DR info

Clinical trials : 645 / Drugs : 589 - (DrugBank : 163) / Drug target genes : 150 - Drug target pathways : 225

Amyotrophic lateral sclerosis and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
2	Amyotrophic lateral sclerosis	-
13	Multiple sclerosis/Neuromyelitis optica	116.536
6	Parkinson disease	85.629
96	Crohn disease	75.223
46	Malignant rheumatoid arthritis	69.225
156	Rett syndrome	60.189
8	Huntington disease	53.019
5	Progressive supranuclear palsy	52.309
97	Ulcerative colitis	51.216
206	Fragile X syndrome	42.572
17	Multiple system atrophy	42.107
3	Spinal muscular atrophy	38.440
140	Dorabe syndrome	38.032
21	Mitochondrial disease	37.014
144	Lennox-Gastaut syndrome	35.902
65	Primary immunodeficiency	34.238
34	Neurofibromatosis	32.488
70	Spinal stenosis	30.457
18	Spinocerebellar degeneration	30.307
85	Idiopathic interstitial pneumonia	29.059
193	Prader-Willi syndrome	27.628
226	Interstitial cystitis with Hunners ulcer	27.220
36	Epidermolysis bullosa	27.035
49	Systemic lupus erythematosus	26.925
299	Cystic fibrosis	25.195
113	Muscular dystrophy	24.903
158	Tuberous sclerosis	24.867
26	HTLV-1-associated myelopathy	24.786
51	Scleroderma	24.006
86	Pulmonary arterial hypertension	23.588
145	West syndrome	23.417
98	Eosinophilic gastrointestinal disease	23.355
22	Moyamoya disease	22.711
201	Angelman syndrome	22.000
205	Fragile X syndrome related disease	21.406
127	Frontotemporal lobar degeneration	20.967
28	Systemic amyloidosis	20.774
231	Alpha-1-antitrypsin deficiency	20.325
84	Sarcoidosis	20.032
78	Hypopituitarism	18.206
298	Hereditary pancreatitis	18.082
107	Juvenile idiopathic arthritis	17.181
56	Behcet disease	17.116
152	PCDH19 related syndrome	16.000
42	Polyarteritis nodosa	15.921
296	Biliary atresia	15.504
331	Idiopathic multicentric castleman disease	15.053
90	Retinitis pigmentosa	14.535
63	Idiopathic thrombocytopenic purpura	14.363
75	Cushing disease	14.151
203	22q11.2 deletion syndrome	14.000
53	Sjogren syndrome	13.346
222	Primary nephrotic syndrome	13.337
272	Fibrodysplasia ossificans progressiva	13.041
4	Primary lateral sclerosis	12.118
38	Stevens-Johnson syndrome	11.398
62	Paroxysmal nocturnal hemoglobinuria	11.088
58	Hypertrophic cardiomyopathy	10.630
254	Porphyria	10.616
265	Lipodystrophy	10.419
266	Familial mediterranean fever	10.405
11	Myasthenia gravis	10.181
149	Hemiconvulsion hemiplegia epilepsy syndrome	10.172
93	Primary biliary cholangitis	10.172
256	Muscle glycogenosis	10.081
1	Spinal and bulbar muscular atrophy	10.000
283	Acquired pure red cell aplasia	9.662
155	Acquired aphasia with convulsive disorder	9.495
50	Dermatomyositis	8.789
210	Single Ventricle	8.744
162	Pemphigoid	8.524
164	Oculocutaneous albinism	8.317
215	Tetralogy of Fallot	8.279
285	Fanconi anemia	8.154
66	IgA nephropathy	8.122
35	Pemphigus	8.084
95	Autoimmune hepatitis	7.887
89	Lymphangioleiomyomatosis	7.808
39	Toxic epidermal necrolysis	7.449
233	Wolfram syndrome	7.449
19	Lysosomal storage disease	7.449
280	Huge arteriovenous malformation with cervicofacial or limb lesion	7.309
61	Autoimmune hemolytic anemia	7.232
7	Corticobasal degeneration	7.152
60	Aplastic anemia	7.017
102	Rubinstein-Taybi syndrome	7.000
284	Diamond-Blackfan anemia	6.926
20	Adrenoleukodystrophy	6.926
224	Purpura nephritis	6.860
236	Pseudohypoparathyroidism	6.367
118	Myelomeningocele	6.161
151	Rasmussen encephalitis	6.000
45	Eosinophilic granulomatosis with Polyangiitis	5.814
228	Bronchiolitis obliterans	5.717
169	Menkes disease	5.508
170	Occipital horn syndrome	5.508
74	Prolactin secreting pituitary adenoma	5.269
302	Leber hereditary optic neuropathy	5.000
294	Congenital diaphragmatic hernia	5.000
10	Charcot-Marie-Tooth disease	4.558
269	Pyogenic arthritis	4.440
55	Relapsing polychondritis	4.202
234	Peroxisomal disease (except Adrenoleukodystrophy)	4.202
83	Addison disease	4.191
76	Pituitary gonadotropin secretion hyperthyroidism	4.191
64	Thrombotic thrombocytopenic purpura	4.186
41	Giant cell arteritis	4.136
271	Ankylosing spondylitis	4.104
168	Ehlers-Danlos syndrome	4.070
57	Idiopathic dilated cardiomyopathy	4.070
309	Progressive myoclonus epilepsy	4.000
246	Methylmalonic acidemia	3.962
227	Osler disease	3.808
160	Congenital ichthyosis	3.762
94	Primary sclerosing cholangitis	3.584
40	Takayasu arteritis	3.541
300	IgG4-related disease	3.419
15	Inclusion body myositis	3.368
157	Sturge-Weber syndrome	3.219
286	Hereditary sideroblastic anemia	3.180
81	Congenital adrenal hyperplasia	3.105
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion	3.000
187	Kabuki syndrome	3.000
323	Aromatic L-amino acid decarboxylase deficiency	3.000
288	Autoimmune acquired coagulation factor deficiency	2.896
43	Microscopic polyangiitis	2.691
274	Osteogenesis Imperfecta	2.691
67	Polycystic kidney disease	2.491
71	Idiopathic osteonecrosis of the femoral head	2.263
212	Tricuspid atresia	2.047
77	Growth hormone secreting pituitary adenoma	2.000
282	Congenital dyserythropoietic anemia	2.000
307	Canavan disease	2.000
278	Huge lymphatic malformation with cervicofacial lesion	1.821
16	Crow-Fukase syndrome	1.821
211	Hypoplastic left heart syndrome	1.821
326	Osteopetrosis	1.662
47	Buerger disease	1.526
114	Non-dystrophic myotonia syndrome	1.494
14	Chronic inflammatory demyelinating polyneuropathy	1.395
225	Congenital nephrogenic diabetes insipidus	1.367
37	Generalised pustular psoriasis	1.359
44	Wegener granulomatosis	1.301
301	Macular dystrophy	1.035
179	Williams syndrome	1.035
87	Pulmonary veno-occlusive disease	1.012
106	Cryopyrin-associated periodic syndrome	1.012
251	Urea cycle disorder	1.012
137	Focal cortical dysplasia	1.000
192	Cockayne syndrome	1.000
277	Lymphangiomatosis	1.000
281	Klippel-Trenaunay-Weber syndrome	1.000
111	Congenital myopathy	1.000
54	Adult still disease	1.000
191	Werner syndrome	1.000
220	Rapidly progressive glomerulonephritis	1.000
30	Distal myopathy	1.000