[1] 13 💬

8

Baclofen ER Capsules (GRS) 20 mg
(D00241)

[1] Baclofen (D00241) 💬

[2] GABBR1,
GABBR2 💬

[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬

[1] 13 💬

9

Baclofen ER Capsules (GRS) 30mg
(D00241)

[1] Baclofen (D00241) 💬

[2] GABBR1,
GABBR2 💬

[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬

[1] 13 💬

10

Baclofen ER Capsules (GRS) 40mg
(D00241)

[1] Baclofen (D00241) 💬

[2] GABBR1,
GABBR2 💬

[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬

[1] 13 💬

11

Baclofen ER Capsules (GRS) 50 mg
(D00241)

[1] Baclofen (D00241) 💬

[2] GABBR1,
GABBR2 💬

[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬

[1] 13 💬

12

Baclofen IR
(D00241)

[1] Baclofen (D00241) 💬

[2] GABBR1,
GABBR2 💬

[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬

[1] 13 💬

13

Baclofen Tablets USP
(D00241)

[1] Baclofen (D00241) 💬

[2] GABBR1,
GABBR2 💬

[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬

[1] 13 💬

14

Baclofen Tablets USP 10 mg
(D00241)

[1] Baclofen (D00241) 💬

[2] GABBR1,
GABBR2 💬

[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬

[1] 13 💬

15

Encapsulated Baclofen 20 mg
(D00241)

[1] Baclofen (D00241) 💬

[2] GABBR1,
GABBR2 💬

[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬

[1] 13 💬

16

RS-BACLOFEN
(D00241)

[1] Baclofen (D00241) 💬

[2] GABBR1,
GABBR2 💬

[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬

[1] 10 💬