DR info

Clinical trials : 112 / Drugs : 71 - (DrugBank : 19) / Drug target genes : 35 - Drug target pathways : 118

Tuberous sclerosis and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
158	Tuberous sclerosis	-
6	Parkinson disease	35.000
46	Malignant rheumatoid arthritis	31.451
13	Multiple sclerosis/Neuromyelitis optica	31.348
96	Crohn disease	28.111
97	Ulcerative colitis	25.037
2	Amyotrophic lateral sclerosis	24.867
36	Epidermolysis bullosa	21.501
22	Moyamoya disease	18.900
206	Fragile X syndrome	18.473
298	Hereditary pancreatitis	17.220
5	Progressive supranuclear palsy	16.594
145	West syndrome	16.426
152	PCDH19 related syndrome	16.000
34	Neurofibromatosis	15.895
70	Spinal stenosis	15.273
296	Biliary atresia	15.238
231	Alpha-1-antitrypsin deficiency	15.029
193	Prader-Willi syndrome	14.790
3	Spinal muscular atrophy	14.663
17	Multiple system atrophy	14.239
201	Angelman syndrome	13.631
8	Huntington disease	13.469
98	Eosinophilic gastrointestinal disease	13.095
75	Cushing disease	12.976
205	Fragile X syndrome related disease	12.873
18	Spinocerebellar degeneration	12.754
272	Fibrodysplasia ossificans progressiva	12.659
21	Mitochondrial disease	12.605
140	Dorabe syndrome	12.536
144	Lennox-Gastaut syndrome	12.469
156	Rett syndrome	12.458
84	Sarcoidosis	12.327
155	Acquired aphasia with convulsive disorder	12.106
299	Cystic fibrosis	5.935
49	Systemic lupus erythematosus	5.760
113	Muscular dystrophy	5.718
65	Primary immunodeficiency	5.166
302	Leber hereditary optic neuropathy	5.000
157	Sturge-Weber syndrome	5.000
226	Interstitial cystitis with Hunners ulcer	4.754
11	Myasthenia gravis	4.444
151	Rasmussen encephalitis	4.286
51	Scleroderma	4.191
222	Primary nephrotic syndrome	4.028
227	Osler disease	3.975
60	Aplastic anemia	3.747
85	Idiopathic interstitial pneumonia	3.579
58	Hypertrophic cardiomyopathy	3.568
285	Fanconi anemia	3.474
95	Autoimmune hepatitis	3.463
286	Hereditary sideroblastic anemia	3.393
228	Bronchiolitis obliterans	3.325
278	Huge lymphatic malformation with cervicofacial lesion	3.291
66	IgA nephropathy	3.239
326	Osteopetrosis	2.893
107	Juvenile idiopathic arthritis	2.778
283	Acquired pure red cell aplasia	2.686
160	Congenital ichthyosis	2.686
39	Toxic epidermal necrolysis	2.662
162	Pemphigoid	2.588
28	Systemic amyloidosis	2.577
55	Relapsing polychondritis	2.500
234	Peroxisomal disease (except Adrenoleukodystrophy)	2.500
56	Behcet disease	2.489
62	Paroxysmal nocturnal hemoglobinuria	2.449
20	Adrenoleukodystrophy	2.384
86	Pulmonary arterial hypertension	2.322
63	Idiopathic thrombocytopenic purpura	2.271
274	Osteogenesis Imperfecta	2.245
61	Autoimmune hemolytic anemia	2.222
50	Dermatomyositis	2.217
38	Stevens-Johnson syndrome	2.143
269	Pyogenic arthritis	2.143
224	Purpura nephritis	2.143
53	Sjogren syndrome	2.113
64	Thrombotic thrombocytopenic purpura	2.054
77	Growth hormone secreting pituitary adenoma	2.000
337	Homocystinuria	2.000
19	Lysosomal storage disease	1.968
41	Giant cell arteritis	1.932
164	Oculocutaneous albinism	1.906
45	Eosinophilic granulomatosis with Polyangiitis	1.905
93	Primary biliary cholangitis	1.881
26	HTLV-1-associated myelopathy	1.814
271	Ankylosing spondylitis	1.756
284	Diamond-Blackfan anemia	1.688
90	Retinitis pigmentosa	1.637
40	Takayasu arteritis	1.571
42	Polyarteritis nodosa	1.538
89	Lymphangioleiomyomatosis	1.508
225	Congenital nephrogenic diabetes insipidus	1.429
256	Muscle glycogenosis	1.406
67	Polycystic kidney disease	1.278
127	Frontotemporal lobar degeneration	1.250
169	Menkes disease	1.171
170	Occipital horn syndrome	1.171
167	Marfan syndrome	1.080
251	Urea cycle disorder	1.057
233	Wolfram syndrome	1.005
192	Cockayne syndrome	1.000
277	Lymphangiomatosis	1.000
281	Klippel-Trenaunay-Weber syndrome	1.000
111	Congenital myopathy	1.000
137	Focal cortical dysplasia	1.000